2AYQA

3-isopropylmalate dehydrogenase from the moderate facultative thermophile, bacillus coagulans
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
356
structure length
356
Chain Sequence
MKMKLAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAIDEAGTPLPEETLDICRRSDAILLGAVGGPKWDHNPASLRPEKGLLGLRKEMGLFANLRPVKAYATLLNASPLKRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTLAYTREEIERIIEKAFQLAQIRRKKLASVDKANVLESSRMWREIAEETAKKYPDVELSHMLVDSTSMQLIANPGQFDVIVTENMFGDILSDEASVITGSLGMLPSASLRSDRFGMYEPVHGSAPDIAGQGKANPLGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDGYCTGDLQVANGKVVSTIELTDRLIEKLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of 3-isopropylmalate dehydrogenase from the moderate facultative thermophile, Bacillus coagulans: two strategies for thermostabilization of protein structures.
pubmed rcsb
molecule tags Oxidoreductase
source organism Bacillus coagulans
molecule keywords 3-ISOPROPYLMALATE DEHYDROGENASE
total genus 122
structure length 356
sequence length 356
chains with identical sequence B
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 1998-02-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 2ayqA00
4AJ3A 1R8KA 3ASJA 5J32A 4IWHA 3INMA 1V5BA 3MAPA 3MASA 1DR0A 5GRIB 3ICDA 4P69C 1IDDA 1XACA 1WALA 3U1HA 1DR8A 5GRHA 3TY4A 5HN4A 3VMKA 1CM7A 3BLVA 1CW7A 2QFVA 3VL6A 1A05A 1VI1A 3VL7A 4JA8A 3BLXB 1XAAA 5I96A 3R8WA 5GREB 1LWDA 3UF6A 1P8FA 1DPZA 5J34A 1OSJA 5J33A 4AJBA 5L57A 1PS7A 5L58A 2E5MA 4XRXA 2G4OA 4AOUA 5GRLB 1IDEA 3WZVA 4YB4A 1XKDA 1HEXA 4XXVA 5GRHB 3AH3A 2QFWA 3WZYA 2HI1A 3FLKA 3VMLA 5LGEA 6ICDA 3MARA 4WUOA 4I3LA 3UDOA 1PB3A 3LXYA 2Y42A 3VL4A 1IDMA 1XABA 2D4VA 1AI2A 1WPWA 1SJSA 5GRFA 1T0LA 2Y40A 3TNGA 4AJSA 1ZORA 5I95A 1GC8A 5GRIA 1V53A 9ICDA 2DHTA 3MASB 4UMXA 5ICDA 1U7NA 1PB1A 1HJ6A 4Y1PA 1X0LA 1AI3A 2QFYA 3DMSA 4L03A 4AJRA 3FMXX 4XS3A 5HN5A 2UXQA 4I3KA 1ISOA 1TYOA 3TY3A 3UDUA 4L06A 1G2UA 1GC9A 3BLVB 1CW1A 1IKAA 1IDFA 3WZXA 1XGVA 2QFXA 3WZWA 4F7IA 2AYQA 2D1CA 5GREA 1PS6A 1W0DA 1YXOA 1IPDA 4AJCA 2E0CA 4AJAA 1VLCA 3VMJA 1CNZA 3VL3A 2UXRA 5GRFB 2Y3ZA 8ICDA 5DE1A 4AOYA 3US8A 4KZOA 1T09A 1PTMA 3LCBC 2ZTWA 3U9EA 4JQPA 4HCXA 5GRLA 3VL2A 4ICDA 1IDCA 3TSNA 1V94A 7ICDA 5HN3A 3VKZA 5HN6A 1XADA 5K10A 2Y41A 1OSIA 4ATYA 5K11A 1GRPA 1BL5A 4AOVA 1CW4A 4UMYA 2IV0A 4BNPA 1GROA 1YCOA 4L04A 3BLXA 1HQSA
chains in the Genus database with same CATH superfamily
4AJ3A 1R8KA 3ASJA 5J32A 4IWHA 3INMA 1V5BA 3MAPA 3MASA 1DR0A 5GRIB 3ICDA 4P69C 1IDDA 1XACA 1WALA 3U1HA 1DR8A 5GRHA 3TY4A 5HN4A 3VMKA 1CM7A 3BLVA 1CW7A 2QFVA 3VL6A 1A05A 1VI1A 3VL7A 4JA8A 3BLXB 1XAAA 5I96A 3R8WA 5GREB 1LWDA 3UF6A 1P8FA 1DPZA 5J34A 1OSJA 5J33A 4AJBA 5L57A 1PS7A 5L58A 2E5MA 4XRXA 2G4OA 4AOUA 5GRLB 1IDEA 3WZVA 4YB4A 1XKDA 1HEXA 4XXVA 5GRHB 3AH3A 2QFWA 3WZYA 2HI1A 3FLKA 3VMLA 5LGEA 6ICDA 3MARA 4WUOA 4I3LA 3UDOA 1PB3A 3LXYA 2Y42A 3VL4A 1IDMA 1XABA 2D4VA 1AI2A 1WPWA 1SJSA 5GRFA 1T0LA 2Y40A 3TNGA 4AJSA 1ZORA 5I95A 1GC8A 5GRIA 1V53A 9ICDA 2DHTA 3MASB 4UMXA 5ICDA 1U7NA 1PB1A 1HJ6A 4Y1PA 1X0LA 1AI3A 2QFYA 3DMSA 4L03A 4AJRA 3FMXX 4XS3A 5HN5A 2UXQA 4I3KA 1ISOA 1TYOA 3TY3A 3UDUA 4L06A 1G2UA 1GC9A 3BLVB 1CW1A 1IKAA 1IDFA 3WZXA 1XGVA 2QFXA 3WZWA 4F7IA 2AYQA 2D1CA 5GREA 1PS6A 1W0DA 1YXOA 1IPDA 4AJCA 2E0CA 4AJAA 1VLCA 3VMJA 1CNZA 3VL3A 2UXRA 5GRFB 2Y3ZA 8ICDA 5DE1A 4AOYA 3US8A 4KZOA 1T09A 1PTMA 3LCBC 2ZTWA 3U9EA 4JQPA 4HCXA 5GRLA 3VL2A 4ICDA 1IDCA 3TSNA 1V94A 7ICDA 5HN3A 3VKZA 5HN6A 1XADA 5K10A 2Y41A 1OSIA 4ATYA 5K11A 1GRPA 1BL5A 4AOVA 1CW4A 4UMYA 2IV0A 4BNPA 1GROA 1YCOA 4L04A 3BLXA 1HQSA
chains in the Genus database with same CATH topology
4AJ3A 1R8KA 3ASJA 5J32A 4IWHA 3INMA 1V5BA 3MAPA 3MASA 1DR0A 5GRIB 3ICDA 4P69C 1IDDA 1XACA 1WALA 3U1HA 1DR8A 5GRHA 3TY4A 5HN4A 3VMKA 1CM7A 3BLVA 1CW7A 2QFVA 3VL6A 1A05A 1VI1A 3VL7A 4JA8A 3BLXB 1XAAA 5I96A 3R8WA 5GREB 1LWDA 3UF6A 1P8FA 1DPZA 5J34A 1OSJA 5J33A 4AJBA 5L57A 1PS7A 5L58A 2E5MA 4XRXA 2G4OA 4AOUA 5GRLB 1IDEA 3WZVA 4YB4A 1XKDA 1HEXA 4XXVA 5GRHB 3AH3A 2QFWA 3WZYA 2HI1A 3FLKA 3VMLA 5LGEA 6ICDA 3MARA 4WUOA 4I3LA 3UDOA 1PB3A 3LXYA 2Y42A 3VL4A 1IDMA 1XABA 2D4VA 1AI2A 1WPWA 1SJSA 5GRFA 1T0LA 2Y40A 3TNGA 4AJSA 1ZORA 5I95A 1GC8A 5GRIA 1V53A 9ICDA 2DHTA 3MASB 4UMXA 5ICDA 1U7NA 1PB1A 1HJ6A 4Y1PA 1X0LA 1AI3A 2QFYA 3DMSA 4L03A 4AJRA 3FMXX 4XS3A 5HN5A 2UXQA 4I3KA 1ISOA 1TYOA 3TY3A 3UDUA 4L06A 1G2UA 1GC9A 3BLVB 1CW1A 1IKAA 1IDFA 3WZXA 1XGVA 2QFXA 3WZWA 4F7IA 2AYQA 2D1CA 5GREA 1PS6A 1W0DA 1YXOA 1IPDA 4AJCA 2E0CA 4AJAA 1VLCA 3VMJA 1CNZA 3VL3A 2UXRA 5GRFB 2Y3ZA 8ICDA 5DE1A 4AOYA 3US8A 4KZOA 1T09A 1PTMA 3LCBC 2ZTWA 3U9EA 4JQPA 4HCXA 5GRLA 3VL2A 4ICDA 1IDCA 3TSNA 1V94A 7ICDA 5HN3A 3VKZA 5HN6A 1XADA 5K10A 2Y41A 1OSIA 4ATYA 5K11A 1GRPA 1BL5A 4AOVA 1CW4A 4UMYA 2IV0A 4BNPA 1GROA 1YCOA 4L04A 3BLXA 1HQSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AJ3 A;  1R8K A;  3ASJ A;  5J32 A;  4IWH A;  3INM A;  1V5B A;  3MAP A;  3MAS A;  1DR0 A;  5GRI B;  3ICD A;  4P69 C;  1IDD A;  1XAC A;  1WAL A;  3U1H A;  1DR8 A;  5GRH A;  3TY4 A;  5HN4 A;  3VMK A;  1CM7 A;  3BLV A;  1CW7 A;  2QFV A;  3VL6 A;  1A05 A;  1VI1 A;  3VL7 A;  4JA8 A;  3BLX B;  1XAA A;  5I96 A;  3R8W A;  5GRE B;  1LWD A;  3UF6 A;  1P8F A;  1DPZ A;  5J34 A;  1OSJ A;  5J33 A;  4AJB A;  5L57 A;  1PS7 A;  5L58 A;  2E5M A;  4XRX A;  2G4O A;  4AOU A;  5GRL B;  1IDE A;  3WZV A;  4YB4 A;  1XKD A;  1HEX A;  4XXV A;  5GRH B;  3AH3 A;  2QFW A;  3WZY A;  2HI1 A;  3FLK A;  3VML A;  5LGE A;  6ICD A;  3MAR A;  4WUO A;  4I3L A;  3UDO A;  1PB3 A;  3LXY A;  2Y42 A;  3VL4 A;  1IDM A;  1XAB A;  2D4V A;  1AI2 A;  1WPW A;  1SJS A;  5GRF A;  1T0L A;  2Y40 A;  3TNG A;  4AJS A;  1ZOR A;  5I95 A;  1GC8 A;  5GRI A;  1V53 A;  9ICD A;  2DHT A;  3MAS B;  4UMX A;  5ICD A;  1U7N A;  1PB1 A;  1HJ6 A;  4Y1P A;  1X0L A;  1AI3 A;  2QFY A;  3DMS A;  4L03 A;  4AJR A;  3FMX X;  4XS3 A;  5HN5 A;  2UXQ A;  4I3K A;  1ISO A;  1TYO A;  3TY3 A;  3UDU A;  4L06 A;  1G2U A;  1GC9 A;  3BLV B;  1CW1 A;  1IKA A;  1IDF A;  3WZX A;  1XGV A;  2QFX A;  3WZW A;  4F7I A;  2AYQ A;  2D1C A;  5GRE A;  1PS6 A;  1W0D A;  1YXO A;  1IPD A;  4AJC A;  2E0C A;  4AJA A;  1VLC A;  3VMJ A;  1CNZ A;  3VL3 A;  2UXR A;  5GRF B;  2Y3Z A;  8ICD A;  5DE1 A;  4AOY A;  3US8 A;  4KZO A;  1T09 A;  1PTM A;  3LCB C;  2ZTW A;  3U9E A;  4JQP A;  4HCX A;  5GRL A;  3VL2 A;  4ICD A;  1IDC A;  3TSN A;  1V94 A;  7ICD A;  5HN3 A;  3VKZ A;  5HN6 A;  1XAD A;  5K10 A;  2Y41 A;  1OSI A;  4ATY A;  5K11 A;  1GRP A;  1BL5 A;  4AOV A;  1CW4 A;  4UMY A;  2IV0 A;  4BNP A;  1GRO A;  1YCO A;  4L04 A;  3BLX A;  1HQS A; 
#chains in the Genus database with same CATH topology
 4AJ3 A;  1R8K A;  3ASJ A;  5J32 A;  4IWH A;  3INM A;  1V5B A;  3MAP A;  3MAS A;  1DR0 A;  5GRI B;  3ICD A;  4P69 C;  1IDD A;  1XAC A;  1WAL A;  3U1H A;  1DR8 A;  5GRH A;  3TY4 A;  5HN4 A;  3VMK A;  1CM7 A;  3BLV A;  1CW7 A;  2QFV A;  3VL6 A;  1A05 A;  1VI1 A;  3VL7 A;  4JA8 A;  3BLX B;  1XAA A;  5I96 A;  3R8W A;  5GRE B;  1LWD A;  3UF6 A;  1P8F A;  1DPZ A;  5J34 A;  1OSJ A;  5J33 A;  4AJB A;  5L57 A;  1PS7 A;  5L58 A;  2E5M A;  4XRX A;  2G4O A;  4AOU A;  5GRL B;  1IDE A;  3WZV A;  4YB4 A;  1XKD A;  1HEX A;  4XXV A;  5GRH B;  3AH3 A;  2QFW A;  3WZY A;  2HI1 A;  3FLK A;  3VML A;  5LGE A;  6ICD A;  3MAR A;  4WUO A;  4I3L A;  3UDO A;  1PB3 A;  3LXY A;  2Y42 A;  3VL4 A;  1IDM A;  1XAB A;  2D4V A;  1AI2 A;  1WPW A;  1SJS A;  5GRF A;  1T0L A;  2Y40 A;  3TNG A;  4AJS A;  1ZOR A;  5I95 A;  1GC8 A;  5GRI A;  1V53 A;  9ICD A;  2DHT A;  3MAS B;  4UMX A;  5ICD A;  1U7N A;  1PB1 A;  1HJ6 A;  4Y1P A;  1X0L A;  1AI3 A;  2QFY A;  3DMS A;  4L03 A;  4AJR A;  3FMX X;  4XS3 A;  5HN5 A;  2UXQ A;  4I3K A;  1ISO A;  1TYO A;  3TY3 A;  3UDU A;  4L06 A;  1G2U A;  1GC9 A;  3BLV B;  1CW1 A;  1IKA A;  1IDF A;  3WZX A;  1XGV A;  2QFX A;  3WZW A;  4F7I A;  2AYQ A;  2D1C A;  5GRE A;  1PS6 A;  1W0D A;  1YXO A;  1IPD A;  4AJC A;  2E0C A;  4AJA A;  1VLC A;  3VMJ A;  1CNZ A;  3VL3 A;  2UXR A;  5GRF B;  2Y3Z A;  8ICD A;  5DE1 A;  4AOY A;  3US8 A;  4KZO A;  1T09 A;  1PTM A;  3LCB C;  2ZTW A;  3U9E A;  4JQP A;  4HCX A;  5GRL A;  3VL2 A;  4ICD A;  1IDC A;  3TSN A;  1V94 A;  7ICD A;  5HN3 A;  3VKZ A;  5HN6 A;  1XAD A;  5K10 A;  2Y41 A;  1OSI A;  4ATY A;  5K11 A;  1GRP A;  1BL5 A;  4AOV A;  1CW4 A;  4UMY A;  2IV0 A;  4BNP A;  1GRO A;  1YCO A;  4L04 A;  3BLX A;  1HQS A; 
#chains in the Genus database with same CATH homology
 4AJ3 A;  1R8K A;  3ASJ A;  5J32 A;  4IWH A;  3INM A;  1V5B A;  3MAP A;  3MAS A;  1DR0 A;  5GRI B;  3ICD A;  4P69 C;  1IDD A;  1XAC A;  1WAL A;  3U1H A;  1DR8 A;  5GRH A;  3TY4 A;  5HN4 A;  3VMK A;  1CM7 A;  3BLV A;  1CW7 A;  2QFV A;  3VL6 A;  1A05 A;  1VI1 A;  3VL7 A;  4JA8 A;  3BLX B;  1XAA A;  5I96 A;  3R8W A;  5GRE B;  1LWD A;  3UF6 A;  1P8F A;  1DPZ A;  5J34 A;  1OSJ A;  5J33 A;  4AJB A;  5L57 A;  1PS7 A;  5L58 A;  2E5M A;  4XRX A;  2G4O A;  4AOU A;  5GRL B;  1IDE A;  3WZV A;  4YB4 A;  1XKD A;  1HEX A;  4XXV A;  5GRH B;  3AH3 A;  2QFW A;  3WZY A;  2HI1 A;  3FLK A;  3VML A;  5LGE A;  6ICD A;  3MAR A;  4WUO A;  4I3L A;  3UDO A;  1PB3 A;  3LXY A;  2Y42 A;  3VL4 A;  1IDM A;  1XAB A;  2D4V A;  1AI2 A;  1WPW A;  1SJS A;  5GRF A;  1T0L A;  2Y40 A;  3TNG A;  4AJS A;  1ZOR A;  5I95 A;  1GC8 A;  5GRI A;  1V53 A;  9ICD A;  2DHT A;  3MAS B;  4UMX A;  5ICD A;  1U7N A;  1PB1 A;  1HJ6 A;  4Y1P A;  1X0L A;  1AI3 A;  2QFY A;  3DMS A;  4L03 A;  4AJR A;  3FMX X;  4XS3 A;  5HN5 A;  2UXQ A;  4I3K A;  1ISO A;  1TYO A;  3TY3 A;  3UDU A;  4L06 A;  1G2U A;  1GC9 A;  3BLV B;  1CW1 A;  1IKA A;  1IDF A;  3WZX A;  1XGV A;  2QFX A;  3WZW A;  4F7I A;  2AYQ A;  2D1C A;  5GRE A;  1PS6 A;  1W0D A;  1YXO A;  1IPD A;  4AJC A;  2E0C A;  4AJA A;  1VLC A;  3VMJ A;  1CNZ A;  3VL3 A;  2UXR A;  5GRF B;  2Y3Z A;  8ICD A;  5DE1 A;  4AOY A;  3US8 A;  4KZO A;  1T09 A;  1PTM A;  3LCB C;  2ZTW A;  3U9E A;  4JQP A;  4HCX A;  5GRL A;  3VL2 A;  4ICD A;  1IDC A;  3TSN A;  1V94 A;  7ICD A;  5HN3 A;  3VKZ A;  5HN6 A;  1XAD A;  5K10 A;  2Y41 A;  1OSI A;  4ATY A;  5K11 A;  1GRP A;  1BL5 A;  4AOV A;  1CW4 A;  4UMY A;  2IV0 A;  4BNP A;  1GRO A;  1YCO A;  4L04 A;  3BLX A;  1HQS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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