1XABA

3-isopropylmalate dehydrogenase, low temperature (150k) structure
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
345
structure length
345
Chain Sequence
MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
total genus 122
structure length 345
sequence length 345
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 1995-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 1xabA00
1IKAA 1W0DA 1IDMA 1GC8A 1U7NA 3VL6A 3U1HA 1LWDA 3US8A 3LCBC 2D4VA 3VMJA 4JA8A 4XXVA 3WZYA 3BLXA 5L58A 1CNZA 1YXOA 1AI3A 3TY3A 1DR8A 1XKDA 5GRFB 1A05A 2IV0A 1CM7A 1PS6A 9ICDA 5ICDA 3WZXA 3ICDA 1XACA 5GRHA 4UMYA 2UXRA 3UF6A 6ICDA 5I96A 1PS7A 3BLVA 1X0LA 3LXYA 1SJSA 1WPWA 2ZTWA 2HI1A 4I3LA 2QFXA 1IDEA 1PTMA 1V5BA 4HCXA 1ISOA 8ICDA 2DHTA 3ASJA 4L03A 2E0CA 5K10A 4UMXA 4ATYA 1AI2A 1BL5A 1PB3A 5GREA 2QFVA 1GC9A 4F7IA 3WZVA 1P8FA 3VMLA 4AJBA 5J33A 3UDUA 5GRLB 1OSIA 1DR0A 1CW1A 3VMKA 4KZOA 4AOVA 3VL7A 3FLKA 4IWHA 4AJ3A 3INMA 5GRIA 3BLXB 5DE1A 4WUOA 4Y1PA 5L57A 2Y40A 1CW4A 3MASA 1ZORA 2Y41A 1CW7A 4AJAA 5I95A 5HN6A 4XRXA 4P69C 5LGEA 1T0LA 1G2UA 5GRHB 1XADA 3BLVB 5HN3A 5HN4A 3TNGA 1HEXA 1WALA 3DMSA 3VKZA 1PB1A 3MARA 1HJ6A 1YCOA 1GROA 3TSNA 1IDFA 2AYQA 3VL3A 5GREB 4XS3A 1T09A 1IDDA 5K11A 4AJSA 2UXQA 3VL4A 5GRFA 1V94A 4I3KA 4L04A 1V53A 1VI1A 4L06A 1GRPA 3MAPA 3U9EA 4YB4A 5J32A 3AH3A 1IDCA 1XGVA 2E5MA 3TY4A 1HQSA 5GRIB 2QFWA 4ICDA 2QFYA 3MASB 1XABA 4AOUA 1VLCA 3WZWA 3UDOA 2G4OA 3R8WA 3FMXX 4JQPA 4AJRA 1IPDA 2Y3ZA 3VL2A 5HN5A 4AOYA 2Y42A 1DPZA 1OSJA 4BNPA 1TYOA 4AJCA 7ICDA 1XAAA 5J34A 5GRLA 1R8KA 2D1CA
chains in the Genus database with same CATH superfamily
1IKAA 1W0DA 1IDMA 1GC8A 1U7NA 3VL6A 3U1HA 1LWDA 3US8A 3LCBC 2D4VA 3VMJA 4JA8A 4XXVA 3WZYA 3BLXA 5L58A 1CNZA 1YXOA 1AI3A 3TY3A 1DR8A 1XKDA 5GRFB 1A05A 2IV0A 1CM7A 1PS6A 9ICDA 5ICDA 3WZXA 3ICDA 1XACA 5GRHA 4UMYA 2UXRA 3UF6A 6ICDA 5I96A 1PS7A 3BLVA 1X0LA 3LXYA 1SJSA 1WPWA 2ZTWA 2HI1A 4I3LA 2QFXA 1IDEA 1PTMA 1V5BA 4HCXA 1ISOA 8ICDA 2DHTA 3ASJA 4L03A 2E0CA 5K10A 4UMXA 4ATYA 1AI2A 1BL5A 1PB3A 5GREA 2QFVA 1GC9A 4F7IA 3WZVA 1P8FA 3VMLA 4AJBA 5J33A 3UDUA 5GRLB 1OSIA 1DR0A 1CW1A 3VMKA 4KZOA 4AOVA 3VL7A 3FLKA 4IWHA 4AJ3A 3INMA 5GRIA 3BLXB 5DE1A 4WUOA 4Y1PA 5L57A 2Y40A 1CW4A 3MASA 1ZORA 2Y41A 1CW7A 4AJAA 5I95A 5HN6A 4XRXA 4P69C 5LGEA 1T0LA 1G2UA 5GRHB 1XADA 3BLVB 5HN3A 5HN4A 3TNGA 1HEXA 1WALA 3DMSA 3VKZA 1PB1A 3MARA 1HJ6A 1YCOA 1GROA 3TSNA 1IDFA 2AYQA 3VL3A 5GREB 4XS3A 1T09A 1IDDA 5K11A 4AJSA 2UXQA 3VL4A 5GRFA 1V94A 4I3KA 4L04A 1V53A 1VI1A 4L06A 1GRPA 3MAPA 3U9EA 4YB4A 5J32A 3AH3A 1IDCA 1XGVA 2E5MA 3TY4A 1HQSA 5GRIB 2QFWA 4ICDA 2QFYA 3MASB 1XABA 4AOUA 1VLCA 3WZWA 3UDOA 2G4OA 3R8WA 3FMXX 4JQPA 4AJRA 1IPDA 2Y3ZA 3VL2A 5HN5A 4AOYA 2Y42A 1DPZA 1OSJA 4BNPA 1TYOA 4AJCA 7ICDA 1XAAA 5J34A 5GRLA 1R8KA 2D1CA
chains in the Genus database with same CATH topology
1IKAA 1W0DA 1IDMA 1GC8A 1U7NA 3VL6A 3U1HA 1LWDA 3US8A 3LCBC 2D4VA 3VMJA 4JA8A 4XXVA 3WZYA 3BLXA 5L58A 1CNZA 1YXOA 1AI3A 3TY3A 1DR8A 1XKDA 5GRFB 1A05A 2IV0A 1CM7A 1PS6A 9ICDA 5ICDA 3WZXA 3ICDA 1XACA 5GRHA 4UMYA 2UXRA 3UF6A 6ICDA 5I96A 1PS7A 3BLVA 1X0LA 3LXYA 1SJSA 1WPWA 2ZTWA 2HI1A 4I3LA 2QFXA 1IDEA 1PTMA 1V5BA 4HCXA 1ISOA 8ICDA 2DHTA 3ASJA 4L03A 2E0CA 5K10A 4UMXA 4ATYA 1AI2A 1BL5A 1PB3A 5GREA 2QFVA 1GC9A 4F7IA 3WZVA 1P8FA 3VMLA 4AJBA 5J33A 3UDUA 5GRLB 1OSIA 1DR0A 1CW1A 3VMKA 4KZOA 4AOVA 3VL7A 3FLKA 4IWHA 4AJ3A 3INMA 5GRIA 3BLXB 5DE1A 4WUOA 4Y1PA 5L57A 2Y40A 1CW4A 3MASA 1ZORA 2Y41A 1CW7A 4AJAA 5I95A 5HN6A 4XRXA 4P69C 5LGEA 1T0LA 1G2UA 5GRHB 1XADA 3BLVB 5HN3A 5HN4A 3TNGA 1HEXA 1WALA 3DMSA 3VKZA 1PB1A 3MARA 1HJ6A 1YCOA 1GROA 3TSNA 1IDFA 2AYQA 3VL3A 5GREB 4XS3A 1T09A 1IDDA 5K11A 4AJSA 2UXQA 3VL4A 5GRFA 1V94A 4I3KA 4L04A 1V53A 1VI1A 4L06A 1GRPA 3MAPA 3U9EA 4YB4A 5J32A 3AH3A 1IDCA 1XGVA 2E5MA 3TY4A 1HQSA 5GRIB 2QFWA 4ICDA 2QFYA 3MASB 1XABA 4AOUA 1VLCA 3WZWA 3UDOA 2G4OA 3R8WA 3FMXX 4JQPA 4AJRA 1IPDA 2Y3ZA 3VL2A 5HN5A 4AOYA 2Y42A 1DPZA 1OSJA 4BNPA 1TYOA 4AJCA 7ICDA 1XAAA 5J34A 5GRLA 1R8KA 2D1CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IKA A;  1W0D A;  1IDM A;  1GC8 A;  1U7N A;  3VL6 A;  3U1H A;  1LWD A;  3US8 A;  3LCB C;  2D4V A;  3VMJ A;  4JA8 A;  4XXV A;  3WZY A;  3BLX A;  5L58 A;  1CNZ A;  1YXO A;  1AI3 A;  3TY3 A;  1DR8 A;  1XKD A;  5GRF B;  1A05 A;  2IV0 A;  1CM7 A;  1PS6 A;  9ICD A;  5ICD A;  3WZX A;  3ICD A;  1XAC A;  5GRH A;  4UMY A;  2UXR A;  3UF6 A;  6ICD A;  5I96 A;  1PS7 A;  3BLV A;  1X0L A;  3LXY A;  1SJS A;  1WPW A;  2ZTW A;  2HI1 A;  4I3L A;  2QFX A;  1IDE A;  1PTM A;  1V5B A;  4HCX A;  1ISO A;  8ICD A;  2DHT A;  3ASJ A;  4L03 A;  2E0C A;  5K10 A;  4UMX A;  4ATY A;  1AI2 A;  1BL5 A;  1PB3 A;  5GRE A;  2QFV A;  1GC9 A;  4F7I A;  3WZV A;  1P8F A;  3VML A;  4AJB A;  5J33 A;  3UDU A;  5GRL B;  1OSI A;  1DR0 A;  1CW1 A;  3VMK A;  4KZO A;  4AOV A;  3VL7 A;  3FLK A;  4IWH A;  4AJ3 A;  3INM A;  5GRI A;  3BLX B;  5DE1 A;  4WUO A;  4Y1P A;  5L57 A;  2Y40 A;  1CW4 A;  3MAS A;  1ZOR A;  2Y41 A;  1CW7 A;  4AJA A;  5I95 A;  5HN6 A;  4XRX A;  4P69 C;  5LGE A;  1T0L A;  1G2U A;  5GRH B;  1XAD A;  3BLV B;  5HN3 A;  5HN4 A;  3TNG A;  1HEX A;  1WAL A;  3DMS A;  3VKZ A;  1PB1 A;  3MAR A;  1HJ6 A;  1YCO A;  1GRO A;  3TSN A;  1IDF A;  2AYQ A;  3VL3 A;  5GRE B;  4XS3 A;  1T09 A;  1IDD A;  5K11 A;  4AJS A;  2UXQ A;  3VL4 A;  5GRF A;  1V94 A;  4I3K A;  4L04 A;  1V53 A;  1VI1 A;  4L06 A;  1GRP A;  3MAP A;  3U9E A;  4YB4 A;  5J32 A;  3AH3 A;  1IDC A;  1XGV A;  2E5M A;  3TY4 A;  1HQS A;  5GRI B;  2QFW A;  4ICD A;  2QFY A;  3MAS B;  1XAB A;  4AOU A;  1VLC A;  3WZW A;  3UDO A;  2G4O A;  3R8W A;  3FMX X;  4JQP A;  4AJR A;  1IPD A;  2Y3Z A;  3VL2 A;  5HN5 A;  4AOY A;  2Y42 A;  1DPZ A;  1OSJ A;  4BNP A;  1TYO A;  4AJC A;  7ICD A;  1XAA A;  5J34 A;  5GRL A;  1R8K A;  2D1C A; 
#chains in the Genus database with same CATH topology
 1IKA A;  1W0D A;  1IDM A;  1GC8 A;  1U7N A;  3VL6 A;  3U1H A;  1LWD A;  3US8 A;  3LCB C;  2D4V A;  3VMJ A;  4JA8 A;  4XXV A;  3WZY A;  3BLX A;  5L58 A;  1CNZ A;  1YXO A;  1AI3 A;  3TY3 A;  1DR8 A;  1XKD A;  5GRF B;  1A05 A;  2IV0 A;  1CM7 A;  1PS6 A;  9ICD A;  5ICD A;  3WZX A;  3ICD A;  1XAC A;  5GRH A;  4UMY A;  2UXR A;  3UF6 A;  6ICD A;  5I96 A;  1PS7 A;  3BLV A;  1X0L A;  3LXY A;  1SJS A;  1WPW A;  2ZTW A;  2HI1 A;  4I3L A;  2QFX A;  1IDE A;  1PTM A;  1V5B A;  4HCX A;  1ISO A;  8ICD A;  2DHT A;  3ASJ A;  4L03 A;  2E0C A;  5K10 A;  4UMX A;  4ATY A;  1AI2 A;  1BL5 A;  1PB3 A;  5GRE A;  2QFV A;  1GC9 A;  4F7I A;  3WZV A;  1P8F A;  3VML A;  4AJB A;  5J33 A;  3UDU A;  5GRL B;  1OSI A;  1DR0 A;  1CW1 A;  3VMK A;  4KZO A;  4AOV A;  3VL7 A;  3FLK A;  4IWH A;  4AJ3 A;  3INM A;  5GRI A;  3BLX B;  5DE1 A;  4WUO A;  4Y1P A;  5L57 A;  2Y40 A;  1CW4 A;  3MAS A;  1ZOR A;  2Y41 A;  1CW7 A;  4AJA A;  5I95 A;  5HN6 A;  4XRX A;  4P69 C;  5LGE A;  1T0L A;  1G2U A;  5GRH B;  1XAD A;  3BLV B;  5HN3 A;  5HN4 A;  3TNG A;  1HEX A;  1WAL A;  3DMS A;  3VKZ A;  1PB1 A;  3MAR A;  1HJ6 A;  1YCO A;  1GRO A;  3TSN A;  1IDF A;  2AYQ A;  3VL3 A;  5GRE B;  4XS3 A;  1T09 A;  1IDD A;  5K11 A;  4AJS A;  2UXQ A;  3VL4 A;  5GRF A;  1V94 A;  4I3K A;  4L04 A;  1V53 A;  1VI1 A;  4L06 A;  1GRP A;  3MAP A;  3U9E A;  4YB4 A;  5J32 A;  3AH3 A;  1IDC A;  1XGV A;  2E5M A;  3TY4 A;  1HQS A;  5GRI B;  2QFW A;  4ICD A;  2QFY A;  3MAS B;  1XAB A;  4AOU A;  1VLC A;  3WZW A;  3UDO A;  2G4O A;  3R8W A;  3FMX X;  4JQP A;  4AJR A;  1IPD A;  2Y3Z A;  3VL2 A;  5HN5 A;  4AOY A;  2Y42 A;  1DPZ A;  1OSJ A;  4BNP A;  1TYO A;  4AJC A;  7ICD A;  1XAA A;  5J34 A;  5GRL A;  1R8K A;  2D1C A; 
#chains in the Genus database with same CATH homology
 1IKA A;  1W0D A;  1IDM A;  1GC8 A;  1U7N A;  3VL6 A;  3U1H A;  1LWD A;  3US8 A;  3LCB C;  2D4V A;  3VMJ A;  4JA8 A;  4XXV A;  3WZY A;  3BLX A;  5L58 A;  1CNZ A;  1YXO A;  1AI3 A;  3TY3 A;  1DR8 A;  1XKD A;  5GRF B;  1A05 A;  2IV0 A;  1CM7 A;  1PS6 A;  9ICD A;  5ICD A;  3WZX A;  3ICD A;  1XAC A;  5GRH A;  4UMY A;  2UXR A;  3UF6 A;  6ICD A;  5I96 A;  1PS7 A;  3BLV A;  1X0L A;  3LXY A;  1SJS A;  1WPW A;  2ZTW A;  2HI1 A;  4I3L A;  2QFX A;  1IDE A;  1PTM A;  1V5B A;  4HCX A;  1ISO A;  8ICD A;  2DHT A;  3ASJ A;  4L03 A;  2E0C A;  5K10 A;  4UMX A;  4ATY A;  1AI2 A;  1BL5 A;  1PB3 A;  5GRE A;  2QFV A;  1GC9 A;  4F7I A;  3WZV A;  1P8F A;  3VML A;  4AJB A;  5J33 A;  3UDU A;  5GRL B;  1OSI A;  1DR0 A;  1CW1 A;  3VMK A;  4KZO A;  4AOV A;  3VL7 A;  3FLK A;  4IWH A;  4AJ3 A;  3INM A;  5GRI A;  3BLX B;  5DE1 A;  4WUO A;  4Y1P A;  5L57 A;  2Y40 A;  1CW4 A;  3MAS A;  1ZOR A;  2Y41 A;  1CW7 A;  4AJA A;  5I95 A;  5HN6 A;  4XRX A;  4P69 C;  5LGE A;  1T0L A;  1G2U A;  5GRH B;  1XAD A;  3BLV B;  5HN3 A;  5HN4 A;  3TNG A;  1HEX A;  1WAL A;  3DMS A;  3VKZ A;  1PB1 A;  3MAR A;  1HJ6 A;  1YCO A;  1GRO A;  3TSN A;  1IDF A;  2AYQ A;  3VL3 A;  5GRE B;  4XS3 A;  1T09 A;  1IDD A;  5K11 A;  4AJS A;  2UXQ A;  3VL4 A;  5GRF A;  1V94 A;  4I3K A;  4L04 A;  1V53 A;  1VI1 A;  4L06 A;  1GRP A;  3MAP A;  3U9E A;  4YB4 A;  5J32 A;  3AH3 A;  1IDC A;  1XGV A;  2E5M A;  3TY4 A;  1HQS A;  5GRI B;  2QFW A;  4ICD A;  2QFY A;  3MAS B;  1XAB A;  4AOU A;  1VLC A;  3WZW A;  3UDO A;  2G4O A;  3R8W A;  3FMX X;  4JQP A;  4AJR A;  1IPD A;  2Y3Z A;  3VL2 A;  5HN5 A;  4AOY A;  2Y42 A;  1DPZ A;  1OSJ A;  4BNP A;  1TYO A;  4AJC A;  7ICD A;  1XAA A;  5J34 A;  5GRL A;  1R8K A;  2D1C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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