1SJS | Genus

Total Genus 132

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	132
sequence length	415
structure length	415
Chain Sequence	ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Escherichia coli
publication title	Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting. pubmed doi rcsb
molecule keywords	ISOCITRATE DEHYDROGENASE
total genus	132
structure length	415
sequence length	415
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	1997-07-08

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	1sjsA00

3MASB 3LXYA 5L57A 5GRHB 4P69C 3US8A 3UDOA 1U7NA 5ICDA 1XKDA 3BLVA 1V53A 1XACA 3TY4A 1IDCA 3LCBC 1GROA 1CW1A 1OSIA 1XADA 1AI2A 1VI1A 4YB4A 4BNPA 4F7IA 3DMSA 1G2UA 1WPWA 5L58A 4XS3A 4AJSA 3U1HA 1OSJA 1T0LA 3U9EA 3TY3A 4ICDA 1YXOA 1PTMA 1CM7A 1ZORA 1XGVA 2UXQA 4L04A 1W0DA 2Y41A 4HCXA 4JQPA 2G4OA 2QFXA 4AOUA 1HQSA 1PB3A 1GRPA 5J33A 5GRIA 2QFYA 2DHTA 3INMA 4KZOA 5DE1A 3VL6A 1DPZA 4AOYA 2E0CA 4L03A 2QFWA 5GRIB 3BLXA 4AJBA 8ICDA 1IDFA 1IKAA 3BLVB 3R8WA 2E5MA 4WUOA 4AJAA 1P8FA 2IV0A 1X0LA 5GRFA 4I3LA 3VL7A 3BLXB 1V94A 3FLKA 3TSNA 2QFVA 2Y3ZA 1XABA 5HN4A 2D1CA 5J34A 3WZWA 5GRLA 5HN6A 2AYQA 5I95A 3FMXX 2HI1A 5K11A 4JA8A 3UF6A 3VL2A 4AJCA 2D4VA 5GRLB 3AH3A 1HJ6A 1GC9A 5K10A 4XXVA 2Y42A 3MAPA 4UMYA 5I96A 1WALA 1PB1A 3WZVA 5LGEA 5GREA 2ZTWA 4AJ3A 4IWHA 3MASA 3ASJA 1PS6A 3VL3A 5GRHA 1VLCA 4AOVA 1R8KA 2Y40A 4XRXA 5HN3A 5GRFB 3UDUA 9ICDA 1CW7A 5J32A 3WZXA 4ATYA 1TYOA 1XAAA 1AI3A 1BL5A 3ICDA 3WZYA 1SJSA 1IDEA 1IDMA 1YCOA 4L06A 3VMJA 1ISOA 3TNGA 1GC8A 4I3KA 1HEXA 1PS7A 3MARA 1DR8A 1V5BA 1DR0A 1LWDA 1CW4A 5HN5A 1CNZA 4AJRA 6ICDA 4UMXA 4Y1PA 3VMLA 3VL4A 3VMKA 1IPDA 1A05A 3VKZA 1IDDA 7ICDA 2UXRA 1T09A 5GREB
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3MAS B;  3LXY A;  5L57 A;  5GRH B;  4P69 C;  3US8 A;  3UDO A;  1U7N A;  5ICD A;  1XKD A;  3BLV A;  1V53 A;  1XAC A;  3TY4 A;  1IDC A;  3LCB C;  1GRO A;  1CW1 A;  1OSI A;  1XAD A;  1AI2 A;  1VI1 A;  4YB4 A;  4BNP A;  4F7I A;  3DMS A;  1G2U A;  1WPW A;  5L58 A;  4XS3 A;  4AJS A;  3U1H A;  1OSJ A;  1T0L A;  3U9E A;  3TY3 A;  4ICD A;  1YXO A;  1PTM A;  1CM7 A;  1ZOR A;  1XGV A;  2UXQ A;  4L04 A;  1W0D A;  2Y41 A;  4HCX A;  4JQP A;  2G4O A;  2QFX A;  4AOU A;  1HQS A;  1PB3 A;  1GRP A;  5J33 A;  5GRI A;  2QFY A;  2DHT A;  3INM A;  4KZO A;  5DE1 A;  3VL6 A;  1DPZ A;  4AOY A;  2E0C A;  4L03 A;  2QFW A;  5GRI B;  3BLX A;  4AJB A;  8ICD A;  1IDF A;  1IKA A;  3BLV B;  3R8W A;  2E5M A;  4WUO A;  4AJA A;  1P8F A;  2IV0 A;  1X0L A;  5GRF A;  4I3L A;  3VL7 A;  3BLX B;  1V94 A;  3FLK A;  3TSN A;  2QFV A;  2Y3Z A;  1XAB A;  5HN4 A;  2D1C A;  5J34 A;  3WZW A;  5GRL A;  5HN6 A;  2AYQ A;  5I95 A;  3FMX X;  2HI1 A;  5K11 A;  4JA8 A;  3UF6 A;  3VL2 A;  4AJC A;  2D4V A;  5GRL B;  3AH3 A;  1HJ6 A;  1GC9 A;  5K10 A;  4XXV A;  2Y42 A;  3MAP A;  4UMY A;  5I96 A;  1WAL A;  1PB1 A;  3WZV A;  5LGE A;  5GRE A;  2ZTW A;  4AJ3 A;  4IWH A;  3MAS A;  3ASJ A;  1PS6 A;  3VL3 A;  5GRH A;  1VLC A;  4AOV A;  1R8K A;  2Y40 A;  4XRX A;  5HN3 A;  5GRF B;  3UDU A;  9ICD A;  1CW7 A;  5J32 A;  3WZX A;  4ATY A;  1TYO A;  1XAA A;  1AI3 A;  1BL5 A;  3ICD A;  3WZY A;  1SJS A;  1IDE A;  1IDM A;  1YCO A;  4L06 A;  3VMJ A;  1ISO A;  3TNG A;  1GC8 A;  4I3K A;  1HEX A;  1PS7 A;  3MAR A;  1DR8 A;  1V5B A;  1DR0 A;  1LWD A;  1CW4 A;  5HN5 A;  1CNZ A;  4AJR A;  6ICD A;  4UMX A;  4Y1P A;  3VML A;  3VL4 A;  3VMK A;  1IPD A;  1A05 A;  3VKZ A;  1IDD A;  7ICD A;  2UXR A;  1T09 A;  5GRE B; 
#chains in the Genus database with same CATH topology
 3MAS B;  3LXY A;  5L57 A;  5GRH B;  4P69 C;  3US8 A;  3UDO A;  1U7N A;  5ICD A;  1XKD A;  3BLV A;  1V53 A;  1XAC A;  3TY4 A;  1IDC A;  3LCB C;  1GRO A;  1CW1 A;  1OSI A;  1XAD A;  1AI2 A;  1VI1 A;  4YB4 A;  4BNP A;  4F7I A;  3DMS A;  1G2U A;  1WPW A;  5L58 A;  4XS3 A;  4AJS A;  3U1H A;  1OSJ A;  1T0L A;  3U9E A;  3TY3 A;  4ICD A;  1YXO A;  1PTM A;  1CM7 A;  1ZOR A;  1XGV A;  2UXQ A;  4L04 A;  1W0D A;  2Y41 A;  4HCX A;  4JQP A;  2G4O A;  2QFX A;  4AOU A;  1HQS A;  1PB3 A;  1GRP A;  5J33 A;  5GRI A;  2QFY A;  2DHT A;  3INM A;  4KZO A;  5DE1 A;  3VL6 A;  1DPZ A;  4AOY A;  2E0C A;  4L03 A;  2QFW A;  5GRI B;  3BLX A;  4AJB A;  8ICD A;  1IDF A;  1IKA A;  3BLV B;  3R8W A;  2E5M A;  4WUO A;  4AJA A;  1P8F A;  2IV0 A;  1X0L A;  5GRF A;  4I3L A;  3VL7 A;  3BLX B;  1V94 A;  3FLK A;  3TSN A;  2QFV A;  2Y3Z A;  1XAB A;  5HN4 A;  2D1C A;  5J34 A;  3WZW A;  5GRL A;  5HN6 A;  2AYQ A;  5I95 A;  3FMX X;  2HI1 A;  5K11 A;  4JA8 A;  3UF6 A;  3VL2 A;  4AJC A;  2D4V A;  5GRL B;  3AH3 A;  1HJ6 A;  1GC9 A;  5K10 A;  4XXV A;  2Y42 A;  3MAP A;  4UMY A;  5I96 A;  1WAL A;  1PB1 A;  3WZV A;  5LGE A;  5GRE A;  2ZTW A;  4AJ3 A;  4IWH A;  3MAS A;  3ASJ A;  1PS6 A;  3VL3 A;  5GRH A;  1VLC A;  4AOV A;  1R8K A;  2Y40 A;  4XRX A;  5HN3 A;  5GRF B;  3UDU A;  9ICD A;  1CW7 A;  5J32 A;  3WZX A;  4ATY A;  1TYO A;  1XAA A;  1AI3 A;  1BL5 A;  3ICD A;  3WZY A;  1SJS A;  1IDE A;  1IDM A;  1YCO A;  4L06 A;  3VMJ A;  1ISO A;  3TNG A;  1GC8 A;  4I3K A;  1HEX A;  1PS7 A;  3MAR A;  1DR8 A;  1V5B A;  1DR0 A;  1LWD A;  1CW4 A;  5HN5 A;  1CNZ A;  4AJR A;  6ICD A;  4UMX A;  4Y1P A;  3VML A;  3VL4 A;  3VMK A;  1IPD A;  1A05 A;  3VKZ A;  1IDD A;  7ICD A;  2UXR A;  1T09 A;  5GRE B; 
#chains in the Genus database with same CATH homology
 3MAS B;  3LXY A;  5L57 A;  5GRH B;  4P69 C;  3US8 A;  3UDO A;  1U7N A;  5ICD A;  1XKD A;  3BLV A;  1V53 A;  1XAC A;  3TY4 A;  1IDC A;  3LCB C;  1GRO A;  1CW1 A;  1OSI A;  1XAD A;  1AI2 A;  1VI1 A;  4YB4 A;  4BNP A;  4F7I A;  3DMS A;  1G2U A;  1WPW A;  5L58 A;  4XS3 A;  4AJS A;  3U1H A;  1OSJ A;  1T0L A;  3U9E A;  3TY3 A;  4ICD A;  1YXO A;  1PTM A;  1CM7 A;  1ZOR A;  1XGV A;  2UXQ A;  4L04 A;  1W0D A;  2Y41 A;  4HCX A;  4JQP A;  2G4O A;  2QFX A;  4AOU A;  1HQS A;  1PB3 A;  1GRP A;  5J33 A;  5GRI A;  2QFY A;  2DHT A;  3INM A;  4KZO A;  5DE1 A;  3VL6 A;  1DPZ A;  4AOY A;  2E0C A;  4L03 A;  2QFW A;  5GRI B;  3BLX A;  4AJB A;  8ICD A;  1IDF A;  1IKA A;  3BLV B;  3R8W A;  2E5M A;  4WUO A;  4AJA A;  1P8F A;  2IV0 A;  1X0L A;  5GRF A;  4I3L A;  3VL7 A;  3BLX B;  1V94 A;  3FLK A;  3TSN A;  2QFV A;  2Y3Z A;  1XAB A;  5HN4 A;  2D1C A;  5J34 A;  3WZW A;  5GRL A;  5HN6 A;  2AYQ A;  5I95 A;  3FMX X;  2HI1 A;  5K11 A;  4JA8 A;  3UF6 A;  3VL2 A;  4AJC A;  2D4V A;  5GRL B;  3AH3 A;  1HJ6 A;  1GC9 A;  5K10 A;  4XXV A;  2Y42 A;  3MAP A;  4UMY A;  5I96 A;  1WAL A;  1PB1 A;  3WZV A;  5LGE A;  5GRE A;  2ZTW A;  4AJ3 A;  4IWH A;  3MAS A;  3ASJ A;  1PS6 A;  3VL3 A;  5GRH A;  1VLC A;  4AOV A;  1R8K A;  2Y40 A;  4XRX A;  5HN3 A;  5GRF B;  3UDU A;  9ICD A;  1CW7 A;  5J32 A;  3WZX A;  4ATY A;  1TYO A;  1XAA A;  1AI3 A;  1BL5 A;  3ICD A;  3WZY A;  1SJS A;  1IDE A;  1IDM A;  1YCO A;  4L06 A;  3VMJ A;  1ISO A;  3TNG A;  1GC8 A;  4I3K A;  1HEX A;  1PS7 A;  3MAR A;  1DR8 A;  1V5B A;  1DR0 A;  1LWD A;  1CW4 A;  5HN5 A;  1CNZ A;  4AJR A;  6ICD A;  4UMX A;  4Y1P A;  3VML A;  3VL4 A;  3VMK A;  1IPD A;  1A05 A;  3VKZ A;  1IDD A;  7ICD A;  2UXR A;  1T09 A;  5GRE B;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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1SJSA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations