2FOOA

The crystal structure of the n-terminal domain of hausp/usp7 complexed with p53 peptide 359-362
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
143
structure length
137
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular recognition of p53 and MDM2 by USP7/HAUSP
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 24
structure length 137
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2006-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2fooA00
1CZZA 1YZEA 1K2FA 1L0AA 3MQSC 2AN6A 3HQLA 3HU6A 4I7BA 4Z8MA 1CA9A 1CA4A 1CZYA 1D0AA 3IVVA 1LB5A 1LB6A 1D00A 1D0JA 1LB4A 1QSCA 1YY6A 4KG9A 3HQHA 4YSIA 4CA1A 4C9ZA 2F1ZA 4I7DA 3ZJBA 1KZZA 1D01A 3HSVA 2FOJA 3MQRA 2GKWA 4JJQA 2A25A 4I7CA 3HQMA 3IVQA 3IVBA 4GHUA 4M4EA 1FLKA 1ZMSA 4GWNA 4GJHA 2FOPA 4GWMA 4O1VA 5H9MA 4X3GA 2CR2A 4K8UA 1FLLA 1F3VB 2XXNA 5E1TA 1RF3A 2FOOA 2F1XA 3HQIA 2F1WA 2F1YA
chains in the Genus database with same CATH superfamily
1CZZA 1YZEA 1K2FA 1L0AA 3MQSC 2AN6A 3HQLA 3HU6A 4I7BA 4Z8MA 1CA9A 1CA4A 1CZYA 1D0AA 3IVVA 1LB5A 1LB6A 1D00A 1D0JA 1LB4A 1QSCA 1YY6A 4KG9A 3HQHA 4YSIA 4CA1A 4C9ZA 2F1ZA 4I7DA 3ZJBA 1KZZA 1D01A 3HSVA 2FOJA 3MQRA 2GKWA 4JJQA 2A25A 4I7CA 3HQMA 3IVQA 3IVBA 4GHUA 4M4EA 1FLKA 1ZMSA 4GWNA 4GJHA 2FOPA 4GWMA 4O1VA 5H9MA 4X3GA 2CR2A 4K8UA 1FLLA 1F3VB 2XXNA 5E1TA 1RF3A 2FOOA 2F1XA 3HQIA 2F1WA 2F1YA
chains in the Genus database with same CATH topology
1CZZA 1YZEA 1K2FA 1L0AA 3MQSC 2AN6A 3HQLA 3HU6A 4I7BA 4Z8MA 1CA9A 1CA4A 1CZYA 1D0AA 3IVVA 1LB5A 1LB6A 1D00A 1D0JA 1LB4A 1QSCA 1YY6A 4KG9A 3HQHA 4YSIA 4CA1A 4C9ZA 2F1ZA 4I7DA 3ZJBA 1KZZA 1D01A 3HSVA 2FOJA 3MQRA 2GKWA 4JJQA 2A25A 4I7CA 3HQMA 3IVQA 3IVBA 4GHUA 4M4EA 1FLKA 1ZMSA 4GWNA 4GJHA 2FOPA 4GWMA 4O1VA 5H9MA 4X3GA 2CR2A 4K8UA 1FLLA 1F3VB 2XXNA 5E1TA 1RF3A 2FOOA 2F1XA 3HQIA 2F1WA 2F1YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CZZ A;  1YZE A;  1K2F A;  1L0A A;  3MQS C;  2AN6 A;  3HQL A;  3HU6 A;  4I7B A;  4Z8M A;  1CA9 A;  1CA4 A;  1CZY A;  1D0A A;  3IVV A;  1LB5 A;  1LB6 A;  1D00 A;  1D0J A;  1LB4 A;  1QSC A;  1YY6 A;  4KG9 A;  3HQH A;  4YSI A;  4CA1 A;  4C9Z A;  2F1Z A;  4I7D A;  3ZJB A;  1KZZ A;  1D01 A;  3HSV A;  2FOJ A;  3MQR A;  2GKW A;  4JJQ A;  2A25 A;  4I7C A;  3HQM A;  3IVQ A;  3IVB A;  4GHU A;  4M4E A;  1FLK A;  1ZMS A;  4GWN A;  4GJH A;  2FOP A;  4GWM A;  4O1V A;  5H9M A;  4X3G A;  2CR2 A;  4K8U A;  1FLL A;  1F3V B;  2XXN A;  5E1T A;  1RF3 A;  2FOO A;  2F1X A;  3HQI A;  2F1W A;  2F1Y A; 
#chains in the Genus database with same CATH topology
 1CZZ A;  1YZE A;  1K2F A;  1L0A A;  3MQS C;  2AN6 A;  3HQL A;  3HU6 A;  4I7B A;  4Z8M A;  1CA9 A;  1CA4 A;  1CZY A;  1D0A A;  3IVV A;  1LB5 A;  1LB6 A;  1D00 A;  1D0J A;  1LB4 A;  1QSC A;  1YY6 A;  4KG9 A;  3HQH A;  4YSI A;  4CA1 A;  4C9Z A;  2F1Z A;  4I7D A;  3ZJB A;  1KZZ A;  1D01 A;  3HSV A;  2FOJ A;  3MQR A;  2GKW A;  4JJQ A;  2A25 A;  4I7C A;  3HQM A;  3IVQ A;  3IVB A;  4GHU A;  4M4E A;  1FLK A;  1ZMS A;  4GWN A;  4GJH A;  2FOP A;  4GWM A;  4O1V A;  5H9M A;  4X3G A;  2CR2 A;  4K8U A;  1FLL A;  1F3V B;  2XXN A;  5E1T A;  1RF3 A;  2FOO A;  2F1X A;  3HQI A;  2F1W A;  2F1Y A; 
#chains in the Genus database with same CATH homology
 1CZZ A;  1YZE A;  1K2F A;  1L0A A;  3MQS C;  2AN6 A;  3HQL A;  3HU6 A;  4I7B A;  4Z8M A;  1CA9 A;  1CA4 A;  1CZY A;  1D0A A;  3IVV A;  1LB5 A;  1LB6 A;  1D00 A;  1D0J A;  1LB4 A;  1QSC A;  1YY6 A;  4KG9 A;  3HQH A;  4YSI A;  4CA1 A;  4C9Z A;  2F1Z A;  4I7D A;  3ZJB A;  1KZZ A;  1D01 A;  3HSV A;  2FOJ A;  3MQR A;  2GKW A;  4JJQ A;  2A25 A;  4I7C A;  3HQM A;  3IVQ A;  3IVB A;  4GHU A;  4M4E A;  1FLK A;  1ZMS A;  4GWN A;  4GJH A;  2FOP A;  4GWM A;  4O1V A;  5H9M A;  4X3G A;  2CR2 A;  4K8U A;  1FLL A;  1F3V B;  2XXN A;  5E1T A;  1RF3 A;  2FOO A;  2F1X A;  3HQI A;  2F1W A;  2F1Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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