2DHTA

Crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii strain7
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
409
structure length
403
Chain Sequence
MLYKEPEDGEKIKFDKGKWIVPNKPVILYIEGDGIGPEITNAAIKVINKAVERAYGSSREIKWLEVYAGEKAEKLVNDRFPKETQEMLLKYRVVLKGPLETPSVNVAIRLMLDLYANIRPVKYIEGLESPLKHPEKVDMIIFRENTDDLYRGIEYPFNSEEAKKIRDFLRKELKVEIEDDTGIGIKVMSKYKTQRITRLAIQYAIEHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEYRDFIVTEEEINQGKPDQGKIILNDRIADNMFQQIIIRPEEYDIILAPNVNGDYISDAAGALIGNIGMLGGANIGDEGGMFEAIHGTAPKYAGKNVANPTGIIKAGELMLRWMGWNEAADLIEKAINMAIRDKKVTQDIARFMGVKALGTKEYADELIKIMDTI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of isocitrate dehydrogenase of Sulfolobus tokodaii strain7
rcsb
molecule tags Oxidoreductase
source organism Sulfolobus tokodaii
molecule keywords 409aa long hypothetical NADP-dependent isocitrate dehydrogen
total genus 131
structure length 403
sequence length 409
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2006-03-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 2dhtA00
1DR8A 3VMLA 3TNGA 5GRLA 1CNZA 1X0LA 4WUOA 1DR0A 5L58A 1BL5A 2E0CA 5ICDA 9ICDA 3BLVB 4L04A 3TSNA 1DPZA 2Y3ZA 4I3KA 3UF6A 1V53A 4HCXA 1AI2A 4XS3A 1GC8A 3US8A 1PB3A 2E5MA 1W0DA 3FLKA 4AOVA 5LGEA 2QFVA 1T09A 3BLVA 4Y1PA 5J33A 4AJCA 5L57A 3INMA 5I96A 1GC9A 1XGVA 2QFWA 1WALA 1XAAA 2ZTWA 5K10A 1IKAA 1R8KA 1T0LA 4I3LA 5GREB 3BLXB 5HN3A 2D1CA 4L03A 1IDDA 5HN5A 4ATYA 2Y40A 1VI1A 1OSIA 2Y41A 3VL7A 3VL6A 1VLCA 4AJBA 4JQPA 1V5BA 5J32A 5GRFB 2UXRA 4AOUA 3VL4A 1LWDA 1OSJA 3DMSA 4JA8A 1IPDA 2QFXA 6ICDA 3ASJA 4AJRA 3UDOA 3MASB 1IDEA 3LCBC 4F7IA 3WZWA 4AJAA 2QFYA 5HN4A 1HQSA 2HI1A 4UMXA 1XACA 3MARA 3ICDA 1PS7A 7ICDA 1ISOA 1XADA 1YXOA 3UDUA 8ICDA 3LXYA 1AI3A 1XKDA 1CW1A 3MAPA 5GRHB 4XRXA 1HEXA 2AYQA 1P8FA 1XABA 2G4OA 5DE1A 3AH3A 1CM7A 1ZORA 5GRIB 3VMKA 5GREA 5GRHA 3BLXA 5K11A 1HJ6A 3VL2A 4P69C 5I95A 3VMJA 1CW7A 4IWHA 3TY4A 3U9EA 1WPWA 1PB1A 4YB4A 5GRFA 2DHTA 1CW4A 4L06A 5HN6A 1IDCA 5GRIA 2Y42A 1PS6A 1YCOA 1PTMA 4KZOA 3MASA 3WZYA 3WZVA 4BNPA 3FMXX 3R8WA 4ICDA 3U1HA 4AJSA 1U7NA 2UXQA 1GROA 1SJSA 3VL3A 4AOYA 1IDFA 4AJ3A 3VKZA 5GRLB 1G2UA 1IDMA 1TYOA 1A05A 4XXVA 1GRPA 3TY3A 4UMYA 3WZXA 5J34A 2D4VA 1V94A 2IV0A
chains in the Genus database with same CATH superfamily
1DR8A 3VMLA 3TNGA 5GRLA 1CNZA 1X0LA 4WUOA 1DR0A 5L58A 1BL5A 2E0CA 5ICDA 9ICDA 3BLVB 4L04A 3TSNA 1DPZA 2Y3ZA 4I3KA 3UF6A 1V53A 4HCXA 1AI2A 4XS3A 1GC8A 3US8A 1PB3A 2E5MA 1W0DA 3FLKA 4AOVA 5LGEA 2QFVA 1T09A 3BLVA 4Y1PA 5J33A 4AJCA 5L57A 3INMA 5I96A 1GC9A 1XGVA 2QFWA 1WALA 1XAAA 2ZTWA 5K10A 1IKAA 1R8KA 1T0LA 4I3LA 5GREB 3BLXB 5HN3A 2D1CA 4L03A 1IDDA 5HN5A 4ATYA 2Y40A 1VI1A 1OSIA 2Y41A 3VL7A 3VL6A 1VLCA 4AJBA 4JQPA 1V5BA 5J32A 5GRFB 2UXRA 4AOUA 3VL4A 1LWDA 1OSJA 3DMSA 4JA8A 1IPDA 2QFXA 6ICDA 3ASJA 4AJRA 3UDOA 3MASB 1IDEA 3LCBC 4F7IA 3WZWA 4AJAA 2QFYA 5HN4A 1HQSA 2HI1A 4UMXA 1XACA 3MARA 3ICDA 1PS7A 7ICDA 1ISOA 1XADA 1YXOA 3UDUA 8ICDA 3LXYA 1AI3A 1XKDA 1CW1A 3MAPA 5GRHB 4XRXA 1HEXA 2AYQA 1P8FA 1XABA 2G4OA 5DE1A 3AH3A 1CM7A 1ZORA 5GRIB 3VMKA 5GREA 5GRHA 3BLXA 5K11A 1HJ6A 3VL2A 4P69C 5I95A 3VMJA 1CW7A 4IWHA 3TY4A 3U9EA 1WPWA 1PB1A 4YB4A 5GRFA 2DHTA 1CW4A 4L06A 5HN6A 1IDCA 5GRIA 2Y42A 1PS6A 1YCOA 1PTMA 4KZOA 3MASA 3WZYA 3WZVA 4BNPA 3FMXX 3R8WA 4ICDA 3U1HA 4AJSA 1U7NA 2UXQA 1GROA 1SJSA 3VL3A 4AOYA 1IDFA 4AJ3A 3VKZA 5GRLB 1G2UA 1IDMA 1TYOA 1A05A 4XXVA 1GRPA 3TY3A 4UMYA 3WZXA 5J34A 2D4VA 1V94A 2IV0A
chains in the Genus database with same CATH topology
1DR8A 3VMLA 3TNGA 5GRLA 1CNZA 1X0LA 4WUOA 1DR0A 5L58A 1BL5A 2E0CA 5ICDA 9ICDA 3BLVB 4L04A 3TSNA 1DPZA 2Y3ZA 4I3KA 3UF6A 1V53A 4HCXA 1AI2A 4XS3A 1GC8A 3US8A 1PB3A 2E5MA 1W0DA 3FLKA 4AOVA 5LGEA 2QFVA 1T09A 3BLVA 4Y1PA 5J33A 4AJCA 5L57A 3INMA 5I96A 1GC9A 1XGVA 2QFWA 1WALA 1XAAA 2ZTWA 5K10A 1IKAA 1R8KA 1T0LA 4I3LA 5GREB 3BLXB 5HN3A 2D1CA 4L03A 1IDDA 5HN5A 4ATYA 2Y40A 1VI1A 1OSIA 2Y41A 3VL7A 3VL6A 1VLCA 4AJBA 4JQPA 1V5BA 5J32A 5GRFB 2UXRA 4AOUA 3VL4A 1LWDA 1OSJA 3DMSA 4JA8A 1IPDA 2QFXA 6ICDA 3ASJA 4AJRA 3UDOA 3MASB 1IDEA 3LCBC 4F7IA 3WZWA 4AJAA 2QFYA 5HN4A 1HQSA 2HI1A 4UMXA 1XACA 3MARA 3ICDA 1PS7A 7ICDA 1ISOA 1XADA 1YXOA 3UDUA 8ICDA 3LXYA 1AI3A 1XKDA 1CW1A 3MAPA 5GRHB 4XRXA 1HEXA 2AYQA 1P8FA 1XABA 2G4OA 5DE1A 3AH3A 1CM7A 1ZORA 5GRIB 3VMKA 5GREA 5GRHA 3BLXA 5K11A 1HJ6A 3VL2A 4P69C 5I95A 3VMJA 1CW7A 4IWHA 3TY4A 3U9EA 1WPWA 1PB1A 4YB4A 5GRFA 2DHTA 1CW4A 4L06A 5HN6A 1IDCA 5GRIA 2Y42A 1PS6A 1YCOA 1PTMA 4KZOA 3MASA 3WZYA 3WZVA 4BNPA 3FMXX 3R8WA 4ICDA 3U1HA 4AJSA 1U7NA 2UXQA 1GROA 1SJSA 3VL3A 4AOYA 1IDFA 4AJ3A 3VKZA 5GRLB 1G2UA 1IDMA 1TYOA 1A05A 4XXVA 1GRPA 3TY3A 4UMYA 3WZXA 5J34A 2D4VA 1V94A 2IV0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DR8 A;  3VML A;  3TNG A;  5GRL A;  1CNZ A;  1X0L A;  4WUO A;  1DR0 A;  5L58 A;  1BL5 A;  2E0C A;  5ICD A;  9ICD A;  3BLV B;  4L04 A;  3TSN A;  1DPZ A;  2Y3Z A;  4I3K A;  3UF6 A;  1V53 A;  4HCX A;  1AI2 A;  4XS3 A;  1GC8 A;  3US8 A;  1PB3 A;  2E5M A;  1W0D A;  3FLK A;  4AOV A;  5LGE A;  2QFV A;  1T09 A;  3BLV A;  4Y1P A;  5J33 A;  4AJC A;  5L57 A;  3INM A;  5I96 A;  1GC9 A;  1XGV A;  2QFW A;  1WAL A;  1XAA A;  2ZTW A;  5K10 A;  1IKA A;  1R8K A;  1T0L A;  4I3L A;  5GRE B;  3BLX B;  5HN3 A;  2D1C A;  4L03 A;  1IDD A;  5HN5 A;  4ATY A;  2Y40 A;  1VI1 A;  1OSI A;  2Y41 A;  3VL7 A;  3VL6 A;  1VLC A;  4AJB A;  4JQP A;  1V5B A;  5J32 A;  5GRF B;  2UXR A;  4AOU A;  3VL4 A;  1LWD A;  1OSJ A;  3DMS A;  4JA8 A;  1IPD A;  2QFX A;  6ICD A;  3ASJ A;  4AJR A;  3UDO A;  3MAS B;  1IDE A;  3LCB C;  4F7I A;  3WZW A;  4AJA A;  2QFY A;  5HN4 A;  1HQS A;  2HI1 A;  4UMX A;  1XAC A;  3MAR A;  3ICD A;  1PS7 A;  7ICD A;  1ISO A;  1XAD A;  1YXO A;  3UDU A;  8ICD A;  3LXY A;  1AI3 A;  1XKD A;  1CW1 A;  3MAP A;  5GRH B;  4XRX A;  1HEX A;  2AYQ A;  1P8F A;  1XAB A;  2G4O A;  5DE1 A;  3AH3 A;  1CM7 A;  1ZOR A;  5GRI B;  3VMK A;  5GRE A;  5GRH A;  3BLX A;  5K11 A;  1HJ6 A;  3VL2 A;  4P69 C;  5I95 A;  3VMJ A;  1CW7 A;  4IWH A;  3TY4 A;  3U9E A;  1WPW A;  1PB1 A;  4YB4 A;  5GRF A;  2DHT A;  1CW4 A;  4L06 A;  5HN6 A;  1IDC A;  5GRI A;  2Y42 A;  1PS6 A;  1YCO A;  1PTM A;  4KZO A;  3MAS A;  3WZY A;  3WZV A;  4BNP A;  3FMX X;  3R8W A;  4ICD A;  3U1H A;  4AJS A;  1U7N A;  2UXQ A;  1GRO A;  1SJS A;  3VL3 A;  4AOY A;  1IDF A;  4AJ3 A;  3VKZ A;  5GRL B;  1G2U A;  1IDM A;  1TYO A;  1A05 A;  4XXV A;  1GRP A;  3TY3 A;  4UMY A;  3WZX A;  5J34 A;  2D4V A;  1V94 A;  2IV0 A; 
#chains in the Genus database with same CATH topology
 1DR8 A;  3VML A;  3TNG A;  5GRL A;  1CNZ A;  1X0L A;  4WUO A;  1DR0 A;  5L58 A;  1BL5 A;  2E0C A;  5ICD A;  9ICD A;  3BLV B;  4L04 A;  3TSN A;  1DPZ A;  2Y3Z A;  4I3K A;  3UF6 A;  1V53 A;  4HCX A;  1AI2 A;  4XS3 A;  1GC8 A;  3US8 A;  1PB3 A;  2E5M A;  1W0D A;  3FLK A;  4AOV A;  5LGE A;  2QFV A;  1T09 A;  3BLV A;  4Y1P A;  5J33 A;  4AJC A;  5L57 A;  3INM A;  5I96 A;  1GC9 A;  1XGV A;  2QFW A;  1WAL A;  1XAA A;  2ZTW A;  5K10 A;  1IKA A;  1R8K A;  1T0L A;  4I3L A;  5GRE B;  3BLX B;  5HN3 A;  2D1C A;  4L03 A;  1IDD A;  5HN5 A;  4ATY A;  2Y40 A;  1VI1 A;  1OSI A;  2Y41 A;  3VL7 A;  3VL6 A;  1VLC A;  4AJB A;  4JQP A;  1V5B A;  5J32 A;  5GRF B;  2UXR A;  4AOU A;  3VL4 A;  1LWD A;  1OSJ A;  3DMS A;  4JA8 A;  1IPD A;  2QFX A;  6ICD A;  3ASJ A;  4AJR A;  3UDO A;  3MAS B;  1IDE A;  3LCB C;  4F7I A;  3WZW A;  4AJA A;  2QFY A;  5HN4 A;  1HQS A;  2HI1 A;  4UMX A;  1XAC A;  3MAR A;  3ICD A;  1PS7 A;  7ICD A;  1ISO A;  1XAD A;  1YXO A;  3UDU A;  8ICD A;  3LXY A;  1AI3 A;  1XKD A;  1CW1 A;  3MAP A;  5GRH B;  4XRX A;  1HEX A;  2AYQ A;  1P8F A;  1XAB A;  2G4O A;  5DE1 A;  3AH3 A;  1CM7 A;  1ZOR A;  5GRI B;  3VMK A;  5GRE A;  5GRH A;  3BLX A;  5K11 A;  1HJ6 A;  3VL2 A;  4P69 C;  5I95 A;  3VMJ A;  1CW7 A;  4IWH A;  3TY4 A;  3U9E A;  1WPW A;  1PB1 A;  4YB4 A;  5GRF A;  2DHT A;  1CW4 A;  4L06 A;  5HN6 A;  1IDC A;  5GRI A;  2Y42 A;  1PS6 A;  1YCO A;  1PTM A;  4KZO A;  3MAS A;  3WZY A;  3WZV A;  4BNP A;  3FMX X;  3R8W A;  4ICD A;  3U1H A;  4AJS A;  1U7N A;  2UXQ A;  1GRO A;  1SJS A;  3VL3 A;  4AOY A;  1IDF A;  4AJ3 A;  3VKZ A;  5GRL B;  1G2U A;  1IDM A;  1TYO A;  1A05 A;  4XXV A;  1GRP A;  3TY3 A;  4UMY A;  3WZX A;  5J34 A;  2D4V A;  1V94 A;  2IV0 A; 
#chains in the Genus database with same CATH homology
 1DR8 A;  3VML A;  3TNG A;  5GRL A;  1CNZ A;  1X0L A;  4WUO A;  1DR0 A;  5L58 A;  1BL5 A;  2E0C A;  5ICD A;  9ICD A;  3BLV B;  4L04 A;  3TSN A;  1DPZ A;  2Y3Z A;  4I3K A;  3UF6 A;  1V53 A;  4HCX A;  1AI2 A;  4XS3 A;  1GC8 A;  3US8 A;  1PB3 A;  2E5M A;  1W0D A;  3FLK A;  4AOV A;  5LGE A;  2QFV A;  1T09 A;  3BLV A;  4Y1P A;  5J33 A;  4AJC A;  5L57 A;  3INM A;  5I96 A;  1GC9 A;  1XGV A;  2QFW A;  1WAL A;  1XAA A;  2ZTW A;  5K10 A;  1IKA A;  1R8K A;  1T0L A;  4I3L A;  5GRE B;  3BLX B;  5HN3 A;  2D1C A;  4L03 A;  1IDD A;  5HN5 A;  4ATY A;  2Y40 A;  1VI1 A;  1OSI A;  2Y41 A;  3VL7 A;  3VL6 A;  1VLC A;  4AJB A;  4JQP A;  1V5B A;  5J32 A;  5GRF B;  2UXR A;  4AOU A;  3VL4 A;  1LWD A;  1OSJ A;  3DMS A;  4JA8 A;  1IPD A;  2QFX A;  6ICD A;  3ASJ A;  4AJR A;  3UDO A;  3MAS B;  1IDE A;  3LCB C;  4F7I A;  3WZW A;  4AJA A;  2QFY A;  5HN4 A;  1HQS A;  2HI1 A;  4UMX A;  1XAC A;  3MAR A;  3ICD A;  1PS7 A;  7ICD A;  1ISO A;  1XAD A;  1YXO A;  3UDU A;  8ICD A;  3LXY A;  1AI3 A;  1XKD A;  1CW1 A;  3MAP A;  5GRH B;  4XRX A;  1HEX A;  2AYQ A;  1P8F A;  1XAB A;  2G4O A;  5DE1 A;  3AH3 A;  1CM7 A;  1ZOR A;  5GRI B;  3VMK A;  5GRE A;  5GRH A;  3BLX A;  5K11 A;  1HJ6 A;  3VL2 A;  4P69 C;  5I95 A;  3VMJ A;  1CW7 A;  4IWH A;  3TY4 A;  3U9E A;  1WPW A;  1PB1 A;  4YB4 A;  5GRF A;  2DHT A;  1CW4 A;  4L06 A;  5HN6 A;  1IDC A;  5GRI A;  2Y42 A;  1PS6 A;  1YCO A;  1PTM A;  4KZO A;  3MAS A;  3WZY A;  3WZV A;  4BNP A;  3FMX X;  3R8W A;  4ICD A;  3U1H A;  4AJS A;  1U7N A;  2UXQ A;  1GRO A;  1SJS A;  3VL3 A;  4AOY A;  1IDF A;  4AJ3 A;  3VKZ A;  5GRL B;  1G2U A;  1IDM A;  1TYO A;  1A05 A;  4XXV A;  1GRP A;  3TY3 A;  4UMY A;  3WZX A;  5J34 A;  2D4V A;  1V94 A;  2IV0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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