2QFY | Genus

Total Genus 142

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	142
sequence length	411
structure length	411
Chain Sequence	FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSI

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NADP]
molecule tags	Oxidoreductase
source organism	Saccharomyces cerevisiae
total genus	142
structure length	411
sequence length	411
chains with identical sequence	B, C, D, E, F
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	2007-06-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	2qfyA00

1T09A 2UXRA 4XXVA 2Y41A 4HCXA 3BLXB 4JQPA 3MAPA 5GRLB 1XGVA 2Y40A 7ICDA 1ISOA 2Y42A 2AYQA 4L03A 1WALA 1PS6A 3MARA 1OSIA 3VL4A 1HQSA 3MASA 3FLKA 4AJAA 1XACA 4UMYA 1AI3A 1YCOA 1W0DA 1XKDA 3U1HA 1A05A 1PTMA 4I3KA 3UDOA 5I96A 1XADA 5HN4A 4L04A 5GRIB 1GRPA 2QFYA 5K11A 1CW7A 1DR8A 5GRFB 3VMLA 1VI1A 1IDDA 1XAAA 4P69C 3WZWA 3VL7A 1G2UA 3INMA 4AJCA 1HEXA 4JA8A 3TNGA 1DR0A 1V5BA 3WZXA 2D1CA 5K10A 5DE1A 1HJ6A 3AH3A 3TY3A 2G4OA 3VKZA 1T0LA 1ZORA 4ATYA 3UDUA 4ICDA 2UXQA 3BLVA 4XRXA 4AOUA 5J32A 3MASB 1CW1A 1IDEA 1IDFA 5HN3A 3WZVA 5GREA 3TY4A 1BL5A 2ZTWA 3VL3A 1GC9A 3VL6A 5GRHA 1GC8A 3LXYA 2DHTA 2Y3ZA 4I3LA 3LCBC 1DPZA 5J34A 5ICDA 1IPDA 2QFXA 1R8KA 2HI1A 1PB3A 5HN6A 4WUOA 5J33A 1XABA 3FMXX 3ICDA 1CM7A 4AJSA 4BNPA 5I95A 5L57A 3VL2A 1AI2A 1IDMA 1PS7A 4Y1PA 1GROA 4YB4A 3BLXA 1CNZA 5LGEA 3VMKA 6ICDA 3TSNA 1SJSA 4AJBA 2QFVA 4XS3A 3R8WA 1V53A 4AOVA 1X0LA 1OSJA 2QFWA 1CW4A 3BLVB 3VMJA 4KZOA 9ICDA 1IDCA 3WZYA 1V94A 5GREB 1VLCA 4AOYA 1PB1A 4IWHA 2D4VA 1YXOA 1P8FA 4AJRA 1U7NA 5GRHB 5HN5A 3US8A 4UMXA 1LWDA 2IV0A 5L58A 3U9EA 4L06A 5GRIA 3UF6A 2E5MA 3DMSA 4AJ3A 8ICDA 5GRFA 4F7IA 5GRLA 1IKAA 3ASJA 2E0CA 1TYOA 1WPWA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1T09 A;  2UXR A;  4XXV A;  2Y41 A;  4HCX A;  3BLX B;  4JQP A;  3MAP A;  5GRL B;  1XGV A;  2Y40 A;  7ICD A;  1ISO A;  2Y42 A;  2AYQ A;  4L03 A;  1WAL A;  1PS6 A;  3MAR A;  1OSI A;  3VL4 A;  1HQS A;  3MAS A;  3FLK A;  4AJA A;  1XAC A;  4UMY A;  1AI3 A;  1YCO A;  1W0D A;  1XKD A;  3U1H A;  1A05 A;  1PTM A;  4I3K A;  3UDO A;  5I96 A;  1XAD A;  5HN4 A;  4L04 A;  5GRI B;  1GRP A;  2QFY A;  5K11 A;  1CW7 A;  1DR8 A;  5GRF B;  3VML A;  1VI1 A;  1IDD A;  1XAA A;  4P69 C;  3WZW A;  3VL7 A;  1G2U A;  3INM A;  4AJC A;  1HEX A;  4JA8 A;  3TNG A;  1DR0 A;  1V5B A;  3WZX A;  2D1C A;  5K10 A;  5DE1 A;  1HJ6 A;  3AH3 A;  3TY3 A;  2G4O A;  3VKZ A;  1T0L A;  1ZOR A;  4ATY A;  3UDU A;  4ICD A;  2UXQ A;  3BLV A;  4XRX A;  4AOU A;  5J32 A;  3MAS B;  1CW1 A;  1IDE A;  1IDF A;  5HN3 A;  3WZV A;  5GRE A;  3TY4 A;  1BL5 A;  2ZTW A;  3VL3 A;  1GC9 A;  3VL6 A;  5GRH A;  1GC8 A;  3LXY A;  2DHT A;  2Y3Z A;  4I3L A;  3LCB C;  1DPZ A;  5J34 A;  5ICD A;  1IPD A;  2QFX A;  1R8K A;  2HI1 A;  1PB3 A;  5HN6 A;  4WUO A;  5J33 A;  1XAB A;  3FMX X;  3ICD A;  1CM7 A;  4AJS A;  4BNP A;  5I95 A;  5L57 A;  3VL2 A;  1AI2 A;  1IDM A;  1PS7 A;  4Y1P A;  1GRO A;  4YB4 A;  3BLX A;  1CNZ A;  5LGE A;  3VMK A;  6ICD A;  3TSN A;  1SJS A;  4AJB A;  2QFV A;  4XS3 A;  3R8W A;  1V53 A;  4AOV A;  1X0L A;  1OSJ A;  2QFW A;  1CW4 A;  3BLV B;  3VMJ A;  4KZO A;  9ICD A;  1IDC A;  3WZY A;  1V94 A;  5GRE B;  1VLC A;  4AOY A;  1PB1 A;  4IWH A;  2D4V A;  1YXO A;  1P8F A;  4AJR A;  1U7N A;  5GRH B;  5HN5 A;  3US8 A;  4UMX A;  1LWD A;  2IV0 A;  5L58 A;  3U9E A;  4L06 A;  5GRI A;  3UF6 A;  2E5M A;  3DMS A;  4AJ3 A;  8ICD A;  5GRF A;  4F7I A;  5GRL A;  1IKA A;  3ASJ A;  2E0C A;  1TYO A;  1WPW A; 
#chains in the Genus database with same CATH topology
 1T09 A;  2UXR A;  4XXV A;  2Y41 A;  4HCX A;  3BLX B;  4JQP A;  3MAP A;  5GRL B;  1XGV A;  2Y40 A;  7ICD A;  1ISO A;  2Y42 A;  2AYQ A;  4L03 A;  1WAL A;  1PS6 A;  3MAR A;  1OSI A;  3VL4 A;  1HQS A;  3MAS A;  3FLK A;  4AJA A;  1XAC A;  4UMY A;  1AI3 A;  1YCO A;  1W0D A;  1XKD A;  3U1H A;  1A05 A;  1PTM A;  4I3K A;  3UDO A;  5I96 A;  1XAD A;  5HN4 A;  4L04 A;  5GRI B;  1GRP A;  2QFY A;  5K11 A;  1CW7 A;  1DR8 A;  5GRF B;  3VML A;  1VI1 A;  1IDD A;  1XAA A;  4P69 C;  3WZW A;  3VL7 A;  1G2U A;  3INM A;  4AJC A;  1HEX A;  4JA8 A;  3TNG A;  1DR0 A;  1V5B A;  3WZX A;  2D1C A;  5K10 A;  5DE1 A;  1HJ6 A;  3AH3 A;  3TY3 A;  2G4O A;  3VKZ A;  1T0L A;  1ZOR A;  4ATY A;  3UDU A;  4ICD A;  2UXQ A;  3BLV A;  4XRX A;  4AOU A;  5J32 A;  3MAS B;  1CW1 A;  1IDE A;  1IDF A;  5HN3 A;  3WZV A;  5GRE A;  3TY4 A;  1BL5 A;  2ZTW A;  3VL3 A;  1GC9 A;  3VL6 A;  5GRH A;  1GC8 A;  3LXY A;  2DHT A;  2Y3Z A;  4I3L A;  3LCB C;  1DPZ A;  5J34 A;  5ICD A;  1IPD A;  2QFX A;  1R8K A;  2HI1 A;  1PB3 A;  5HN6 A;  4WUO A;  5J33 A;  1XAB A;  3FMX X;  3ICD A;  1CM7 A;  4AJS A;  4BNP A;  5I95 A;  5L57 A;  3VL2 A;  1AI2 A;  1IDM A;  1PS7 A;  4Y1P A;  1GRO A;  4YB4 A;  3BLX A;  1CNZ A;  5LGE A;  3VMK A;  6ICD A;  3TSN A;  1SJS A;  4AJB A;  2QFV A;  4XS3 A;  3R8W A;  1V53 A;  4AOV A;  1X0L A;  1OSJ A;  2QFW A;  1CW4 A;  3BLV B;  3VMJ A;  4KZO A;  9ICD A;  1IDC A;  3WZY A;  1V94 A;  5GRE B;  1VLC A;  4AOY A;  1PB1 A;  4IWH A;  2D4V A;  1YXO A;  1P8F A;  4AJR A;  1U7N A;  5GRH B;  5HN5 A;  3US8 A;  4UMX A;  1LWD A;  2IV0 A;  5L58 A;  3U9E A;  4L06 A;  5GRI A;  3UF6 A;  2E5M A;  3DMS A;  4AJ3 A;  8ICD A;  5GRF A;  4F7I A;  5GRL A;  1IKA A;  3ASJ A;  2E0C A;  1TYO A;  1WPW A; 
#chains in the Genus database with same CATH homology
 1T09 A;  2UXR A;  4XXV A;  2Y41 A;  4HCX A;  3BLX B;  4JQP A;  3MAP A;  5GRL B;  1XGV A;  2Y40 A;  7ICD A;  1ISO A;  2Y42 A;  2AYQ A;  4L03 A;  1WAL A;  1PS6 A;  3MAR A;  1OSI A;  3VL4 A;  1HQS A;  3MAS A;  3FLK A;  4AJA A;  1XAC A;  4UMY A;  1AI3 A;  1YCO A;  1W0D A;  1XKD A;  3U1H A;  1A05 A;  1PTM A;  4I3K A;  3UDO A;  5I96 A;  1XAD A;  5HN4 A;  4L04 A;  5GRI B;  1GRP A;  2QFY A;  5K11 A;  1CW7 A;  1DR8 A;  5GRF B;  3VML A;  1VI1 A;  1IDD A;  1XAA A;  4P69 C;  3WZW A;  3VL7 A;  1G2U A;  3INM A;  4AJC A;  1HEX A;  4JA8 A;  3TNG A;  1DR0 A;  1V5B A;  3WZX A;  2D1C A;  5K10 A;  5DE1 A;  1HJ6 A;  3AH3 A;  3TY3 A;  2G4O A;  3VKZ A;  1T0L A;  1ZOR A;  4ATY A;  3UDU A;  4ICD A;  2UXQ A;  3BLV A;  4XRX A;  4AOU A;  5J32 A;  3MAS B;  1CW1 A;  1IDE A;  1IDF A;  5HN3 A;  3WZV A;  5GRE A;  3TY4 A;  1BL5 A;  2ZTW A;  3VL3 A;  1GC9 A;  3VL6 A;  5GRH A;  1GC8 A;  3LXY A;  2DHT A;  2Y3Z A;  4I3L A;  3LCB C;  1DPZ A;  5J34 A;  5ICD A;  1IPD A;  2QFX A;  1R8K A;  2HI1 A;  1PB3 A;  5HN6 A;  4WUO A;  5J33 A;  1XAB A;  3FMX X;  3ICD A;  1CM7 A;  4AJS A;  4BNP A;  5I95 A;  5L57 A;  3VL2 A;  1AI2 A;  1IDM A;  1PS7 A;  4Y1P A;  1GRO A;  4YB4 A;  3BLX A;  1CNZ A;  5LGE A;  3VMK A;  6ICD A;  3TSN A;  1SJS A;  4AJB A;  2QFV A;  4XS3 A;  3R8W A;  1V53 A;  4AOV A;  1X0L A;  1OSJ A;  2QFW A;  1CW4 A;  3BLV B;  3VMJ A;  4KZO A;  9ICD A;  1IDC A;  3WZY A;  1V94 A;  5GRE B;  1VLC A;  4AOY A;  1PB1 A;  4IWH A;  2D4V A;  1YXO A;  1P8F A;  4AJR A;  1U7N A;  5GRH B;  5HN5 A;  3US8 A;  4UMX A;  1LWD A;  2IV0 A;  5L58 A;  3U9E A;  4L06 A;  5GRI A;  3UF6 A;  2E5M A;  3DMS A;  4AJ3 A;  8ICD A;  5GRF A;  4F7I A;  5GRL A;  1IKA A;  3ASJ A;  2E0C A;  1TYO A;  1WPW A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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2QFYA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations