2NL9A

Crystal structure of the mcl-1:bim bh3 complex
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
151
structure length
142
Chain Sequence
DDLYRQSLEIISRYLREQATGSGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural insights into the degradation of Mcl-1 induced by BH3 domains.
pubmed doi rcsb
molecule tags Apoptosis
source organism Mus musculus
molecule keywords FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell d
total genus 56
structure length 142
sequence length 151
ec nomenclature
pdb deposition date 2006-10-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 2nl9A01
4ZBFA 4OQ6A 3WIXA 2XPXA 2NLAA 2NL9A 5FMIA 4HW4A 4YK9A 3PK1A 5FDRA 3MQPA 2ABOA 4ZIIA 3MK8A 3IHCA 1YSGA 4OQ5A 3WIYA 2WH6A 4B4SA 2MHSA 3ILCA 5IEZA 4BD2A 2O21A 3IIHA 3QBRA 4ZEQA 4BD6A 2K7WA 1YSWA 4BD7A 1TY4A 3CVAX 1LXLA 2O2MA 4S0PA 4MI8A 5JSBA 1R2GA 2RODA 4HW3A 4K5BC 1PQ1A 3I1HA 4S0OA 2A5YA 2KUAA 3IHEA 1ZY3A 1R2IA 1MAZA 3KJ2A 1K3KA 2B48A 2O22A 2ROCA 4YJ4A 4G35A 1YSNA 2BZWA 2VOGA 4BPIA 2O2NA 3D7VA 2ME8A 2MEJA 3DVUA 3KJ0A 3KJ1A 4QVXA 5IF4A 3IO9A 3IHDA 2VM6A 5FC4A 2IMTA 4HW2A 1OHUA 4OYDA 4ZIFA 5C6HA 2PQKA 3BL2A 1O0LA 3IIGA 4ZIEA 4BDUA 4WMRA 2VOIA 1DDBA 2KBWA 1G5JA 1BXLA 2JM6B 2LR1A 2V6QA 4U2UA 2JCNA 1MK3A 2W3LA 1G5MA 3KZ0A 1Q59A 4BPJA 2VOHA 1AF3A 5KTGA 2BIDA 2M5BA 1F16A 4U2VA 1WSXA 4BD8A 2VOFA 4ZBIA 1YSIA 1PQ0A 5FDOA 5C3FA 4QNQA 2YV6A 5KU9A 1R2EA 2O2FA 2XA0A 2IMSA 1R2HA 4ZIHA 4ZIGA 1GJHA 1R2DA
chains in the Genus database with same CATH superfamily
4ZBFA 4OQ6A 3WIXA 2XPXA 4D2MA 2NLAA 2NL9A 4UF2A 5FMIA 2VTYA 4HW4A 4YK9A 3PK1A 5FDRA 3MQPA 2ABOA 4ZIIA 3MK8A 3IHCA 1YSGA 4OQ5A 3WIYA 2WH6A 4B4SA 2MHSA 3ILCA 2O42A 5IEZA 4BD2A 2O21A 4BBBA 3IIHA 3QBRA 4ZEQA 4BD6A 2K7WA 1YSWA 4BD7A 1TY4A 3CVAX 1LXLA 2O2MA 4S0PA 4MI8A 4LQKA 5JSBA 4BBDA 1R2GA 4UF1A 2RODA 4HW3A 4K5BC 4BBCA 4M0SA 1PQ1A 3I1HA 4S0OA 2A5YA 2KUAA 3IHEA 1ZY3A 4D2LA 1R2IA 1MAZA 3KJ2A 1K3KA 2B48A 2O22A 2ROCA 4YJ4A 2JBXA 4G35A 4UF3A 1YSNA 2BZWA 2VOGA 4BPIA 2O2NA 3D7VA 2ME8A 2MEJA 3DVUA 3KJ0A 3KJ1A 4QVXA 2VVYA 5IF4A 3IO9A 3IHDA 2VVWA 2VM6A 5FC4A 2IMTA 4HW2A 1OHUA 4OYDA 4ZIFA 5C6HA 2PQKA 3BL2A 2K36A 1O0LA 3IIGA 4ZIEA 4BDUA 4WMRA 2VOIA 1DDBA 2KBWA 1G5JA 1BXLA 2JM6B 2LR1A 2V6QA 4U2UA 2JCNA 1MK3A 2W3LA 1G5MA 3KZ0A 1Q59A 4BPJA 2VOHA 1AF3A 2VVXA 2BIDA 5KTGA 2M5BA 1F16A 4U2VA 1WSXA 4BD8A 2VOFA 4ZBIA 2I39A 1YSIA 1PQ0A 5FDOA 5C3FA 4QNQA 2YV6A 2JBYA 5KU9A 1R2EA 2O2FA 2XA0A 2UXEA 3JRVA 2IMSA 1R2HA 4ZIHA 4ZIGA 1GJHA 1R2DA
chains in the Genus database with same CATH topology
4ZBFA 4OQ6A 3WIXA 2XPXA 2NLAA 2NL9A 5FMIA 4HW4A 4YK9A 3PK1A 5FDRA 3MQPA 2ABOA 4ZIIA 3MK8A 3IHCA 1YSGA 4OQ5A 3WIYA 2WH6A 4B4SA 2MHSA 3ILCA 5IEZA 4BD2A 2O21A 3IIHA 3QBRA 4ZEQA 4BD6A 2K7WA 1YSWA 4BD7A 1TY4A 3CVAX 1LXLA 2O2MA 4S0PA 4MI8A 5JSBA 1R2GA 2RODA 4HW3A 4K5BC 1PQ1A 3I1HA 4S0OA 2A5YA 2KUAA 3IHEA 1ZY3A 1R2IA 1MAZA 3KJ2A 1K3KA 2B48A 2O22A 2ROCA 4YJ4A 4G35A 1YSNA 2BZWA 2VOGA 4BPIA 2O2NA 3D7VA 2ME8A 2MEJA 3DVUA 3KJ0A 3KJ1A 4QVXA 5IF4A 3IO9A 3IHDA 2VM6A 5FC4A 2IMTA 4HW2A 1OHUA 4OYDA 4ZIFA 5C6HA 2PQKA 3BL2A 1O0LA 3IIGA 4ZIEA 4BDUA 4WMRA 2VOIA 1DDBA 2KBWA 1G5JA 1BXLA 2JM6B 2LR1A 2V6QA 4U2UA 2JCNA 1MK3A 2W3LA 1G5MA 3KZ0A 1Q59A 4BPJA 2VOHA 1AF3A 5KTGA 2BIDA 2M5BA 1F16A 4U2VA 1WSXA 4BD8A 2VOFA 4ZBIA 1YSIA 1PQ0A 5FDOA 5C3FA 4QNQA 2YV6A 5KU9A 1R2EA 2O2FA 2XA0A 2IMSA 1R2HA 4ZIHA 4ZIGA 1GJHA 1R2DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZBF A;  4OQ6 A;  3WIX A;  2XPX A;  2NLA A;  2NL9 A;  5FMI A;  4HW4 A;  4YK9 A;  3PK1 A;  5FDR A;  3MQP A;  2ABO A;  4ZII A;  3MK8 A;  3IHC A;  1YSG A;  4OQ5 A;  3WIY A;  2WH6 A;  4B4S A;  2MHS A;  3ILC A;  5IEZ A;  4BD2 A;  2O21 A;  3IIH A;  3QBR A;  4ZEQ A;  4BD6 A;  2K7W A;  1YSW A;  4BD7 A;  1TY4 A;  3CVA X;  1LXL A;  2O2M A;  4S0P A;  4MI8 A;  5JSB A;  1R2G A;  2ROD A;  4HW3 A;  4K5B C;  1PQ1 A;  3I1H A;  4S0O A;  2A5Y A;  2KUA A;  3IHE A;  1ZY3 A;  1R2I A;  1MAZ A;  3KJ2 A;  1K3K A;  2B48 A;  2O22 A;  2ROC A;  4YJ4 A;  4G35 A;  1YSN A;  2BZW A;  2VOG A;  4BPI A;  2O2N A;  3D7V A;  2ME8 A;  2MEJ A;  3DVU A;  3KJ0 A;  3KJ1 A;  4QVX A;  5IF4 A;  3IO9 A;  3IHD A;  2VM6 A;  5FC4 A;  2IMT A;  4HW2 A;  1OHU A;  4OYD A;  4ZIF A;  5C6H A;  2PQK A;  3BL2 A;  1O0L A;  3IIG A;  4ZIE A;  4BDU A;  4WMR A;  2VOI A;  1DDB A;  2KBW A;  1G5J A;  1BXL A;  2JM6 B;  2LR1 A;  2V6Q A;  4U2U A;  2JCN A;  1MK3 A;  2W3L A;  1G5M A;  3KZ0 A;  1Q59 A;  4BPJ A;  2VOH A;  1AF3 A;  5KTG A;  2BID A;  2M5B A;  1F16 A;  4U2V A;  1WSX A;  4BD8 A;  2VOF A;  4ZBI A;  1YSI A;  1PQ0 A;  5FDO A;  5C3F A;  4QNQ A;  2YV6 A;  5KU9 A;  1R2E A;  2O2F A;  2XA0 A;  2IMS A;  1R2H A;  4ZIH A;  4ZIG A;  1GJH A;  1R2D A; 
#chains in the Genus database with same CATH topology
 4ZBF A;  4OQ6 A;  3WIX A;  2XPX A;  4D2M A;  2NLA A;  2NL9 A;  4UF2 A;  5FMI A;  2VTY A;  4HW4 A;  4YK9 A;  3PK1 A;  5FDR A;  3MQP A;  2ABO A;  4ZII A;  3MK8 A;  3IHC A;  1YSG A;  4OQ5 A;  3WIY A;  2WH6 A;  4B4S A;  2MHS A;  3ILC A;  2O42 A;  5IEZ A;  4BD2 A;  2O21 A;  4BBB A;  3IIH A;  3QBR A;  4ZEQ A;  4BD6 A;  2K7W A;  1YSW A;  4BD7 A;  1TY4 A;  3CVA X;  1LXL A;  2O2M A;  4S0P A;  4MI8 A;  4LQK A;  5JSB A;  4BBD A;  1R2G A;  4UF1 A;  2ROD A;  4HW3 A;  4K5B C;  4BBC A;  4M0S A;  1PQ1 A;  3I1H A;  4S0O A;  2A5Y A;  2KUA A;  3IHE A;  1ZY3 A;  4D2L A;  1R2I A;  1MAZ A;  3KJ2 A;  1K3K A;  2B48 A;  2O22 A;  2ROC A;  4YJ4 A;  2JBX A;  4G35 A;  4UF3 A;  1YSN A;  2BZW A;  2VOG A;  4BPI A;  2O2N A;  3D7V A;  2ME8 A;  2MEJ A;  3DVU A;  3KJ0 A;  3KJ1 A;  4QVX A;  2VVY A;  5IF4 A;  3IO9 A;  3IHD A;  2VVW A;  2VM6 A;  5FC4 A;  2IMT A;  4HW2 A;  1OHU A;  4OYD A;  4ZIF A;  5C6H A;  2PQK A;  3BL2 A;  2K36 A;  1O0L A;  3IIG A;  4ZIE A;  4BDU A;  4WMR A;  2VOI A;  1DDB A;  2KBW A;  1G5J A;  1BXL A;  2JM6 B;  2LR1 A;  2V6Q A;  4U2U A;  2JCN A;  1MK3 A;  2W3L A;  1G5M A;  3KZ0 A;  1Q59 A;  4BPJ A;  2VOH A;  1AF3 A;  2VVX A;  2BID A;  5KTG A;  2M5B A;  1F16 A;  4U2V A;  1WSX A;  4BD8 A;  2VOF A;  4ZBI A;  2I39 A;  1YSI A;  1PQ0 A;  5FDO A;  5C3F A;  4QNQ A;  2YV6 A;  2JBY A;  5KU9 A;  1R2E A;  2O2F A;  2XA0 A;  2UXE A;  3JRV A;  2IMS A;  1R2H A;  4ZIH A;  4ZIG A;  1GJH A;  1R2D A; 
#chains in the Genus database with same CATH homology
 4ZBF A;  4OQ6 A;  3WIX A;  2XPX A;  2NLA A;  2NL9 A;  5FMI A;  4HW4 A;  4YK9 A;  3PK1 A;  5FDR A;  3MQP A;  2ABO A;  4ZII A;  3MK8 A;  3IHC A;  1YSG A;  4OQ5 A;  3WIY A;  2WH6 A;  4B4S A;  2MHS A;  3ILC A;  5IEZ A;  4BD2 A;  2O21 A;  3IIH A;  3QBR A;  4ZEQ A;  4BD6 A;  2K7W A;  1YSW A;  4BD7 A;  1TY4 A;  3CVA X;  1LXL A;  2O2M A;  4S0P A;  4MI8 A;  5JSB A;  1R2G A;  2ROD A;  4HW3 A;  4K5B C;  1PQ1 A;  3I1H A;  4S0O A;  2A5Y A;  2KUA A;  3IHE A;  1ZY3 A;  1R2I A;  1MAZ A;  3KJ2 A;  1K3K A;  2B48 A;  2O22 A;  2ROC A;  4YJ4 A;  4G35 A;  1YSN A;  2BZW A;  2VOG A;  4BPI A;  2O2N A;  3D7V A;  2ME8 A;  2MEJ A;  3DVU A;  3KJ0 A;  3KJ1 A;  4QVX A;  5IF4 A;  3IO9 A;  3IHD A;  2VM6 A;  5FC4 A;  2IMT A;  4HW2 A;  1OHU A;  4OYD A;  4ZIF A;  5C6H A;  2PQK A;  3BL2 A;  1O0L A;  3IIG A;  4ZIE A;  4BDU A;  4WMR A;  2VOI A;  1DDB A;  2KBW A;  1G5J A;  1BXL A;  2JM6 B;  2LR1 A;  2V6Q A;  4U2U A;  2JCN A;  1MK3 A;  2W3L A;  1G5M A;  3KZ0 A;  1Q59 A;  4BPJ A;  2VOH A;  1AF3 A;  5KTG A;  2BID A;  2M5B A;  1F16 A;  4U2V A;  1WSX A;  4BD8 A;  2VOF A;  4ZBI A;  1YSI A;  1PQ0 A;  5FDO A;  5C3F A;  4QNQ A;  2YV6 A;  5KU9 A;  1R2E A;  2O2F A;  2XA0 A;  2IMS A;  1R2H A;  4ZIH A;  4ZIG A;  1GJH A;  1R2D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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