1V94A

Crystal structure of isocitrate dehydrogenase from aeropyrum pernix
Total Genus 139
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
139
sequence length
429
structure length
429
Chain Sequence
PPCTTEELSPPPGGSLVEYSGGSLRVPDNPVVAFIRGDGVGPEVVESALKVVDAAVKKVYGGSRRIVWWELLAGHLAREKCGELLPKATLEGIRLARVALKGPLETPVGTGYRSLNVAIRQALDLYANIRPVRYYGQPAPHKYADRVDMVIFRENTEDVYAGIEWPHDSPEAARIRRFLAEEFGISIREDAGIGVKPISRFATRRLMERALEWALRNGNTVVTIMHKGNIMKYTEGAFMRWAYEVALEKFREHVVTEQEVQEKYGGVRPEGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNGDYISDAASALVGGIGMAAGMNMGDGIAVAEPVHGTAPKYAGKDLINPSAEILSASLLIGEFMGWREVKSIVEYAIRKAVQSKKVTQDLARHMPGVQPLRTSEYTETLIAYIDEADLNEVLAGKRG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of isocitrate dehydrogenase from Aeropyrum pernix
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Aeropyrum pernix
molecule keywords isocitrate dehydrogenase
total genus 139
structure length 429
sequence length 429
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2004-01-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1v94A00
1DR0A 5I96A 3LXYA 3VKZA 1PTMA 4P69C 2IV0A 1G2UA 1V94A 2G4OA 3VMKA 4AJBA 1IDEA 1IDMA 2UXRA 2Y3ZA 2E5MA 5DE1A 1U7NA 1GRPA 4AJAA 3VL2A 5GREA 4F7IA 4L03A 5HN4A 3WZYA 1CW1A 2AYQA 5GRIA 3MASB 4I3LA 1XAAA 3R8WA 1R8KA 1AI3A 1SJSA 3DMSA 5J32A 5GRLA 4XRXA 4AJSA 5GRFA 4BNPA 1ISOA 2HI1A 4JQPA 2Y41A 5GRHB 3VMJA 1PB3A 4AOVA 5HN6A 3BLVB 3WZVA 3BLXB 4I3KA 3U9EA 2D1CA 5K10A 1XACA 4L06A 1VLCA 1GC8A 1YXOA 3MARA 4WUOA 4XS3A 2QFXA 5J34A 1WPWA 3TY4A 1W0DA 4Y1PA 1PB1A 4L04A 4KZOA 1CW7A 3MASA 5J33A 4ATYA 3UDUA 3WZXA 1V53A 3TY3A 2QFVA 5GRHA 2QFYA 5HN3A 2DHTA 2UXQA 1TYOA 3TNGA 1WALA 4AOUA 3U1HA 5L58A 1T0LA 1HEXA 3AH3A 5L57A 2Y42A 5LGEA 1CW4A 2D4VA 3FMXX 5GREB 1XKDA 3US8A 1HJ6A 2E0CA 3INMA 1YCOA 2Y40A 2ZTWA 4XXVA 3ICDA 1XABA 5I95A 1A05A 1LWDA 1PS7A 5ICDA 4IWHA 3VL4A 1GC9A 3UDOA 4ICDA 1PS6A 1V5BA 5GRLB 3UF6A 1IPDA 4AOYA 7ICDA 3TSNA 6ICDA 1BL5A 1HQSA 1VI1A 1ZORA 3MAPA 1DR8A 1GROA 3ASJA 9ICDA 1DPZA 3VL3A 4HCXA 3FLKA 1IDFA 4UMYA 1IDCA 1P8FA 3BLVA 3VMLA 3LCBC 5HN5A 1XADA 3VL7A 4AJRA 4AJCA 8ICDA 1CM7A 1OSIA 3BLXA 4JA8A 1X0LA 1XGVA 3WZWA 4AJ3A 1AI2A 3VL6A 1IDDA 1T09A 4YB4A 5GRIB 1IKAA 4UMXA 2QFWA 1CNZA 1OSJA 5K11A 5GRFB
chains in the Genus database with same CATH superfamily
1DR0A 5I96A 3LXYA 3VKZA 1PTMA 4P69C 2IV0A 1G2UA 1V94A 2G4OA 3VMKA 4AJBA 1IDEA 1IDMA 2UXRA 2Y3ZA 2E5MA 5DE1A 1U7NA 1GRPA 4AJAA 3VL2A 5GREA 4F7IA 4L03A 5HN4A 3WZYA 1CW1A 2AYQA 5GRIA 3MASB 4I3LA 1XAAA 3R8WA 1R8KA 1AI3A 1SJSA 3DMSA 5J32A 5GRLA 4XRXA 4AJSA 5GRFA 4BNPA 1ISOA 2HI1A 4JQPA 2Y41A 5GRHB 3VMJA 1PB3A 4AOVA 5HN6A 3BLVB 3WZVA 3BLXB 4I3KA 3U9EA 2D1CA 5K10A 1XACA 4L06A 1VLCA 1GC8A 1YXOA 3MARA 4WUOA 4XS3A 2QFXA 5J34A 1WPWA 3TY4A 1W0DA 4Y1PA 1PB1A 4L04A 4KZOA 1CW7A 3MASA 5J33A 4ATYA 3UDUA 3WZXA 1V53A 3TY3A 2QFVA 5GRHA 2QFYA 5HN3A 2DHTA 2UXQA 1TYOA 3TNGA 1WALA 4AOUA 3U1HA 5L58A 1T0LA 1HEXA 3AH3A 5L57A 2Y42A 5LGEA 1CW4A 2D4VA 3FMXX 5GREB 1XKDA 3US8A 1HJ6A 2E0CA 3INMA 1YCOA 2Y40A 2ZTWA 4XXVA 3ICDA 1XABA 5I95A 1A05A 1LWDA 1PS7A 5ICDA 4IWHA 3VL4A 1GC9A 3UDOA 4ICDA 1PS6A 1V5BA 5GRLB 3UF6A 1IPDA 4AOYA 7ICDA 3TSNA 6ICDA 1BL5A 1HQSA 1VI1A 1ZORA 3MAPA 1DR8A 1GROA 3ASJA 9ICDA 1DPZA 3VL3A 4HCXA 3FLKA 1IDFA 4UMYA 1IDCA 1P8FA 3BLVA 3VMLA 3LCBC 5HN5A 1XADA 3VL7A 4AJRA 4AJCA 8ICDA 1CM7A 1OSIA 3BLXA 4JA8A 1X0LA 1XGVA 3WZWA 4AJ3A 1AI2A 3VL6A 1IDDA 1T09A 4YB4A 5GRIB 1IKAA 4UMXA 2QFWA 1CNZA 1OSJA 5K11A 5GRFB
chains in the Genus database with same CATH topology
1DR0A 5I96A 3LXYA 3VKZA 1PTMA 4P69C 2IV0A 1G2UA 1V94A 2G4OA 3VMKA 4AJBA 1IDEA 1IDMA 2UXRA 2Y3ZA 2E5MA 5DE1A 1U7NA 1GRPA 4AJAA 3VL2A 5GREA 4F7IA 4L03A 5HN4A 3WZYA 1CW1A 2AYQA 5GRIA 3MASB 4I3LA 1XAAA 3R8WA 1R8KA 1AI3A 1SJSA 3DMSA 5J32A 5GRLA 4XRXA 4AJSA 5GRFA 4BNPA 1ISOA 2HI1A 4JQPA 2Y41A 5GRHB 3VMJA 1PB3A 4AOVA 5HN6A 3BLVB 3WZVA 3BLXB 4I3KA 3U9EA 2D1CA 5K10A 1XACA 4L06A 1VLCA 1GC8A 1YXOA 3MARA 4WUOA 4XS3A 2QFXA 5J34A 1WPWA 3TY4A 1W0DA 4Y1PA 1PB1A 4L04A 4KZOA 1CW7A 3MASA 5J33A 4ATYA 3UDUA 3WZXA 1V53A 3TY3A 2QFVA 5GRHA 2QFYA 5HN3A 2DHTA 2UXQA 1TYOA 3TNGA 1WALA 4AOUA 3U1HA 5L58A 1T0LA 1HEXA 3AH3A 5L57A 2Y42A 5LGEA 1CW4A 2D4VA 3FMXX 5GREB 1XKDA 3US8A 1HJ6A 2E0CA 3INMA 1YCOA 2Y40A 2ZTWA 4XXVA 3ICDA 1XABA 5I95A 1A05A 1LWDA 1PS7A 5ICDA 4IWHA 3VL4A 1GC9A 3UDOA 4ICDA 1PS6A 1V5BA 5GRLB 3UF6A 1IPDA 4AOYA 7ICDA 3TSNA 6ICDA 1BL5A 1HQSA 1VI1A 1ZORA 3MAPA 1DR8A 1GROA 3ASJA 9ICDA 1DPZA 3VL3A 4HCXA 3FLKA 1IDFA 4UMYA 1IDCA 1P8FA 3BLVA 3VMLA 3LCBC 5HN5A 1XADA 3VL7A 4AJRA 4AJCA 8ICDA 1CM7A 1OSIA 3BLXA 4JA8A 1X0LA 1XGVA 3WZWA 4AJ3A 1AI2A 3VL6A 1IDDA 1T09A 4YB4A 5GRIB 1IKAA 4UMXA 2QFWA 1CNZA 1OSJA 5K11A 5GRFB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DR0 A;  5I96 A;  3LXY A;  3VKZ A;  1PTM A;  4P69 C;  2IV0 A;  1G2U A;  1V94 A;  2G4O A;  3VMK A;  4AJB A;  1IDE A;  1IDM A;  2UXR A;  2Y3Z A;  2E5M A;  5DE1 A;  1U7N A;  1GRP A;  4AJA A;  3VL2 A;  5GRE A;  4F7I A;  4L03 A;  5HN4 A;  3WZY A;  1CW1 A;  2AYQ A;  5GRI A;  3MAS B;  4I3L A;  1XAA A;  3R8W A;  1R8K A;  1AI3 A;  1SJS A;  3DMS A;  5J32 A;  5GRL A;  4XRX A;  4AJS A;  5GRF A;  4BNP A;  1ISO A;  2HI1 A;  4JQP A;  2Y41 A;  5GRH B;  3VMJ A;  1PB3 A;  4AOV A;  5HN6 A;  3BLV B;  3WZV A;  3BLX B;  4I3K A;  3U9E A;  2D1C A;  5K10 A;  1XAC A;  4L06 A;  1VLC A;  1GC8 A;  1YXO A;  3MAR A;  4WUO A;  4XS3 A;  2QFX A;  5J34 A;  1WPW A;  3TY4 A;  1W0D A;  4Y1P A;  1PB1 A;  4L04 A;  4KZO A;  1CW7 A;  3MAS A;  5J33 A;  4ATY A;  3UDU A;  3WZX A;  1V53 A;  3TY3 A;  2QFV A;  5GRH A;  2QFY A;  5HN3 A;  2DHT A;  2UXQ A;  1TYO A;  3TNG A;  1WAL A;  4AOU A;  3U1H A;  5L58 A;  1T0L A;  1HEX A;  3AH3 A;  5L57 A;  2Y42 A;  5LGE A;  1CW4 A;  2D4V A;  3FMX X;  5GRE B;  1XKD A;  3US8 A;  1HJ6 A;  2E0C A;  3INM A;  1YCO A;  2Y40 A;  2ZTW A;  4XXV A;  3ICD A;  1XAB A;  5I95 A;  1A05 A;  1LWD A;  1PS7 A;  5ICD A;  4IWH A;  3VL4 A;  1GC9 A;  3UDO A;  4ICD A;  1PS6 A;  1V5B A;  5GRL B;  3UF6 A;  1IPD A;  4AOY A;  7ICD A;  3TSN A;  6ICD A;  1BL5 A;  1HQS A;  1VI1 A;  1ZOR A;  3MAP A;  1DR8 A;  1GRO A;  3ASJ A;  9ICD A;  1DPZ A;  3VL3 A;  4HCX A;  3FLK A;  1IDF A;  4UMY A;  1IDC A;  1P8F A;  3BLV A;  3VML A;  3LCB C;  5HN5 A;  1XAD A;  3VL7 A;  4AJR A;  4AJC A;  8ICD A;  1CM7 A;  1OSI A;  3BLX A;  4JA8 A;  1X0L A;  1XGV A;  3WZW A;  4AJ3 A;  1AI2 A;  3VL6 A;  1IDD A;  1T09 A;  4YB4 A;  5GRI B;  1IKA A;  4UMX A;  2QFW A;  1CNZ A;  1OSJ A;  5K11 A;  5GRF B; 
#chains in the Genus database with same CATH topology
 1DR0 A;  5I96 A;  3LXY A;  3VKZ A;  1PTM A;  4P69 C;  2IV0 A;  1G2U A;  1V94 A;  2G4O A;  3VMK A;  4AJB A;  1IDE A;  1IDM A;  2UXR A;  2Y3Z A;  2E5M A;  5DE1 A;  1U7N A;  1GRP A;  4AJA A;  3VL2 A;  5GRE A;  4F7I A;  4L03 A;  5HN4 A;  3WZY A;  1CW1 A;  2AYQ A;  5GRI A;  3MAS B;  4I3L A;  1XAA A;  3R8W A;  1R8K A;  1AI3 A;  1SJS A;  3DMS A;  5J32 A;  5GRL A;  4XRX A;  4AJS A;  5GRF A;  4BNP A;  1ISO A;  2HI1 A;  4JQP A;  2Y41 A;  5GRH B;  3VMJ A;  1PB3 A;  4AOV A;  5HN6 A;  3BLV B;  3WZV A;  3BLX B;  4I3K A;  3U9E A;  2D1C A;  5K10 A;  1XAC A;  4L06 A;  1VLC A;  1GC8 A;  1YXO A;  3MAR A;  4WUO A;  4XS3 A;  2QFX A;  5J34 A;  1WPW A;  3TY4 A;  1W0D A;  4Y1P A;  1PB1 A;  4L04 A;  4KZO A;  1CW7 A;  3MAS A;  5J33 A;  4ATY A;  3UDU A;  3WZX A;  1V53 A;  3TY3 A;  2QFV A;  5GRH A;  2QFY A;  5HN3 A;  2DHT A;  2UXQ A;  1TYO A;  3TNG A;  1WAL A;  4AOU A;  3U1H A;  5L58 A;  1T0L A;  1HEX A;  3AH3 A;  5L57 A;  2Y42 A;  5LGE A;  1CW4 A;  2D4V A;  3FMX X;  5GRE B;  1XKD A;  3US8 A;  1HJ6 A;  2E0C A;  3INM A;  1YCO A;  2Y40 A;  2ZTW A;  4XXV A;  3ICD A;  1XAB A;  5I95 A;  1A05 A;  1LWD A;  1PS7 A;  5ICD A;  4IWH A;  3VL4 A;  1GC9 A;  3UDO A;  4ICD A;  1PS6 A;  1V5B A;  5GRL B;  3UF6 A;  1IPD A;  4AOY A;  7ICD A;  3TSN A;  6ICD A;  1BL5 A;  1HQS A;  1VI1 A;  1ZOR A;  3MAP A;  1DR8 A;  1GRO A;  3ASJ A;  9ICD A;  1DPZ A;  3VL3 A;  4HCX A;  3FLK A;  1IDF A;  4UMY A;  1IDC A;  1P8F A;  3BLV A;  3VML A;  3LCB C;  5HN5 A;  1XAD A;  3VL7 A;  4AJR A;  4AJC A;  8ICD A;  1CM7 A;  1OSI A;  3BLX A;  4JA8 A;  1X0L A;  1XGV A;  3WZW A;  4AJ3 A;  1AI2 A;  3VL6 A;  1IDD A;  1T09 A;  4YB4 A;  5GRI B;  1IKA A;  4UMX A;  2QFW A;  1CNZ A;  1OSJ A;  5K11 A;  5GRF B; 
#chains in the Genus database with same CATH homology
 1DR0 A;  5I96 A;  3LXY A;  3VKZ A;  1PTM A;  4P69 C;  2IV0 A;  1G2U A;  1V94 A;  2G4O A;  3VMK A;  4AJB A;  1IDE A;  1IDM A;  2UXR A;  2Y3Z A;  2E5M A;  5DE1 A;  1U7N A;  1GRP A;  4AJA A;  3VL2 A;  5GRE A;  4F7I A;  4L03 A;  5HN4 A;  3WZY A;  1CW1 A;  2AYQ A;  5GRI A;  3MAS B;  4I3L A;  1XAA A;  3R8W A;  1R8K A;  1AI3 A;  1SJS A;  3DMS A;  5J32 A;  5GRL A;  4XRX A;  4AJS A;  5GRF A;  4BNP A;  1ISO A;  2HI1 A;  4JQP A;  2Y41 A;  5GRH B;  3VMJ A;  1PB3 A;  4AOV A;  5HN6 A;  3BLV B;  3WZV A;  3BLX B;  4I3K A;  3U9E A;  2D1C A;  5K10 A;  1XAC A;  4L06 A;  1VLC A;  1GC8 A;  1YXO A;  3MAR A;  4WUO A;  4XS3 A;  2QFX A;  5J34 A;  1WPW A;  3TY4 A;  1W0D A;  4Y1P A;  1PB1 A;  4L04 A;  4KZO A;  1CW7 A;  3MAS A;  5J33 A;  4ATY A;  3UDU A;  3WZX A;  1V53 A;  3TY3 A;  2QFV A;  5GRH A;  2QFY A;  5HN3 A;  2DHT A;  2UXQ A;  1TYO A;  3TNG A;  1WAL A;  4AOU A;  3U1H A;  5L58 A;  1T0L A;  1HEX A;  3AH3 A;  5L57 A;  2Y42 A;  5LGE A;  1CW4 A;  2D4V A;  3FMX X;  5GRE B;  1XKD A;  3US8 A;  1HJ6 A;  2E0C A;  3INM A;  1YCO A;  2Y40 A;  2ZTW A;  4XXV A;  3ICD A;  1XAB A;  5I95 A;  1A05 A;  1LWD A;  1PS7 A;  5ICD A;  4IWH A;  3VL4 A;  1GC9 A;  3UDO A;  4ICD A;  1PS6 A;  1V5B A;  5GRL B;  3UF6 A;  1IPD A;  4AOY A;  7ICD A;  3TSN A;  6ICD A;  1BL5 A;  1HQS A;  1VI1 A;  1ZOR A;  3MAP A;  1DR8 A;  1GRO A;  3ASJ A;  9ICD A;  1DPZ A;  3VL3 A;  4HCX A;  3FLK A;  1IDF A;  4UMY A;  1IDC A;  1P8F A;  3BLV A;  3VML A;  3LCB C;  5HN5 A;  1XAD A;  3VL7 A;  4AJR A;  4AJC A;  8ICD A;  1CM7 A;  1OSI A;  3BLX A;  4JA8 A;  1X0L A;  1XGV A;  3WZW A;  4AJ3 A;  1AI2 A;  3VL6 A;  1IDD A;  1T09 A;  4YB4 A;  5GRI B;  1IKA A;  4UMX A;  2QFW A;  1CNZ A;  1OSJ A;  5K11 A;  5GRF B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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