2RODA

Solution structure of mcl-1 complexed with noxaa
Total Genus 65
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
162
structure length
162
Chain Sequence
GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1
pubmed doi rcsb
molecule tags Apoptosis
source organism Mus musculus
molecule keywords Induced myeloid leukemia cell differentiation protein Mcl-1
total genus 65
structure length 162
sequence length 162
ec nomenclature
pdb deposition date 2008-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 2rodA01
5JSBA 5IF4A 2M5BA 5KU9A 4ZIGA 2ABOA 2BIDA 4MI8A 2JM6B 1WSXA 2O21A 1DDBA 1G5MA 4OYDA 4YK9A 4BD2A 3MK8A 2VOHA 2V6QA 4WMRA 3PK1A 2VOGA 4ZEQA 1YSGA 3KJ2A 3I1HA 3IHCA 1MK3A 4BD8A 1O0LA 2BZWA 4QVXA 3MQPA 2VM6A 1AF3A 5KTGA 3IO9A 2W3LA 5FDRA 1OHUA 4ZBIA 2LR1A 4OQ6A 5FDOA 4BPIA 1GJHA 2O2MA 2O2NA 2ROCA 4ZIFA 4U2VA 3QBRA 2MEJA 1R2EA 3CVAX 1LXLA 1YSIA 3D7VA 1ZY3A 5FMIA 4ZIIA 2KUAA 3KZ0A 4U2UA 1F16A 1BXLA 2KBWA 2NLAA 2MHSA 4YJ4A 1PQ1A 2YV6A 2A5YA 4HW4A 2XA0A 2JCNA 3IIGA 3IHEA 3IIHA 2K7WA 2B48A 4BDUA 1YSNA 2VOIA 4BPJA 4ZIHA 1R2HA 4K5BC 4ZBFA 2RODA 4G35A 3WIYA 1YSWA 4QNQA 5IEZA 1K3KA 1Q59A 1R2DA 1MAZA 1TY4A 2O2FA 1G5JA 4BD6A 3IHDA 4ZIEA 4OQ5A 1PQ0A 3KJ1A 5C3FA 3WIXA 2NL9A 2O22A 3BL2A 2PQKA 4HW3A 2VOFA 4B4SA 2WH6A 5C6HA 3DVUA 4S0PA 1R2GA 4S0OA 3KJ0A 4HW2A 1R2IA 2IMSA 5FC4A 3ILCA 4BD7A 2IMTA 2XPXA 2ME8A
chains in the Genus database with same CATH superfamily
5JSBA 5IF4A 2M5BA 5KU9A 4ZIGA 2ABOA 2BIDA 4MI8A 2JM6B 1WSXA 2O21A 1DDBA 1G5MA 4OYDA 4YK9A 4BD2A 3MK8A 2VOHA 2V6QA 4WMRA 3PK1A 2VOGA 2K36A 4ZEQA 1YSGA 3KJ2A 3I1HA 3IHCA 4LQKA 1MK3A 4BD8A 2JBYA 1O0LA 2BZWA 4QVXA 3MQPA 4BBBA 2VM6A 1AF3A 5KTGA 3IO9A 4UF3A 2W3LA 4M0SA 5FDRA 1OHUA 4ZBIA 2LR1A 4OQ6A 5FDOA 4BPIA 1GJHA 2O2MA 2O2NA 2ROCA 2UXEA 4ZIFA 4D2LA 4U2VA 3QBRA 2MEJA 1R2EA 3CVAX 1LXLA 1YSIA 3D7VA 1ZY3A 5FMIA 4ZIIA 4UF2A 2KUAA 3KZ0A 4U2UA 1F16A 1BXLA 2KBWA 2NLAA 2MHSA 4YJ4A 4BBCA 1PQ1A 2YV6A 2JBXA 2A5YA 4HW4A 2XA0A 2JCNA 3IIGA 4D2MA 3IHEA 3IIHA 2K7WA 2B48A 4BDUA 1YSNA 2VOIA 4BPJA 4ZIHA 1R2HA 2I39A 4K5BC 4ZBFA 2RODA 3JRVA 4G35A 3WIYA 1YSWA 4QNQA 5IEZA 1K3KA 1Q59A 1R2DA 1MAZA 1TY4A 2O2FA 2VTYA 1G5JA 4BD6A 3IHDA 4ZIEA 4OQ5A 1PQ0A 4UF1A 3KJ1A 5C3FA 3WIXA 2NL9A 2O22A 2VVXA 4BBDA 2O42A 3BL2A 2PQKA 4HW3A 2VOFA 4B4SA 2WH6A 5C6HA 3DVUA 4S0PA 1R2GA 2VVYA 4S0OA 3KJ0A 4HW2A 1R2IA 2IMSA 5FC4A 3ILCA 4BD7A 2IMTA 2VVWA 2XPXA 2ME8A
chains in the Genus database with same CATH topology
5JSBA 5IF4A 2M5BA 5KU9A 4ZIGA 2ABOA 2BIDA 4MI8A 2JM6B 1WSXA 2O21A 1DDBA 1G5MA 4OYDA 4YK9A 4BD2A 3MK8A 2VOHA 2V6QA 4WMRA 3PK1A 2VOGA 4ZEQA 1YSGA 3KJ2A 3I1HA 3IHCA 1MK3A 4BD8A 1O0LA 2BZWA 4QVXA 3MQPA 2VM6A 1AF3A 5KTGA 3IO9A 2W3LA 5FDRA 1OHUA 4ZBIA 2LR1A 4OQ6A 5FDOA 4BPIA 1GJHA 2O2MA 2O2NA 2ROCA 4ZIFA 4U2VA 3QBRA 2MEJA 1R2EA 3CVAX 1LXLA 1YSIA 3D7VA 1ZY3A 5FMIA 4ZIIA 2KUAA 3KZ0A 4U2UA 1F16A 1BXLA 2KBWA 2NLAA 2MHSA 4YJ4A 1PQ1A 2YV6A 2A5YA 4HW4A 2XA0A 2JCNA 3IIGA 3IHEA 3IIHA 2K7WA 2B48A 4BDUA 1YSNA 2VOIA 4BPJA 4ZIHA 1R2HA 4K5BC 4ZBFA 2RODA 4G35A 3WIYA 1YSWA 4QNQA 5IEZA 1K3KA 1Q59A 1R2DA 1MAZA 1TY4A 2O2FA 1G5JA 4BD6A 3IHDA 4ZIEA 4OQ5A 1PQ0A 3KJ1A 5C3FA 3WIXA 2NL9A 2O22A 3BL2A 2PQKA 4HW3A 2VOFA 4B4SA 2WH6A 5C6HA 3DVUA 4S0PA 1R2GA 4S0OA 3KJ0A 4HW2A 1R2IA 2IMSA 5FC4A 3ILCA 4BD7A 2IMTA 2XPXA 2ME8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JSB A;  5IF4 A;  2M5B A;  5KU9 A;  4ZIG A;  2ABO A;  2BID A;  4MI8 A;  2JM6 B;  1WSX A;  2O21 A;  1DDB A;  1G5M A;  4OYD A;  4YK9 A;  4BD2 A;  3MK8 A;  2VOH A;  2V6Q A;  4WMR A;  3PK1 A;  2VOG A;  4ZEQ A;  1YSG A;  3KJ2 A;  3I1H A;  3IHC A;  1MK3 A;  4BD8 A;  1O0L A;  2BZW A;  4QVX A;  3MQP A;  2VM6 A;  1AF3 A;  5KTG A;  3IO9 A;  2W3L A;  5FDR A;  1OHU A;  4ZBI A;  2LR1 A;  4OQ6 A;  5FDO A;  4BPI A;  1GJH A;  2O2M A;  2O2N A;  2ROC A;  4ZIF A;  4U2V A;  3QBR A;  2MEJ A;  1R2E A;  3CVA X;  1LXL A;  1YSI A;  3D7V A;  1ZY3 A;  5FMI A;  4ZII A;  2KUA A;  3KZ0 A;  4U2U A;  1F16 A;  1BXL A;  2KBW A;  2NLA A;  2MHS A;  4YJ4 A;  1PQ1 A;  2YV6 A;  2A5Y A;  4HW4 A;  2XA0 A;  2JCN A;  3IIG A;  3IHE A;  3IIH A;  2K7W A;  2B48 A;  4BDU A;  1YSN A;  2VOI A;  4BPJ A;  4ZIH A;  1R2H A;  4K5B C;  4ZBF A;  2ROD A;  4G35 A;  3WIY A;  1YSW A;  4QNQ A;  5IEZ A;  1K3K A;  1Q59 A;  1R2D A;  1MAZ A;  1TY4 A;  2O2F A;  1G5J A;  4BD6 A;  3IHD A;  4ZIE A;  4OQ5 A;  1PQ0 A;  3KJ1 A;  5C3F A;  3WIX A;  2NL9 A;  2O22 A;  3BL2 A;  2PQK A;  4HW3 A;  2VOF A;  4B4S A;  2WH6 A;  5C6H A;  3DVU A;  4S0P A;  1R2G A;  4S0O A;  3KJ0 A;  4HW2 A;  1R2I A;  2IMS A;  5FC4 A;  3ILC A;  4BD7 A;  2IMT A;  2XPX A;  2ME8 A; 
#chains in the Genus database with same CATH topology
 5JSB A;  5IF4 A;  2M5B A;  5KU9 A;  4ZIG A;  2ABO A;  2BID A;  4MI8 A;  2JM6 B;  1WSX A;  2O21 A;  1DDB A;  1G5M A;  4OYD A;  4YK9 A;  4BD2 A;  3MK8 A;  2VOH A;  2V6Q A;  4WMR A;  3PK1 A;  2VOG A;  2K36 A;  4ZEQ A;  1YSG A;  3KJ2 A;  3I1H A;  3IHC A;  4LQK A;  1MK3 A;  4BD8 A;  2JBY A;  1O0L A;  2BZW A;  4QVX A;  3MQP A;  4BBB A;  2VM6 A;  1AF3 A;  5KTG A;  3IO9 A;  4UF3 A;  2W3L A;  4M0S A;  5FDR A;  1OHU A;  4ZBI A;  2LR1 A;  4OQ6 A;  5FDO A;  4BPI A;  1GJH A;  2O2M A;  2O2N A;  2ROC A;  2UXE A;  4ZIF A;  4D2L A;  4U2V A;  3QBR A;  2MEJ A;  1R2E A;  3CVA X;  1LXL A;  1YSI A;  3D7V A;  1ZY3 A;  5FMI A;  4ZII A;  4UF2 A;  2KUA A;  3KZ0 A;  4U2U A;  1F16 A;  1BXL A;  2KBW A;  2NLA A;  2MHS A;  4YJ4 A;  4BBC A;  1PQ1 A;  2YV6 A;  2JBX A;  2A5Y A;  4HW4 A;  2XA0 A;  2JCN A;  3IIG A;  4D2M A;  3IHE A;  3IIH A;  2K7W A;  2B48 A;  4BDU A;  1YSN A;  2VOI A;  4BPJ A;  4ZIH A;  1R2H A;  2I39 A;  4K5B C;  4ZBF A;  2ROD A;  3JRV A;  4G35 A;  3WIY A;  1YSW A;  4QNQ A;  5IEZ A;  1K3K A;  1Q59 A;  1R2D A;  1MAZ A;  1TY4 A;  2O2F A;  2VTY A;  1G5J A;  4BD6 A;  3IHD A;  4ZIE A;  4OQ5 A;  1PQ0 A;  4UF1 A;  3KJ1 A;  5C3F A;  3WIX A;  2NL9 A;  2O22 A;  2VVX A;  4BBD A;  2O42 A;  3BL2 A;  2PQK A;  4HW3 A;  2VOF A;  4B4S A;  2WH6 A;  5C6H A;  3DVU A;  4S0P A;  1R2G A;  2VVY A;  4S0O A;  3KJ0 A;  4HW2 A;  1R2I A;  2IMS A;  5FC4 A;  3ILC A;  4BD7 A;  2IMT A;  2VVW A;  2XPX A;  2ME8 A; 
#chains in the Genus database with same CATH homology
 5JSB A;  5IF4 A;  2M5B A;  5KU9 A;  4ZIG A;  2ABO A;  2BID A;  4MI8 A;  2JM6 B;  1WSX A;  2O21 A;  1DDB A;  1G5M A;  4OYD A;  4YK9 A;  4BD2 A;  3MK8 A;  2VOH A;  2V6Q A;  4WMR A;  3PK1 A;  2VOG A;  4ZEQ A;  1YSG A;  3KJ2 A;  3I1H A;  3IHC A;  1MK3 A;  4BD8 A;  1O0L A;  2BZW A;  4QVX A;  3MQP A;  2VM6 A;  1AF3 A;  5KTG A;  3IO9 A;  2W3L A;  5FDR A;  1OHU A;  4ZBI A;  2LR1 A;  4OQ6 A;  5FDO A;  4BPI A;  1GJH A;  2O2M A;  2O2N A;  2ROC A;  4ZIF A;  4U2V A;  3QBR A;  2MEJ A;  1R2E A;  3CVA X;  1LXL A;  1YSI A;  3D7V A;  1ZY3 A;  5FMI A;  4ZII A;  2KUA A;  3KZ0 A;  4U2U A;  1F16 A;  1BXL A;  2KBW A;  2NLA A;  2MHS A;  4YJ4 A;  1PQ1 A;  2YV6 A;  2A5Y A;  4HW4 A;  2XA0 A;  2JCN A;  3IIG A;  3IHE A;  3IIH A;  2K7W A;  2B48 A;  4BDU A;  1YSN A;  2VOI A;  4BPJ A;  4ZIH A;  1R2H A;  4K5B C;  4ZBF A;  2ROD A;  4G35 A;  3WIY A;  1YSW A;  4QNQ A;  5IEZ A;  1K3K A;  1Q59 A;  1R2D A;  1MAZ A;  1TY4 A;  2O2F A;  1G5J A;  4BD6 A;  3IHD A;  4ZIE A;  4OQ5 A;  1PQ0 A;  3KJ1 A;  5C3F A;  3WIX A;  2NL9 A;  2O22 A;  3BL2 A;  2PQK A;  4HW3 A;  2VOF A;  4B4S A;  2WH6 A;  5C6H A;  3DVU A;  4S0P A;  1R2G A;  4S0O A;  3KJ0 A;  4HW2 A;  1R2I A;  2IMS A;  5FC4 A;  3ILC A;  4BD7 A;  2IMT A;  2XPX A;  2ME8 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...