2FOPA

The crystal structure of the n-terminal domain of hausp/usp7 complexed with mdm2 peptide 147-150
Total Genus 23

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
143
structure length
137
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
EMPTYTIV3 (103-112)S6 (131-140)TI1 (63-66)S3 (90-92)S1 (68-75)S2 (85-86)TI2 (122-125)TIV6 (120-123)TIV4 (104-113)3H1 (78-80)TIV2 (91-94)S5 (114-121)TIV7 (127-130)TIV1 (75-78)S4 (95-104)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Molecular recognition of p53 and MDM2 by USP7/HAUSP
pubmed doi rcsb
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 23
structure length 137
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2006-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2fopA00
1YZEA 3IVVA 1D01A 4GHUA 3HQMA 1L0AA 1YY6A 3IVQA 2CR2A 1LB6A 1FLLA 1LB5A 2F1YA 1CA4A 4JJQA 4KG9A 2FOPA 1KZZA 1RF3A 4CA1A 1LB4A 1FLKA 4I7CA 3HQLA 3HU6A 4X3GA 4GWMA 1K2FA 1CA9A 5E1TA 2F1WA 2GKWA 3IVBA 2F1ZA 3ZJBA 4I7DA 4M4EA 1QSCA 3HQIA 4GJHA 1D0AA 3HQHA 2AN6A 4GWNA 5H9MA 2XXNA 4Z8MA 1CZZA 2FOJA 4YSIA 3MQSC 4O1VA 3MQRA 4I7BA 1ZMSA 1D0JA 2A25A 2F1XA 1CZYA 3HSVA 4K8UA 2FOOA 4C9ZA 1D00A 1F3VB
chains in the Genus database with same CATH superfamily
1YZEA 3IVVA 1D01A 4GHUA 3HQMA 1L0AA 1YY6A 3IVQA 2CR2A 1LB6A 1FLLA 1LB5A 2F1YA 1CA4A 4JJQA 4KG9A 2FOPA 1KZZA 1RF3A 4CA1A 1LB4A 1FLKA 4I7CA 3HQLA 3HU6A 4X3GA 4GWMA 1K2FA 1CA9A 5E1TA 2F1WA 2GKWA 3IVBA 2F1ZA 3ZJBA 4I7DA 4M4EA 1QSCA 3HQIA 4GJHA 1D0AA 3HQHA 2AN6A 4GWNA 5H9MA 2XXNA 4Z8MA 1CZZA 2FOJA 4YSIA 3MQSC 4O1VA 3MQRA 4I7BA 1ZMSA 1D0JA 2A25A 2F1XA 1CZYA 3HSVA 4K8UA 2FOOA 4C9ZA 1D00A 1F3VB
chains in the Genus database with same CATH topology
1YZEA 3IVVA 1D01A 4GHUA 3HQMA 1L0AA 1YY6A 3IVQA 2CR2A 1LB6A 1FLLA 1LB5A 2F1YA 1CA4A 4JJQA 4KG9A 2FOPA 1KZZA 1RF3A 4CA1A 1LB4A 1FLKA 4I7CA 3HQLA 3HU6A 4X3GA 4GWMA 1K2FA 1CA9A 5E1TA 2F1WA 2GKWA 3IVBA 2F1ZA 3ZJBA 4I7DA 4M4EA 1QSCA 3HQIA 4GJHA 1D0AA 3HQHA 2AN6A 4GWNA 5H9MA 2XXNA 4Z8MA 1CZZA 2FOJA 4YSIA 3MQSC 4O1VA 3MQRA 4I7BA 1ZMSA 1D0JA 2A25A 2F1XA 1CZYA 3HSVA 4K8UA 2FOOA 4C9ZA 1D00A 1F3VB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YZE A;  3IVV A;  1D01 A;  4GHU A;  3HQM A;  1L0A A;  1YY6 A;  3IVQ A;  2CR2 A;  1LB6 A;  1FLL A;  1LB5 A;  2F1Y A;  1CA4 A;  4JJQ A;  4KG9 A;  2FOP A;  1KZZ A;  1RF3 A;  4CA1 A;  1LB4 A;  1FLK A;  4I7C A;  3HQL A;  3HU6 A;  4X3G A;  4GWM A;  1K2F A;  1CA9 A;  5E1T A;  2F1W A;  2GKW A;  3IVB A;  2F1Z A;  3ZJB A;  4I7D A;  4M4E A;  1QSC A;  3HQI A;  4GJH A;  1D0A A;  3HQH A;  2AN6 A;  4GWN A;  5H9M A;  2XXN A;  4Z8M A;  1CZZ A;  2FOJ A;  4YSI A;  3MQS C;  4O1V A;  3MQR A;  4I7B A;  1ZMS A;  1D0J A;  2A25 A;  2F1X A;  1CZY A;  3HSV A;  4K8U A;  2FOO A;  4C9Z A;  1D00 A;  1F3V B; 
#chains in the Genus database with same CATH topology
 1YZE A;  3IVV A;  1D01 A;  4GHU A;  3HQM A;  1L0A A;  1YY6 A;  3IVQ A;  2CR2 A;  1LB6 A;  1FLL A;  1LB5 A;  2F1Y A;  1CA4 A;  4JJQ A;  4KG9 A;  2FOP A;  1KZZ A;  1RF3 A;  4CA1 A;  1LB4 A;  1FLK A;  4I7C A;  3HQL A;  3HU6 A;  4X3G A;  4GWM A;  1K2F A;  1CA9 A;  5E1T A;  2F1W A;  2GKW A;  3IVB A;  2F1Z A;  3ZJB A;  4I7D A;  4M4E A;  1QSC A;  3HQI A;  4GJH A;  1D0A A;  3HQH A;  2AN6 A;  4GWN A;  5H9M A;  2XXN A;  4Z8M A;  1CZZ A;  2FOJ A;  4YSI A;  3MQS C;  4O1V A;  3MQR A;  4I7B A;  1ZMS A;  1D0J A;  2A25 A;  2F1X A;  1CZY A;  3HSV A;  4K8U A;  2FOO A;  4C9Z A;  1D00 A;  1F3V B; 
#chains in the Genus database with same CATH homology
 1YZE A;  3IVV A;  1D01 A;  4GHU A;  3HQM A;  1L0A A;  1YY6 A;  3IVQ A;  2CR2 A;  1LB6 A;  1FLL A;  1LB5 A;  2F1Y A;  1CA4 A;  4JJQ A;  4KG9 A;  2FOP A;  1KZZ A;  1RF3 A;  4CA1 A;  1LB4 A;  1FLK A;  4I7C A;  3HQL A;  3HU6 A;  4X3G A;  4GWM A;  1K2F A;  1CA9 A;  5E1T A;  2F1W A;  2GKW A;  3IVB A;  2F1Z A;  3ZJB A;  4I7D A;  4M4E A;  1QSC A;  3HQI A;  4GJH A;  1D0A A;  3HQH A;  2AN6 A;  4GWN A;  5H9M A;  2XXN A;  4Z8M A;  1CZZ A;  2FOJ A;  4YSI A;  3MQS C;  4O1V A;  3MQR A;  4I7B A;  1ZMS A;  1D0J A;  2A25 A;  2F1X A;  1CZY A;  3HSV A;  4K8U A;  2FOO A;  4C9Z A;  1D00 A;  1F3V B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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