2F1YA

Crystal structure of the traf-like domain of hausp/usp7 bound to a mdm2 peptide
Total Genus 21

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
143
structure length
136
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADLDAGVSE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
EMPTYTI2 (122-125)S6 (131-140)TI1 (63-66)S2 (85-86)S1 (68-75)TIV5 (120-123)TIV1 (75-78)3H1 (78-80)TIV3 (103-113)S3 (90-92)TIV2 (91-94)S5 (114-121)S4 (95-104)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
pubmed doi rcsb
molecule keywords HAUSP/USP7
total genus 21
structure length 136
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2005-11-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2f1yA00
1K2FA 4KG9A 3HQMA 1FLKA 1F3VB 1FLLA 3MQRA 4GJHA 1KZZA 4GWNA 1D0AA 1YY6A 4X3GA 4Z8MA 4I7DA 3ZJBA 4YSIA 1LB5A 2GKWA 4GWMA 3HU6A 2FOOA 3HQLA 3HQIA 1CA9A 2FOPA 4JJQA 1CZZA 2F1WA 2CR2A 1QSCA 2AN6A 2A25A 4GHUA 5E1TA 1D0JA 3IVVA 3MQSC 3IVBA 1D01A 1LB6A 1ZMSA 2FOJA 4O1VA 3IVQA 2F1ZA 4K8UA 2F1XA 1L0AA 4M4EA 3HSVA 2XXNA 4CA1A 2F1YA 1D00A 1CZYA 1LB4A 1RF3A 4C9ZA 4I7CA 1YZEA 4I7BA 1CA4A 3HQHA 5H9MA
chains in the Genus database with same CATH superfamily
1K2FA 4KG9A 3HQMA 1FLKA 1F3VB 1FLLA 3MQRA 4GJHA 1KZZA 4GWNA 1D0AA 1YY6A 4X3GA 4Z8MA 4I7DA 3ZJBA 4YSIA 1LB5A 2GKWA 4GWMA 3HU6A 2FOOA 3HQLA 3HQIA 1CA9A 2FOPA 4JJQA 1CZZA 2F1WA 2CR2A 1QSCA 2AN6A 2A25A 4GHUA 5E1TA 1D0JA 3IVVA 3MQSC 3IVBA 1D01A 1LB6A 1ZMSA 2FOJA 4O1VA 3IVQA 2F1ZA 4K8UA 2F1XA 1L0AA 4M4EA 3HSVA 2XXNA 4CA1A 2F1YA 1D00A 1CZYA 1LB4A 1RF3A 4C9ZA 4I7CA 1YZEA 4I7BA 1CA4A 3HQHA 5H9MA
chains in the Genus database with same CATH topology
1K2FA 4KG9A 3HQMA 1FLKA 1F3VB 1FLLA 3MQRA 4GJHA 1KZZA 4GWNA 1D0AA 1YY6A 4X3GA 4Z8MA 4I7DA 3ZJBA 4YSIA 1LB5A 2GKWA 4GWMA 3HU6A 2FOOA 3HQLA 3HQIA 1CA9A 2FOPA 4JJQA 1CZZA 2F1WA 2CR2A 1QSCA 2AN6A 2A25A 4GHUA 5E1TA 1D0JA 3IVVA 3MQSC 3IVBA 1D01A 1LB6A 1ZMSA 2FOJA 4O1VA 3IVQA 2F1ZA 4K8UA 2F1XA 1L0AA 4M4EA 3HSVA 2XXNA 4CA1A 2F1YA 1D00A 1CZYA 1LB4A 1RF3A 4C9ZA 4I7CA 1YZEA 4I7BA 1CA4A 3HQHA 5H9MA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1K2F A;  4KG9 A;  3HQM A;  1FLK A;  1F3V B;  1FLL A;  3MQR A;  4GJH A;  1KZZ A;  4GWN A;  1D0A A;  1YY6 A;  4X3G A;  4Z8M A;  4I7D A;  3ZJB A;  4YSI A;  1LB5 A;  2GKW A;  4GWM A;  3HU6 A;  2FOO A;  3HQL A;  3HQI A;  1CA9 A;  2FOP A;  4JJQ A;  1CZZ A;  2F1W A;  2CR2 A;  1QSC A;  2AN6 A;  2A25 A;  4GHU A;  5E1T A;  1D0J A;  3IVV A;  3MQS C;  3IVB A;  1D01 A;  1LB6 A;  1ZMS A;  2FOJ A;  4O1V A;  3IVQ A;  2F1Z A;  4K8U A;  2F1X A;  1L0A A;  4M4E A;  3HSV A;  2XXN A;  4CA1 A;  2F1Y A;  1D00 A;  1CZY A;  1LB4 A;  1RF3 A;  4C9Z A;  4I7C A;  1YZE A;  4I7B A;  1CA4 A;  3HQH A;  5H9M A; 
#chains in the Genus database with same CATH topology
 1K2F A;  4KG9 A;  3HQM A;  1FLK A;  1F3V B;  1FLL A;  3MQR A;  4GJH A;  1KZZ A;  4GWN A;  1D0A A;  1YY6 A;  4X3G A;  4Z8M A;  4I7D A;  3ZJB A;  4YSI A;  1LB5 A;  2GKW A;  4GWM A;  3HU6 A;  2FOO A;  3HQL A;  3HQI A;  1CA9 A;  2FOP A;  4JJQ A;  1CZZ A;  2F1W A;  2CR2 A;  1QSC A;  2AN6 A;  2A25 A;  4GHU A;  5E1T A;  1D0J A;  3IVV A;  3MQS C;  3IVB A;  1D01 A;  1LB6 A;  1ZMS A;  2FOJ A;  4O1V A;  3IVQ A;  2F1Z A;  4K8U A;  2F1X A;  1L0A A;  4M4E A;  3HSV A;  2XXN A;  4CA1 A;  2F1Y A;  1D00 A;  1CZY A;  1LB4 A;  1RF3 A;  4C9Z A;  4I7C A;  1YZE A;  4I7B A;  1CA4 A;  3HQH A;  5H9M A; 
#chains in the Genus database with same CATH homology
 1K2F A;  4KG9 A;  3HQM A;  1FLK A;  1F3V B;  1FLL A;  3MQR A;  4GJH A;  1KZZ A;  4GWN A;  1D0A A;  1YY6 A;  4X3G A;  4Z8M A;  4I7D A;  3ZJB A;  4YSI A;  1LB5 A;  2GKW A;  4GWM A;  3HU6 A;  2FOO A;  3HQL A;  3HQI A;  1CA9 A;  2FOP A;  4JJQ A;  1CZZ A;  2F1W A;  2CR2 A;  1QSC A;  2AN6 A;  2A25 A;  4GHU A;  5E1T A;  1D0J A;  3IVV A;  3MQS C;  3IVB A;  1D01 A;  1LB6 A;  1ZMS A;  2FOJ A;  4O1V A;  3IVQ A;  2F1Z A;  4K8U A;  2F1X A;  1L0A A;  4M4E A;  3HSV A;  2XXN A;  4CA1 A;  2F1Y A;  1D00 A;  1CZY A;  1LB4 A;  1RF3 A;  4C9Z A;  4I7C A;  1YZE A;  4I7B A;  1CA4 A;  3HQH A;  5H9M A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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