1T0L | Genus

Total Genus 156

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	156
sequence length	414
structure length	414
Chain Sequence	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NADP] cytoplasmic
molecule tags	Oxidoreductase
source organism	Homo sapiens
total genus	156
structure length	414
sequence length	414
chains with identical sequence	B, C, D
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	2004-04-10

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	1t0lA00

3VL6A 5J32A 1IDDA 1PS7A 3UDUA 1X0LA 1CW4A 1CM7A 1V53A 3U1HA 1AI3A 4ATYA 1CW7A 1WALA 4I3LA 3TSNA 2Y40A 1PS6A 3VL3A 6ICDA 1G2UA 3WZXA 1BL5A 4AOVA 9ICDA 4JA8A 2Y42A 1XAAA 2Y3ZA 4AOYA 1SJSA 1P8FA 1V94A 4AOUA 4F7IA 1YCOA 5GRFB 4ICDA 1T09A 1DPZA 1U7NA 3DMSA 1CW1A 3VMJA 4AJCA 4IWHA 1R8KA 3INMA 4L03A 4AJBA 1ZORA 5ICDA 1GROA 1XABA 7ICDA 5DE1A 4UMXA 3MARA 5GRFA 1DR8A 3ICDA 1AI2A 3BLVB 5L58A 5K10A 1A05A 4L04A 3VL2A 1IDEA 1IDMA 4KZOA 3VMLA 2Y41A 3FLKA 4L06A 1T0LA 1TYOA 1XACA 3BLVA 4P69C 4XRXA 3VL4A 1GC8A 1V5BA 2DHTA 5HN5A 4UMYA 2G4OA 3VL7A 1XADA 5HN3A 4I3KA 2QFVA 1IPDA 3WZYA 2UXQA 1PB3A 5HN4A 3WZWA 4AJRA 2IV0A 3TY4A 5J33A 2E5MA 1DR0A 5L57A 1CNZA 8ICDA 3MAPA 5GRLB 4AJ3A 4JQPA 5GRHB 1WPWA 2D4VA 2QFWA 4XXVA 3LXYA 1XKDA 1HQSA 3TNGA 4XS3A 5GRLA 1IKAA 3U9EA 5GRHA 3ASJA 3MASB 1LWDA 5GREB 2QFYA 3VMKA 1VLCA 3FMXX 1IDCA 3UF6A 3WZVA 4YB4A 4WUOA 3MASA 3R8WA 1YXOA 5GREA 4Y1PA 1PB1A 3TY3A 1GC9A 4HCXA 1HJ6A 5GRIB 1HEXA 2E0CA 5K11A 3BLXA 4AJSA 1IDFA 1OSJA 1ISOA 2UXRA 1PTMA 1VI1A 5J34A 2D1CA 3US8A 5GRIA 5I96A 1W0DA 2AYQA 4AJAA 1OSIA 3AH3A 2QFXA 1GRPA 5HN6A 3UDOA 2ZTWA 3LCBC 2HI1A 4BNPA 1XGVA 3BLXB 5LGEA 3VKZA 5I95A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3VL6 A;  5J32 A;  1IDD A;  1PS7 A;  3UDU A;  1X0L A;  1CW4 A;  1CM7 A;  1V53 A;  3U1H A;  1AI3 A;  4ATY A;  1CW7 A;  1WAL A;  4I3L A;  3TSN A;  2Y40 A;  1PS6 A;  3VL3 A;  6ICD A;  1G2U A;  3WZX A;  1BL5 A;  4AOV A;  9ICD A;  4JA8 A;  2Y42 A;  1XAA A;  2Y3Z A;  4AOY A;  1SJS A;  1P8F A;  1V94 A;  4AOU A;  4F7I A;  1YCO A;  5GRF B;  4ICD A;  1T09 A;  1DPZ A;  1U7N A;  3DMS A;  1CW1 A;  3VMJ A;  4AJC A;  4IWH A;  1R8K A;  3INM A;  4L03 A;  4AJB A;  1ZOR A;  5ICD A;  1GRO A;  1XAB A;  7ICD A;  5DE1 A;  4UMX A;  3MAR A;  5GRF A;  1DR8 A;  3ICD A;  1AI2 A;  3BLV B;  5L58 A;  5K10 A;  1A05 A;  4L04 A;  3VL2 A;  1IDE A;  1IDM A;  4KZO A;  3VML A;  2Y41 A;  3FLK A;  4L06 A;  1T0L A;  1TYO A;  1XAC A;  3BLV A;  4P69 C;  4XRX A;  3VL4 A;  1GC8 A;  1V5B A;  2DHT A;  5HN5 A;  4UMY A;  2G4O A;  3VL7 A;  1XAD A;  5HN3 A;  4I3K A;  2QFV A;  1IPD A;  3WZY A;  2UXQ A;  1PB3 A;  5HN4 A;  3WZW A;  4AJR A;  2IV0 A;  3TY4 A;  5J33 A;  2E5M A;  1DR0 A;  5L57 A;  1CNZ A;  8ICD A;  3MAP A;  5GRL B;  4AJ3 A;  4JQP A;  5GRH B;  1WPW A;  2D4V A;  2QFW A;  4XXV A;  3LXY A;  1XKD A;  1HQS A;  3TNG A;  4XS3 A;  5GRL A;  1IKA A;  3U9E A;  5GRH A;  3ASJ A;  3MAS B;  1LWD A;  5GRE B;  2QFY A;  3VMK A;  1VLC A;  3FMX X;  1IDC A;  3UF6 A;  3WZV A;  4YB4 A;  4WUO A;  3MAS A;  3R8W A;  1YXO A;  5GRE A;  4Y1P A;  1PB1 A;  3TY3 A;  1GC9 A;  4HCX A;  1HJ6 A;  5GRI B;  1HEX A;  2E0C A;  5K11 A;  3BLX A;  4AJS A;  1IDF A;  1OSJ A;  1ISO A;  2UXR A;  1PTM A;  1VI1 A;  5J34 A;  2D1C A;  3US8 A;  5GRI A;  5I96 A;  1W0D A;  2AYQ A;  4AJA A;  1OSI A;  3AH3 A;  2QFX A;  1GRP A;  5HN6 A;  3UDO A;  2ZTW A;  3LCB C;  2HI1 A;  4BNP A;  1XGV A;  3BLX B;  5LGE A;  3VKZ A;  5I95 A; 
#chains in the Genus database with same CATH topology
 3VL6 A;  5J32 A;  1IDD A;  1PS7 A;  3UDU A;  1X0L A;  1CW4 A;  1CM7 A;  1V53 A;  3U1H A;  1AI3 A;  4ATY A;  1CW7 A;  1WAL A;  4I3L A;  3TSN A;  2Y40 A;  1PS6 A;  3VL3 A;  6ICD A;  1G2U A;  3WZX A;  1BL5 A;  4AOV A;  9ICD A;  4JA8 A;  2Y42 A;  1XAA A;  2Y3Z A;  4AOY A;  1SJS A;  1P8F A;  1V94 A;  4AOU A;  4F7I A;  1YCO A;  5GRF B;  4ICD A;  1T09 A;  1DPZ A;  1U7N A;  3DMS A;  1CW1 A;  3VMJ A;  4AJC A;  4IWH A;  1R8K A;  3INM A;  4L03 A;  4AJB A;  1ZOR A;  5ICD A;  1GRO A;  1XAB A;  7ICD A;  5DE1 A;  4UMX A;  3MAR A;  5GRF A;  1DR8 A;  3ICD A;  1AI2 A;  3BLV B;  5L58 A;  5K10 A;  1A05 A;  4L04 A;  3VL2 A;  1IDE A;  1IDM A;  4KZO A;  3VML A;  2Y41 A;  3FLK A;  4L06 A;  1T0L A;  1TYO A;  1XAC A;  3BLV A;  4P69 C;  4XRX A;  3VL4 A;  1GC8 A;  1V5B A;  2DHT A;  5HN5 A;  4UMY A;  2G4O A;  3VL7 A;  1XAD A;  5HN3 A;  4I3K A;  2QFV A;  1IPD A;  3WZY A;  2UXQ A;  1PB3 A;  5HN4 A;  3WZW A;  4AJR A;  2IV0 A;  3TY4 A;  5J33 A;  2E5M A;  1DR0 A;  5L57 A;  1CNZ A;  8ICD A;  3MAP A;  5GRL B;  4AJ3 A;  4JQP A;  5GRH B;  1WPW A;  2D4V A;  2QFW A;  4XXV A;  3LXY A;  1XKD A;  1HQS A;  3TNG A;  4XS3 A;  5GRL A;  1IKA A;  3U9E A;  5GRH A;  3ASJ A;  3MAS B;  1LWD A;  5GRE B;  2QFY A;  3VMK A;  1VLC A;  3FMX X;  1IDC A;  3UF6 A;  3WZV A;  4YB4 A;  4WUO A;  3MAS A;  3R8W A;  1YXO A;  5GRE A;  4Y1P A;  1PB1 A;  3TY3 A;  1GC9 A;  4HCX A;  1HJ6 A;  5GRI B;  1HEX A;  2E0C A;  5K11 A;  3BLX A;  4AJS A;  1IDF A;  1OSJ A;  1ISO A;  2UXR A;  1PTM A;  1VI1 A;  5J34 A;  2D1C A;  3US8 A;  5GRI A;  5I96 A;  1W0D A;  2AYQ A;  4AJA A;  1OSI A;  3AH3 A;  2QFX A;  1GRP A;  5HN6 A;  3UDO A;  2ZTW A;  3LCB C;  2HI1 A;  4BNP A;  1XGV A;  3BLX B;  5LGE A;  3VKZ A;  5I95 A; 
#chains in the Genus database with same CATH homology
 3VL6 A;  5J32 A;  1IDD A;  1PS7 A;  3UDU A;  1X0L A;  1CW4 A;  1CM7 A;  1V53 A;  3U1H A;  1AI3 A;  4ATY A;  1CW7 A;  1WAL A;  4I3L A;  3TSN A;  2Y40 A;  1PS6 A;  3VL3 A;  6ICD A;  1G2U A;  3WZX A;  1BL5 A;  4AOV A;  9ICD A;  4JA8 A;  2Y42 A;  1XAA A;  2Y3Z A;  4AOY A;  1SJS A;  1P8F A;  1V94 A;  4AOU A;  4F7I A;  1YCO A;  5GRF B;  4ICD A;  1T09 A;  1DPZ A;  1U7N A;  3DMS A;  1CW1 A;  3VMJ A;  4AJC A;  4IWH A;  1R8K A;  3INM A;  4L03 A;  4AJB A;  1ZOR A;  5ICD A;  1GRO A;  1XAB A;  7ICD A;  5DE1 A;  4UMX A;  3MAR A;  5GRF A;  1DR8 A;  3ICD A;  1AI2 A;  3BLV B;  5L58 A;  5K10 A;  1A05 A;  4L04 A;  3VL2 A;  1IDE A;  1IDM A;  4KZO A;  3VML A;  2Y41 A;  3FLK A;  4L06 A;  1T0L A;  1TYO A;  1XAC A;  3BLV A;  4P69 C;  4XRX A;  3VL4 A;  1GC8 A;  1V5B A;  2DHT A;  5HN5 A;  4UMY A;  2G4O A;  3VL7 A;  1XAD A;  5HN3 A;  4I3K A;  2QFV A;  1IPD A;  3WZY A;  2UXQ A;  1PB3 A;  5HN4 A;  3WZW A;  4AJR A;  2IV0 A;  3TY4 A;  5J33 A;  2E5M A;  1DR0 A;  5L57 A;  1CNZ A;  8ICD A;  3MAP A;  5GRL B;  4AJ3 A;  4JQP A;  5GRH B;  1WPW A;  2D4V A;  2QFW A;  4XXV A;  3LXY A;  1XKD A;  1HQS A;  3TNG A;  4XS3 A;  5GRL A;  1IKA A;  3U9E A;  5GRH A;  3ASJ A;  3MAS B;  1LWD A;  5GRE B;  2QFY A;  3VMK A;  1VLC A;  3FMX X;  1IDC A;  3UF6 A;  3WZV A;  4YB4 A;  4WUO A;  3MAS A;  3R8W A;  1YXO A;  5GRE A;  4Y1P A;  1PB1 A;  3TY3 A;  1GC9 A;  4HCX A;  1HJ6 A;  5GRI B;  1HEX A;  2E0C A;  5K11 A;  3BLX A;  4AJS A;  1IDF A;  1OSJ A;  1ISO A;  2UXR A;  1PTM A;  1VI1 A;  5J34 A;  2D1C A;  3US8 A;  5GRI A;  5I96 A;  1W0D A;  2AYQ A;  4AJA A;  1OSI A;  3AH3 A;  2QFX A;  1GRP A;  5HN6 A;  3UDO A;  2ZTW A;  3LCB C;  2HI1 A;  4BNP A;  1XGV A;  3BLX B;  5LGE A;  3VKZ A;  5I95 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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1T0LA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations