3AH3 | Genus

Total Genus 109

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	109
sequence length	333
structure length	333
Chain Sequence	AYRICLIEGDGIGYEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPEETVVKILSCHATLFGAATIPTRKVPGFFGAIMALRRRLDLYANVRPAKSRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCATQLVMRPERYDVIVTTNLLGDILSDLAAGLMGGLGLAPSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVLERGPMTPDLGGDATTEAFTEAVVEALKSL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution pubmed doi rcsb
molecule keywords	Homoisocitrate dehydrogenase
molecule tags	Oxidoreductase
source organism	Thermus thermophilus
total genus	109
structure length	333
sequence length	333
chains with identical sequence	B, C, D
ec nomenclature	ec 1.1.1.87: Homoisocitrate dehydrogenase.
pdb deposition date	2010-04-13

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	3ah3A00

1LWDA 1XKDA 1AI3A 1YXOA 3R8WA 1IDEA 3MASB 5L58A 5L57A 4I3LA 3UDOA 4UMXA 4AOUA 2Y40A 1X0LA 4ATYA 1GRPA 4JQPA 5GRLB 5LGEA 4XRXA 1CW7A 2QFVA 4JA8A 2Y41A 3INMA 9ICDA 3MASA 1YCOA 1A05A 2ZTWA 5GRHB 4AJBA 1U7NA 3ASJA 4AOYA 1XABA 1PS7A 2E5MA 1PTMA 5GRIA 1ISOA 1GC8A 1IDMA 3ICDA 5GRHA 3BLXA 4IWHA 3TY4A 3UDUA 3MAPA 2IV0A 1VI1A 5GREB 3WZYA 7ICDA 4UMYA 4AJAA 1DR0A 1CW1A 5I95A 1WPWA 1W0DA 5J34A 5DE1A 2HI1A 2Y42A 3VMLA 5GREA 1OSIA 1PS6A 6ICDA 3LXYA 1WALA 4XXVA 1HJ6A 1PB3A 3FLKA 4L06A 3WZVA 3MARA 3BLVB 1IDCA 4L04A 2D4VA 4AJCA 5GRLA 1VLCA 1IKAA 1ZORA 3VL4A 5I96A 2UXQA 3VL6A 1IPDA 5HN6A 1XGVA 1GROA 1V5BA 3FMXX 1GC9A 2DHTA 4BNPA 3BLVA 4AOVA 5ICDA 3U9EA 4I3KA 3US8A 8ICDA 4XS3A 5J32A 3VL3A 1PB1A 5HN4A 3VKZA 4P69C 1HEXA 1IDFA 4ICDA 1SJSA 4AJRA 1CM7A 3TNGA 3UF6A 4HCXA 1XADA 3TY3A 1IDDA 4AJ3A 3WZWA 4WUOA 1TYOA 1XACA 2UXRA 5K10A 1HQSA 4L03A 2AYQA 1R8KA 5HN5A 1V94A 4KZOA 3TSNA 1DR8A 3VMJA 4Y1PA 2QFYA 3U1HA 1CW4A 3VMKA 3VL2A 1P8FA 5HN3A 2QFWA 1BL5A 4YB4A 5GRIB 4AJSA 1T09A 3VL7A 1DPZA 5GRFB 2E0CA 1G2UA 3AH3A 3BLXB 2G4OA 5J33A 3WZXA 2D1CA 1CNZA 1AI2A 3LCBC 5GRFA 1T0LA 1XAAA 1OSJA 3DMSA 4F7IA 1V53A 2QFXA 2Y3ZA 5K11A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1LWD A;  1XKD A;  1AI3 A;  1YXO A;  3R8W A;  1IDE A;  3MAS B;  5L58 A;  5L57 A;  4I3L A;  3UDO A;  4UMX A;  4AOU A;  2Y40 A;  1X0L A;  4ATY A;  1GRP A;  4JQP A;  5GRL B;  5LGE A;  4XRX A;  1CW7 A;  2QFV A;  4JA8 A;  2Y41 A;  3INM A;  9ICD A;  3MAS A;  1YCO A;  1A05 A;  2ZTW A;  5GRH B;  4AJB A;  1U7N A;  3ASJ A;  4AOY A;  1XAB A;  1PS7 A;  2E5M A;  1PTM A;  5GRI A;  1ISO A;  1GC8 A;  1IDM A;  3ICD A;  5GRH A;  3BLX A;  4IWH A;  3TY4 A;  3UDU A;  3MAP A;  2IV0 A;  1VI1 A;  5GRE B;  3WZY A;  7ICD A;  4UMY A;  4AJA A;  1DR0 A;  1CW1 A;  5I95 A;  1WPW A;  1W0D A;  5J34 A;  5DE1 A;  2HI1 A;  2Y42 A;  3VML A;  5GRE A;  1OSI A;  1PS6 A;  6ICD A;  3LXY A;  1WAL A;  4XXV A;  1HJ6 A;  1PB3 A;  3FLK A;  4L06 A;  3WZV A;  3MAR A;  3BLV B;  1IDC A;  4L04 A;  2D4V A;  4AJC A;  5GRL A;  1VLC A;  1IKA A;  1ZOR A;  3VL4 A;  5I96 A;  2UXQ A;  3VL6 A;  1IPD A;  5HN6 A;  1XGV A;  1GRO A;  1V5B A;  3FMX X;  1GC9 A;  2DHT A;  4BNP A;  3BLV A;  4AOV A;  5ICD A;  3U9E A;  4I3K A;  3US8 A;  8ICD A;  4XS3 A;  5J32 A;  3VL3 A;  1PB1 A;  5HN4 A;  3VKZ A;  4P69 C;  1HEX A;  1IDF A;  4ICD A;  1SJS A;  4AJR A;  1CM7 A;  3TNG A;  3UF6 A;  4HCX A;  1XAD A;  3TY3 A;  1IDD A;  4AJ3 A;  3WZW A;  4WUO A;  1TYO A;  1XAC A;  2UXR A;  5K10 A;  1HQS A;  4L03 A;  2AYQ A;  1R8K A;  5HN5 A;  1V94 A;  4KZO A;  3TSN A;  1DR8 A;  3VMJ A;  4Y1P A;  2QFY A;  3U1H A;  1CW4 A;  3VMK A;  3VL2 A;  1P8F A;  5HN3 A;  2QFW A;  1BL5 A;  4YB4 A;  5GRI B;  4AJS A;  1T09 A;  3VL7 A;  1DPZ A;  5GRF B;  2E0C A;  1G2U A;  3AH3 A;  3BLX B;  2G4O A;  5J33 A;  3WZX A;  2D1C A;  1CNZ A;  1AI2 A;  3LCB C;  5GRF A;  1T0L A;  1XAA A;  1OSJ A;  3DMS A;  4F7I A;  1V53 A;  2QFX A;  2Y3Z A;  5K11 A; 
#chains in the Genus database with same CATH topology
 1LWD A;  1XKD A;  1AI3 A;  1YXO A;  3R8W A;  1IDE A;  3MAS B;  5L58 A;  5L57 A;  4I3L A;  3UDO A;  4UMX A;  4AOU A;  2Y40 A;  1X0L A;  4ATY A;  1GRP A;  4JQP A;  5GRL B;  5LGE A;  4XRX A;  1CW7 A;  2QFV A;  4JA8 A;  2Y41 A;  3INM A;  9ICD A;  3MAS A;  1YCO A;  1A05 A;  2ZTW A;  5GRH B;  4AJB A;  1U7N A;  3ASJ A;  4AOY A;  1XAB A;  1PS7 A;  2E5M A;  1PTM A;  5GRI A;  1ISO A;  1GC8 A;  1IDM A;  3ICD A;  5GRH A;  3BLX A;  4IWH A;  3TY4 A;  3UDU A;  3MAP A;  2IV0 A;  1VI1 A;  5GRE B;  3WZY A;  7ICD A;  4UMY A;  4AJA A;  1DR0 A;  1CW1 A;  5I95 A;  1WPW A;  1W0D A;  5J34 A;  5DE1 A;  2HI1 A;  2Y42 A;  3VML A;  5GRE A;  1OSI A;  1PS6 A;  6ICD A;  3LXY A;  1WAL A;  4XXV A;  1HJ6 A;  1PB3 A;  3FLK A;  4L06 A;  3WZV A;  3MAR A;  3BLV B;  1IDC A;  4L04 A;  2D4V A;  4AJC A;  5GRL A;  1VLC A;  1IKA A;  1ZOR A;  3VL4 A;  5I96 A;  2UXQ A;  3VL6 A;  1IPD A;  5HN6 A;  1XGV A;  1GRO A;  1V5B A;  3FMX X;  1GC9 A;  2DHT A;  4BNP A;  3BLV A;  4AOV A;  5ICD A;  3U9E A;  4I3K A;  3US8 A;  8ICD A;  4XS3 A;  5J32 A;  3VL3 A;  1PB1 A;  5HN4 A;  3VKZ A;  4P69 C;  1HEX A;  1IDF A;  4ICD A;  1SJS A;  4AJR A;  1CM7 A;  3TNG A;  3UF6 A;  4HCX A;  1XAD A;  3TY3 A;  1IDD A;  4AJ3 A;  3WZW A;  4WUO A;  1TYO A;  1XAC A;  2UXR A;  5K10 A;  1HQS A;  4L03 A;  2AYQ A;  1R8K A;  5HN5 A;  1V94 A;  4KZO A;  3TSN A;  1DR8 A;  3VMJ A;  4Y1P A;  2QFY A;  3U1H A;  1CW4 A;  3VMK A;  3VL2 A;  1P8F A;  5HN3 A;  2QFW A;  1BL5 A;  4YB4 A;  5GRI B;  4AJS A;  1T09 A;  3VL7 A;  1DPZ A;  5GRF B;  2E0C A;  1G2U A;  3AH3 A;  3BLX B;  2G4O A;  5J33 A;  3WZX A;  2D1C A;  1CNZ A;  1AI2 A;  3LCB C;  5GRF A;  1T0L A;  1XAA A;  1OSJ A;  3DMS A;  4F7I A;  1V53 A;  2QFX A;  2Y3Z A;  5K11 A; 
#chains in the Genus database with same CATH homology
 1LWD A;  1XKD A;  1AI3 A;  1YXO A;  3R8W A;  1IDE A;  3MAS B;  5L58 A;  5L57 A;  4I3L A;  3UDO A;  4UMX A;  4AOU A;  2Y40 A;  1X0L A;  4ATY A;  1GRP A;  4JQP A;  5GRL B;  5LGE A;  4XRX A;  1CW7 A;  2QFV A;  4JA8 A;  2Y41 A;  3INM A;  9ICD A;  3MAS A;  1YCO A;  1A05 A;  2ZTW A;  5GRH B;  4AJB A;  1U7N A;  3ASJ A;  4AOY A;  1XAB A;  1PS7 A;  2E5M A;  1PTM A;  5GRI A;  1ISO A;  1GC8 A;  1IDM A;  3ICD A;  5GRH A;  3BLX A;  4IWH A;  3TY4 A;  3UDU A;  3MAP A;  2IV0 A;  1VI1 A;  5GRE B;  3WZY A;  7ICD A;  4UMY A;  4AJA A;  1DR0 A;  1CW1 A;  5I95 A;  1WPW A;  1W0D A;  5J34 A;  5DE1 A;  2HI1 A;  2Y42 A;  3VML A;  5GRE A;  1OSI A;  1PS6 A;  6ICD A;  3LXY A;  1WAL A;  4XXV A;  1HJ6 A;  1PB3 A;  3FLK A;  4L06 A;  3WZV A;  3MAR A;  3BLV B;  1IDC A;  4L04 A;  2D4V A;  4AJC A;  5GRL A;  1VLC A;  1IKA A;  1ZOR A;  3VL4 A;  5I96 A;  2UXQ A;  3VL6 A;  1IPD A;  5HN6 A;  1XGV A;  1GRO A;  1V5B A;  3FMX X;  1GC9 A;  2DHT A;  4BNP A;  3BLV A;  4AOV A;  5ICD A;  3U9E A;  4I3K A;  3US8 A;  8ICD A;  4XS3 A;  5J32 A;  3VL3 A;  1PB1 A;  5HN4 A;  3VKZ A;  4P69 C;  1HEX A;  1IDF A;  4ICD A;  1SJS A;  4AJR A;  1CM7 A;  3TNG A;  3UF6 A;  4HCX A;  1XAD A;  3TY3 A;  1IDD A;  4AJ3 A;  3WZW A;  4WUO A;  1TYO A;  1XAC A;  2UXR A;  5K10 A;  1HQS A;  4L03 A;  2AYQ A;  1R8K A;  5HN5 A;  1V94 A;  4KZO A;  3TSN A;  1DR8 A;  3VMJ A;  4Y1P A;  2QFY A;  3U1H A;  1CW4 A;  3VMK A;  3VL2 A;  1P8F A;  5HN3 A;  2QFW A;  1BL5 A;  4YB4 A;  5GRI B;  4AJS A;  1T09 A;  3VL7 A;  1DPZ A;  5GRF B;  2E0C A;  1G2U A;  3AH3 A;  3BLX B;  2G4O A;  5J33 A;  3WZX A;  2D1C A;  1CNZ A;  1AI2 A;  3LCB C;  5GRF A;  1T0L A;  1XAA A;  1OSJ A;  3DMS A;  4F7I A;  1V53 A;  2QFX A;  2Y3Z A;  5K11 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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3AH3A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations