2F1WA

Crystal structure of the traf-like domain of hausp/usp7
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
144
structure length
144
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 26
structure length 144
sequence length 144
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2005-11-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2f1wA00
4I7DA 1QSCA 2FOPA 3HQIA 3HSVA 1L0AA 4I7BA 4K8UA 4M4EA 4YSIA 1K2FA 3ZJBA 4Z8MA 4GHUA 4GWNA 1LB4A 1CZYA 2GKWA 1FLKA 1YY6A 1LB5A 2F1XA 2A25A 4I7CA 3IVBA 4GJHA 4O1VA 4CA1A 1D00A 3HQLA 3HU6A 3IVQA 1KZZA 1D01A 1CA9A 1D0JA 3MQSC 5H9MA 1CZZA 1YZEA 1ZMSA 2F1ZA 3MQRA 4C9ZA 1RF3A 3HQHA 4X3GA 1LB6A 3IVVA 2AN6A 2CR2A 4JJQA 4KG9A 2F1YA 1D0AA 2F1WA 2FOOA 1FLLA 3HQMA 4GWMA 5E1TA 2XXNA 2FOJA 1F3VB 1CA4A
chains in the Genus database with same CATH superfamily
4I7DA 1QSCA 2FOPA 3HQIA 3HSVA 1L0AA 4I7BA 4K8UA 4M4EA 4YSIA 1K2FA 3ZJBA 4Z8MA 4GHUA 4GWNA 1LB4A 1CZYA 2GKWA 1FLKA 1YY6A 1LB5A 2F1XA 2A25A 4I7CA 3IVBA 4GJHA 4O1VA 4CA1A 1D00A 3HQLA 3HU6A 3IVQA 1KZZA 1D01A 1CA9A 1D0JA 3MQSC 5H9MA 1CZZA 1YZEA 1ZMSA 2F1ZA 3MQRA 4C9ZA 1RF3A 3HQHA 4X3GA 1LB6A 3IVVA 2AN6A 2CR2A 4JJQA 4KG9A 2F1YA 1D0AA 2F1WA 2FOOA 1FLLA 3HQMA 4GWMA 5E1TA 2XXNA 2FOJA 1F3VB 1CA4A
chains in the Genus database with same CATH topology
4I7DA 1QSCA 2FOPA 3HQIA 3HSVA 1L0AA 4I7BA 4K8UA 4M4EA 4YSIA 1K2FA 3ZJBA 4Z8MA 4GHUA 4GWNA 1LB4A 1CZYA 2GKWA 1FLKA 1YY6A 1LB5A 2F1XA 2A25A 4I7CA 3IVBA 4GJHA 4O1VA 4CA1A 1D00A 3HQLA 3HU6A 3IVQA 1KZZA 1D01A 1CA9A 1D0JA 3MQSC 5H9MA 1CZZA 1YZEA 1ZMSA 2F1ZA 3MQRA 4C9ZA 1RF3A 3HQHA 4X3GA 1LB6A 3IVVA 2AN6A 2CR2A 4JJQA 4KG9A 2F1YA 1D0AA 2F1WA 2FOOA 1FLLA 3HQMA 4GWMA 5E1TA 2XXNA 2FOJA 1F3VB 1CA4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I7D A;  1QSC A;  2FOP A;  3HQI A;  3HSV A;  1L0A A;  4I7B A;  4K8U A;  4M4E A;  4YSI A;  1K2F A;  3ZJB A;  4Z8M A;  4GHU A;  4GWN A;  1LB4 A;  1CZY A;  2GKW A;  1FLK A;  1YY6 A;  1LB5 A;  2F1X A;  2A25 A;  4I7C A;  3IVB A;  4GJH A;  4O1V A;  4CA1 A;  1D00 A;  3HQL A;  3HU6 A;  3IVQ A;  1KZZ A;  1D01 A;  1CA9 A;  1D0J A;  3MQS C;  5H9M A;  1CZZ A;  1YZE A;  1ZMS A;  2F1Z A;  3MQR A;  4C9Z A;  1RF3 A;  3HQH A;  4X3G A;  1LB6 A;  3IVV A;  2AN6 A;  2CR2 A;  4JJQ A;  4KG9 A;  2F1Y A;  1D0A A;  2F1W A;  2FOO A;  1FLL A;  3HQM A;  4GWM A;  5E1T A;  2XXN A;  2FOJ A;  1F3V B;  1CA4 A; 
#chains in the Genus database with same CATH topology
 4I7D A;  1QSC A;  2FOP A;  3HQI A;  3HSV A;  1L0A A;  4I7B A;  4K8U A;  4M4E A;  4YSI A;  1K2F A;  3ZJB A;  4Z8M A;  4GHU A;  4GWN A;  1LB4 A;  1CZY A;  2GKW A;  1FLK A;  1YY6 A;  1LB5 A;  2F1X A;  2A25 A;  4I7C A;  3IVB A;  4GJH A;  4O1V A;  4CA1 A;  1D00 A;  3HQL A;  3HU6 A;  3IVQ A;  1KZZ A;  1D01 A;  1CA9 A;  1D0J A;  3MQS C;  5H9M A;  1CZZ A;  1YZE A;  1ZMS A;  2F1Z A;  3MQR A;  4C9Z A;  1RF3 A;  3HQH A;  4X3G A;  1LB6 A;  3IVV A;  2AN6 A;  2CR2 A;  4JJQ A;  4KG9 A;  2F1Y A;  1D0A A;  2F1W A;  2FOO A;  1FLL A;  3HQM A;  4GWM A;  5E1T A;  2XXN A;  2FOJ A;  1F3V B;  1CA4 A; 
#chains in the Genus database with same CATH homology
 4I7D A;  1QSC A;  2FOP A;  3HQI A;  3HSV A;  1L0A A;  4I7B A;  4K8U A;  4M4E A;  4YSI A;  1K2F A;  3ZJB A;  4Z8M A;  4GHU A;  4GWN A;  1LB4 A;  1CZY A;  2GKW A;  1FLK A;  1YY6 A;  1LB5 A;  2F1X A;  2A25 A;  4I7C A;  3IVB A;  4GJH A;  4O1V A;  4CA1 A;  1D00 A;  3HQL A;  3HU6 A;  3IVQ A;  1KZZ A;  1D01 A;  1CA9 A;  1D0J A;  3MQS C;  5H9M A;  1CZZ A;  1YZE A;  1ZMS A;  2F1Z A;  3MQR A;  4C9Z A;  1RF3 A;  3HQH A;  4X3G A;  1LB6 A;  3IVV A;  2AN6 A;  2CR2 A;  4JJQ A;  4KG9 A;  2F1Y A;  1D0A A;  2F1W A;  2FOO A;  1FLL A;  3HQM A;  4GWM A;  5E1T A;  2XXN A;  2FOJ A;  1F3V B;  1CA4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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