2FOJA

The crystal structure of the n-terminal domain of hausp/usp7 complexed with p53 peptide 364-367
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
143
structure length
137
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular recognition of p53 and MDM2 by USP7/HAUSP
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 23
structure length 137
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2006-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2fojA00
1D0AA 1LB6A 3IVBA 1LB5A 3IVQA 2CR2A 1RF3A 1FLLA 3HQLA 3HQIA 4GJHA 4GWMA 4K8UA 1CZYA 4KG9A 1LB4A 4C9ZA 1QSCA 2FOPA 2XXNA 1D00A 1K2FA 4GHUA 4I7CA 3IVVA 4M4EA 1ZMSA 2F1XA 3HU6A 4I7DA 3MQSC 4JJQA 3ZJBA 3HQMA 1CA4A 3HSVA 2GKWA 1KZZA 1YY6A 3MQRA 5H9MA 4X3GA 4YSIA 1F3VB 2FOOA 1CZZA 1YZEA 1D0JA 2F1ZA 1CA9A 4I7BA 4CA1A 4Z8MA 2F1WA 2AN6A 5E1TA 4O1VA 1D01A 1FLKA 2FOJA 2F1YA 2A25A 4GWNA 3HQHA 1L0AA
chains in the Genus database with same CATH superfamily
1D0AA 1LB6A 3IVBA 1LB5A 3IVQA 2CR2A 1RF3A 1FLLA 3HQLA 3HQIA 4GJHA 4GWMA 4K8UA 1CZYA 4KG9A 1LB4A 4C9ZA 1QSCA 2FOPA 2XXNA 1D00A 1K2FA 4GHUA 4I7CA 3IVVA 4M4EA 1ZMSA 2F1XA 3HU6A 4I7DA 3MQSC 4JJQA 3ZJBA 3HQMA 1CA4A 3HSVA 2GKWA 1KZZA 1YY6A 3MQRA 5H9MA 4X3GA 4YSIA 1F3VB 2FOOA 1CZZA 1YZEA 1D0JA 2F1ZA 1CA9A 4I7BA 4CA1A 4Z8MA 2F1WA 2AN6A 5E1TA 4O1VA 1D01A 1FLKA 2FOJA 2F1YA 2A25A 4GWNA 3HQHA 1L0AA
chains in the Genus database with same CATH topology
1D0AA 1LB6A 3IVBA 1LB5A 3IVQA 2CR2A 1RF3A 1FLLA 3HQLA 3HQIA 4GJHA 4GWMA 4K8UA 1CZYA 4KG9A 1LB4A 4C9ZA 1QSCA 2FOPA 2XXNA 1D00A 1K2FA 4GHUA 4I7CA 3IVVA 4M4EA 1ZMSA 2F1XA 3HU6A 4I7DA 3MQSC 4JJQA 3ZJBA 3HQMA 1CA4A 3HSVA 2GKWA 1KZZA 1YY6A 3MQRA 5H9MA 4X3GA 4YSIA 1F3VB 2FOOA 1CZZA 1YZEA 1D0JA 2F1ZA 1CA9A 4I7BA 4CA1A 4Z8MA 2F1WA 2AN6A 5E1TA 4O1VA 1D01A 1FLKA 2FOJA 2F1YA 2A25A 4GWNA 3HQHA 1L0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D0A A;  1LB6 A;  3IVB A;  1LB5 A;  3IVQ A;  2CR2 A;  1RF3 A;  1FLL A;  3HQL A;  3HQI A;  4GJH A;  4GWM A;  4K8U A;  1CZY A;  4KG9 A;  1LB4 A;  4C9Z A;  1QSC A;  2FOP A;  2XXN A;  1D00 A;  1K2F A;  4GHU A;  4I7C A;  3IVV A;  4M4E A;  1ZMS A;  2F1X A;  3HU6 A;  4I7D A;  3MQS C;  4JJQ A;  3ZJB A;  3HQM A;  1CA4 A;  3HSV A;  2GKW A;  1KZZ A;  1YY6 A;  3MQR A;  5H9M A;  4X3G A;  4YSI A;  1F3V B;  2FOO A;  1CZZ A;  1YZE A;  1D0J A;  2F1Z A;  1CA9 A;  4I7B A;  4CA1 A;  4Z8M A;  2F1W A;  2AN6 A;  5E1T A;  4O1V A;  1D01 A;  1FLK A;  2FOJ A;  2F1Y A;  2A25 A;  4GWN A;  3HQH A;  1L0A A; 
#chains in the Genus database with same CATH topology
 1D0A A;  1LB6 A;  3IVB A;  1LB5 A;  3IVQ A;  2CR2 A;  1RF3 A;  1FLL A;  3HQL A;  3HQI A;  4GJH A;  4GWM A;  4K8U A;  1CZY A;  4KG9 A;  1LB4 A;  4C9Z A;  1QSC A;  2FOP A;  2XXN A;  1D00 A;  1K2F A;  4GHU A;  4I7C A;  3IVV A;  4M4E A;  1ZMS A;  2F1X A;  3HU6 A;  4I7D A;  3MQS C;  4JJQ A;  3ZJB A;  3HQM A;  1CA4 A;  3HSV A;  2GKW A;  1KZZ A;  1YY6 A;  3MQR A;  5H9M A;  4X3G A;  4YSI A;  1F3V B;  2FOO A;  1CZZ A;  1YZE A;  1D0J A;  2F1Z A;  1CA9 A;  4I7B A;  4CA1 A;  4Z8M A;  2F1W A;  2AN6 A;  5E1T A;  4O1V A;  1D01 A;  1FLK A;  2FOJ A;  2F1Y A;  2A25 A;  4GWN A;  3HQH A;  1L0A A; 
#chains in the Genus database with same CATH homology
 1D0A A;  1LB6 A;  3IVB A;  1LB5 A;  3IVQ A;  2CR2 A;  1RF3 A;  1FLL A;  3HQL A;  3HQI A;  4GJH A;  4GWM A;  4K8U A;  1CZY A;  4KG9 A;  1LB4 A;  4C9Z A;  1QSC A;  2FOP A;  2XXN A;  1D00 A;  1K2F A;  4GHU A;  4I7C A;  3IVV A;  4M4E A;  1ZMS A;  2F1X A;  3HU6 A;  4I7D A;  3MQS C;  4JJQ A;  3ZJB A;  3HQM A;  1CA4 A;  3HSV A;  2GKW A;  1KZZ A;  1YY6 A;  3MQR A;  5H9M A;  4X3G A;  4YSI A;  1F3V B;  2FOO A;  1CZZ A;  1YZE A;  1D0J A;  2F1Z A;  1CA9 A;  4I7B A;  4CA1 A;  4Z8M A;  2F1W A;  2AN6 A;  5E1T A;  4O1V A;  1D01 A;  1FLK A;  2FOJ A;  2F1Y A;  2A25 A;  4GWN A;  3HQH A;  1L0A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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