1GC9A

The crystal structure of thermus thermophilus 3-isopropylmalate dehydrogenase mutated at 172th from ala to gly
Total Genus 123

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
345
structure length
345
Chain Sequence
MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEGARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS2 (35-38)AH3 (55-63)S1 (2-8)AH1 (11-30)TII3 (279-282)O1 (283-285)TIV1 (51-54)AH4 (86-97)3H1 (75-77)TIV2 (77-80)3H2 (82-84)S4 (99-107)S12 (268-271)TIV4 (133-136)TII2 (123-126)TII1 (109-112)3H3 (113-115)AH5 (120-123)AH9 (237-250)S5 (127-133)AH6 (159-175)TI1 (137-140)TIV5 (136-139)TIV6 (141-144)S6 (145-147)TI3 (147-150)TIV8 (204-207)TI5 (206-209)AH11 (305-321)S9 (210-215)S8 (179-184)TI4 (185-188)AH8 (216-226)TIV7 (186-189)AH7 (190-204)3H4 (227-229)TI7 (254-257)3H5 (277-279)AH12 (333-343)AH10 (287-302)O2 (303-305)S3 (66-71)AH2 (43-49)S7 (150-152)S11 (258-263)3H6 (325-327)S10 (232-235)Updating...
connected with : NaN
publication title Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
pubmed doi rcsb
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
molecule tags Oxidoreductase
source organism Thermus thermophilus
total genus 123
structure length 345
sequence length 345
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2000-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1gc9A00
1SJSA 1GROA 5J34A 4P69C 5L57A 2Y3ZA 2DHTA 2UXRA 4XRXA 3TNGA 2D4VA 5I95A 2Y41A 3VKZA 1G2UA 3MARA 5J33A 1IDMA 1GRPA 3LXYA 1P8FA 1XAAA 3BLVB 1AI2A 4AJRA 1DR8A 4JA8A 5K11A 3ICDA 4AJBA 1GC9A 2ZTWA 4Y1PA 3U9EA 1PS6A 1R8KA 1XKDA 4AJAA 4ATYA 3U1HA 3AH3A 5HN3A 9ICDA 2HI1A 1IPDA 1HJ6A 4BNPA 1CM7A 1CW1A 1T0LA 1DPZA 1X0LA 1XGVA 4L06A 3VL7A 3VMJA 4I3KA 5L58A 1PTMA 1W0DA 6ICDA 1TYOA 3ASJA 3DMSA 1U7NA 3FMXX 5GRFA 1CW7A 4I3LA 3MASB 2UXQA 1YXOA 1IDEA 1V94A 4AOYA 1VLCA 2E0CA 1ZORA 2G4OA 5GRHB 5LGEA 1IDDA 3TY3A 4HCXA 1PB3A 5GRIB 1T09A 4WUOA 3MASA 2QFYA 5GRLA 3VL4A 2D1CA 5GRHA 1CNZA 5HN5A 3LCBC 2Y42A 1XABA 5GRIA 5GRFB 3VL2A 1WPWA 5DE1A 4AOVA 7ICDA 2IV0A 1PB1A 5K10A 1OSIA 1DR0A 4L03A 3MAPA 1XADA 1V5BA 1IDCA 4KZOA 4AOUA 2Y40A 3UDUA 4IWHA 1VI1A 4AJSA 4JQPA 3R8WA 3VL3A 4AJCA 3VL6A 5GRLB 3UF6A 4XXVA 5GREA 2QFVA 1AI3A 2QFXA 3BLXA 3WZWA 1BL5A 5I96A 1A05A 3FLKA 3VMKA 1CW4A 4UMYA 4L04A 5HN4A 3VMLA 1IKAA 3WZXA 3WZVA 5ICDA 2AYQA 1XACA 3US8A 4AJ3A 4YB4A 4XS3A 1GC8A 3TSNA 4ICDA 3UDOA 5J32A 4UMXA 1WALA 3TY4A 5GREB 3BLXB 1ISOA 2QFWA 3INMA 1IDFA 2E5MA 1V53A 4F7IA 1OSJA 1HQSA 1PS7A 3WZYA 8ICDA 1LWDA 3BLVA 1HEXA 1YCOA 5HN6A
chains in the Genus database with same CATH superfamily
1SJSA 1GROA 5J34A 4P69C 5L57A 2Y3ZA 2DHTA 2UXRA 4XRXA 3TNGA 2D4VA 5I95A 2Y41A 3VKZA 1G2UA 3MARA 5J33A 1IDMA 1GRPA 3LXYA 1P8FA 1XAAA 3BLVB 1AI2A 4AJRA 1DR8A 4JA8A 5K11A 3ICDA 4AJBA 1GC9A 2ZTWA 4Y1PA 3U9EA 1PS6A 1R8KA 1XKDA 4AJAA 4ATYA 3U1HA 3AH3A 5HN3A 9ICDA 2HI1A 1IPDA 1HJ6A 4BNPA 1CM7A 1CW1A 1T0LA 1DPZA 1X0LA 1XGVA 4L06A 3VL7A 3VMJA 4I3KA 5L58A 1PTMA 1W0DA 6ICDA 1TYOA 3ASJA 3DMSA 1U7NA 3FMXX 5GRFA 1CW7A 4I3LA 3MASB 2UXQA 1YXOA 1IDEA 1V94A 4AOYA 1VLCA 2E0CA 1ZORA 2G4OA 5GRHB 5LGEA 1IDDA 3TY3A 4HCXA 1PB3A 5GRIB 1T09A 4WUOA 3MASA 2QFYA 5GRLA 3VL4A 2D1CA 5GRHA 1CNZA 5HN5A 3LCBC 2Y42A 1XABA 5GRIA 5GRFB 3VL2A 1WPWA 5DE1A 4AOVA 7ICDA 2IV0A 1PB1A 5K10A 1OSIA 1DR0A 4L03A 3MAPA 1XADA 1V5BA 1IDCA 4KZOA 4AOUA 2Y40A 3UDUA 4IWHA 1VI1A 4AJSA 4JQPA 3R8WA 3VL3A 4AJCA 3VL6A 5GRLB 3UF6A 4XXVA 5GREA 2QFVA 1AI3A 2QFXA 3BLXA 3WZWA 1BL5A 5I96A 1A05A 3FLKA 3VMKA 1CW4A 4UMYA 4L04A 5HN4A 3VMLA 1IKAA 3WZXA 3WZVA 5ICDA 2AYQA 1XACA 3US8A 4AJ3A 4YB4A 4XS3A 1GC8A 3TSNA 4ICDA 3UDOA 5J32A 4UMXA 1WALA 3TY4A 5GREB 3BLXB 1ISOA 2QFWA 3INMA 1IDFA 2E5MA 1V53A 4F7IA 1OSJA 1HQSA 1PS7A 3WZYA 8ICDA 1LWDA 3BLVA 1HEXA 1YCOA 5HN6A
chains in the Genus database with same CATH topology
1SJSA 1GROA 5J34A 4P69C 5L57A 2Y3ZA 2DHTA 2UXRA 4XRXA 3TNGA 2D4VA 5I95A 2Y41A 3VKZA 1G2UA 3MARA 5J33A 1IDMA 1GRPA 3LXYA 1P8FA 1XAAA 3BLVB 1AI2A 4AJRA 1DR8A 4JA8A 5K11A 3ICDA 4AJBA 1GC9A 2ZTWA 4Y1PA 3U9EA 1PS6A 1R8KA 1XKDA 4AJAA 4ATYA 3U1HA 3AH3A 5HN3A 9ICDA 2HI1A 1IPDA 1HJ6A 4BNPA 1CM7A 1CW1A 1T0LA 1DPZA 1X0LA 1XGVA 4L06A 3VL7A 3VMJA 4I3KA 5L58A 1PTMA 1W0DA 6ICDA 1TYOA 3ASJA 3DMSA 1U7NA 3FMXX 5GRFA 1CW7A 4I3LA 3MASB 2UXQA 1YXOA 1IDEA 1V94A 4AOYA 1VLCA 2E0CA 1ZORA 2G4OA 5GRHB 5LGEA 1IDDA 3TY3A 4HCXA 1PB3A 5GRIB 1T09A 4WUOA 3MASA 2QFYA 5GRLA 3VL4A 2D1CA 5GRHA 1CNZA 5HN5A 3LCBC 2Y42A 1XABA 5GRIA 5GRFB 3VL2A 1WPWA 5DE1A 4AOVA 7ICDA 2IV0A 1PB1A 5K10A 1OSIA 1DR0A 4L03A 3MAPA 1XADA 1V5BA 1IDCA 4KZOA 4AOUA 2Y40A 3UDUA 4IWHA 1VI1A 4AJSA 4JQPA 3R8WA 3VL3A 4AJCA 3VL6A 5GRLB 3UF6A 4XXVA 5GREA 2QFVA 1AI3A 2QFXA 3BLXA 3WZWA 1BL5A 5I96A 1A05A 3FLKA 3VMKA 1CW4A 4UMYA 4L04A 5HN4A 3VMLA 1IKAA 3WZXA 3WZVA 5ICDA 2AYQA 1XACA 3US8A 4AJ3A 4YB4A 4XS3A 1GC8A 3TSNA 4ICDA 3UDOA 5J32A 4UMXA 1WALA 3TY4A 5GREB 3BLXB 1ISOA 2QFWA 3INMA 1IDFA 2E5MA 1V53A 4F7IA 1OSJA 1HQSA 1PS7A 3WZYA 8ICDA 1LWDA 3BLVA 1HEXA 1YCOA 5HN6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SJS A;  1GRO A;  5J34 A;  4P69 C;  5L57 A;  2Y3Z A;  2DHT A;  2UXR A;  4XRX A;  3TNG A;  2D4V A;  5I95 A;  2Y41 A;  3VKZ A;  1G2U A;  3MAR A;  5J33 A;  1IDM A;  1GRP A;  3LXY A;  1P8F A;  1XAA A;  3BLV B;  1AI2 A;  4AJR A;  1DR8 A;  4JA8 A;  5K11 A;  3ICD A;  4AJB A;  1GC9 A;  2ZTW A;  4Y1P A;  3U9E A;  1PS6 A;  1R8K A;  1XKD A;  4AJA A;  4ATY A;  3U1H A;  3AH3 A;  5HN3 A;  9ICD A;  2HI1 A;  1IPD A;  1HJ6 A;  4BNP A;  1CM7 A;  1CW1 A;  1T0L A;  1DPZ A;  1X0L A;  1XGV A;  4L06 A;  3VL7 A;  3VMJ A;  4I3K A;  5L58 A;  1PTM A;  1W0D A;  6ICD A;  1TYO A;  3ASJ A;  3DMS A;  1U7N A;  3FMX X;  5GRF A;  1CW7 A;  4I3L A;  3MAS B;  2UXQ A;  1YXO A;  1IDE A;  1V94 A;  4AOY A;  1VLC A;  2E0C A;  1ZOR A;  2G4O A;  5GRH B;  5LGE A;  1IDD A;  3TY3 A;  4HCX A;  1PB3 A;  5GRI B;  1T09 A;  4WUO A;  3MAS A;  2QFY A;  5GRL A;  3VL4 A;  2D1C A;  5GRH A;  1CNZ A;  5HN5 A;  3LCB C;  2Y42 A;  1XAB A;  5GRI A;  5GRF B;  3VL2 A;  1WPW A;  5DE1 A;  4AOV A;  7ICD A;  2IV0 A;  1PB1 A;  5K10 A;  1OSI A;  1DR0 A;  4L03 A;  3MAP A;  1XAD A;  1V5B A;  1IDC A;  4KZO A;  4AOU A;  2Y40 A;  3UDU A;  4IWH A;  1VI1 A;  4AJS A;  4JQP A;  3R8W A;  3VL3 A;  4AJC A;  3VL6 A;  5GRL B;  3UF6 A;  4XXV A;  5GRE A;  2QFV A;  1AI3 A;  2QFX A;  3BLX A;  3WZW A;  1BL5 A;  5I96 A;  1A05 A;  3FLK A;  3VMK A;  1CW4 A;  4UMY A;  4L04 A;  5HN4 A;  3VML A;  1IKA A;  3WZX A;  3WZV A;  5ICD A;  2AYQ A;  1XAC A;  3US8 A;  4AJ3 A;  4YB4 A;  4XS3 A;  1GC8 A;  3TSN A;  4ICD A;  3UDO A;  5J32 A;  4UMX A;  1WAL A;  3TY4 A;  5GRE B;  3BLX B;  1ISO A;  2QFW A;  3INM A;  1IDF A;  2E5M A;  1V53 A;  4F7I A;  1OSJ A;  1HQS A;  1PS7 A;  3WZY A;  8ICD A;  1LWD A;  3BLV A;  1HEX A;  1YCO A;  5HN6 A; 
#chains in the Genus database with same CATH topology
 1SJS A;  1GRO A;  5J34 A;  4P69 C;  5L57 A;  2Y3Z A;  2DHT A;  2UXR A;  4XRX A;  3TNG A;  2D4V A;  5I95 A;  2Y41 A;  3VKZ A;  1G2U A;  3MAR A;  5J33 A;  1IDM A;  1GRP A;  3LXY A;  1P8F A;  1XAA A;  3BLV B;  1AI2 A;  4AJR A;  1DR8 A;  4JA8 A;  5K11 A;  3ICD A;  4AJB A;  1GC9 A;  2ZTW A;  4Y1P A;  3U9E A;  1PS6 A;  1R8K A;  1XKD A;  4AJA A;  4ATY A;  3U1H A;  3AH3 A;  5HN3 A;  9ICD A;  2HI1 A;  1IPD A;  1HJ6 A;  4BNP A;  1CM7 A;  1CW1 A;  1T0L A;  1DPZ A;  1X0L A;  1XGV A;  4L06 A;  3VL7 A;  3VMJ A;  4I3K A;  5L58 A;  1PTM A;  1W0D A;  6ICD A;  1TYO A;  3ASJ A;  3DMS A;  1U7N A;  3FMX X;  5GRF A;  1CW7 A;  4I3L A;  3MAS B;  2UXQ A;  1YXO A;  1IDE A;  1V94 A;  4AOY A;  1VLC A;  2E0C A;  1ZOR A;  2G4O A;  5GRH B;  5LGE A;  1IDD A;  3TY3 A;  4HCX A;  1PB3 A;  5GRI B;  1T09 A;  4WUO A;  3MAS A;  2QFY A;  5GRL A;  3VL4 A;  2D1C A;  5GRH A;  1CNZ A;  5HN5 A;  3LCB C;  2Y42 A;  1XAB A;  5GRI A;  5GRF B;  3VL2 A;  1WPW A;  5DE1 A;  4AOV A;  7ICD A;  2IV0 A;  1PB1 A;  5K10 A;  1OSI A;  1DR0 A;  4L03 A;  3MAP A;  1XAD A;  1V5B A;  1IDC A;  4KZO A;  4AOU A;  2Y40 A;  3UDU A;  4IWH A;  1VI1 A;  4AJS A;  4JQP A;  3R8W A;  3VL3 A;  4AJC A;  3VL6 A;  5GRL B;  3UF6 A;  4XXV A;  5GRE A;  2QFV A;  1AI3 A;  2QFX A;  3BLX A;  3WZW A;  1BL5 A;  5I96 A;  1A05 A;  3FLK A;  3VMK A;  1CW4 A;  4UMY A;  4L04 A;  5HN4 A;  3VML A;  1IKA A;  3WZX A;  3WZV A;  5ICD A;  2AYQ A;  1XAC A;  3US8 A;  4AJ3 A;  4YB4 A;  4XS3 A;  1GC8 A;  3TSN A;  4ICD A;  3UDO A;  5J32 A;  4UMX A;  1WAL A;  3TY4 A;  5GRE B;  3BLX B;  1ISO A;  2QFW A;  3INM A;  1IDF A;  2E5M A;  1V53 A;  4F7I A;  1OSJ A;  1HQS A;  1PS7 A;  3WZY A;  8ICD A;  1LWD A;  3BLV A;  1HEX A;  1YCO A;  5HN6 A; 
#chains in the Genus database with same CATH homology
 1SJS A;  1GRO A;  5J34 A;  4P69 C;  5L57 A;  2Y3Z A;  2DHT A;  2UXR A;  4XRX A;  3TNG A;  2D4V A;  5I95 A;  2Y41 A;  3VKZ A;  1G2U A;  3MAR A;  5J33 A;  1IDM A;  1GRP A;  3LXY A;  1P8F A;  1XAA A;  3BLV B;  1AI2 A;  4AJR A;  1DR8 A;  4JA8 A;  5K11 A;  3ICD A;  4AJB A;  1GC9 A;  2ZTW A;  4Y1P A;  3U9E A;  1PS6 A;  1R8K A;  1XKD A;  4AJA A;  4ATY A;  3U1H A;  3AH3 A;  5HN3 A;  9ICD A;  2HI1 A;  1IPD A;  1HJ6 A;  4BNP A;  1CM7 A;  1CW1 A;  1T0L A;  1DPZ A;  1X0L A;  1XGV A;  4L06 A;  3VL7 A;  3VMJ A;  4I3K A;  5L58 A;  1PTM A;  1W0D A;  6ICD A;  1TYO A;  3ASJ A;  3DMS A;  1U7N A;  3FMX X;  5GRF A;  1CW7 A;  4I3L A;  3MAS B;  2UXQ A;  1YXO A;  1IDE A;  1V94 A;  4AOY A;  1VLC A;  2E0C A;  1ZOR A;  2G4O A;  5GRH B;  5LGE A;  1IDD A;  3TY3 A;  4HCX A;  1PB3 A;  5GRI B;  1T09 A;  4WUO A;  3MAS A;  2QFY A;  5GRL A;  3VL4 A;  2D1C A;  5GRH A;  1CNZ A;  5HN5 A;  3LCB C;  2Y42 A;  1XAB A;  5GRI A;  5GRF B;  3VL2 A;  1WPW A;  5DE1 A;  4AOV A;  7ICD A;  2IV0 A;  1PB1 A;  5K10 A;  1OSI A;  1DR0 A;  4L03 A;  3MAP A;  1XAD A;  1V5B A;  1IDC A;  4KZO A;  4AOU A;  2Y40 A;  3UDU A;  4IWH A;  1VI1 A;  4AJS A;  4JQP A;  3R8W A;  3VL3 A;  4AJC A;  3VL6 A;  5GRL B;  3UF6 A;  4XXV A;  5GRE A;  2QFV A;  1AI3 A;  2QFX A;  3BLX A;  3WZW A;  1BL5 A;  5I96 A;  1A05 A;  3FLK A;  3VMK A;  1CW4 A;  4UMY A;  4L04 A;  5HN4 A;  3VML A;  1IKA A;  3WZX A;  3WZV A;  5ICD A;  2AYQ A;  1XAC A;  3US8 A;  4AJ3 A;  4YB4 A;  4XS3 A;  1GC8 A;  3TSN A;  4ICD A;  3UDO A;  5J32 A;  4UMX A;  1WAL A;  3TY4 A;  5GRE B;  3BLX B;  1ISO A;  2QFW A;  3INM A;  1IDF A;  2E5M A;  1V53 A;  4F7I A;  1OSJ A;  1HQS A;  1PS7 A;  3WZY A;  8ICD A;  1LWD A;  3BLV A;  1HEX A;  1YCO A;  5HN6 A; 
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