8APIA

The s variant of human alpha1-antitrypsin, structure and implications for function and metabolism
Total Genus 95
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
340
structure length
340
Chain Sequence
DHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Proteinase inhibitor
molecule keywords ALPHA-1 ANTITRYPSIN (CHAIN A)
publication title The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
pubmed doi rcsb
total genus 95
structure length 340
sequence length 340
ec nomenclature
pdb deposition date 1988-09-08
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 8apiA01
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 8apiA02
2XN6A 4P0FA 4AU2A 4AU3B 3F1SA 2R9YA 1JVQI 2VH4A 2WXZA 3CVMA 1E03I 1T1FA 1DZHL 2BEHL 2OAYA 3LW2A 3DRUA 1JMJA 3F02A 1SNGA 2QUGA 1DZHI 2BEHI 3NDDA 1IMVA 2V95A 4GA7A 3OZQA 1SR5A 1B3KA 3DY0A 3F5NA 2OL2A 2B4XI 1JRRA 2ACHA 3DRMA 4G8OA 1OC0A 3EOXA 7APIA 1R1LI 5BRRI 2VDYA 1M93B 4AU3A 3Q02A 1DVNA 5IO1A 2D26A 2XN7A 2WXWA 1D5SA 4G8RA 2RIWA 1ATTA 1UHGA 3H5CA 4RSQA 4RO9A 3STOA 5EI0A 1DZGL 2DUTA 4C41A 5C98A 4DY7C 4AQHA 2WXXA 1E05I 3B9FI 1NQ9I 1OVAA 2ZV6A 9PAIA 3CWLA 3PB1I 1SEKA 4P0OA 1E04I 4AJUA 1OO8A 2VDXA 4EB1L 1JJOC 1QMBA 3CWMA 1XU8A 4ROAA 1BR8I 4ZK3A 1AS4A 1OVAC 1YXAA 2HI9A 8APIA 4DY0A 3PZFA 1C5GA 4R9IA 3R4LA 1F0CA 2WY1A 1OPHA 1OVAB 4BB2A 1BY7A 4PYWA 1JTIA 4C49A 3NDFA 4ZK0A 1XQGA 3Q03A 2CEOA 1QLPA 3LE2A 4CAAA 1QMNA 4AJTA 1HP7A 1AZXI 5CDZA 1OYHL 5HGCA 1ATHA 1DZGI 3EVJI 2RIVA 1PSIA 3ZHAA 1C8OA 3CAAA 4AU4A 1OYHI 2HIJL 4Y3KA 3NDAA 4DTEA 1TB6I 2WXYC 1MTPA 2ARRA 2ANTI 2ARQA 4AFXA 2XN3A 2HIJI 3UT3A 1K9OI 3VVJA 2ZNHA 3NE4A 4ROBA 1ATUA 4IF8A 1HLEA 2XN5A 4EB1I 2GD4C 3KCGI 4Y40A 1KCTA 2H4PA 3DLWA 1WZ9A 2WY0C 4YIAA 3T1PA 1LQ8A 1XQJA 2WXZC 4KDSA 1IZ2A 2PEEA 1DVMA 4IC0A 1JMOA 2B4XL 1DB2A 1A7CA 3FGQA 1EZXA 2PEFA 2H4RA 4X30A 1ANTI 5INWA 2H4QA 1LK6I 9APIA 5CDXA 5CE0A 2B5TI 1LJ5A
chains in the Genus database with same CATH superfamily
2XN6A 4P0FA 4AU2A 4AU3B 3F1SA 2R9YA 1JVQI 2VH4A 2WXZA 3CVMA 1E03I 1T1FA 1DZHL 2BEHL 2OAYA 3LW2A 3DRUA 1JMJA 3F02A 1SNGA 2QUGA 1DZHI 2BEHI 3NDDA 1IMVA 2V95A 4GA7A 3OZQA 1SR5A 1B3KA 3DY0A 3F5NA 2OL2A 2B4XI 1JRRA 2ACHA 3DRMA 4G8OA 1OC0A 3EOXA 7APIA 1R1LI 5BRRI 2VDYA 1M93B 4AU3A 3Q02A 1DVNA 5IO1A 2D26A 2XN7A 2WXWA 1D5SA 4G8RA 2RIWA 1ATTA 1UHGA 3H5CA 4RSQA 4RO9A 3STOA 5EI0A 1DZGL 2DUTA 4C41A 5C98A 4DY7C 4AQHA 2WXXA 1E05I 3B9FI 1NQ9I 1OVAA 2ZV6A 9PAIA 3CWLA 3PB1I 1SEKA 4P0OA 1E04I 4AJUA 1OO8A 2VDXA 4EB1L 1JJOC 1QMBA 3CWMA 1XU8A 4ROAA 1BR8I 4ZK3A 1AS4A 1OVAC 1YXAA 2HI9A 8APIA 4DY0A 3PZFA 1C5GA 4R9IA 3R4LA 1F0CA 2WY1A 1OPHA 1OVAB 4BB2A 1BY7A 4PYWA 1JTIA 4C49A 3NDFA 4ZK0A 1XQGA 3Q03A 2CEOA 1QLPA 3LE2A 4CAAA 1QMNA 4AJTA 1HP7A 1AZXI 5CDZA 1OYHL 5HGCA 1ATHA 1DZGI 3EVJI 2RIVA 1PSIA 3ZHAA 1C8OA 3CAAA 4AU4A 1OYHI 2HIJL 4Y3KA 3NDAA 4DTEA 1TB6I 2WXYC 1MTPA 2ARRA 2ANTI 2ARQA 4AFXA 2XN3A 2HIJI 3UT3A 1K9OI 3VVJA 2ZNHA 3NE4A 4ROBA 1ATUA 4IF8A 1HLEA 2XN5A 4EB1I 2GD4C 3KCGI 4Y40A 1KCTA 2H4PA 3DLWA 1WZ9A 2WY0C 4YIAA 3T1PA 1LQ8A 1XQJA 2WXZC 4KDSA 1IZ2A 2PEEA 1DVMA 4IC0A 1JMOA 2B4XL 1DB2A 1A7CA 3FGQA 1EZXA 2PEFA 2H4RA 4X30A 1ANTI 5INWA 2H4QA 1LK6I 9APIA 5CDXA 5CE0A 2B5TI 1LJ5A
chains in the Genus database with same CATH topology
2XN6A 4P0FA 4AU2A 4AU3B 3F1SA 2R9YA 1JVQI 2VH4A 2WXZA 3CVMA 1E03I 1T1FA 1DZHL 2BEHL 2OAYA 3LW2A 3DRUA 1JMJA 3F02A 1SNGA 2QUGA 1DZHI 2BEHI 3NDDA 1IMVA 2V95A 4GA7A 3OZQA 1SR5A 1B3KA 3DY0A 3F5NA 2OL2A 2B4XI 1JRRA 2ACHA 3DRMA 4G8OA 1OC0A 3EOXA 7APIA 1R1LI 5BRRI 2VDYA 1M93B 4AU3A 3Q02A 1DVNA 5IO1A 2D26A 2XN7A 2WXWA 1D5SA 4G8RA 2RIWA 1ATTA 1UHGA 3H5CA 4RSQA 4RO9A 3STOA 5EI0A 1DZGL 2DUTA 4C41A 5C98A 4DY7C 4AQHA 2WXXA 1E05I 3B9FI 1NQ9I 1OVAA 2ZV6A 9PAIA 3CWLA 3PB1I 1SEKA 4P0OA 1E04I 4AJUA 1OO8A 2VDXA 4EB1L 1JJOC 1QMBA 3CWMA 1XU8A 4ROAA 1BR8I 4ZK3A 1AS4A 1OVAC 1YXAA 2HI9A 8APIA 4DY0A 3PZFA 1C5GA 4R9IA 3R4LA 1F0CA 2WY1A 1OPHA 1OVAB 4BB2A 1BY7A 4PYWA 1JTIA 4C49A 3NDFA 4ZK0A 1XQGA 3Q03A 2CEOA 1QLPA 3LE2A 4CAAA 1QMNA 4AJTA 1HP7A 1AZXI 5CDZA 1OYHL 5HGCA 1ATHA 1DZGI 3EVJI 2RIVA 1PSIA 3ZHAA 1C8OA 3CAAA 4AU4A 1OYHI 2HIJL 4Y3KA 3NDAA 4DTEA 1TB6I 2WXYC 1MTPA 2ARRA 2ANTI 2ARQA 4AFXA 2XN3A 2HIJI 3UT3A 1K9OI 3VVJA 2ZNHA 3NE4A 4ROBA 1ATUA 4IF8A 1HLEA 2XN5A 4EB1I 2GD4C 3KCGI 4Y40A 1KCTA 2H4PA 3DLWA 1WZ9A 2WY0C 4YIAA 3T1PA 1LQ8A 1XQJA 2WXZC 4KDSA 1IZ2A 2PEEA 1DVMA 4IC0A 1JMOA 2B4XL 1DB2A 1A7CA 3FGQA 1EZXA 2PEFA 2H4RA 4X30A 1ANTI 5INWA 2H4QA 1LK6I 9APIA 5CDXA 5CE0A 2B5TI 1LJ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XN6 A;  4P0F A;  4AU2 A;  4AU3 B;  3F1S A;  2R9Y A;  1JVQ I;  2VH4 A;  2WXZ A;  3CVM A;  1E03 I;  1T1F A;  1DZH L;  2BEH L;  2OAY A;  3LW2 A;  3DRU A;  1JMJ A;  3F02 A;  1SNG A;  2QUG A;  1DZH I;  2BEH I;  3NDD A;  1IMV A;  2V95 A;  4GA7 A;  3OZQ A;  1SR5 A;  1B3K A;  3DY0 A;  3F5N A;  2OL2 A;  2B4X I;  1JRR A;  2ACH A;  3DRM A;  4G8O A;  1OC0 A;  3EOX A;  7API A;  1R1L I;  5BRR I;  2VDY A;  1M93 B;  4AU3 A;  3Q02 A;  1DVN A;  5IO1 A;  2D26 A;  2XN7 A;  2WXW A;  1D5S A;  4G8R A;  2RIW A;  1ATT A;  1UHG A;  3H5C A;  4RSQ A;  4RO9 A;  3STO A;  5EI0 A;  1DZG L;  2DUT A;  4C41 A;  5C98 A;  4DY7 C;  4AQH A;  2WXX A;  1E05 I;  3B9F I;  1NQ9 I;  1OVA A;  2ZV6 A;  9PAI A;  3CWL A;  3PB1 I;  1SEK A;  4P0O A;  1E04 I;  4AJU A;  1OO8 A;  2VDX A;  4EB1 L;  1JJO C;  1QMB A;  3CWM A;  1XU8 A;  4ROA A;  1BR8 I;  4ZK3 A;  1AS4 A;  1OVA C;  1YXA A;  2HI9 A;  8API A;  4DY0 A;  3PZF A;  1C5G A;  4R9I A;  3R4L A;  1F0C A;  2WY1 A;  1OPH A;  1OVA B;  4BB2 A;  1BY7 A;  4PYW A;  1JTI A;  4C49 A;  3NDF A;  4ZK0 A;  1XQG A;  3Q03 A;  2CEO A;  1QLP A;  3LE2 A;  4CAA A;  1QMN A;  4AJT A;  1HP7 A;  1AZX I;  5CDZ A;  1OYH L;  5HGC A;  1ATH A;  1DZG I;  3EVJ I;  2RIV A;  1PSI A;  3ZHA A;  1C8O A;  3CAA A;  4AU4 A;  1OYH I;  2HIJ L;  4Y3K A;  3NDA A;  4DTE A;  1TB6 I;  2WXY C;  1MTP A;  2ARR A;  2ANT I;  2ARQ A;  4AFX A;  2XN3 A;  2HIJ I;  3UT3 A;  1K9O I;  3VVJ A;  2ZNH A;  3NE4 A;  4ROB A;  1ATU A;  4IF8 A;  1HLE A;  2XN5 A;  4EB1 I;  2GD4 C;  3KCG I;  4Y40 A;  1KCT A;  2H4P A;  3DLW A;  1WZ9 A;  2WY0 C;  4YIA A;  3T1P A;  1LQ8 A;  1XQJ A;  2WXZ C;  4KDS A;  1IZ2 A;  2PEE A;  1DVM A;  4IC0 A;  1JMO A;  2B4X L;  1DB2 A;  1A7C A;  3FGQ A;  1EZX A;  2PEF A;  2H4R A;  4X30 A;  1ANT I;  5INW A;  2H4Q A;  1LK6 I;  9API A;  5CDX A;  5CE0 A;  2B5T I;  1LJ5 A; 
#chains in the Genus database with same CATH topology
 2XN6 A;  4P0F A;  4AU2 A;  4AU3 B;  3F1S A;  2R9Y A;  1JVQ I;  2VH4 A;  2WXZ A;  3CVM A;  1E03 I;  1T1F A;  1DZH L;  2BEH L;  2OAY A;  3LW2 A;  3DRU A;  1JMJ A;  3F02 A;  1SNG A;  2QUG A;  1DZH I;  2BEH I;  3NDD A;  1IMV A;  2V95 A;  4GA7 A;  3OZQ A;  1SR5 A;  1B3K A;  3DY0 A;  3F5N A;  2OL2 A;  2B4X I;  1JRR A;  2ACH A;  3DRM A;  4G8O A;  1OC0 A;  3EOX A;  7API A;  1R1L I;  5BRR I;  2VDY A;  1M93 B;  4AU3 A;  3Q02 A;  1DVN A;  5IO1 A;  2D26 A;  2XN7 A;  2WXW A;  1D5S A;  4G8R A;  2RIW A;  1ATT A;  1UHG A;  3H5C A;  4RSQ A;  4RO9 A;  3STO A;  5EI0 A;  1DZG L;  2DUT A;  4C41 A;  5C98 A;  4DY7 C;  4AQH A;  2WXX A;  1E05 I;  3B9F I;  1NQ9 I;  1OVA A;  2ZV6 A;  9PAI A;  3CWL A;  3PB1 I;  1SEK A;  4P0O A;  1E04 I;  4AJU A;  1OO8 A;  2VDX A;  4EB1 L;  1JJO C;  1QMB A;  3CWM A;  1XU8 A;  4ROA A;  1BR8 I;  4ZK3 A;  1AS4 A;  1OVA C;  1YXA A;  2HI9 A;  8API A;  4DY0 A;  3PZF A;  1C5G A;  4R9I A;  3R4L A;  1F0C A;  2WY1 A;  1OPH A;  1OVA B;  4BB2 A;  1BY7 A;  4PYW A;  1JTI A;  4C49 A;  3NDF A;  4ZK0 A;  1XQG A;  3Q03 A;  2CEO A;  1QLP A;  3LE2 A;  4CAA A;  1QMN A;  4AJT A;  1HP7 A;  1AZX I;  5CDZ A;  1OYH L;  5HGC A;  1ATH A;  1DZG I;  3EVJ I;  2RIV A;  1PSI A;  3ZHA A;  1C8O A;  3CAA A;  4AU4 A;  1OYH I;  2HIJ L;  4Y3K A;  3NDA A;  4DTE A;  1TB6 I;  2WXY C;  1MTP A;  2ARR A;  2ANT I;  2ARQ A;  4AFX A;  2XN3 A;  2HIJ I;  3UT3 A;  1K9O I;  3VVJ A;  2ZNH A;  3NE4 A;  4ROB A;  1ATU A;  4IF8 A;  1HLE A;  2XN5 A;  4EB1 I;  2GD4 C;  3KCG I;  4Y40 A;  1KCT A;  2H4P A;  3DLW A;  1WZ9 A;  2WY0 C;  4YIA A;  3T1P A;  1LQ8 A;  1XQJ A;  2WXZ C;  4KDS A;  1IZ2 A;  2PEE A;  1DVM A;  4IC0 A;  1JMO A;  2B4X L;  1DB2 A;  1A7C A;  3FGQ A;  1EZX A;  2PEF A;  2H4R A;  4X30 A;  1ANT I;  5INW A;  2H4Q A;  1LK6 I;  9API A;  5CDX A;  5CE0 A;  2B5T I;  1LJ5 A; 
#chains in the Genus database with same CATH homology
 2XN6 A;  4P0F A;  4AU2 A;  4AU3 B;  3F1S A;  2R9Y A;  1JVQ I;  2VH4 A;  2WXZ A;  3CVM A;  1E03 I;  1T1F A;  1DZH L;  2BEH L;  2OAY A;  3LW2 A;  3DRU A;  1JMJ A;  3F02 A;  1SNG A;  2QUG A;  1DZH I;  2BEH I;  3NDD A;  1IMV A;  2V95 A;  4GA7 A;  3OZQ A;  1SR5 A;  1B3K A;  3DY0 A;  3F5N A;  2OL2 A;  2B4X I;  1JRR A;  2ACH A;  3DRM A;  4G8O A;  1OC0 A;  3EOX A;  7API A;  1R1L I;  5BRR I;  2VDY A;  1M93 B;  4AU3 A;  3Q02 A;  1DVN A;  5IO1 A;  2D26 A;  2XN7 A;  2WXW A;  1D5S A;  4G8R A;  2RIW A;  1ATT A;  1UHG A;  3H5C A;  4RSQ A;  4RO9 A;  3STO A;  5EI0 A;  1DZG L;  2DUT A;  4C41 A;  5C98 A;  4DY7 C;  4AQH A;  2WXX A;  1E05 I;  3B9F I;  1NQ9 I;  1OVA A;  2ZV6 A;  9PAI A;  3CWL A;  3PB1 I;  1SEK A;  4P0O A;  1E04 I;  4AJU A;  1OO8 A;  2VDX A;  4EB1 L;  1JJO C;  1QMB A;  3CWM A;  1XU8 A;  4ROA A;  1BR8 I;  4ZK3 A;  1AS4 A;  1OVA C;  1YXA A;  2HI9 A;  8API A;  4DY0 A;  3PZF A;  1C5G A;  4R9I A;  3R4L A;  1F0C A;  2WY1 A;  1OPH A;  1OVA B;  4BB2 A;  1BY7 A;  4PYW A;  1JTI A;  4C49 A;  3NDF A;  4ZK0 A;  1XQG A;  3Q03 A;  2CEO A;  1QLP A;  3LE2 A;  4CAA A;  1QMN A;  4AJT A;  1HP7 A;  1AZX I;  5CDZ A;  1OYH L;  5HGC A;  1ATH A;  1DZG I;  3EVJ I;  2RIV A;  1PSI A;  3ZHA A;  1C8O A;  3CAA A;  4AU4 A;  1OYH I;  2HIJ L;  4Y3K A;  3NDA A;  4DTE A;  1TB6 I;  2WXY C;  1MTP A;  2ARR A;  2ANT I;  2ARQ A;  4AFX A;  2XN3 A;  2HIJ I;  3UT3 A;  1K9O I;  3VVJ A;  2ZNH A;  3NE4 A;  4ROB A;  1ATU A;  4IF8 A;  1HLE A;  2XN5 A;  4EB1 I;  2GD4 C;  3KCG I;  4Y40 A;  1KCT A;  2H4P A;  3DLW A;  1WZ9 A;  2WY0 C;  4YIA A;  3T1P A;  1LQ8 A;  1XQJ A;  2WXZ C;  4KDS A;  1IZ2 A;  2PEE A;  1DVM A;  4IC0 A;  1JMO A;  2B4X L;  1DB2 A;  1A7C A;  3FGQ A;  1EZX A;  2PEF A;  2H4R A;  4X30 A;  1ANT I;  5INW A;  2H4Q A;  1LK6 I;  9API A;  5CDX A;  5CE0 A;  2B5T I;  1LJ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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