2FOOA

The crystal structure of the n-terminal domain of hausp/usp7 complexed with p53 peptide 359-362
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
143
structure length
137
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular recognition of p53 and MDM2 by USP7/HAUSP
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 24
structure length 137
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2006-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2fooA00
2GKWA 2CR2A 1D0JA 3IVVA 1KZZA 2AN6A 1ZMSA 5E1TA 3MQRA 1L0AA 3IVBA 4GHUA 3HQIA 1YZEA 2FOJA 1QSCA 1F3VB 1YY6A 2F1XA 1CA9A 1D01A 2F1ZA 1CZYA 4I7DA 4JJQA 1K2FA 4O1VA 2A25A 2FOPA 4CA1A 4M4EA 3HQMA 1FLLA 3HQLA 1FLKA 1LB5A 4KG9A 2F1WA 4X3GA 3HQHA 2FOOA 3HU6A 4GJHA 4Z8MA 1RF3A 1CZZA 1CA4A 2F1YA 3MQSC 3ZJBA 3HSVA 1D0AA 4YSIA 4I7CA 5H9MA 4K8UA 4GWMA 4I7BA 1LB4A 1LB6A 4GWNA 3IVQA 1D00A 4C9ZA 2XXNA
chains in the Genus database with same CATH superfamily
2GKWA 2CR2A 1D0JA 3IVVA 1KZZA 2AN6A 1ZMSA 5E1TA 3MQRA 1L0AA 3IVBA 4GHUA 3HQIA 1YZEA 2FOJA 1QSCA 1F3VB 1YY6A 2F1XA 1CA9A 1D01A 2F1ZA 1CZYA 4I7DA 4JJQA 1K2FA 4O1VA 2A25A 2FOPA 4CA1A 4M4EA 3HQMA 1FLLA 3HQLA 1FLKA 1LB5A 4KG9A 2F1WA 4X3GA 3HQHA 2FOOA 3HU6A 4GJHA 4Z8MA 1RF3A 1CZZA 1CA4A 2F1YA 3MQSC 3ZJBA 3HSVA 1D0AA 4YSIA 4I7CA 5H9MA 4K8UA 4GWMA 4I7BA 1LB4A 1LB6A 4GWNA 3IVQA 1D00A 4C9ZA 2XXNA
chains in the Genus database with same CATH topology
2GKWA 2CR2A 1D0JA 3IVVA 1KZZA 2AN6A 1ZMSA 5E1TA 3MQRA 1L0AA 3IVBA 4GHUA 3HQIA 1YZEA 2FOJA 1QSCA 1F3VB 1YY6A 2F1XA 1CA9A 1D01A 2F1ZA 1CZYA 4I7DA 4JJQA 1K2FA 4O1VA 2A25A 2FOPA 4CA1A 4M4EA 3HQMA 1FLLA 3HQLA 1FLKA 1LB5A 4KG9A 2F1WA 4X3GA 3HQHA 2FOOA 3HU6A 4GJHA 4Z8MA 1RF3A 1CZZA 1CA4A 2F1YA 3MQSC 3ZJBA 3HSVA 1D0AA 4YSIA 4I7CA 5H9MA 4K8UA 4GWMA 4I7BA 1LB4A 1LB6A 4GWNA 3IVQA 1D00A 4C9ZA 2XXNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GKW A;  2CR2 A;  1D0J A;  3IVV A;  1KZZ A;  2AN6 A;  1ZMS A;  5E1T A;  3MQR A;  1L0A A;  3IVB A;  4GHU A;  3HQI A;  1YZE A;  2FOJ A;  1QSC A;  1F3V B;  1YY6 A;  2F1X A;  1CA9 A;  1D01 A;  2F1Z A;  1CZY A;  4I7D A;  4JJQ A;  1K2F A;  4O1V A;  2A25 A;  2FOP A;  4CA1 A;  4M4E A;  3HQM A;  1FLL A;  3HQL A;  1FLK A;  1LB5 A;  4KG9 A;  2F1W A;  4X3G A;  3HQH A;  2FOO A;  3HU6 A;  4GJH A;  4Z8M A;  1RF3 A;  1CZZ A;  1CA4 A;  2F1Y A;  3MQS C;  3ZJB A;  3HSV A;  1D0A A;  4YSI A;  4I7C A;  5H9M A;  4K8U A;  4GWM A;  4I7B A;  1LB4 A;  1LB6 A;  4GWN A;  3IVQ A;  1D00 A;  4C9Z A;  2XXN A; 
#chains in the Genus database with same CATH topology
 2GKW A;  2CR2 A;  1D0J A;  3IVV A;  1KZZ A;  2AN6 A;  1ZMS A;  5E1T A;  3MQR A;  1L0A A;  3IVB A;  4GHU A;  3HQI A;  1YZE A;  2FOJ A;  1QSC A;  1F3V B;  1YY6 A;  2F1X A;  1CA9 A;  1D01 A;  2F1Z A;  1CZY A;  4I7D A;  4JJQ A;  1K2F A;  4O1V A;  2A25 A;  2FOP A;  4CA1 A;  4M4E A;  3HQM A;  1FLL A;  3HQL A;  1FLK A;  1LB5 A;  4KG9 A;  2F1W A;  4X3G A;  3HQH A;  2FOO A;  3HU6 A;  4GJH A;  4Z8M A;  1RF3 A;  1CZZ A;  1CA4 A;  2F1Y A;  3MQS C;  3ZJB A;  3HSV A;  1D0A A;  4YSI A;  4I7C A;  5H9M A;  4K8U A;  4GWM A;  4I7B A;  1LB4 A;  1LB6 A;  4GWN A;  3IVQ A;  1D00 A;  4C9Z A;  2XXN A; 
#chains in the Genus database with same CATH homology
 2GKW A;  2CR2 A;  1D0J A;  3IVV A;  1KZZ A;  2AN6 A;  1ZMS A;  5E1T A;  3MQR A;  1L0A A;  3IVB A;  4GHU A;  3HQI A;  1YZE A;  2FOJ A;  1QSC A;  1F3V B;  1YY6 A;  2F1X A;  1CA9 A;  1D01 A;  2F1Z A;  1CZY A;  4I7D A;  4JJQ A;  1K2F A;  4O1V A;  2A25 A;  2FOP A;  4CA1 A;  4M4E A;  3HQM A;  1FLL A;  3HQL A;  1FLK A;  1LB5 A;  4KG9 A;  2F1W A;  4X3G A;  3HQH A;  2FOO A;  3HU6 A;  4GJH A;  4Z8M A;  1RF3 A;  1CZZ A;  1CA4 A;  2F1Y A;  3MQS C;  3ZJB A;  3HSV A;  1D0A A;  4YSI A;  4I7C A;  5H9M A;  4K8U A;  4GWM A;  4I7B A;  1LB4 A;  1LB6 A;  4GWN A;  3IVQ A;  1D00 A;  4C9Z A;  2XXN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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