1CW4 | Genus

Total Genus 139

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	139
sequence length	415
structure length	415
Chain Sequence	ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHMGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase. pubmed doi rcsb
molecule keywords	ISOCITRATE DEHYDROGENASE
molecule tags	Oxidoreductase
source organism	Escherichia coli
total genus	139
structure length	415
sequence length	415
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	1999-08-25

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	1cw4A00

1IPDA 2UXRA 2QFVA 3WZYA 1GRPA 3FMXX 1IDDA 2AYQA 3VMKA 2D4VA 2Y41A 2Y42A 5I96A 2DHTA 5GRIB 4XXVA 1GC9A 5DE1A 1T0LA 3R8WA 1PS6A 3TNGA 4HCXA 2QFYA 9ICDA 5GRHB 1YCOA 1OSJA 3VL2A 3TSNA 4KZOA 3BLVA 3MAPA 4AJBA 4Y1PA 3MASB 5HN5A 3UF6A 6ICDA 1ISOA 1IDEA 5GREA 1XKDA 1ZORA 4L04A 5GRFB 4I3LA 1A05A 3DMSA 1U7NA 3WZWA 4BNPA 1CM7A 5GRLB 5J34A 1XGVA 3ASJA 4AOUA 4JQPA 5ICDA 2D1CA 3BLXB 1PTMA 1DR8A 1PB1A 4WUOA 4ICDA 3TY4A 1XACA 1CW7A 4F7IA 5J32A 1T09A 1CW1A 2UXQA 1XAAA 1V5BA 1HQSA 1LWDA 2E0CA 2G4OA 1V94A 5HN3A 4AJSA 1X0LA 3LCBC 1AI3A 7ICDA 2HI1A 3U9EA 5GRIA 1WALA 1WPWA 4XRXA 5K11A 1VLCA 5GRHA 1TYOA 5HN4A 1BL5A 4YB4A 1GROA 4UMXA 3MARA 3MASA 1SJSA 2ZTWA 3ICDA 3FLKA 1YXOA 3VL7A 2QFWA 1G2UA 1HJ6A 4I3KA 3WZXA 3BLVB 5L57A 4IWHA 5L58A 4AOVA 5GRFA 5K10A 3WZVA 3VL6A 4XS3A 3UDUA 1PB3A 2IV0A 4P69C 1OSIA 1CNZA 4UMYA 3VL3A 3LXYA 1V53A 2Y40A 5HN6A 1CW4A 1IKAA 1P8FA 1AI2A 1R8KA 1XADA 5GREB 5GRLA 2QFXA 1XABA 1DPZA 1IDCA 3BLXA 5LGEA 4L03A 2Y3ZA 1GC8A 4L06A 4ATYA 4AJCA 1IDMA 3U1HA 5J33A 8ICDA 1DR0A 5I95A 1HEXA 3INMA 3TY3A 4AJ3A 3UDOA 1W0DA 2E5MA 3AH3A 4AJRA 3US8A 3VL4A 3VMJA 3VKZA 4AJAA 1VI1A 4JA8A 1PS7A 4AOYA 3VMLA 1IDFA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1IPD A;  2UXR A;  2QFV A;  3WZY A;  1GRP A;  3FMX X;  1IDD A;  2AYQ A;  3VMK A;  2D4V A;  2Y41 A;  2Y42 A;  5I96 A;  2DHT A;  5GRI B;  4XXV A;  1GC9 A;  5DE1 A;  1T0L A;  3R8W A;  1PS6 A;  3TNG A;  4HCX A;  2QFY A;  9ICD A;  5GRH B;  1YCO A;  1OSJ A;  3VL2 A;  3TSN A;  4KZO A;  3BLV A;  3MAP A;  4AJB A;  4Y1P A;  3MAS B;  5HN5 A;  3UF6 A;  6ICD A;  1ISO A;  1IDE A;  5GRE A;  1XKD A;  1ZOR A;  4L04 A;  5GRF B;  4I3L A;  1A05 A;  3DMS A;  1U7N A;  3WZW A;  4BNP A;  1CM7 A;  5GRL B;  5J34 A;  1XGV A;  3ASJ A;  4AOU A;  4JQP A;  5ICD A;  2D1C A;  3BLX B;  1PTM A;  1DR8 A;  1PB1 A;  4WUO A;  4ICD A;  3TY4 A;  1XAC A;  1CW7 A;  4F7I A;  5J32 A;  1T09 A;  1CW1 A;  2UXQ A;  1XAA A;  1V5B A;  1HQS A;  1LWD A;  2E0C A;  2G4O A;  1V94 A;  5HN3 A;  4AJS A;  1X0L A;  3LCB C;  1AI3 A;  7ICD A;  2HI1 A;  3U9E A;  5GRI A;  1WAL A;  1WPW A;  4XRX A;  5K11 A;  1VLC A;  5GRH A;  1TYO A;  5HN4 A;  1BL5 A;  4YB4 A;  1GRO A;  4UMX A;  3MAR A;  3MAS A;  1SJS A;  2ZTW A;  3ICD A;  3FLK A;  1YXO A;  3VL7 A;  2QFW A;  1G2U A;  1HJ6 A;  4I3K A;  3WZX A;  3BLV B;  5L57 A;  4IWH A;  5L58 A;  4AOV A;  5GRF A;  5K10 A;  3WZV A;  3VL6 A;  4XS3 A;  3UDU A;  1PB3 A;  2IV0 A;  4P69 C;  1OSI A;  1CNZ A;  4UMY A;  3VL3 A;  3LXY A;  1V53 A;  2Y40 A;  5HN6 A;  1CW4 A;  1IKA A;  1P8F A;  1AI2 A;  1R8K A;  1XAD A;  5GRE B;  5GRL A;  2QFX A;  1XAB A;  1DPZ A;  1IDC A;  3BLX A;  5LGE A;  4L03 A;  2Y3Z A;  1GC8 A;  4L06 A;  4ATY A;  4AJC A;  1IDM A;  3U1H A;  5J33 A;  8ICD A;  1DR0 A;  5I95 A;  1HEX A;  3INM A;  3TY3 A;  4AJ3 A;  3UDO A;  1W0D A;  2E5M A;  3AH3 A;  4AJR A;  3US8 A;  3VL4 A;  3VMJ A;  3VKZ A;  4AJA A;  1VI1 A;  4JA8 A;  1PS7 A;  4AOY A;  3VML A;  1IDF A; 
#chains in the Genus database with same CATH topology
 1IPD A;  2UXR A;  2QFV A;  3WZY A;  1GRP A;  3FMX X;  1IDD A;  2AYQ A;  3VMK A;  2D4V A;  2Y41 A;  2Y42 A;  5I96 A;  2DHT A;  5GRI B;  4XXV A;  1GC9 A;  5DE1 A;  1T0L A;  3R8W A;  1PS6 A;  3TNG A;  4HCX A;  2QFY A;  9ICD A;  5GRH B;  1YCO A;  1OSJ A;  3VL2 A;  3TSN A;  4KZO A;  3BLV A;  3MAP A;  4AJB A;  4Y1P A;  3MAS B;  5HN5 A;  3UF6 A;  6ICD A;  1ISO A;  1IDE A;  5GRE A;  1XKD A;  1ZOR A;  4L04 A;  5GRF B;  4I3L A;  1A05 A;  3DMS A;  1U7N A;  3WZW A;  4BNP A;  1CM7 A;  5GRL B;  5J34 A;  1XGV A;  3ASJ A;  4AOU A;  4JQP A;  5ICD A;  2D1C A;  3BLX B;  1PTM A;  1DR8 A;  1PB1 A;  4WUO A;  4ICD A;  3TY4 A;  1XAC A;  1CW7 A;  4F7I A;  5J32 A;  1T09 A;  1CW1 A;  2UXQ A;  1XAA A;  1V5B A;  1HQS A;  1LWD A;  2E0C A;  2G4O A;  1V94 A;  5HN3 A;  4AJS A;  1X0L A;  3LCB C;  1AI3 A;  7ICD A;  2HI1 A;  3U9E A;  5GRI A;  1WAL A;  1WPW A;  4XRX A;  5K11 A;  1VLC A;  5GRH A;  1TYO A;  5HN4 A;  1BL5 A;  4YB4 A;  1GRO A;  4UMX A;  3MAR A;  3MAS A;  1SJS A;  2ZTW A;  3ICD A;  3FLK A;  1YXO A;  3VL7 A;  2QFW A;  1G2U A;  1HJ6 A;  4I3K A;  3WZX A;  3BLV B;  5L57 A;  4IWH A;  5L58 A;  4AOV A;  5GRF A;  5K10 A;  3WZV A;  3VL6 A;  4XS3 A;  3UDU A;  1PB3 A;  2IV0 A;  4P69 C;  1OSI A;  1CNZ A;  4UMY A;  3VL3 A;  3LXY A;  1V53 A;  2Y40 A;  5HN6 A;  1CW4 A;  1IKA A;  1P8F A;  1AI2 A;  1R8K A;  1XAD A;  5GRE B;  5GRL A;  2QFX A;  1XAB A;  1DPZ A;  1IDC A;  3BLX A;  5LGE A;  4L03 A;  2Y3Z A;  1GC8 A;  4L06 A;  4ATY A;  4AJC A;  1IDM A;  3U1H A;  5J33 A;  8ICD A;  1DR0 A;  5I95 A;  1HEX A;  3INM A;  3TY3 A;  4AJ3 A;  3UDO A;  1W0D A;  2E5M A;  3AH3 A;  4AJR A;  3US8 A;  3VL4 A;  3VMJ A;  3VKZ A;  4AJA A;  1VI1 A;  4JA8 A;  1PS7 A;  4AOY A;  3VML A;  1IDF A; 
#chains in the Genus database with same CATH homology
 1IPD A;  2UXR A;  2QFV A;  3WZY A;  1GRP A;  3FMX X;  1IDD A;  2AYQ A;  3VMK A;  2D4V A;  2Y41 A;  2Y42 A;  5I96 A;  2DHT A;  5GRI B;  4XXV A;  1GC9 A;  5DE1 A;  1T0L A;  3R8W A;  1PS6 A;  3TNG A;  4HCX A;  2QFY A;  9ICD A;  5GRH B;  1YCO A;  1OSJ A;  3VL2 A;  3TSN A;  4KZO A;  3BLV A;  3MAP A;  4AJB A;  4Y1P A;  3MAS B;  5HN5 A;  3UF6 A;  6ICD A;  1ISO A;  1IDE A;  5GRE A;  1XKD A;  1ZOR A;  4L04 A;  5GRF B;  4I3L A;  1A05 A;  3DMS A;  1U7N A;  3WZW A;  4BNP A;  1CM7 A;  5GRL B;  5J34 A;  1XGV A;  3ASJ A;  4AOU A;  4JQP A;  5ICD A;  2D1C A;  3BLX B;  1PTM A;  1DR8 A;  1PB1 A;  4WUO A;  4ICD A;  3TY4 A;  1XAC A;  1CW7 A;  4F7I A;  5J32 A;  1T09 A;  1CW1 A;  2UXQ A;  1XAA A;  1V5B A;  1HQS A;  1LWD A;  2E0C A;  2G4O A;  1V94 A;  5HN3 A;  4AJS A;  1X0L A;  3LCB C;  1AI3 A;  7ICD A;  2HI1 A;  3U9E A;  5GRI A;  1WAL A;  1WPW A;  4XRX A;  5K11 A;  1VLC A;  5GRH A;  1TYO A;  5HN4 A;  1BL5 A;  4YB4 A;  1GRO A;  4UMX A;  3MAR A;  3MAS A;  1SJS A;  2ZTW A;  3ICD A;  3FLK A;  1YXO A;  3VL7 A;  2QFW A;  1G2U A;  1HJ6 A;  4I3K A;  3WZX A;  3BLV B;  5L57 A;  4IWH A;  5L58 A;  4AOV A;  5GRF A;  5K10 A;  3WZV A;  3VL6 A;  4XS3 A;  3UDU A;  1PB3 A;  2IV0 A;  4P69 C;  1OSI A;  1CNZ A;  4UMY A;  3VL3 A;  3LXY A;  1V53 A;  2Y40 A;  5HN6 A;  1CW4 A;  1IKA A;  1P8F A;  1AI2 A;  1R8K A;  1XAD A;  5GRE B;  5GRL A;  2QFX A;  1XAB A;  1DPZ A;  1IDC A;  3BLX A;  5LGE A;  4L03 A;  2Y3Z A;  1GC8 A;  4L06 A;  4ATY A;  4AJC A;  1IDM A;  3U1H A;  5J33 A;  8ICD A;  1DR0 A;  5I95 A;  1HEX A;  3INM A;  3TY3 A;  4AJ3 A;  3UDO A;  1W0D A;  2E5M A;  3AH3 A;  4AJR A;  3US8 A;  3VL4 A;  3VMJ A;  3VKZ A;  4AJA A;  1VI1 A;  4JA8 A;  1PS7 A;  4AOY A;  3VML A;  1IDF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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1CW4A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations