1W0DA

The high resolution structure of mycobacterium tuberculosis leub (rv2995c)
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
337
structure length
337
Chain Sequence
MSKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVVVREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRGSERLATSDVGERIAAAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The High Resolution Structure of Leub (Rv2995C) from Mycobacterium Tuberculosis
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Mycobacterium tuberculosis
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
total genus 123
structure length 337
sequence length 337
chains with identical sequence B, C, D
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2004-06-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1w0dA00
1WPWA 1P8FA 1W0DA 2E5MA 5K10A 1XACA 1V53A 5GRLB 1GC9A 2UXQA 1IPDA 4L06A 1TYOA 2Y41A 1IDDA 2D1CA 2Y40A 2UXRA 3R8WA 1HJ6A 4JQPA 5I95A 4UMXA 3LCBC 4JA8A 1U7NA 3BLXB 3UDUA 1V94A 3BLVA 4IWHA 4I3KA 4XS3A 2DHTA 1GC8A 4AJCA 3ICDA 1YCOA 3UF6A 4L04A 1IKAA 1DR0A 1LWDA 2G4OA 1BL5A 3VL4A 4BNPA 2ZTWA 1XKDA 1XAAA 4AOVA 3VMLA 1AI2A 5GRFB 3VKZA 5GRFA 5J34A 1DPZA 2QFXA 4AJSA 1R8KA 1HQSA 1OSIA 4AJ3A 3MASA 5LGEA 2D4VA 3WZYA 3LXYA 1CW7A 5GREB 2Y42A 3TNGA 5GREA 1DR8A 4AJRA 3MAPA 5I96A 3WZVA 5J33A 3VMJA 1PS7A 4ICDA 1YXOA 2AYQA 4I3LA 3BLVB 4HCXA 1T09A 1PB1A 2Y3ZA 4YB4A 3VL2A 1CW1A 4XXVA 4F7IA 1X0LA 1CM7A 4AOUA 5HN5A 4AJBA 1IDCA 4ATYA 3AH3A 7ICDA 1GRPA 3U1HA 3MASB 1ZORA 1IDFA 2E0CA 6ICDA 5GRIB 5K11A 3VL3A 5GRIA 8ICDA 1XABA 2QFVA 3MARA 4Y1PA 1HEXA 1IDEA 4XRXA 5GRHB 3TSNA 5HN6A 2IV0A 3TY3A 3WZWA 5GRHA 3US8A 4UMYA 1CW4A 3FMXX 3UDOA 1CNZA 1OSJA 5HN4A 3VL7A 4AJAA 1ISOA 3WZXA 3U9EA 1VLCA 1T0LA 5L58A 3ASJA 1V5BA 1G2UA 1PTMA 5GRLA 9ICDA 5J32A 3VL6A 4AOYA 5HN3A 3TY4A 1PB3A 4KZOA 1AI3A 4WUOA 1XADA 3INMA 1A05A 4P69C 1XGVA 5L57A 1SJSA 5ICDA 1PS6A 3DMSA 1WALA 1GROA 3BLXA 3VMKA 2HI1A 1VI1A 1IDMA 3FLKA 4L03A 2QFYA 2QFWA 5DE1A
chains in the Genus database with same CATH superfamily
1WPWA 1P8FA 1W0DA 2E5MA 5K10A 1XACA 1V53A 5GRLB 1GC9A 2UXQA 1IPDA 4L06A 1TYOA 2Y41A 1IDDA 2D1CA 2Y40A 2UXRA 3R8WA 1HJ6A 4JQPA 5I95A 4UMXA 3LCBC 4JA8A 1U7NA 3BLXB 3UDUA 1V94A 3BLVA 4IWHA 4I3KA 4XS3A 2DHTA 1GC8A 4AJCA 3ICDA 1YCOA 3UF6A 4L04A 1IKAA 1DR0A 1LWDA 2G4OA 1BL5A 3VL4A 4BNPA 2ZTWA 1XKDA 1XAAA 4AOVA 3VMLA 1AI2A 5GRFB 3VKZA 5GRFA 5J34A 1DPZA 2QFXA 4AJSA 1R8KA 1HQSA 1OSIA 4AJ3A 3MASA 5LGEA 2D4VA 3WZYA 3LXYA 1CW7A 5GREB 2Y42A 3TNGA 5GREA 1DR8A 4AJRA 3MAPA 5I96A 3WZVA 5J33A 3VMJA 1PS7A 4ICDA 1YXOA 2AYQA 4I3LA 3BLVB 4HCXA 1T09A 1PB1A 2Y3ZA 4YB4A 3VL2A 1CW1A 4XXVA 4F7IA 1X0LA 1CM7A 4AOUA 5HN5A 4AJBA 1IDCA 4ATYA 3AH3A 7ICDA 1GRPA 3U1HA 3MASB 1ZORA 1IDFA 2E0CA 6ICDA 5GRIB 5K11A 3VL3A 5GRIA 8ICDA 1XABA 2QFVA 3MARA 4Y1PA 1HEXA 1IDEA 4XRXA 5GRHB 3TSNA 5HN6A 2IV0A 3TY3A 3WZWA 5GRHA 3US8A 4UMYA 1CW4A 3FMXX 3UDOA 1CNZA 1OSJA 5HN4A 3VL7A 4AJAA 1ISOA 3WZXA 3U9EA 1VLCA 1T0LA 5L58A 3ASJA 1V5BA 1G2UA 1PTMA 5GRLA 9ICDA 5J32A 3VL6A 4AOYA 5HN3A 3TY4A 1PB3A 4KZOA 1AI3A 4WUOA 1XADA 3INMA 1A05A 4P69C 1XGVA 5L57A 1SJSA 5ICDA 1PS6A 3DMSA 1WALA 1GROA 3BLXA 3VMKA 2HI1A 1VI1A 1IDMA 3FLKA 4L03A 2QFYA 2QFWA 5DE1A
chains in the Genus database with same CATH topology
1WPWA 1P8FA 1W0DA 2E5MA 5K10A 1XACA 1V53A 5GRLB 1GC9A 2UXQA 1IPDA 4L06A 1TYOA 2Y41A 1IDDA 2D1CA 2Y40A 2UXRA 3R8WA 1HJ6A 4JQPA 5I95A 4UMXA 3LCBC 4JA8A 1U7NA 3BLXB 3UDUA 1V94A 3BLVA 4IWHA 4I3KA 4XS3A 2DHTA 1GC8A 4AJCA 3ICDA 1YCOA 3UF6A 4L04A 1IKAA 1DR0A 1LWDA 2G4OA 1BL5A 3VL4A 4BNPA 2ZTWA 1XKDA 1XAAA 4AOVA 3VMLA 1AI2A 5GRFB 3VKZA 5GRFA 5J34A 1DPZA 2QFXA 4AJSA 1R8KA 1HQSA 1OSIA 4AJ3A 3MASA 5LGEA 2D4VA 3WZYA 3LXYA 1CW7A 5GREB 2Y42A 3TNGA 5GREA 1DR8A 4AJRA 3MAPA 5I96A 3WZVA 5J33A 3VMJA 1PS7A 4ICDA 1YXOA 2AYQA 4I3LA 3BLVB 4HCXA 1T09A 1PB1A 2Y3ZA 4YB4A 3VL2A 1CW1A 4XXVA 4F7IA 1X0LA 1CM7A 4AOUA 5HN5A 4AJBA 1IDCA 4ATYA 3AH3A 7ICDA 1GRPA 3U1HA 3MASB 1ZORA 1IDFA 2E0CA 6ICDA 5GRIB 5K11A 3VL3A 5GRIA 8ICDA 1XABA 2QFVA 3MARA 4Y1PA 1HEXA 1IDEA 4XRXA 5GRHB 3TSNA 5HN6A 2IV0A 3TY3A 3WZWA 5GRHA 3US8A 4UMYA 1CW4A 3FMXX 3UDOA 1CNZA 1OSJA 5HN4A 3VL7A 4AJAA 1ISOA 3WZXA 3U9EA 1VLCA 1T0LA 5L58A 3ASJA 1V5BA 1G2UA 1PTMA 5GRLA 9ICDA 5J32A 3VL6A 4AOYA 5HN3A 3TY4A 1PB3A 4KZOA 1AI3A 4WUOA 1XADA 3INMA 1A05A 4P69C 1XGVA 5L57A 1SJSA 5ICDA 1PS6A 3DMSA 1WALA 1GROA 3BLXA 3VMKA 2HI1A 1VI1A 1IDMA 3FLKA 4L03A 2QFYA 2QFWA 5DE1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WPW A;  1P8F A;  1W0D A;  2E5M A;  5K10 A;  1XAC A;  1V53 A;  5GRL B;  1GC9 A;  2UXQ A;  1IPD A;  4L06 A;  1TYO A;  2Y41 A;  1IDD A;  2D1C A;  2Y40 A;  2UXR A;  3R8W A;  1HJ6 A;  4JQP A;  5I95 A;  4UMX A;  3LCB C;  4JA8 A;  1U7N A;  3BLX B;  3UDU A;  1V94 A;  3BLV A;  4IWH A;  4I3K A;  4XS3 A;  2DHT A;  1GC8 A;  4AJC A;  3ICD A;  1YCO A;  3UF6 A;  4L04 A;  1IKA A;  1DR0 A;  1LWD A;  2G4O A;  1BL5 A;  3VL4 A;  4BNP A;  2ZTW A;  1XKD A;  1XAA A;  4AOV A;  3VML A;  1AI2 A;  5GRF B;  3VKZ A;  5GRF A;  5J34 A;  1DPZ A;  2QFX A;  4AJS A;  1R8K A;  1HQS A;  1OSI A;  4AJ3 A;  3MAS A;  5LGE A;  2D4V A;  3WZY A;  3LXY A;  1CW7 A;  5GRE B;  2Y42 A;  3TNG A;  5GRE A;  1DR8 A;  4AJR A;  3MAP A;  5I96 A;  3WZV A;  5J33 A;  3VMJ A;  1PS7 A;  4ICD A;  1YXO A;  2AYQ A;  4I3L A;  3BLV B;  4HCX A;  1T09 A;  1PB1 A;  2Y3Z A;  4YB4 A;  3VL2 A;  1CW1 A;  4XXV A;  4F7I A;  1X0L A;  1CM7 A;  4AOU A;  5HN5 A;  4AJB A;  1IDC A;  4ATY A;  3AH3 A;  7ICD A;  1GRP A;  3U1H A;  3MAS B;  1ZOR A;  1IDF A;  2E0C A;  6ICD A;  5GRI B;  5K11 A;  3VL3 A;  5GRI A;  8ICD A;  1XAB A;  2QFV A;  3MAR A;  4Y1P A;  1HEX A;  1IDE A;  4XRX A;  5GRH B;  3TSN A;  5HN6 A;  2IV0 A;  3TY3 A;  3WZW A;  5GRH A;  3US8 A;  4UMY A;  1CW4 A;  3FMX X;  3UDO A;  1CNZ A;  1OSJ A;  5HN4 A;  3VL7 A;  4AJA A;  1ISO A;  3WZX A;  3U9E A;  1VLC A;  1T0L A;  5L58 A;  3ASJ A;  1V5B A;  1G2U A;  1PTM A;  5GRL A;  9ICD A;  5J32 A;  3VL6 A;  4AOY A;  5HN3 A;  3TY4 A;  1PB3 A;  4KZO A;  1AI3 A;  4WUO A;  1XAD A;  3INM A;  1A05 A;  4P69 C;  1XGV A;  5L57 A;  1SJS A;  5ICD A;  1PS6 A;  3DMS A;  1WAL A;  1GRO A;  3BLX A;  3VMK A;  2HI1 A;  1VI1 A;  1IDM A;  3FLK A;  4L03 A;  2QFY A;  2QFW A;  5DE1 A; 
#chains in the Genus database with same CATH topology
 1WPW A;  1P8F A;  1W0D A;  2E5M A;  5K10 A;  1XAC A;  1V53 A;  5GRL B;  1GC9 A;  2UXQ A;  1IPD A;  4L06 A;  1TYO A;  2Y41 A;  1IDD A;  2D1C A;  2Y40 A;  2UXR A;  3R8W A;  1HJ6 A;  4JQP A;  5I95 A;  4UMX A;  3LCB C;  4JA8 A;  1U7N A;  3BLX B;  3UDU A;  1V94 A;  3BLV A;  4IWH A;  4I3K A;  4XS3 A;  2DHT A;  1GC8 A;  4AJC A;  3ICD A;  1YCO A;  3UF6 A;  4L04 A;  1IKA A;  1DR0 A;  1LWD A;  2G4O A;  1BL5 A;  3VL4 A;  4BNP A;  2ZTW A;  1XKD A;  1XAA A;  4AOV A;  3VML A;  1AI2 A;  5GRF B;  3VKZ A;  5GRF A;  5J34 A;  1DPZ A;  2QFX A;  4AJS A;  1R8K A;  1HQS A;  1OSI A;  4AJ3 A;  3MAS A;  5LGE A;  2D4V A;  3WZY A;  3LXY A;  1CW7 A;  5GRE B;  2Y42 A;  3TNG A;  5GRE A;  1DR8 A;  4AJR A;  3MAP A;  5I96 A;  3WZV A;  5J33 A;  3VMJ A;  1PS7 A;  4ICD A;  1YXO A;  2AYQ A;  4I3L A;  3BLV B;  4HCX A;  1T09 A;  1PB1 A;  2Y3Z A;  4YB4 A;  3VL2 A;  1CW1 A;  4XXV A;  4F7I A;  1X0L A;  1CM7 A;  4AOU A;  5HN5 A;  4AJB A;  1IDC A;  4ATY A;  3AH3 A;  7ICD A;  1GRP A;  3U1H A;  3MAS B;  1ZOR A;  1IDF A;  2E0C A;  6ICD A;  5GRI B;  5K11 A;  3VL3 A;  5GRI A;  8ICD A;  1XAB A;  2QFV A;  3MAR A;  4Y1P A;  1HEX A;  1IDE A;  4XRX A;  5GRH B;  3TSN A;  5HN6 A;  2IV0 A;  3TY3 A;  3WZW A;  5GRH A;  3US8 A;  4UMY A;  1CW4 A;  3FMX X;  3UDO A;  1CNZ A;  1OSJ A;  5HN4 A;  3VL7 A;  4AJA A;  1ISO A;  3WZX A;  3U9E A;  1VLC A;  1T0L A;  5L58 A;  3ASJ A;  1V5B A;  1G2U A;  1PTM A;  5GRL A;  9ICD A;  5J32 A;  3VL6 A;  4AOY A;  5HN3 A;  3TY4 A;  1PB3 A;  4KZO A;  1AI3 A;  4WUO A;  1XAD A;  3INM A;  1A05 A;  4P69 C;  1XGV A;  5L57 A;  1SJS A;  5ICD A;  1PS6 A;  3DMS A;  1WAL A;  1GRO A;  3BLX A;  3VMK A;  2HI1 A;  1VI1 A;  1IDM A;  3FLK A;  4L03 A;  2QFY A;  2QFW A;  5DE1 A; 
#chains in the Genus database with same CATH homology
 1WPW A;  1P8F A;  1W0D A;  2E5M A;  5K10 A;  1XAC A;  1V53 A;  5GRL B;  1GC9 A;  2UXQ A;  1IPD A;  4L06 A;  1TYO A;  2Y41 A;  1IDD A;  2D1C A;  2Y40 A;  2UXR A;  3R8W A;  1HJ6 A;  4JQP A;  5I95 A;  4UMX A;  3LCB C;  4JA8 A;  1U7N A;  3BLX B;  3UDU A;  1V94 A;  3BLV A;  4IWH A;  4I3K A;  4XS3 A;  2DHT A;  1GC8 A;  4AJC A;  3ICD A;  1YCO A;  3UF6 A;  4L04 A;  1IKA A;  1DR0 A;  1LWD A;  2G4O A;  1BL5 A;  3VL4 A;  4BNP A;  2ZTW A;  1XKD A;  1XAA A;  4AOV A;  3VML A;  1AI2 A;  5GRF B;  3VKZ A;  5GRF A;  5J34 A;  1DPZ A;  2QFX A;  4AJS A;  1R8K A;  1HQS A;  1OSI A;  4AJ3 A;  3MAS A;  5LGE A;  2D4V A;  3WZY A;  3LXY A;  1CW7 A;  5GRE B;  2Y42 A;  3TNG A;  5GRE A;  1DR8 A;  4AJR A;  3MAP A;  5I96 A;  3WZV A;  5J33 A;  3VMJ A;  1PS7 A;  4ICD A;  1YXO A;  2AYQ A;  4I3L A;  3BLV B;  4HCX A;  1T09 A;  1PB1 A;  2Y3Z A;  4YB4 A;  3VL2 A;  1CW1 A;  4XXV A;  4F7I A;  1X0L A;  1CM7 A;  4AOU A;  5HN5 A;  4AJB A;  1IDC A;  4ATY A;  3AH3 A;  7ICD A;  1GRP A;  3U1H A;  3MAS B;  1ZOR A;  1IDF A;  2E0C A;  6ICD A;  5GRI B;  5K11 A;  3VL3 A;  5GRI A;  8ICD A;  1XAB A;  2QFV A;  3MAR A;  4Y1P A;  1HEX A;  1IDE A;  4XRX A;  5GRH B;  3TSN A;  5HN6 A;  2IV0 A;  3TY3 A;  3WZW A;  5GRH A;  3US8 A;  4UMY A;  1CW4 A;  3FMX X;  3UDO A;  1CNZ A;  1OSJ A;  5HN4 A;  3VL7 A;  4AJA A;  1ISO A;  3WZX A;  3U9E A;  1VLC A;  1T0L A;  5L58 A;  3ASJ A;  1V5B A;  1G2U A;  1PTM A;  5GRL A;  9ICD A;  5J32 A;  3VL6 A;  4AOY A;  5HN3 A;  3TY4 A;  1PB3 A;  4KZO A;  1AI3 A;  4WUO A;  1XAD A;  3INM A;  1A05 A;  4P69 C;  1XGV A;  5L57 A;  1SJS A;  5ICD A;  1PS6 A;  3DMS A;  1WAL A;  1GRO A;  3BLX A;  3VMK A;  2HI1 A;  1VI1 A;  1IDM A;  3FLK A;  4L03 A;  2QFY A;  2QFW A;  5DE1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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