3AH3 | Genus

Total Genus 109

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	109
sequence length	333
structure length	333
Chain Sequence	AYRICLIEGDGIGYEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPEETVVKILSCHATLFGAATIPTRKVPGFFGAIMALRRRLDLYANVRPAKSRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCATQLVMRPERYDVIVTTNLLGDILSDLAAGLMGGLGLAPSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVLERGPMTPDLGGDATTEAFTEAVVEALKSL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Thermus thermophilus
publication title	Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution pubmed doi rcsb
molecule keywords	Homoisocitrate dehydrogenase
total genus	109
structure length	333
sequence length	333
chains with identical sequence	B, C, D
ec nomenclature	ec 1.1.1.87: Homoisocitrate dehydrogenase.
pdb deposition date	2010-04-13

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	3ah3A00

2QFYA 5GRIB 1V53A 3UF6A 1V5BA 1TYOA 4AJ3A 4XXVA 1X0LA 1AI2A 4YB4A 1CNZA 2ZTWA 1GC9A 5DE1A 3VL7A 3MAPA 5GRHA 5GREB 4L06A 3WZWA 2DHTA 2AYQA 5HN6A 1SJSA 4F7IA 1WPWA 1XGVA 4AJSA 1DR0A 3VMKA 4UMYA 2D1CA 5J34A 5ICDA 3VL3A 3VL4A 3R8WA 4AOVA 1VI1A 5J32A 2E0CA 1PB3A 4ICDA 4BNPA 3U1HA 1PS6A 5K10A 3ASJA 3MASA 1T09A 1GRPA 1AI3A 4JQPA 3UDUA 5HN4A 3AH3A 1HJ6A 3ICDA 3FLKA 5L57A 5HN5A 5GRFA 4JA8A 4UMXA 5I95A 4AJBA 3TY4A 4I3LA 4IWHA 4KZOA 1YCOA 3DMSA 3BLXA 1IDMA 1P8FA 1DPZA 1IDFA 2QFWA 1XABA 3BLVA 4AJAA 2UXRA 8ICDA 1XAAA 4L04A 7ICDA 3TNGA 3WZVA 1GC8A 1W0DA 1CW4A 3US8A 2HI1A 1IDCA 3LXYA 3MASB 3VKZA 5LGEA 1XACA 9ICDA 5HN3A 4AJCA 1IPDA 1T0LA 3TY3A 1CW1A 1CM7A 3WZYA 4ATYA 5J33A 3VMJA 1OSJA 2Y3ZA 2UXQA 2G4OA 5GRFB 5GRHB 3INMA 5K11A 2Y41A 1GROA 2D4VA 4L03A 3UDOA 3VMLA 1VLCA 3BLXB 3BLVB 5GRLA 1LWDA 1IDEA 1XKDA 1IKAA 4P69C 3U9EA 2QFXA 3FMXX 5I96A 1OSIA 1PB1A 3VL6A 1BL5A 1CW7A 3WZXA 1R8KA 5GRIA 1U7NA 4AOYA 4AOUA 5L58A 1G2UA 1ZORA 4I3KA 4HCXA 4XS3A 4WUOA 4AJRA 1YXOA 1WALA 2Y42A 3LCBC 3VL2A 1V94A 4Y1PA 6ICDA 3TSNA 2IV0A 5GREA 5GRLB 1HQSA 1IDDA 1XADA 4XRXA 2QFVA 3MARA 2E5MA 1PTMA 2Y40A 1HEXA 1PS7A 1ISOA 1DR8A 1A05A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 2QFY A;  5GRI B;  1V53 A;  3UF6 A;  1V5B A;  1TYO A;  4AJ3 A;  4XXV A;  1X0L A;  1AI2 A;  4YB4 A;  1CNZ A;  2ZTW A;  1GC9 A;  5DE1 A;  3VL7 A;  3MAP A;  5GRH A;  5GRE B;  4L06 A;  3WZW A;  2DHT A;  2AYQ A;  5HN6 A;  1SJS A;  4F7I A;  1WPW A;  1XGV A;  4AJS A;  1DR0 A;  3VMK A;  4UMY A;  2D1C A;  5J34 A;  5ICD A;  3VL3 A;  3VL4 A;  3R8W A;  4AOV A;  1VI1 A;  5J32 A;  2E0C A;  1PB3 A;  4ICD A;  4BNP A;  3U1H A;  1PS6 A;  5K10 A;  3ASJ A;  3MAS A;  1T09 A;  1GRP A;  1AI3 A;  4JQP A;  3UDU A;  5HN4 A;  3AH3 A;  1HJ6 A;  3ICD A;  3FLK A;  5L57 A;  5HN5 A;  5GRF A;  4JA8 A;  4UMX A;  5I95 A;  4AJB A;  3TY4 A;  4I3L A;  4IWH A;  4KZO A;  1YCO A;  3DMS A;  3BLX A;  1IDM A;  1P8F A;  1DPZ A;  1IDF A;  2QFW A;  1XAB A;  3BLV A;  4AJA A;  2UXR A;  8ICD A;  1XAA A;  4L04 A;  7ICD A;  3TNG A;  3WZV A;  1GC8 A;  1W0D A;  1CW4 A;  3US8 A;  2HI1 A;  1IDC A;  3LXY A;  3MAS B;  3VKZ A;  5LGE A;  1XAC A;  9ICD A;  5HN3 A;  4AJC A;  1IPD A;  1T0L A;  3TY3 A;  1CW1 A;  1CM7 A;  3WZY A;  4ATY A;  5J33 A;  3VMJ A;  1OSJ A;  2Y3Z A;  2UXQ A;  2G4O A;  5GRF B;  5GRH B;  3INM A;  5K11 A;  2Y41 A;  1GRO A;  2D4V A;  4L03 A;  3UDO A;  3VML A;  1VLC A;  3BLX B;  3BLV B;  5GRL A;  1LWD A;  1IDE A;  1XKD A;  1IKA A;  4P69 C;  3U9E A;  2QFX A;  3FMX X;  5I96 A;  1OSI A;  1PB1 A;  3VL6 A;  1BL5 A;  1CW7 A;  3WZX A;  1R8K A;  5GRI A;  1U7N A;  4AOY A;  4AOU A;  5L58 A;  1G2U A;  1ZOR A;  4I3K A;  4HCX A;  4XS3 A;  4WUO A;  4AJR A;  1YXO A;  1WAL A;  2Y42 A;  3LCB C;  3VL2 A;  1V94 A;  4Y1P A;  6ICD A;  3TSN A;  2IV0 A;  5GRE A;  5GRL B;  1HQS A;  1IDD A;  1XAD A;  4XRX A;  2QFV A;  3MAR A;  2E5M A;  1PTM A;  2Y40 A;  1HEX A;  1PS7 A;  1ISO A;  1DR8 A;  1A05 A; 
#chains in the Genus database with same CATH topology
 2QFY A;  5GRI B;  1V53 A;  3UF6 A;  1V5B A;  1TYO A;  4AJ3 A;  4XXV A;  1X0L A;  1AI2 A;  4YB4 A;  1CNZ A;  2ZTW A;  1GC9 A;  5DE1 A;  3VL7 A;  3MAP A;  5GRH A;  5GRE B;  4L06 A;  3WZW A;  2DHT A;  2AYQ A;  5HN6 A;  1SJS A;  4F7I A;  1WPW A;  1XGV A;  4AJS A;  1DR0 A;  3VMK A;  4UMY A;  2D1C A;  5J34 A;  5ICD A;  3VL3 A;  3VL4 A;  3R8W A;  4AOV A;  1VI1 A;  5J32 A;  2E0C A;  1PB3 A;  4ICD A;  4BNP A;  3U1H A;  1PS6 A;  5K10 A;  3ASJ A;  3MAS A;  1T09 A;  1GRP A;  1AI3 A;  4JQP A;  3UDU A;  5HN4 A;  3AH3 A;  1HJ6 A;  3ICD A;  3FLK A;  5L57 A;  5HN5 A;  5GRF A;  4JA8 A;  4UMX A;  5I95 A;  4AJB A;  3TY4 A;  4I3L A;  4IWH A;  4KZO A;  1YCO A;  3DMS A;  3BLX A;  1IDM A;  1P8F A;  1DPZ A;  1IDF A;  2QFW A;  1XAB A;  3BLV A;  4AJA A;  2UXR A;  8ICD A;  1XAA A;  4L04 A;  7ICD A;  3TNG A;  3WZV A;  1GC8 A;  1W0D A;  1CW4 A;  3US8 A;  2HI1 A;  1IDC A;  3LXY A;  3MAS B;  3VKZ A;  5LGE A;  1XAC A;  9ICD A;  5HN3 A;  4AJC A;  1IPD A;  1T0L A;  3TY3 A;  1CW1 A;  1CM7 A;  3WZY A;  4ATY A;  5J33 A;  3VMJ A;  1OSJ A;  2Y3Z A;  2UXQ A;  2G4O A;  5GRF B;  5GRH B;  3INM A;  5K11 A;  2Y41 A;  1GRO A;  2D4V A;  4L03 A;  3UDO A;  3VML A;  1VLC A;  3BLX B;  3BLV B;  5GRL A;  1LWD A;  1IDE A;  1XKD A;  1IKA A;  4P69 C;  3U9E A;  2QFX A;  3FMX X;  5I96 A;  1OSI A;  1PB1 A;  3VL6 A;  1BL5 A;  1CW7 A;  3WZX A;  1R8K A;  5GRI A;  1U7N A;  4AOY A;  4AOU A;  5L58 A;  1G2U A;  1ZOR A;  4I3K A;  4HCX A;  4XS3 A;  4WUO A;  4AJR A;  1YXO A;  1WAL A;  2Y42 A;  3LCB C;  3VL2 A;  1V94 A;  4Y1P A;  6ICD A;  3TSN A;  2IV0 A;  5GRE A;  5GRL B;  1HQS A;  1IDD A;  1XAD A;  4XRX A;  2QFV A;  3MAR A;  2E5M A;  1PTM A;  2Y40 A;  1HEX A;  1PS7 A;  1ISO A;  1DR8 A;  1A05 A; 
#chains in the Genus database with same CATH homology
 2QFY A;  5GRI B;  1V53 A;  3UF6 A;  1V5B A;  1TYO A;  4AJ3 A;  4XXV A;  1X0L A;  1AI2 A;  4YB4 A;  1CNZ A;  2ZTW A;  1GC9 A;  5DE1 A;  3VL7 A;  3MAP A;  5GRH A;  5GRE B;  4L06 A;  3WZW A;  2DHT A;  2AYQ A;  5HN6 A;  1SJS A;  4F7I A;  1WPW A;  1XGV A;  4AJS A;  1DR0 A;  3VMK A;  4UMY A;  2D1C A;  5J34 A;  5ICD A;  3VL3 A;  3VL4 A;  3R8W A;  4AOV A;  1VI1 A;  5J32 A;  2E0C A;  1PB3 A;  4ICD A;  4BNP A;  3U1H A;  1PS6 A;  5K10 A;  3ASJ A;  3MAS A;  1T09 A;  1GRP A;  1AI3 A;  4JQP A;  3UDU A;  5HN4 A;  3AH3 A;  1HJ6 A;  3ICD A;  3FLK A;  5L57 A;  5HN5 A;  5GRF A;  4JA8 A;  4UMX A;  5I95 A;  4AJB A;  3TY4 A;  4I3L A;  4IWH A;  4KZO A;  1YCO A;  3DMS A;  3BLX A;  1IDM A;  1P8F A;  1DPZ A;  1IDF A;  2QFW A;  1XAB A;  3BLV A;  4AJA A;  2UXR A;  8ICD A;  1XAA A;  4L04 A;  7ICD A;  3TNG A;  3WZV A;  1GC8 A;  1W0D A;  1CW4 A;  3US8 A;  2HI1 A;  1IDC A;  3LXY A;  3MAS B;  3VKZ A;  5LGE A;  1XAC A;  9ICD A;  5HN3 A;  4AJC A;  1IPD A;  1T0L A;  3TY3 A;  1CW1 A;  1CM7 A;  3WZY A;  4ATY A;  5J33 A;  3VMJ A;  1OSJ A;  2Y3Z A;  2UXQ A;  2G4O A;  5GRF B;  5GRH B;  3INM A;  5K11 A;  2Y41 A;  1GRO A;  2D4V A;  4L03 A;  3UDO A;  3VML A;  1VLC A;  3BLX B;  3BLV B;  5GRL A;  1LWD A;  1IDE A;  1XKD A;  1IKA A;  4P69 C;  3U9E A;  2QFX A;  3FMX X;  5I96 A;  1OSI A;  1PB1 A;  3VL6 A;  1BL5 A;  1CW7 A;  3WZX A;  1R8K A;  5GRI A;  1U7N A;  4AOY A;  4AOU A;  5L58 A;  1G2U A;  1ZOR A;  4I3K A;  4HCX A;  4XS3 A;  4WUO A;  4AJR A;  1YXO A;  1WAL A;  2Y42 A;  3LCB C;  3VL2 A;  1V94 A;  4Y1P A;  6ICD A;  3TSN A;  2IV0 A;  5GRE A;  5GRL B;  1HQS A;  1IDD A;  1XAD A;  4XRX A;  2QFV A;  3MAR A;  2E5M A;  1PTM A;  2Y40 A;  1HEX A;  1PS7 A;  1ISO A;  1DR8 A;  1A05 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3AH3A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations