2DHTA

Crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii strain7
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
409
structure length
403
Chain Sequence
MLYKEPEDGEKIKFDKGKWIVPNKPVILYIEGDGIGPEITNAAIKVINKAVERAYGSSREIKWLEVYAGEKAEKLVNDRFPKETQEMLLKYRVVLKGPLETPSVNVAIRLMLDLYANIRPVKYIEGLESPLKHPEKVDMIIFRENTDDLYRGIEYPFNSEEAKKIRDFLRKELKVEIEDDTGIGIKVMSKYKTQRITRLAIQYAIEHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEYRDFIVTEEEINQGKPDQGKIILNDRIADNMFQQIIIRPEEYDIILAPNVNGDYISDAAGALIGNIGMLGGANIGDEGGMFEAIHGTAPKYAGKNVANPTGIIKAGELMLRWMGWNEAADLIEKAINMAIRDKKVTQDIARFMGVKALGTKEYADELIKIMDTI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of isocitrate dehydrogenase of Sulfolobus tokodaii strain7
rcsb
molecule tags Oxidoreductase
source organism Sulfolobus tokodaii
molecule keywords 409aa long hypothetical NADP-dependent isocitrate dehydrogen
total genus 131
structure length 403
sequence length 409
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2006-03-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 2dhtA00
5GREA 1IDEA 3AH3A 4AOYA 7ICDA 3US8A 2Y42A 5GRIA 2G4OA 4L03A 4KZOA 1YCOA 5HN4A 4AOVA 1SJSA 2UXQA 1DR0A 2QFWA 3ASJA 1CNZA 1V53A 2ZTWA 1AI2A 1PB1A 1BL5A 1W0DA 3TSNA 3WZXA 5GRHA 1T09A 4XRXA 1DPZA 1VLCA 5I96A 5GRFB 3WZYA 4UMYA 5I95A 2Y3ZA 3BLXB 4F7IA 1XADA 4ICDA 4AJSA 4AOUA 1TYOA 3ICDA 5ICDA 1IPDA 5J34A 1CW7A 9ICDA 1V94A 1ZORA 1V5BA 3VL4A 1IKAA 1HJ6A 3DMSA 3FLKA 5GRLB 3VL6A 4JA8A 1A05A 1OSIA 8ICDA 1PS6A 5LGEA 1DR8A 4Y1PA 3TY4A 2AYQA 3UDUA 3VL7A 5J32A 5J33A 3MASB 4AJCA 3TY3A 1VI1A 4I3KA 3R8WA 4AJAA 3BLVA 3LXYA 2DHTA 1IDDA 1WPWA 1OSJA 4YB4A 5K11A 3MAPA 1PB3A 4L06A 1GROA 4XS3A 1X0LA 5GRFA 2UXRA 5L57A 3BLXA 3UF6A 2QFXA 2E0CA 2Y41A 1G2UA 1IDMA 3WZVA 1GC8A 2IV0A 1P8FA 1XGVA 5HN6A 6ICDA 5HN5A 3VMLA 1U7NA 2E5MA 5HN3A 4ATYA 5K10A 2QFVA 4BNPA 3LCBC 4JQPA 2HI1A 1XABA 5GREB 5GRLA 4AJBA 1HEXA 1WALA 1R8KA 1GRPA 5GRIB 2D4VA 3U9EA 1IDFA 1GC9A 3VMJA 1PTMA 3MASA 4WUOA 1HQSA 1ISOA 1PS7A 5L58A 4XXVA 1T0LA 3FMXX 3VL2A 1CW1A 3TNGA 1IDCA 4I3LA 1XACA 1XAAA 5GRHB 3WZWA 3BLVB 3VL3A 4P69C 1CM7A 1CW4A 5DE1A 1AI3A 3MARA 1LWDA 4UMXA 2D1CA 4HCXA 4IWHA 1YXOA 1XKDA 2QFYA 3UDOA 3VMKA 4L04A 3VKZA 3U1HA 2Y40A 4AJ3A 3INMA 4AJRA
chains in the Genus database with same CATH superfamily
5GREA 1IDEA 3AH3A 4AOYA 7ICDA 3US8A 2Y42A 5GRIA 2G4OA 4L03A 4KZOA 1YCOA 5HN4A 4AOVA 1SJSA 2UXQA 1DR0A 2QFWA 3ASJA 1CNZA 1V53A 2ZTWA 1AI2A 1PB1A 1BL5A 1W0DA 3TSNA 3WZXA 5GRHA 1T09A 4XRXA 1DPZA 1VLCA 5I96A 5GRFB 3WZYA 4UMYA 5I95A 2Y3ZA 3BLXB 4F7IA 1XADA 4ICDA 4AJSA 4AOUA 1TYOA 3ICDA 5ICDA 1IPDA 5J34A 1CW7A 9ICDA 1V94A 1ZORA 1V5BA 3VL4A 1IKAA 1HJ6A 3DMSA 3FLKA 5GRLB 3VL6A 4JA8A 1A05A 1OSIA 8ICDA 1PS6A 5LGEA 1DR8A 4Y1PA 3TY4A 2AYQA 3UDUA 3VL7A 5J32A 5J33A 3MASB 4AJCA 3TY3A 1VI1A 4I3KA 3R8WA 4AJAA 3BLVA 3LXYA 2DHTA 1IDDA 1WPWA 1OSJA 4YB4A 5K11A 3MAPA 1PB3A 4L06A 1GROA 4XS3A 1X0LA 5GRFA 2UXRA 5L57A 3BLXA 3UF6A 2QFXA 2E0CA 2Y41A 1G2UA 1IDMA 3WZVA 1GC8A 2IV0A 1P8FA 1XGVA 5HN6A 6ICDA 5HN5A 3VMLA 1U7NA 2E5MA 5HN3A 4ATYA 5K10A 2QFVA 4BNPA 3LCBC 4JQPA 2HI1A 1XABA 5GREB 5GRLA 4AJBA 1HEXA 1WALA 1R8KA 1GRPA 5GRIB 2D4VA 3U9EA 1IDFA 1GC9A 3VMJA 1PTMA 3MASA 4WUOA 1HQSA 1ISOA 1PS7A 5L58A 4XXVA 1T0LA 3FMXX 3VL2A 1CW1A 3TNGA 1IDCA 4I3LA 1XACA 1XAAA 5GRHB 3WZWA 3BLVB 3VL3A 4P69C 1CM7A 1CW4A 5DE1A 1AI3A 3MARA 1LWDA 4UMXA 2D1CA 4HCXA 4IWHA 1YXOA 1XKDA 2QFYA 3UDOA 3VMKA 4L04A 3VKZA 3U1HA 2Y40A 4AJ3A 3INMA 4AJRA
chains in the Genus database with same CATH topology
5GREA 1IDEA 3AH3A 4AOYA 7ICDA 3US8A 2Y42A 5GRIA 2G4OA 4L03A 4KZOA 1YCOA 5HN4A 4AOVA 1SJSA 2UXQA 1DR0A 2QFWA 3ASJA 1CNZA 1V53A 2ZTWA 1AI2A 1PB1A 1BL5A 1W0DA 3TSNA 3WZXA 5GRHA 1T09A 4XRXA 1DPZA 1VLCA 5I96A 5GRFB 3WZYA 4UMYA 5I95A 2Y3ZA 3BLXB 4F7IA 1XADA 4ICDA 4AJSA 4AOUA 1TYOA 3ICDA 5ICDA 1IPDA 5J34A 1CW7A 9ICDA 1V94A 1ZORA 1V5BA 3VL4A 1IKAA 1HJ6A 3DMSA 3FLKA 5GRLB 3VL6A 4JA8A 1A05A 1OSIA 8ICDA 1PS6A 5LGEA 1DR8A 4Y1PA 3TY4A 2AYQA 3UDUA 3VL7A 5J32A 5J33A 3MASB 4AJCA 3TY3A 1VI1A 4I3KA 3R8WA 4AJAA 3BLVA 3LXYA 2DHTA 1IDDA 1WPWA 1OSJA 4YB4A 5K11A 3MAPA 1PB3A 4L06A 1GROA 4XS3A 1X0LA 5GRFA 2UXRA 5L57A 3BLXA 3UF6A 2QFXA 2E0CA 2Y41A 1G2UA 1IDMA 3WZVA 1GC8A 2IV0A 1P8FA 1XGVA 5HN6A 6ICDA 5HN5A 3VMLA 1U7NA 2E5MA 5HN3A 4ATYA 5K10A 2QFVA 4BNPA 3LCBC 4JQPA 2HI1A 1XABA 5GREB 5GRLA 4AJBA 1HEXA 1WALA 1R8KA 1GRPA 5GRIB 2D4VA 3U9EA 1IDFA 1GC9A 3VMJA 1PTMA 3MASA 4WUOA 1HQSA 1ISOA 1PS7A 5L58A 4XXVA 1T0LA 3FMXX 3VL2A 1CW1A 3TNGA 1IDCA 4I3LA 1XACA 1XAAA 5GRHB 3WZWA 3BLVB 3VL3A 4P69C 1CM7A 1CW4A 5DE1A 1AI3A 3MARA 1LWDA 4UMXA 2D1CA 4HCXA 4IWHA 1YXOA 1XKDA 2QFYA 3UDOA 3VMKA 4L04A 3VKZA 3U1HA 2Y40A 4AJ3A 3INMA 4AJRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GRE A;  1IDE A;  3AH3 A;  4AOY A;  7ICD A;  3US8 A;  2Y42 A;  5GRI A;  2G4O A;  4L03 A;  4KZO A;  1YCO A;  5HN4 A;  4AOV A;  1SJS A;  2UXQ A;  1DR0 A;  2QFW A;  3ASJ A;  1CNZ A;  1V53 A;  2ZTW A;  1AI2 A;  1PB1 A;  1BL5 A;  1W0D A;  3TSN A;  3WZX A;  5GRH A;  1T09 A;  4XRX A;  1DPZ A;  1VLC A;  5I96 A;  5GRF B;  3WZY A;  4UMY A;  5I95 A;  2Y3Z A;  3BLX B;  4F7I A;  1XAD A;  4ICD A;  4AJS A;  4AOU A;  1TYO A;  3ICD A;  5ICD A;  1IPD A;  5J34 A;  1CW7 A;  9ICD A;  1V94 A;  1ZOR A;  1V5B A;  3VL4 A;  1IKA A;  1HJ6 A;  3DMS A;  3FLK A;  5GRL B;  3VL6 A;  4JA8 A;  1A05 A;  1OSI A;  8ICD A;  1PS6 A;  5LGE A;  1DR8 A;  4Y1P A;  3TY4 A;  2AYQ A;  3UDU A;  3VL7 A;  5J32 A;  5J33 A;  3MAS B;  4AJC A;  3TY3 A;  1VI1 A;  4I3K A;  3R8W A;  4AJA A;  3BLV A;  3LXY A;  2DHT A;  1IDD A;  1WPW A;  1OSJ A;  4YB4 A;  5K11 A;  3MAP A;  1PB3 A;  4L06 A;  1GRO A;  4XS3 A;  1X0L A;  5GRF A;  2UXR A;  5L57 A;  3BLX A;  3UF6 A;  2QFX A;  2E0C A;  2Y41 A;  1G2U A;  1IDM A;  3WZV A;  1GC8 A;  2IV0 A;  1P8F A;  1XGV A;  5HN6 A;  6ICD A;  5HN5 A;  3VML A;  1U7N A;  2E5M A;  5HN3 A;  4ATY A;  5K10 A;  2QFV A;  4BNP A;  3LCB C;  4JQP A;  2HI1 A;  1XAB A;  5GRE B;  5GRL A;  4AJB A;  1HEX A;  1WAL A;  1R8K A;  1GRP A;  5GRI B;  2D4V A;  3U9E A;  1IDF A;  1GC9 A;  3VMJ A;  1PTM A;  3MAS A;  4WUO A;  1HQS A;  1ISO A;  1PS7 A;  5L58 A;  4XXV A;  1T0L A;  3FMX X;  3VL2 A;  1CW1 A;  3TNG A;  1IDC A;  4I3L A;  1XAC A;  1XAA A;  5GRH B;  3WZW A;  3BLV B;  3VL3 A;  4P69 C;  1CM7 A;  1CW4 A;  5DE1 A;  1AI3 A;  3MAR A;  1LWD A;  4UMX A;  2D1C A;  4HCX A;  4IWH A;  1YXO A;  1XKD A;  2QFY A;  3UDO A;  3VMK A;  4L04 A;  3VKZ A;  3U1H A;  2Y40 A;  4AJ3 A;  3INM A;  4AJR A; 
#chains in the Genus database with same CATH topology
 5GRE A;  1IDE A;  3AH3 A;  4AOY A;  7ICD A;  3US8 A;  2Y42 A;  5GRI A;  2G4O A;  4L03 A;  4KZO A;  1YCO A;  5HN4 A;  4AOV A;  1SJS A;  2UXQ A;  1DR0 A;  2QFW A;  3ASJ A;  1CNZ A;  1V53 A;  2ZTW A;  1AI2 A;  1PB1 A;  1BL5 A;  1W0D A;  3TSN A;  3WZX A;  5GRH A;  1T09 A;  4XRX A;  1DPZ A;  1VLC A;  5I96 A;  5GRF B;  3WZY A;  4UMY A;  5I95 A;  2Y3Z A;  3BLX B;  4F7I A;  1XAD A;  4ICD A;  4AJS A;  4AOU A;  1TYO A;  3ICD A;  5ICD A;  1IPD A;  5J34 A;  1CW7 A;  9ICD A;  1V94 A;  1ZOR A;  1V5B A;  3VL4 A;  1IKA A;  1HJ6 A;  3DMS A;  3FLK A;  5GRL B;  3VL6 A;  4JA8 A;  1A05 A;  1OSI A;  8ICD A;  1PS6 A;  5LGE A;  1DR8 A;  4Y1P A;  3TY4 A;  2AYQ A;  3UDU A;  3VL7 A;  5J32 A;  5J33 A;  3MAS B;  4AJC A;  3TY3 A;  1VI1 A;  4I3K A;  3R8W A;  4AJA A;  3BLV A;  3LXY A;  2DHT A;  1IDD A;  1WPW A;  1OSJ A;  4YB4 A;  5K11 A;  3MAP A;  1PB3 A;  4L06 A;  1GRO A;  4XS3 A;  1X0L A;  5GRF A;  2UXR A;  5L57 A;  3BLX A;  3UF6 A;  2QFX A;  2E0C A;  2Y41 A;  1G2U A;  1IDM A;  3WZV A;  1GC8 A;  2IV0 A;  1P8F A;  1XGV A;  5HN6 A;  6ICD A;  5HN5 A;  3VML A;  1U7N A;  2E5M A;  5HN3 A;  4ATY A;  5K10 A;  2QFV A;  4BNP A;  3LCB C;  4JQP A;  2HI1 A;  1XAB A;  5GRE B;  5GRL A;  4AJB A;  1HEX A;  1WAL A;  1R8K A;  1GRP A;  5GRI B;  2D4V A;  3U9E A;  1IDF A;  1GC9 A;  3VMJ A;  1PTM A;  3MAS A;  4WUO A;  1HQS A;  1ISO A;  1PS7 A;  5L58 A;  4XXV A;  1T0L A;  3FMX X;  3VL2 A;  1CW1 A;  3TNG A;  1IDC A;  4I3L A;  1XAC A;  1XAA A;  5GRH B;  3WZW A;  3BLV B;  3VL3 A;  4P69 C;  1CM7 A;  1CW4 A;  5DE1 A;  1AI3 A;  3MAR A;  1LWD A;  4UMX A;  2D1C A;  4HCX A;  4IWH A;  1YXO A;  1XKD A;  2QFY A;  3UDO A;  3VMK A;  4L04 A;  3VKZ A;  3U1H A;  2Y40 A;  4AJ3 A;  3INM A;  4AJR A; 
#chains in the Genus database with same CATH homology
 5GRE A;  1IDE A;  3AH3 A;  4AOY A;  7ICD A;  3US8 A;  2Y42 A;  5GRI A;  2G4O A;  4L03 A;  4KZO A;  1YCO A;  5HN4 A;  4AOV A;  1SJS A;  2UXQ A;  1DR0 A;  2QFW A;  3ASJ A;  1CNZ A;  1V53 A;  2ZTW A;  1AI2 A;  1PB1 A;  1BL5 A;  1W0D A;  3TSN A;  3WZX A;  5GRH A;  1T09 A;  4XRX A;  1DPZ A;  1VLC A;  5I96 A;  5GRF B;  3WZY A;  4UMY A;  5I95 A;  2Y3Z A;  3BLX B;  4F7I A;  1XAD A;  4ICD A;  4AJS A;  4AOU A;  1TYO A;  3ICD A;  5ICD A;  1IPD A;  5J34 A;  1CW7 A;  9ICD A;  1V94 A;  1ZOR A;  1V5B A;  3VL4 A;  1IKA A;  1HJ6 A;  3DMS A;  3FLK A;  5GRL B;  3VL6 A;  4JA8 A;  1A05 A;  1OSI A;  8ICD A;  1PS6 A;  5LGE A;  1DR8 A;  4Y1P A;  3TY4 A;  2AYQ A;  3UDU A;  3VL7 A;  5J32 A;  5J33 A;  3MAS B;  4AJC A;  3TY3 A;  1VI1 A;  4I3K A;  3R8W A;  4AJA A;  3BLV A;  3LXY A;  2DHT A;  1IDD A;  1WPW A;  1OSJ A;  4YB4 A;  5K11 A;  3MAP A;  1PB3 A;  4L06 A;  1GRO A;  4XS3 A;  1X0L A;  5GRF A;  2UXR A;  5L57 A;  3BLX A;  3UF6 A;  2QFX A;  2E0C A;  2Y41 A;  1G2U A;  1IDM A;  3WZV A;  1GC8 A;  2IV0 A;  1P8F A;  1XGV A;  5HN6 A;  6ICD A;  5HN5 A;  3VML A;  1U7N A;  2E5M A;  5HN3 A;  4ATY A;  5K10 A;  2QFV A;  4BNP A;  3LCB C;  4JQP A;  2HI1 A;  1XAB A;  5GRE B;  5GRL A;  4AJB A;  1HEX A;  1WAL A;  1R8K A;  1GRP A;  5GRI B;  2D4V A;  3U9E A;  1IDF A;  1GC9 A;  3VMJ A;  1PTM A;  3MAS A;  4WUO A;  1HQS A;  1ISO A;  1PS7 A;  5L58 A;  4XXV A;  1T0L A;  3FMX X;  3VL2 A;  1CW1 A;  3TNG A;  1IDC A;  4I3L A;  1XAC A;  1XAA A;  5GRH B;  3WZW A;  3BLV B;  3VL3 A;  4P69 C;  1CM7 A;  1CW4 A;  5DE1 A;  1AI3 A;  3MAR A;  1LWD A;  4UMX A;  2D1C A;  4HCX A;  4IWH A;  1YXO A;  1XKD A;  2QFY A;  3UDO A;  3VMK A;  4L04 A;  3VKZ A;  3U1H A;  2Y40 A;  4AJ3 A;  3INM A;  4AJR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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