2FOJA

The crystal structure of the n-terminal domain of hausp/usp7 complexed with p53 peptide 364-367
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
143
structure length
137
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular recognition of p53 and MDM2 by USP7/HAUSP
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 23
structure length 137
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2006-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2fojA00
1D00A 5H9MA 1RF3A 4Z8MA 3ZJBA 2F1ZA 2AN6A 1LB5A 2FOJA 1D0JA 1CZYA 2GKWA 5E1TA 4I7DA 3HQIA 4X3GA 4I7BA 1LB4A 3MQSC 4C9ZA 2A25A 1D01A 2CR2A 4KG9A 1CA9A 1YY6A 1QSCA 4O1VA 3HSVA 1D0AA 1FLKA 2FOPA 4CA1A 1F3VB 4I7CA 2XXNA 2FOOA 3MQRA 2F1XA 3HQMA 1CA4A 4GJHA 1KZZA 1ZMSA 3HQHA 3HU6A 4K8UA 3IVQA 1YZEA 2F1WA 1L0AA 1LB6A 1CZZA 4GHUA 4M4EA 4GWNA 3HQLA 4GWMA 4JJQA 4YSIA 1K2FA 3IVVA 1FLLA 3IVBA 2F1YA
chains in the Genus database with same CATH superfamily
1D00A 5H9MA 1RF3A 4Z8MA 3ZJBA 2F1ZA 2AN6A 1LB5A 2FOJA 1D0JA 1CZYA 2GKWA 5E1TA 4I7DA 3HQIA 4X3GA 4I7BA 1LB4A 3MQSC 4C9ZA 2A25A 1D01A 2CR2A 4KG9A 1CA9A 1YY6A 1QSCA 4O1VA 3HSVA 1D0AA 1FLKA 2FOPA 4CA1A 1F3VB 4I7CA 2XXNA 2FOOA 3MQRA 2F1XA 3HQMA 1CA4A 4GJHA 1KZZA 1ZMSA 3HQHA 3HU6A 4K8UA 3IVQA 1YZEA 2F1WA 1L0AA 1LB6A 1CZZA 4GHUA 4M4EA 4GWNA 3HQLA 4GWMA 4JJQA 4YSIA 1K2FA 3IVVA 1FLLA 3IVBA 2F1YA
chains in the Genus database with same CATH topology
1D00A 5H9MA 1RF3A 4Z8MA 3ZJBA 2F1ZA 2AN6A 1LB5A 2FOJA 1D0JA 1CZYA 2GKWA 5E1TA 4I7DA 3HQIA 4X3GA 4I7BA 1LB4A 3MQSC 4C9ZA 2A25A 1D01A 2CR2A 4KG9A 1CA9A 1YY6A 1QSCA 4O1VA 3HSVA 1D0AA 1FLKA 2FOPA 4CA1A 1F3VB 4I7CA 2XXNA 2FOOA 3MQRA 2F1XA 3HQMA 1CA4A 4GJHA 1KZZA 1ZMSA 3HQHA 3HU6A 4K8UA 3IVQA 1YZEA 2F1WA 1L0AA 1LB6A 1CZZA 4GHUA 4M4EA 4GWNA 3HQLA 4GWMA 4JJQA 4YSIA 1K2FA 3IVVA 1FLLA 3IVBA 2F1YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D00 A;  5H9M A;  1RF3 A;  4Z8M A;  3ZJB A;  2F1Z A;  2AN6 A;  1LB5 A;  2FOJ A;  1D0J A;  1CZY A;  2GKW A;  5E1T A;  4I7D A;  3HQI A;  4X3G A;  4I7B A;  1LB4 A;  3MQS C;  4C9Z A;  2A25 A;  1D01 A;  2CR2 A;  4KG9 A;  1CA9 A;  1YY6 A;  1QSC A;  4O1V A;  3HSV A;  1D0A A;  1FLK A;  2FOP A;  4CA1 A;  1F3V B;  4I7C A;  2XXN A;  2FOO A;  3MQR A;  2F1X A;  3HQM A;  1CA4 A;  4GJH A;  1KZZ A;  1ZMS A;  3HQH A;  3HU6 A;  4K8U A;  3IVQ A;  1YZE A;  2F1W A;  1L0A A;  1LB6 A;  1CZZ A;  4GHU A;  4M4E A;  4GWN A;  3HQL A;  4GWM A;  4JJQ A;  4YSI A;  1K2F A;  3IVV A;  1FLL A;  3IVB A;  2F1Y A; 
#chains in the Genus database with same CATH topology
 1D00 A;  5H9M A;  1RF3 A;  4Z8M A;  3ZJB A;  2F1Z A;  2AN6 A;  1LB5 A;  2FOJ A;  1D0J A;  1CZY A;  2GKW A;  5E1T A;  4I7D A;  3HQI A;  4X3G A;  4I7B A;  1LB4 A;  3MQS C;  4C9Z A;  2A25 A;  1D01 A;  2CR2 A;  4KG9 A;  1CA9 A;  1YY6 A;  1QSC A;  4O1V A;  3HSV A;  1D0A A;  1FLK A;  2FOP A;  4CA1 A;  1F3V B;  4I7C A;  2XXN A;  2FOO A;  3MQR A;  2F1X A;  3HQM A;  1CA4 A;  4GJH A;  1KZZ A;  1ZMS A;  3HQH A;  3HU6 A;  4K8U A;  3IVQ A;  1YZE A;  2F1W A;  1L0A A;  1LB6 A;  1CZZ A;  4GHU A;  4M4E A;  4GWN A;  3HQL A;  4GWM A;  4JJQ A;  4YSI A;  1K2F A;  3IVV A;  1FLL A;  3IVB A;  2F1Y A; 
#chains in the Genus database with same CATH homology
 1D00 A;  5H9M A;  1RF3 A;  4Z8M A;  3ZJB A;  2F1Z A;  2AN6 A;  1LB5 A;  2FOJ A;  1D0J A;  1CZY A;  2GKW A;  5E1T A;  4I7D A;  3HQI A;  4X3G A;  4I7B A;  1LB4 A;  3MQS C;  4C9Z A;  2A25 A;  1D01 A;  2CR2 A;  4KG9 A;  1CA9 A;  1YY6 A;  1QSC A;  4O1V A;  3HSV A;  1D0A A;  1FLK A;  2FOP A;  4CA1 A;  1F3V B;  4I7C A;  2XXN A;  2FOO A;  3MQR A;  2F1X A;  3HQM A;  1CA4 A;  4GJH A;  1KZZ A;  1ZMS A;  3HQH A;  3HU6 A;  4K8U A;  3IVQ A;  1YZE A;  2F1W A;  1L0A A;  1LB6 A;  1CZZ A;  4GHU A;  4M4E A;  4GWN A;  3HQL A;  4GWM A;  4JJQ A;  4YSI A;  1K2F A;  3IVV A;  1FLL A;  3IVB A;  2F1Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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