8APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 95
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
340
structure length
340
Chain Sequence
DHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Proteinase inhibitor
molecule keywords ALPHA-1 ANTITRYPSIN (CHAIN A)
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
total genus 95
structure length 340
sequence length 340
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 8apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 8apiA02
2WY0C 4P0FA 4AU2A 2VH4A 1PSIA 4AU3A 3F1SA 1ATHA 1OC0A 4IF8A 2R9YA 4AFXA 2ARRA 4AJUA 4ROBA 4ZK0A 1DVMA 4EB1L 1OVAC 1QMBA 3PZFA 2RIVA 3ZHAA 9APIA 1JVQI 1LJ5A 1DZGI 1OYHL 3FGQA 2PEEA 3CWMA 1TB6I 3R4LA 1C5GA 1QMNA 2ZV6A 3B9FI 4DY0A 3NDFA 1JMOA 1MTPA 2WXXA 2WY1A 2WXZC 1IZ2A 1WZ9A 1OVAA 7APIA 2CEOA 1K9OI 2QUGA 4RO9A 3EOXA 2ACHA 4G8RA 4KDSA 3F02A 1HP7A 5CE0A 1IMVA 1AZXI 2RIWA 4ZK3A 1SEKA 1JJOC 4X30A 4R9IA 1BR8I 2B5TI 2ANTI 2WXZA 1DZGL 2VDYA 1ATUA 2H4PA 2XN5A 3LE2A 1OVAB 1KCTA 3T1PA 1A7CA 2H4RA 1JMJA 1OPHA 3OZQA 2D26A 1E04I 1E03I 4P0OA 1OO8A 4IC0A 2V95A 1JRRA 2BEHI 4GA7A 1AS4A 3CWLA 2WXWA 2XN3A 1DVNA 3LW2A 5C98A 2OL2A 2OAYA 2ZNHA 3EVJI 3DRMA 4DTEA 5HGCA 8APIA 2B4XI 1DZHI 1SR5A 5CDXA 2XN6A 3Q02A 5EI0A 4YIAA 1LQ8A 2GD4C 1SNGA 4PYWA 1NQ9I 5BRRI 4Y40A 3DY0A 5CDZA 1EZXA 3VVJA 1HLEA 1T1FA 3UT3A 4G8OA 3DLWA 1JTIA 2PEFA 4AU4A 3H5CA 4BB2A 2BEHL 1D5SA 1F0CA 3PB1I 5INWA 4DY7C 1R1LI 5IO1A 1ATTA 1XQGA 4Y3KA 3NE4A 2VDXA 2HIJL 4AJTA 4ROAA 3CAAA 4RSQA 2B4XL 1DZHL 2HIJI 2XN7A 1LK6I 3NDAA 4AQHA 4CAAA 1ANTI 2WXYC 9PAIA 1M93B 1E05I 3F5NA 3Q03A 1B3KA 3KCGI 2HI9A 3NDDA 4EB1I 2DUTA 1DB2A 1YXAA 1C8OA 1XU8A 4AU3B 2H4QA 4C49A 3DRUA 1OYHI 1XQJA 2ARQA 3CVMA 1QLPA 4C41A 1BY7A 3STOA 1UHGA
chains in the Genus database with same CATH superfamily
2WY0C 4P0FA 4AU2A 2VH4A 1PSIA 4AU3A 3F1SA 1ATHA 1OC0A 4IF8A 2R9YA 4AFXA 2ARRA 4AJUA 4ROBA 4ZK0A 1DVMA 4EB1L 1OVAC 1QMBA 3PZFA 2RIVA 3ZHAA 9APIA 1JVQI 1LJ5A 1DZGI 1OYHL 3FGQA 2PEEA 3CWMA 1TB6I 3R4LA 1C5GA 1QMNA 2ZV6A 3B9FI 4DY0A 3NDFA 1JMOA 1MTPA 2WXXA 2WY1A 2WXZC 1IZ2A 1WZ9A 1OVAA 7APIA 2CEOA 1K9OI 2QUGA 4RO9A 3EOXA 2ACHA 4G8RA 4KDSA 3F02A 1HP7A 5CE0A 1IMVA 1AZXI 2RIWA 4ZK3A 1SEKA 1JJOC 4X30A 4R9IA 1BR8I 2B5TI 2ANTI 2WXZA 1DZGL 2VDYA 1ATUA 2H4PA 2XN5A 3LE2A 1OVAB 1KCTA 3T1PA 1A7CA 2H4RA 1JMJA 1OPHA 3OZQA 2D26A 1E04I 1E03I 4P0OA 1OO8A 4IC0A 2V95A 1JRRA 2BEHI 4GA7A 1AS4A 3CWLA 2WXWA 2XN3A 1DVNA 3LW2A 5C98A 2OL2A 2OAYA 2ZNHA 3EVJI 3DRMA 4DTEA 5HGCA 8APIA 2B4XI 1DZHI 1SR5A 5CDXA 2XN6A 3Q02A 5EI0A 4YIAA 1LQ8A 2GD4C 1SNGA 4PYWA 1NQ9I 5BRRI 4Y40A 3DY0A 5CDZA 1EZXA 3VVJA 1HLEA 1T1FA 3UT3A 4G8OA 3DLWA 1JTIA 2PEFA 4AU4A 3H5CA 4BB2A 2BEHL 1D5SA 1F0CA 3PB1I 5INWA 4DY7C 1R1LI 5IO1A 1ATTA 1XQGA 4Y3KA 3NE4A 2VDXA 2HIJL 4AJTA 4ROAA 3CAAA 4RSQA 2B4XL 1DZHL 2HIJI 2XN7A 1LK6I 3NDAA 4AQHA 4CAAA 1ANTI 2WXYC 9PAIA 1M93B 1E05I 3F5NA 3Q03A 1B3KA 3KCGI 2HI9A 3NDDA 4EB1I 2DUTA 1DB2A 1YXAA 1C8OA 1XU8A 4AU3B 2H4QA 4C49A 3DRUA 1OYHI 1XQJA 2ARQA 3CVMA 1QLPA 4C41A 1BY7A 3STOA 1UHGA
chains in the Genus database with same CATH topology
2WY0C 4P0FA 4AU2A 2VH4A 1PSIA 4AU3A 3F1SA 1ATHA 1OC0A 4IF8A 2R9YA 4AFXA 2ARRA 4AJUA 4ROBA 4ZK0A 1DVMA 4EB1L 1OVAC 1QMBA 3PZFA 2RIVA 3ZHAA 9APIA 1JVQI 1LJ5A 1DZGI 1OYHL 3FGQA 2PEEA 3CWMA 1TB6I 3R4LA 1C5GA 1QMNA 2ZV6A 3B9FI 4DY0A 3NDFA 1JMOA 1MTPA 2WXXA 2WY1A 2WXZC 1IZ2A 1WZ9A 1OVAA 7APIA 2CEOA 1K9OI 2QUGA 4RO9A 3EOXA 2ACHA 4G8RA 4KDSA 3F02A 1HP7A 5CE0A 1IMVA 1AZXI 2RIWA 4ZK3A 1SEKA 1JJOC 4X30A 4R9IA 1BR8I 2B5TI 2ANTI 2WXZA 1DZGL 2VDYA 1ATUA 2H4PA 2XN5A 3LE2A 1OVAB 1KCTA 3T1PA 1A7CA 2H4RA 1JMJA 1OPHA 3OZQA 2D26A 1E04I 1E03I 4P0OA 1OO8A 4IC0A 2V95A 1JRRA 2BEHI 4GA7A 1AS4A 3CWLA 2WXWA 2XN3A 1DVNA 3LW2A 5C98A 2OL2A 2OAYA 2ZNHA 3EVJI 3DRMA 4DTEA 5HGCA 8APIA 2B4XI 1DZHI 1SR5A 5CDXA 2XN6A 3Q02A 5EI0A 4YIAA 1LQ8A 2GD4C 1SNGA 4PYWA 1NQ9I 5BRRI 4Y40A 3DY0A 5CDZA 1EZXA 3VVJA 1HLEA 1T1FA 3UT3A 4G8OA 3DLWA 1JTIA 2PEFA 4AU4A 3H5CA 4BB2A 2BEHL 1D5SA 1F0CA 3PB1I 5INWA 4DY7C 1R1LI 5IO1A 1ATTA 1XQGA 4Y3KA 3NE4A 2VDXA 2HIJL 4AJTA 4ROAA 3CAAA 4RSQA 2B4XL 1DZHL 2HIJI 2XN7A 1LK6I 3NDAA 4AQHA 4CAAA 1ANTI 2WXYC 9PAIA 1M93B 1E05I 3F5NA 3Q03A 1B3KA 3KCGI 2HI9A 3NDDA 4EB1I 2DUTA 1DB2A 1YXAA 1C8OA 1XU8A 4AU3B 2H4QA 4C49A 3DRUA 1OYHI 1XQJA 2ARQA 3CVMA 1QLPA 4C41A 1BY7A 3STOA 1UHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WY0 C;  4P0F A;  4AU2 A;  2VH4 A;  1PSI A;  4AU3 A;  3F1S A;  1ATH A;  1OC0 A;  4IF8 A;  2R9Y A;  4AFX A;  2ARR A;  4AJU A;  4ROB A;  4ZK0 A;  1DVM A;  4EB1 L;  1OVA C;  1QMB A;  3PZF A;  2RIV A;  3ZHA A;  9API A;  1JVQ I;  1LJ5 A;  1DZG I;  1OYH L;  3FGQ A;  2PEE A;  3CWM A;  1TB6 I;  3R4L A;  1C5G A;  1QMN A;  2ZV6 A;  3B9F I;  4DY0 A;  3NDF A;  1JMO A;  1MTP A;  2WXX A;  2WY1 A;  2WXZ C;  1IZ2 A;  1WZ9 A;  1OVA A;  7API A;  2CEO A;  1K9O I;  2QUG A;  4RO9 A;  3EOX A;  2ACH A;  4G8R A;  4KDS A;  3F02 A;  1HP7 A;  5CE0 A;  1IMV A;  1AZX I;  2RIW A;  4ZK3 A;  1SEK A;  1JJO C;  4X30 A;  4R9I A;  1BR8 I;  2B5T I;  2ANT I;  2WXZ A;  1DZG L;  2VDY A;  1ATU A;  2H4P A;  2XN5 A;  3LE2 A;  1OVA B;  1KCT A;  3T1P A;  1A7C A;  2H4R A;  1JMJ A;  1OPH A;  3OZQ A;  2D26 A;  1E04 I;  1E03 I;  4P0O A;  1OO8 A;  4IC0 A;  2V95 A;  1JRR A;  2BEH I;  4GA7 A;  1AS4 A;  3CWL A;  2WXW A;  2XN3 A;  1DVN A;  3LW2 A;  5C98 A;  2OL2 A;  2OAY A;  2ZNH A;  3EVJ I;  3DRM A;  4DTE A;  5HGC A;  8API A;  2B4X I;  1DZH I;  1SR5 A;  5CDX A;  2XN6 A;  3Q02 A;  5EI0 A;  4YIA A;  1LQ8 A;  2GD4 C;  1SNG A;  4PYW A;  1NQ9 I;  5BRR I;  4Y40 A;  3DY0 A;  5CDZ A;  1EZX A;  3VVJ A;  1HLE A;  1T1F A;  3UT3 A;  4G8O A;  3DLW A;  1JTI A;  2PEF A;  4AU4 A;  3H5C A;  4BB2 A;  2BEH L;  1D5S A;  1F0C A;  3PB1 I;  5INW A;  4DY7 C;  1R1L I;  5IO1 A;  1ATT A;  1XQG A;  4Y3K A;  3NE4 A;  2VDX A;  2HIJ L;  4AJT A;  4ROA A;  3CAA A;  4RSQ A;  2B4X L;  1DZH L;  2HIJ I;  2XN7 A;  1LK6 I;  3NDA A;  4AQH A;  4CAA A;  1ANT I;  2WXY C;  9PAI A;  1M93 B;  1E05 I;  3F5N A;  3Q03 A;  1B3K A;  3KCG I;  2HI9 A;  3NDD A;  4EB1 I;  2DUT A;  1DB2 A;  1YXA A;  1C8O A;  1XU8 A;  4AU3 B;  2H4Q A;  4C49 A;  3DRU A;  1OYH I;  1XQJ A;  2ARQ A;  3CVM A;  1QLP A;  4C41 A;  1BY7 A;  3STO A;  1UHG A; 
#chains in the Genus database with same CATH topology
 2WY0 C;  4P0F A;  4AU2 A;  2VH4 A;  1PSI A;  4AU3 A;  3F1S A;  1ATH A;  1OC0 A;  4IF8 A;  2R9Y A;  4AFX A;  2ARR A;  4AJU A;  4ROB A;  4ZK0 A;  1DVM A;  4EB1 L;  1OVA C;  1QMB A;  3PZF A;  2RIV A;  3ZHA A;  9API A;  1JVQ I;  1LJ5 A;  1DZG I;  1OYH L;  3FGQ A;  2PEE A;  3CWM A;  1TB6 I;  3R4L A;  1C5G A;  1QMN A;  2ZV6 A;  3B9F I;  4DY0 A;  3NDF A;  1JMO A;  1MTP A;  2WXX A;  2WY1 A;  2WXZ C;  1IZ2 A;  1WZ9 A;  1OVA A;  7API A;  2CEO A;  1K9O I;  2QUG A;  4RO9 A;  3EOX A;  2ACH A;  4G8R A;  4KDS A;  3F02 A;  1HP7 A;  5CE0 A;  1IMV A;  1AZX I;  2RIW A;  4ZK3 A;  1SEK A;  1JJO C;  4X30 A;  4R9I A;  1BR8 I;  2B5T I;  2ANT I;  2WXZ A;  1DZG L;  2VDY A;  1ATU A;  2H4P A;  2XN5 A;  3LE2 A;  1OVA B;  1KCT A;  3T1P A;  1A7C A;  2H4R A;  1JMJ A;  1OPH A;  3OZQ A;  2D26 A;  1E04 I;  1E03 I;  4P0O A;  1OO8 A;  4IC0 A;  2V95 A;  1JRR A;  2BEH I;  4GA7 A;  1AS4 A;  3CWL A;  2WXW A;  2XN3 A;  1DVN A;  3LW2 A;  5C98 A;  2OL2 A;  2OAY A;  2ZNH A;  3EVJ I;  3DRM A;  4DTE A;  5HGC A;  8API A;  2B4X I;  1DZH I;  1SR5 A;  5CDX A;  2XN6 A;  3Q02 A;  5EI0 A;  4YIA A;  1LQ8 A;  2GD4 C;  1SNG A;  4PYW A;  1NQ9 I;  5BRR I;  4Y40 A;  3DY0 A;  5CDZ A;  1EZX A;  3VVJ A;  1HLE A;  1T1F A;  3UT3 A;  4G8O A;  3DLW A;  1JTI A;  2PEF A;  4AU4 A;  3H5C A;  4BB2 A;  2BEH L;  1D5S A;  1F0C A;  3PB1 I;  5INW A;  4DY7 C;  1R1L I;  5IO1 A;  1ATT A;  1XQG A;  4Y3K A;  3NE4 A;  2VDX A;  2HIJ L;  4AJT A;  4ROA A;  3CAA A;  4RSQ A;  2B4X L;  1DZH L;  2HIJ I;  2XN7 A;  1LK6 I;  3NDA A;  4AQH A;  4CAA A;  1ANT I;  2WXY C;  9PAI A;  1M93 B;  1E05 I;  3F5N A;  3Q03 A;  1B3K A;  3KCG I;  2HI9 A;  3NDD A;  4EB1 I;  2DUT A;  1DB2 A;  1YXA A;  1C8O A;  1XU8 A;  4AU3 B;  2H4Q A;  4C49 A;  3DRU A;  1OYH I;  1XQJ A;  2ARQ A;  3CVM A;  1QLP A;  4C41 A;  1BY7 A;  3STO A;  1UHG A; 
#chains in the Genus database with same CATH homology
 2WY0 C;  4P0F A;  4AU2 A;  2VH4 A;  1PSI A;  4AU3 A;  3F1S A;  1ATH A;  1OC0 A;  4IF8 A;  2R9Y A;  4AFX A;  2ARR A;  4AJU A;  4ROB A;  4ZK0 A;  1DVM A;  4EB1 L;  1OVA C;  1QMB A;  3PZF A;  2RIV A;  3ZHA A;  9API A;  1JVQ I;  1LJ5 A;  1DZG I;  1OYH L;  3FGQ A;  2PEE A;  3CWM A;  1TB6 I;  3R4L A;  1C5G A;  1QMN A;  2ZV6 A;  3B9F I;  4DY0 A;  3NDF A;  1JMO A;  1MTP A;  2WXX A;  2WY1 A;  2WXZ C;  1IZ2 A;  1WZ9 A;  1OVA A;  7API A;  2CEO A;  1K9O I;  2QUG A;  4RO9 A;  3EOX A;  2ACH A;  4G8R A;  4KDS A;  3F02 A;  1HP7 A;  5CE0 A;  1IMV A;  1AZX I;  2RIW A;  4ZK3 A;  1SEK A;  1JJO C;  4X30 A;  4R9I A;  1BR8 I;  2B5T I;  2ANT I;  2WXZ A;  1DZG L;  2VDY A;  1ATU A;  2H4P A;  2XN5 A;  3LE2 A;  1OVA B;  1KCT A;  3T1P A;  1A7C A;  2H4R A;  1JMJ A;  1OPH A;  3OZQ A;  2D26 A;  1E04 I;  1E03 I;  4P0O A;  1OO8 A;  4IC0 A;  2V95 A;  1JRR A;  2BEH I;  4GA7 A;  1AS4 A;  3CWL A;  2WXW A;  2XN3 A;  1DVN A;  3LW2 A;  5C98 A;  2OL2 A;  2OAY A;  2ZNH A;  3EVJ I;  3DRM A;  4DTE A;  5HGC A;  8API A;  2B4X I;  1DZH I;  1SR5 A;  5CDX A;  2XN6 A;  3Q02 A;  5EI0 A;  4YIA A;  1LQ8 A;  2GD4 C;  1SNG A;  4PYW A;  1NQ9 I;  5BRR I;  4Y40 A;  3DY0 A;  5CDZ A;  1EZX A;  3VVJ A;  1HLE A;  1T1F A;  3UT3 A;  4G8O A;  3DLW A;  1JTI A;  2PEF A;  4AU4 A;  3H5C A;  4BB2 A;  2BEH L;  1D5S A;  1F0C A;  3PB1 I;  5INW A;  4DY7 C;  1R1L I;  5IO1 A;  1ATT A;  1XQG A;  4Y3K A;  3NE4 A;  2VDX A;  2HIJ L;  4AJT A;  4ROA A;  3CAA A;  4RSQ A;  2B4X L;  1DZH L;  2HIJ I;  2XN7 A;  1LK6 I;  3NDA A;  4AQH A;  4CAA A;  1ANT I;  2WXY C;  9PAI A;  1M93 B;  1E05 I;  3F5N A;  3Q03 A;  1B3K A;  3KCG I;  2HI9 A;  3NDD A;  4EB1 I;  2DUT A;  1DB2 A;  1YXA A;  1C8O A;  1XU8 A;  4AU3 B;  2H4Q A;  4C49 A;  3DRU A;  1OYH I;  1XQJ A;  2ARQ A;  3CVM A;  1QLP A;  4C41 A;  1BY7 A;  3STO A;  1UHG A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...