1PB1A

A four location model to explain the stereospecificity of proteins.
Total Genus 139
50100150200250300350400020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
139
sequence length
416
structure length
416
Chain Sequence
MESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
50100150200250300350400400300200100
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTIV1 (8-11)S1 (15-17)TIV3 (24-27)TIV4 (59-62)S3 (31-32)S4 (97-100)AH1 (37-41)TII'2 (345-348)3H9 (405-408)3H1 (42-47)TI'7 (408-411)3H2 (49-51)TI'2 (55-58)3H3 (53-55)TI1 (57-60)TVIII1 (82-85)AH2 (72-78)AH3 (86-95)TII1 (79-82)O1 (95-97)TI8 (329-332)S15 (333-337)S7 (164-165)AH4 (114-122)S14 (324-328)3H5 (159-161)S5 (126-132)TIV20 (378-381)TIV7 (134-137)TIV8 (141-144)3H4 (144-146)AH9 (303-317)S6 (148-154)S8 (196-197)TII2 (166-169)TIV9 (191-194)AH5 (170-183)TVIII2 (188-191)TI4 (234-237)AH6 (203-220)TI5 (268-271)S12 (274-281)S9 (224-229)TI2 (230-233)AH8 (282-292)TI3 (231-234)AH7 (238-253)S10 (256-257)S11 (264-267)TII'1 (258-261)TIV12 (257-260)TI6 (269-272)3H6 (293-295)S13 (298-301)TI7 (319-322)TIV13 (320-323)AH10 (355-367)TI'6 (390-393)TIV15 (371-374)TIV14 (370-373)TIV16 (372-375)TIV18 (375-378)TI'3 (376-379)TIV17 (374-377)TIV19 (377-380)TI'4 (379-382)TI'5 (380-383)3H7 (384-386)S16 (388-389)TIV23 (397-400)S17 (401-402)3H8 (394-396)TI'8 (409-412)3H10 (413-415)S2 (20-22)Updating...
connected with : NaN
publication title Structural Biology: A New Model for Protein Stereospecificity.
pubmed rcsb
molecule tags Oxidoreductase
source organism Escherichia coli
molecule keywords Isocitrate dehydrogenase [NADP]
total genus 139
structure length 416
sequence length 416
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2003-05-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1pb1A00
5LGEA 1U7NA 1GC8A 3VL4A 1X0LA 5I95A 2ZTWA 3VKZA 3INMA 1V94A 4AJSA 4AOYA 4BNPA 1OSJA 2DHTA 4AJ3A 2IV0A 1PTMA 1PS7A 3FMXX 4UMXA 1WPWA 1CM7A 1PB3A 1DR0A 1R8KA 2UXRA 3TNGA 3WZYA 1CW7A 3BLVA 4P69C 4XRXA 5GRHB 1ISOA 4YB4A 2QFXA 8ICDA 1HEXA 3TSNA 2HI1A 3MASA 1A05A 2Y42A 4AOUA 3DMSA 1GC9A 5HN6A 5L58A 5HN4A 9ICDA 1T09A 2AYQA 3UDOA 1V53A 3LCBC 2E0CA 3VL6A 1VI1A 1PB1A 5L57A 1AI3A 3VL7A 1CW4A 3TY3A 2Y41A 4L06A 1YXOA 2QFWA 1OSIA 1T0LA 3VL3A 4XS3A 4I3KA 4AJCA 4Y1PA 2D4VA 3VMJA 3BLXB 1XACA 4JQPA 3MAPA 3AH3A 5HN5A 5GRHA 4L03A 1IPDA 5J34A 1GROA 4I3LA 2QFVA 4F7IA 4AJBA 1GRPA 4UMYA 3UDUA 2D1CA 2E5MA 5DE1A 5GRIB 1AI2A 3WZXA 1ZORA 5GREA 3FLKA 4AJAA 1TYOA 5GRLB 3VMKA 1YCOA 4ICDA 5J32A 5J33A 4L04A 4AJRA 1SJSA 1XABA 3ICDA 5HN3A 3WZVA 5I96A 2G4OA 1CW1A 1LWDA 1IDFA 6ICDA 5GRFB 7ICDA 1W0DA 4XXVA 3R8WA 3VL2A 1CNZA 4WUOA 1PS6A 1IDDA 1IDEA 4HCXA 4KZOA 1BL5A 5K10A 2Y40A 1WALA 3U9EA 2UXQA 1HJ6A 2QFYA 3VMLA 5GRIA 3U1HA 4AOVA 4IWHA 2Y3ZA 1HQSA 1DPZA 5GRLA 1P8FA 1VLCA 3BLVB 3TY4A 1IDCA 1IKAA 1IDMA 3UF6A 4ATYA 1V5BA 1XADA 1XKDA 3MASB 3US8A 1DR8A 1G2UA 3ASJA 3LXYA 4JA8A 3WZWA 5GRFA 1XGVA 3MARA 5K11A 1XAAA 3BLXA 5GREB 5ICDA
chains in the Genus database with same CATH superfamily
5LGEA 1U7NA 1GC8A 3VL4A 1X0LA 5I95A 2ZTWA 3VKZA 3INMA 1V94A 4AJSA 4AOYA 4BNPA 1OSJA 2DHTA 4AJ3A 2IV0A 1PTMA 1PS7A 3FMXX 4UMXA 1WPWA 1CM7A 1PB3A 1DR0A 1R8KA 2UXRA 3TNGA 3WZYA 1CW7A 3BLVA 4P69C 4XRXA 5GRHB 1ISOA 4YB4A 2QFXA 8ICDA 1HEXA 3TSNA 2HI1A 3MASA 1A05A 2Y42A 4AOUA 3DMSA 1GC9A 5HN6A 5L58A 5HN4A 9ICDA 1T09A 2AYQA 3UDOA 1V53A 3LCBC 2E0CA 3VL6A 1VI1A 1PB1A 5L57A 1AI3A 3VL7A 1CW4A 3TY3A 2Y41A 4L06A 1YXOA 2QFWA 1OSIA 1T0LA 3VL3A 4XS3A 4I3KA 4AJCA 4Y1PA 2D4VA 3VMJA 3BLXB 1XACA 4JQPA 3MAPA 3AH3A 5HN5A 5GRHA 4L03A 1IPDA 5J34A 1GROA 4I3LA 2QFVA 4F7IA 4AJBA 1GRPA 4UMYA 3UDUA 2D1CA 2E5MA 5DE1A 5GRIB 1AI2A 3WZXA 1ZORA 5GREA 3FLKA 4AJAA 1TYOA 5GRLB 3VMKA 1YCOA 4ICDA 5J32A 5J33A 4L04A 4AJRA 1SJSA 1XABA 3ICDA 5HN3A 3WZVA 5I96A 2G4OA 1CW1A 1LWDA 1IDFA 6ICDA 5GRFB 7ICDA 1W0DA 4XXVA 3R8WA 3VL2A 1CNZA 4WUOA 1PS6A 1IDDA 1IDEA 4HCXA 4KZOA 1BL5A 5K10A 2Y40A 1WALA 3U9EA 2UXQA 1HJ6A 2QFYA 3VMLA 5GRIA 3U1HA 4AOVA 4IWHA 2Y3ZA 1HQSA 1DPZA 5GRLA 1P8FA 1VLCA 3BLVB 3TY4A 1IDCA 1IKAA 1IDMA 3UF6A 4ATYA 1V5BA 1XADA 1XKDA 3MASB 3US8A 1DR8A 1G2UA 3ASJA 3LXYA 4JA8A 3WZWA 5GRFA 1XGVA 3MARA 5K11A 1XAAA 3BLXA 5GREB 5ICDA
chains in the Genus database with same CATH topology
5LGEA 1U7NA 1GC8A 3VL4A 1X0LA 5I95A 2ZTWA 3VKZA 3INMA 1V94A 4AJSA 4AOYA 4BNPA 1OSJA 2DHTA 4AJ3A 2IV0A 1PTMA 1PS7A 3FMXX 4UMXA 1WPWA 1CM7A 1PB3A 1DR0A 1R8KA 2UXRA 3TNGA 3WZYA 1CW7A 3BLVA 4P69C 4XRXA 5GRHB 1ISOA 4YB4A 2QFXA 8ICDA 1HEXA 3TSNA 2HI1A 3MASA 1A05A 2Y42A 4AOUA 3DMSA 1GC9A 5HN6A 5L58A 5HN4A 9ICDA 1T09A 2AYQA 3UDOA 1V53A 3LCBC 2E0CA 3VL6A 1VI1A 1PB1A 5L57A 1AI3A 3VL7A 1CW4A 3TY3A 2Y41A 4L06A 1YXOA 2QFWA 1OSIA 1T0LA 3VL3A 4XS3A 4I3KA 4AJCA 4Y1PA 2D4VA 3VMJA 3BLXB 1XACA 4JQPA 3MAPA 3AH3A 5HN5A 5GRHA 4L03A 1IPDA 5J34A 1GROA 4I3LA 2QFVA 4F7IA 4AJBA 1GRPA 4UMYA 3UDUA 2D1CA 2E5MA 5DE1A 5GRIB 1AI2A 3WZXA 1ZORA 5GREA 3FLKA 4AJAA 1TYOA 5GRLB 3VMKA 1YCOA 4ICDA 5J32A 5J33A 4L04A 4AJRA 1SJSA 1XABA 3ICDA 5HN3A 3WZVA 5I96A 2G4OA 1CW1A 1LWDA 1IDFA 6ICDA 5GRFB 7ICDA 1W0DA 4XXVA 3R8WA 3VL2A 1CNZA 4WUOA 1PS6A 1IDDA 1IDEA 4HCXA 4KZOA 1BL5A 5K10A 2Y40A 1WALA 3U9EA 2UXQA 1HJ6A 2QFYA 3VMLA 5GRIA 3U1HA 4AOVA 4IWHA 2Y3ZA 1HQSA 1DPZA 5GRLA 1P8FA 1VLCA 3BLVB 3TY4A 1IDCA 1IKAA 1IDMA 3UF6A 4ATYA 1V5BA 1XADA 1XKDA 3MASB 3US8A 1DR8A 1G2UA 3ASJA 3LXYA 4JA8A 3WZWA 5GRFA 1XGVA 3MARA 5K11A 1XAAA 3BLXA 5GREB 5ICDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LGE A;  1U7N A;  1GC8 A;  3VL4 A;  1X0L A;  5I95 A;  2ZTW A;  3VKZ A;  3INM A;  1V94 A;  4AJS A;  4AOY A;  4BNP A;  1OSJ A;  2DHT A;  4AJ3 A;  2IV0 A;  1PTM A;  1PS7 A;  3FMX X;  4UMX A;  1WPW A;  1CM7 A;  1PB3 A;  1DR0 A;  1R8K A;  2UXR A;  3TNG A;  3WZY A;  1CW7 A;  3BLV A;  4P69 C;  4XRX A;  5GRH B;  1ISO A;  4YB4 A;  2QFX A;  8ICD A;  1HEX A;  3TSN A;  2HI1 A;  3MAS A;  1A05 A;  2Y42 A;  4AOU A;  3DMS A;  1GC9 A;  5HN6 A;  5L58 A;  5HN4 A;  9ICD A;  1T09 A;  2AYQ A;  3UDO A;  1V53 A;  3LCB C;  2E0C A;  3VL6 A;  1VI1 A;  1PB1 A;  5L57 A;  1AI3 A;  3VL7 A;  1CW4 A;  3TY3 A;  2Y41 A;  4L06 A;  1YXO A;  2QFW A;  1OSI A;  1T0L A;  3VL3 A;  4XS3 A;  4I3K A;  4AJC A;  4Y1P A;  2D4V A;  3VMJ A;  3BLX B;  1XAC A;  4JQP A;  3MAP A;  3AH3 A;  5HN5 A;  5GRH A;  4L03 A;  1IPD A;  5J34 A;  1GRO A;  4I3L A;  2QFV A;  4F7I A;  4AJB A;  1GRP A;  4UMY A;  3UDU A;  2D1C A;  2E5M A;  5DE1 A;  5GRI B;  1AI2 A;  3WZX A;  1ZOR A;  5GRE A;  3FLK A;  4AJA A;  1TYO A;  5GRL B;  3VMK A;  1YCO A;  4ICD A;  5J32 A;  5J33 A;  4L04 A;  4AJR A;  1SJS A;  1XAB A;  3ICD A;  5HN3 A;  3WZV A;  5I96 A;  2G4O A;  1CW1 A;  1LWD A;  1IDF A;  6ICD A;  5GRF B;  7ICD A;  1W0D A;  4XXV A;  3R8W A;  3VL2 A;  1CNZ A;  4WUO A;  1PS6 A;  1IDD A;  1IDE A;  4HCX A;  4KZO A;  1BL5 A;  5K10 A;  2Y40 A;  1WAL A;  3U9E A;  2UXQ A;  1HJ6 A;  2QFY A;  3VML A;  5GRI A;  3U1H A;  4AOV A;  4IWH A;  2Y3Z A;  1HQS A;  1DPZ A;  5GRL A;  1P8F A;  1VLC A;  3BLV B;  3TY4 A;  1IDC A;  1IKA A;  1IDM A;  3UF6 A;  4ATY A;  1V5B A;  1XAD A;  1XKD A;  3MAS B;  3US8 A;  1DR8 A;  1G2U A;  3ASJ A;  3LXY A;  4JA8 A;  3WZW A;  5GRF A;  1XGV A;  3MAR A;  5K11 A;  1XAA A;  3BLX A;  5GRE B;  5ICD A; 
#chains in the Genus database with same CATH topology
 5LGE A;  1U7N A;  1GC8 A;  3VL4 A;  1X0L A;  5I95 A;  2ZTW A;  3VKZ A;  3INM A;  1V94 A;  4AJS A;  4AOY A;  4BNP A;  1OSJ A;  2DHT A;  4AJ3 A;  2IV0 A;  1PTM A;  1PS7 A;  3FMX X;  4UMX A;  1WPW A;  1CM7 A;  1PB3 A;  1DR0 A;  1R8K A;  2UXR A;  3TNG A;  3WZY A;  1CW7 A;  3BLV A;  4P69 C;  4XRX A;  5GRH B;  1ISO A;  4YB4 A;  2QFX A;  8ICD A;  1HEX A;  3TSN A;  2HI1 A;  3MAS A;  1A05 A;  2Y42 A;  4AOU A;  3DMS A;  1GC9 A;  5HN6 A;  5L58 A;  5HN4 A;  9ICD A;  1T09 A;  2AYQ A;  3UDO A;  1V53 A;  3LCB C;  2E0C A;  3VL6 A;  1VI1 A;  1PB1 A;  5L57 A;  1AI3 A;  3VL7 A;  1CW4 A;  3TY3 A;  2Y41 A;  4L06 A;  1YXO A;  2QFW A;  1OSI A;  1T0L A;  3VL3 A;  4XS3 A;  4I3K A;  4AJC A;  4Y1P A;  2D4V A;  3VMJ A;  3BLX B;  1XAC A;  4JQP A;  3MAP A;  3AH3 A;  5HN5 A;  5GRH A;  4L03 A;  1IPD A;  5J34 A;  1GRO A;  4I3L A;  2QFV A;  4F7I A;  4AJB A;  1GRP A;  4UMY A;  3UDU A;  2D1C A;  2E5M A;  5DE1 A;  5GRI B;  1AI2 A;  3WZX A;  1ZOR A;  5GRE A;  3FLK A;  4AJA A;  1TYO A;  5GRL B;  3VMK A;  1YCO A;  4ICD A;  5J32 A;  5J33 A;  4L04 A;  4AJR A;  1SJS A;  1XAB A;  3ICD A;  5HN3 A;  3WZV A;  5I96 A;  2G4O A;  1CW1 A;  1LWD A;  1IDF A;  6ICD A;  5GRF B;  7ICD A;  1W0D A;  4XXV A;  3R8W A;  3VL2 A;  1CNZ A;  4WUO A;  1PS6 A;  1IDD A;  1IDE A;  4HCX A;  4KZO A;  1BL5 A;  5K10 A;  2Y40 A;  1WAL A;  3U9E A;  2UXQ A;  1HJ6 A;  2QFY A;  3VML A;  5GRI A;  3U1H A;  4AOV A;  4IWH A;  2Y3Z A;  1HQS A;  1DPZ A;  5GRL A;  1P8F A;  1VLC A;  3BLV B;  3TY4 A;  1IDC A;  1IKA A;  1IDM A;  3UF6 A;  4ATY A;  1V5B A;  1XAD A;  1XKD A;  3MAS B;  3US8 A;  1DR8 A;  1G2U A;  3ASJ A;  3LXY A;  4JA8 A;  3WZW A;  5GRF A;  1XGV A;  3MAR A;  5K11 A;  1XAA A;  3BLX A;  5GRE B;  5ICD A; 
#chains in the Genus database with same CATH homology
 5LGE A;  1U7N A;  1GC8 A;  3VL4 A;  1X0L A;  5I95 A;  2ZTW A;  3VKZ A;  3INM A;  1V94 A;  4AJS A;  4AOY A;  4BNP A;  1OSJ A;  2DHT A;  4AJ3 A;  2IV0 A;  1PTM A;  1PS7 A;  3FMX X;  4UMX A;  1WPW A;  1CM7 A;  1PB3 A;  1DR0 A;  1R8K A;  2UXR A;  3TNG A;  3WZY A;  1CW7 A;  3BLV A;  4P69 C;  4XRX A;  5GRH B;  1ISO A;  4YB4 A;  2QFX A;  8ICD A;  1HEX A;  3TSN A;  2HI1 A;  3MAS A;  1A05 A;  2Y42 A;  4AOU A;  3DMS A;  1GC9 A;  5HN6 A;  5L58 A;  5HN4 A;  9ICD A;  1T09 A;  2AYQ A;  3UDO A;  1V53 A;  3LCB C;  2E0C A;  3VL6 A;  1VI1 A;  1PB1 A;  5L57 A;  1AI3 A;  3VL7 A;  1CW4 A;  3TY3 A;  2Y41 A;  4L06 A;  1YXO A;  2QFW A;  1OSI A;  1T0L A;  3VL3 A;  4XS3 A;  4I3K A;  4AJC A;  4Y1P A;  2D4V A;  3VMJ A;  3BLX B;  1XAC A;  4JQP A;  3MAP A;  3AH3 A;  5HN5 A;  5GRH A;  4L03 A;  1IPD A;  5J34 A;  1GRO A;  4I3L A;  2QFV A;  4F7I A;  4AJB A;  1GRP A;  4UMY A;  3UDU A;  2D1C A;  2E5M A;  5DE1 A;  5GRI B;  1AI2 A;  3WZX A;  1ZOR A;  5GRE A;  3FLK A;  4AJA A;  1TYO A;  5GRL B;  3VMK A;  1YCO A;  4ICD A;  5J32 A;  5J33 A;  4L04 A;  4AJR A;  1SJS A;  1XAB A;  3ICD A;  5HN3 A;  3WZV A;  5I96 A;  2G4O A;  1CW1 A;  1LWD A;  1IDF A;  6ICD A;  5GRF B;  7ICD A;  1W0D A;  4XXV A;  3R8W A;  3VL2 A;  1CNZ A;  4WUO A;  1PS6 A;  1IDD A;  1IDE A;  4HCX A;  4KZO A;  1BL5 A;  5K10 A;  2Y40 A;  1WAL A;  3U9E A;  2UXQ A;  1HJ6 A;  2QFY A;  3VML A;  5GRI A;  3U1H A;  4AOV A;  4IWH A;  2Y3Z A;  1HQS A;  1DPZ A;  5GRL A;  1P8F A;  1VLC A;  3BLV B;  3TY4 A;  1IDC A;  1IKA A;  1IDM A;  3UF6 A;  4ATY A;  1V5B A;  1XAD A;  1XKD A;  3MAS B;  3US8 A;  1DR8 A;  1G2U A;  3ASJ A;  3LXY A;  4JA8 A;  3WZW A;  5GRF A;  1XGV A;  3MAR A;  5K11 A;  1XAA A;  3BLX A;  5GRE B;  5ICD A; 
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