2FOPA

The crystal structure of the n-terminal domain of hausp/usp7 complexed with mdm2 peptide 147-150
Total Genus 23
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
23
sequence length
143
structure length
137
Chain Sequence
TSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Molecular recognition of p53 and MDM2 by USP7/HAUSP
pubmed doi rcsb
molecule keywords Ubiquitin carboxyl-terminal hydrolase 7
total genus 23
structure length 137
sequence length 143
ec nomenclature ec 3.4.19.12: Ubiquitinyl hydrolase 1.
pdb deposition date 2006-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 2fopA00
3HU6A 2A25A 1D00A 4X3GA 5H9MA 1LB5A 1YY6A 4YSIA 4O1VA 2FOPA 2CR2A 4Z8MA 1F3VB 3MQRA 1CZYA 4JJQA 2F1WA 1L0AA 3HSVA 3ZJBA 3HQMA 1LB6A 4I7CA 1CA9A 2FOJA 3IVBA 3MQSC 4GHUA 3HQIA 3IVQA 4CA1A 2F1XA 1D0JA 2F1YA 4KG9A 4M4EA 1KZZA 2XXNA 4GWNA 1D0AA 1LB4A 1YZEA 1RF3A 3HQHA 5E1TA 4C9ZA 3HQLA 1CZZA 2AN6A 2GKWA 3IVVA 1QSCA 4K8UA 4I7BA 1FLKA 1CA4A 1ZMSA 1D01A 4GJHA 4GWMA 4I7DA 1FLLA 1K2FA 2FOOA 2F1ZA
chains in the Genus database with same CATH superfamily
3HU6A 2A25A 1D00A 4X3GA 5H9MA 1LB5A 1YY6A 4YSIA 4O1VA 2FOPA 2CR2A 4Z8MA 1F3VB 3MQRA 1CZYA 4JJQA 2F1WA 1L0AA 3HSVA 3ZJBA 3HQMA 1LB6A 4I7CA 1CA9A 2FOJA 3IVBA 3MQSC 4GHUA 3HQIA 3IVQA 4CA1A 2F1XA 1D0JA 2F1YA 4KG9A 4M4EA 1KZZA 2XXNA 4GWNA 1D0AA 1LB4A 1YZEA 1RF3A 3HQHA 5E1TA 4C9ZA 3HQLA 1CZZA 2AN6A 2GKWA 3IVVA 1QSCA 4K8UA 4I7BA 1FLKA 1CA4A 1ZMSA 1D01A 4GJHA 4GWMA 4I7DA 1FLLA 1K2FA 2FOOA 2F1ZA
chains in the Genus database with same CATH topology
3HU6A 2A25A 1D00A 4X3GA 5H9MA 1LB5A 1YY6A 4YSIA 4O1VA 2FOPA 2CR2A 4Z8MA 1F3VB 3MQRA 1CZYA 4JJQA 2F1WA 1L0AA 3HSVA 3ZJBA 3HQMA 1LB6A 4I7CA 1CA9A 2FOJA 3IVBA 3MQSC 4GHUA 3HQIA 3IVQA 4CA1A 2F1XA 1D0JA 2F1YA 4KG9A 4M4EA 1KZZA 2XXNA 4GWNA 1D0AA 1LB4A 1YZEA 1RF3A 3HQHA 5E1TA 4C9ZA 3HQLA 1CZZA 2AN6A 2GKWA 3IVVA 1QSCA 4K8UA 4I7BA 1FLKA 1CA4A 1ZMSA 1D01A 4GJHA 4GWMA 4I7DA 1FLLA 1K2FA 2FOOA 2F1ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HU6 A;  2A25 A;  1D00 A;  4X3G A;  5H9M A;  1LB5 A;  1YY6 A;  4YSI A;  4O1V A;  2FOP A;  2CR2 A;  4Z8M A;  1F3V B;  3MQR A;  1CZY A;  4JJQ A;  2F1W A;  1L0A A;  3HSV A;  3ZJB A;  3HQM A;  1LB6 A;  4I7C A;  1CA9 A;  2FOJ A;  3IVB A;  3MQS C;  4GHU A;  3HQI A;  3IVQ A;  4CA1 A;  2F1X A;  1D0J A;  2F1Y A;  4KG9 A;  4M4E A;  1KZZ A;  2XXN A;  4GWN A;  1D0A A;  1LB4 A;  1YZE A;  1RF3 A;  3HQH A;  5E1T A;  4C9Z A;  3HQL A;  1CZZ A;  2AN6 A;  2GKW A;  3IVV A;  1QSC A;  4K8U A;  4I7B A;  1FLK A;  1CA4 A;  1ZMS A;  1D01 A;  4GJH A;  4GWM A;  4I7D A;  1FLL A;  1K2F A;  2FOO A;  2F1Z A; 
#chains in the Genus database with same CATH topology
 3HU6 A;  2A25 A;  1D00 A;  4X3G A;  5H9M A;  1LB5 A;  1YY6 A;  4YSI A;  4O1V A;  2FOP A;  2CR2 A;  4Z8M A;  1F3V B;  3MQR A;  1CZY A;  4JJQ A;  2F1W A;  1L0A A;  3HSV A;  3ZJB A;  3HQM A;  1LB6 A;  4I7C A;  1CA9 A;  2FOJ A;  3IVB A;  3MQS C;  4GHU A;  3HQI A;  3IVQ A;  4CA1 A;  2F1X A;  1D0J A;  2F1Y A;  4KG9 A;  4M4E A;  1KZZ A;  2XXN A;  4GWN A;  1D0A A;  1LB4 A;  1YZE A;  1RF3 A;  3HQH A;  5E1T A;  4C9Z A;  3HQL A;  1CZZ A;  2AN6 A;  2GKW A;  3IVV A;  1QSC A;  4K8U A;  4I7B A;  1FLK A;  1CA4 A;  1ZMS A;  1D01 A;  4GJH A;  4GWM A;  4I7D A;  1FLL A;  1K2F A;  2FOO A;  2F1Z A; 
#chains in the Genus database with same CATH homology
 3HU6 A;  2A25 A;  1D00 A;  4X3G A;  5H9M A;  1LB5 A;  1YY6 A;  4YSI A;  4O1V A;  2FOP A;  2CR2 A;  4Z8M A;  1F3V B;  3MQR A;  1CZY A;  4JJQ A;  2F1W A;  1L0A A;  3HSV A;  3ZJB A;  3HQM A;  1LB6 A;  4I7C A;  1CA9 A;  2FOJ A;  3IVB A;  3MQS C;  4GHU A;  3HQI A;  3IVQ A;  4CA1 A;  2F1X A;  1D0J A;  2F1Y A;  4KG9 A;  4M4E A;  1KZZ A;  2XXN A;  4GWN A;  1D0A A;  1LB4 A;  1YZE A;  1RF3 A;  3HQH A;  5E1T A;  4C9Z A;  3HQL A;  1CZZ A;  2AN6 A;  2GKW A;  3IVV A;  1QSC A;  4K8U A;  4I7B A;  1FLK A;  1CA4 A;  1ZMS A;  1D01 A;  4GJH A;  4GWM A;  4I7D A;  1FLL A;  1K2F A;  2FOO A;  2F1Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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