2K7WA

Bax activation is initiated at a novel interaction site
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
192
structure length
192
Chain Sequence
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title BAX activation is initiated at a novel interaction site.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Apoptosis regulator BAX
total genus 69
structure length 192
sequence length 192
ec nomenclature
pdb deposition date 2008-08-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 2k7wA00
2XA0A 2O2NA 2ABOA 1WSXA 1MK3A 3KJ2A 1R2IA 1F16A 3KJ0A 1PQ1A 4U2UA 4ZIFA 2O2FA 1BXLA 1YSGA 4ZBIA 4BPIA 4YJ4A 4HW3A 5KU9A 4MI8A 2W3LA 1Q59A 5C6HA 5KTGA 4U2VA 4ZIEA 1GJHA 4QVXA 2VOGA 1G5MA 3IHDA 2IMSA 5IEZA 4B4SA 2MEJA 5FMIA 2B48A 2A5YA 3BL2A 2VOFA 4S0OA 3MK8A 3WIXA 3KZ0A 4ZIHA 2O21A 1YSNA 2O2MA 4WMRA 2WH6A 3QBRA 2JCNA 3IIGA 3IHEA 3MQPA 1R2HA 5FC4A 4S0PA 2BZWA 1K3KA 1YSIA 2M5BA 3IO9A 3DVUA 4BDUA 4BD2A 5C3FA 2IMTA 5FDRA 5JSBA 5IF4A 4OQ6A 2O22A 1PQ0A 2XPXA 3KJ1A 4BPJA 4G35A 4YK9A 2ME8A 1DDBA 3IIHA 2RODA 2NLAA 3ILCA 1O0LA 1AF3A 2VM6A 1R2EA 1TY4A 3CVAX 2MHSA 2V6QA 2KUAA 1G5JA 4ZIIA 4K5BC 1YSWA 2K7WA 4OYDA 2NL9A 3PK1A 2KBWA 2YV6A 4BD8A 3D7VA 4OQ5A 4BD7A 3WIYA 1R2GA 1MAZA 1OHUA 4ZBFA 2BIDA 1LXLA 4HW2A 1R2DA 2VOHA 5FDOA 2JM6B 4QNQA 4ZIGA 4HW4A 2PQKA 4ZEQA 1ZY3A 2VOIA 4BD6A 2LR1A 2ROCA 3I1HA 3IHCA
chains in the Genus database with same CATH superfamily
2XA0A 2O2NA 2ABOA 2VVXA 1WSXA 1MK3A 3KJ2A 1R2IA 1F16A 3KJ0A 1PQ1A 4UF3A 4U2UA 4ZIFA 3JRVA 2O2FA 4D2MA 1BXLA 1YSGA 4ZBIA 4BPIA 4YJ4A 4HW3A 5KU9A 4MI8A 2W3LA 1Q59A 5C6HA 5KTGA 4U2VA 4ZIEA 1GJHA 4QVXA 2VOGA 1G5MA 3IHDA 2IMSA 5IEZA 4B4SA 2MEJA 5FMIA 2B48A 4M0SA 2A5YA 3BL2A 2VOFA 4S0OA 3MK8A 3WIXA 3KZ0A 4ZIHA 2O21A 1YSNA 2O2MA 4WMRA 2WH6A 3QBRA 2JCNA 3IIGA 4D2LA 3IHEA 3MQPA 1R2HA 5FC4A 4S0PA 2BZWA 1K3KA 1YSIA 2JBYA 2VVYA 4BBBA 2UXEA 2JBXA 2M5BA 3IO9A 3DVUA 4BBCA 4BDUA 4BD2A 5C3FA 2IMTA 5FDRA 2VVWA 5JSBA 5IF4A 4OQ6A 2O22A 1PQ0A 2XPXA 3KJ1A 4BPJA 2O42A 4G35A 4YK9A 2ME8A 1DDBA 3IIHA 2RODA 2NLAA 3ILCA 1O0LA 1AF3A 2VM6A 1R2EA 1TY4A 3CVAX 2MHSA 2V6QA 2KUAA 1G5JA 4ZIIA 4K5BC 1YSWA 4LQKA 2K7WA 4OYDA 2NL9A 2I39A 3PK1A 2KBWA 2YV6A 4BD8A 3D7VA 4OQ5A 4UF1A 4BD7A 3WIYA 4BBDA 1R2GA 1MAZA 1OHUA 4ZBFA 2BIDA 1LXLA 4HW2A 1R2DA 2VOHA 5FDOA 2VTYA 2JM6B 4QNQA 4ZIGA 4HW4A 2PQKA 4ZEQA 1ZY3A 2K36A 2VOIA 4BD6A 4UF2A 2LR1A 2ROCA 3I1HA 3IHCA
chains in the Genus database with same CATH topology
2XA0A 2O2NA 2ABOA 1WSXA 1MK3A 3KJ2A 1R2IA 1F16A 3KJ0A 1PQ1A 4U2UA 4ZIFA 2O2FA 1BXLA 1YSGA 4ZBIA 4BPIA 4YJ4A 4HW3A 5KU9A 4MI8A 2W3LA 1Q59A 5C6HA 5KTGA 4U2VA 4ZIEA 1GJHA 4QVXA 2VOGA 1G5MA 3IHDA 2IMSA 5IEZA 4B4SA 2MEJA 5FMIA 2B48A 2A5YA 3BL2A 2VOFA 4S0OA 3MK8A 3WIXA 3KZ0A 4ZIHA 2O21A 1YSNA 2O2MA 4WMRA 2WH6A 3QBRA 2JCNA 3IIGA 3IHEA 3MQPA 1R2HA 5FC4A 4S0PA 2BZWA 1K3KA 1YSIA 2M5BA 3IO9A 3DVUA 4BDUA 4BD2A 5C3FA 2IMTA 5FDRA 5JSBA 5IF4A 4OQ6A 2O22A 1PQ0A 2XPXA 3KJ1A 4BPJA 4G35A 4YK9A 2ME8A 1DDBA 3IIHA 2RODA 2NLAA 3ILCA 1O0LA 1AF3A 2VM6A 1R2EA 1TY4A 3CVAX 2MHSA 2V6QA 2KUAA 1G5JA 4ZIIA 4K5BC 1YSWA 2K7WA 4OYDA 2NL9A 3PK1A 2KBWA 2YV6A 4BD8A 3D7VA 4OQ5A 4BD7A 3WIYA 1R2GA 1MAZA 1OHUA 4ZBFA 2BIDA 1LXLA 4HW2A 1R2DA 2VOHA 5FDOA 2JM6B 4QNQA 4ZIGA 4HW4A 2PQKA 4ZEQA 1ZY3A 2VOIA 4BD6A 2LR1A 2ROCA 3I1HA 3IHCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XA0 A;  2O2N A;  2ABO A;  1WSX A;  1MK3 A;  3KJ2 A;  1R2I A;  1F16 A;  3KJ0 A;  1PQ1 A;  4U2U A;  4ZIF A;  2O2F A;  1BXL A;  1YSG A;  4ZBI A;  4BPI A;  4YJ4 A;  4HW3 A;  5KU9 A;  4MI8 A;  2W3L A;  1Q59 A;  5C6H A;  5KTG A;  4U2V A;  4ZIE A;  1GJH A;  4QVX A;  2VOG A;  1G5M A;  3IHD A;  2IMS A;  5IEZ A;  4B4S A;  2MEJ A;  5FMI A;  2B48 A;  2A5Y A;  3BL2 A;  2VOF A;  4S0O A;  3MK8 A;  3WIX A;  3KZ0 A;  4ZIH A;  2O21 A;  1YSN A;  2O2M A;  4WMR A;  2WH6 A;  3QBR A;  2JCN A;  3IIG A;  3IHE A;  3MQP A;  1R2H A;  5FC4 A;  4S0P A;  2BZW A;  1K3K A;  1YSI A;  2M5B A;  3IO9 A;  3DVU A;  4BDU A;  4BD2 A;  5C3F A;  2IMT A;  5FDR A;  5JSB A;  5IF4 A;  4OQ6 A;  2O22 A;  1PQ0 A;  2XPX A;  3KJ1 A;  4BPJ A;  4G35 A;  4YK9 A;  2ME8 A;  1DDB A;  3IIH A;  2ROD A;  2NLA A;  3ILC A;  1O0L A;  1AF3 A;  2VM6 A;  1R2E A;  1TY4 A;  3CVA X;  2MHS A;  2V6Q A;  2KUA A;  1G5J A;  4ZII A;  4K5B C;  1YSW A;  2K7W A;  4OYD A;  2NL9 A;  3PK1 A;  2KBW A;  2YV6 A;  4BD8 A;  3D7V A;  4OQ5 A;  4BD7 A;  3WIY A;  1R2G A;  1MAZ A;  1OHU A;  4ZBF A;  2BID A;  1LXL A;  4HW2 A;  1R2D A;  2VOH A;  5FDO A;  2JM6 B;  4QNQ A;  4ZIG A;  4HW4 A;  2PQK A;  4ZEQ A;  1ZY3 A;  2VOI A;  4BD6 A;  2LR1 A;  2ROC A;  3I1H A;  3IHC A; 
#chains in the Genus database with same CATH topology
 2XA0 A;  2O2N A;  2ABO A;  2VVX A;  1WSX A;  1MK3 A;  3KJ2 A;  1R2I A;  1F16 A;  3KJ0 A;  1PQ1 A;  4UF3 A;  4U2U A;  4ZIF A;  3JRV A;  2O2F A;  4D2M A;  1BXL A;  1YSG A;  4ZBI A;  4BPI A;  4YJ4 A;  4HW3 A;  5KU9 A;  4MI8 A;  2W3L A;  1Q59 A;  5C6H A;  5KTG A;  4U2V A;  4ZIE A;  1GJH A;  4QVX A;  2VOG A;  1G5M A;  3IHD A;  2IMS A;  5IEZ A;  4B4S A;  2MEJ A;  5FMI A;  2B48 A;  4M0S A;  2A5Y A;  3BL2 A;  2VOF A;  4S0O A;  3MK8 A;  3WIX A;  3KZ0 A;  4ZIH A;  2O21 A;  1YSN A;  2O2M A;  4WMR A;  2WH6 A;  3QBR A;  2JCN A;  3IIG A;  4D2L A;  3IHE A;  3MQP A;  1R2H A;  5FC4 A;  4S0P A;  2BZW A;  1K3K A;  1YSI A;  2JBY A;  2VVY A;  4BBB A;  2UXE A;  2JBX A;  2M5B A;  3IO9 A;  3DVU A;  4BBC A;  4BDU A;  4BD2 A;  5C3F A;  2IMT A;  5FDR A;  2VVW A;  5JSB A;  5IF4 A;  4OQ6 A;  2O22 A;  1PQ0 A;  2XPX A;  3KJ1 A;  4BPJ A;  2O42 A;  4G35 A;  4YK9 A;  2ME8 A;  1DDB A;  3IIH A;  2ROD A;  2NLA A;  3ILC A;  1O0L A;  1AF3 A;  2VM6 A;  1R2E A;  1TY4 A;  3CVA X;  2MHS A;  2V6Q A;  2KUA A;  1G5J A;  4ZII A;  4K5B C;  1YSW A;  4LQK A;  2K7W A;  4OYD A;  2NL9 A;  2I39 A;  3PK1 A;  2KBW A;  2YV6 A;  4BD8 A;  3D7V A;  4OQ5 A;  4UF1 A;  4BD7 A;  3WIY A;  4BBD A;  1R2G A;  1MAZ A;  1OHU A;  4ZBF A;  2BID A;  1LXL A;  4HW2 A;  1R2D A;  2VOH A;  5FDO A;  2VTY A;  2JM6 B;  4QNQ A;  4ZIG A;  4HW4 A;  2PQK A;  4ZEQ A;  1ZY3 A;  2K36 A;  2VOI A;  4BD6 A;  4UF2 A;  2LR1 A;  2ROC A;  3I1H A;  3IHC A; 
#chains in the Genus database with same CATH homology
 2XA0 A;  2O2N A;  2ABO A;  1WSX A;  1MK3 A;  3KJ2 A;  1R2I A;  1F16 A;  3KJ0 A;  1PQ1 A;  4U2U A;  4ZIF A;  2O2F A;  1BXL A;  1YSG A;  4ZBI A;  4BPI A;  4YJ4 A;  4HW3 A;  5KU9 A;  4MI8 A;  2W3L A;  1Q59 A;  5C6H A;  5KTG A;  4U2V A;  4ZIE A;  1GJH A;  4QVX A;  2VOG A;  1G5M A;  3IHD A;  2IMS A;  5IEZ A;  4B4S A;  2MEJ A;  5FMI A;  2B48 A;  2A5Y A;  3BL2 A;  2VOF A;  4S0O A;  3MK8 A;  3WIX A;  3KZ0 A;  4ZIH A;  2O21 A;  1YSN A;  2O2M A;  4WMR A;  2WH6 A;  3QBR A;  2JCN A;  3IIG A;  3IHE A;  3MQP A;  1R2H A;  5FC4 A;  4S0P A;  2BZW A;  1K3K A;  1YSI A;  2M5B A;  3IO9 A;  3DVU A;  4BDU A;  4BD2 A;  5C3F A;  2IMT A;  5FDR A;  5JSB A;  5IF4 A;  4OQ6 A;  2O22 A;  1PQ0 A;  2XPX A;  3KJ1 A;  4BPJ A;  4G35 A;  4YK9 A;  2ME8 A;  1DDB A;  3IIH A;  2ROD A;  2NLA A;  3ILC A;  1O0L A;  1AF3 A;  2VM6 A;  1R2E A;  1TY4 A;  3CVA X;  2MHS A;  2V6Q A;  2KUA A;  1G5J A;  4ZII A;  4K5B C;  1YSW A;  2K7W A;  4OYD A;  2NL9 A;  3PK1 A;  2KBW A;  2YV6 A;  4BD8 A;  3D7V A;  4OQ5 A;  4BD7 A;  3WIY A;  1R2G A;  1MAZ A;  1OHU A;  4ZBF A;  2BID A;  1LXL A;  4HW2 A;  1R2D A;  2VOH A;  5FDO A;  2JM6 B;  4QNQ A;  4ZIG A;  4HW4 A;  2PQK A;  4ZEQ A;  1ZY3 A;  2VOI A;  4BD6 A;  2LR1 A;  2ROC A;  3I1H A;  3IHC A; 
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similar chains in the Genus database (?% sequence similarity)
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