The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
56
|
sequence length |
151
|
structure length |
144
|
Chain Sequence |
DDLYRQSLEIISRYLREQATGSKDGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
pubmed doi rcsb |
| molecule keywords |
Induced myeloid leukemia cell differentiation protein Mcl-1
|
| molecule tags |
Apoptosis
|
| source organism |
Mus musculus
|
| total genus |
56
|
| structure length |
144
|
| sequence length |
151
|
| ec nomenclature | |
| pdb deposition date | 2008-05-22 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Apoptosis Regulator Bcl-x | Blc2-like |
#chains in the Genus database with same CATH superfamily 4B4S A; 4BPJ A; 4OYD A; 4K5B C; 5C3F A; 2B48 A; 3D7V A; 1OHU A; 2VOF A; 5FDO A; 5JSB A; 1R2D A; 1R2I A; 1AF3 A; 4QNQ A; 3IO9 A; 2JCN A; 2NLA A; 3QBR A; 1LXL A; 2KBW A; 4YJ4 A; 1ZY3 A; 2O21 A; 3CVA X; 2MHS A; 4WMR A; 2XPX A; 4ZIF A; 3BL2 A; 3IHE A; 2JM6 B; 3KJ2 A; 4HW2 A; 3WIY A; 1G5J A; 2VOI A; 3WIX A; 3I1H A; 1Q59 A; 3IHC A; 2O2F A; 4G35 A; 1TY4 A; 3DVU A; 4QVX A; 2K7W A; 2MEJ A; 5IEZ A; 5KU9 A; 5IF4 A; 2O22 A; 2VOH A; 1K3K A; 3ILC A; 2BZW A; 4S0P A; 4OQ5 A; 4U2V A; 2BID A; 2ME8 A; 4BDU A; 1O0L A; 5FC4 A; 2WH6 A; 1F16 A; 4ZII A; 2M5B A; 3MQP A; 2VM6 A; 1MK3 A; 2IMT A; 2LR1 A; 2ROC A; 3IHD A; 4S0O A; 2ABO A; 4BD7 A; 5KTG A; 1WSX A; 2O2M A; 1R2G A; 4MI8 A; 2YV6 A; 2PQK A; 4OQ6 A; 5C6H A; 3IIG A; 1YSG A; 4HW4 A; 4HW3 A; 4BD6 A; 4BD2 A; 1PQ1 A; 1G5M A; 4BD8 A; 1YSI A; 4ZIH A; 1PQ0 A; 1MAZ A; 3MK8 A; 5FMI A; 3KJ0 A; 4BPI A; 2W3L A; 2ROD A; 1YSN A; 2VOG A; 4ZBF A; 1YSW A; 4U2U A; 1R2H A; 4ZIG A; 2KUA A; 2IMS A; 1DDB A; 4ZIE A; 2V6Q A; 2XA0 A; 4ZBI A; 3PK1 A; 1BXL A; 5FDR A; 3KZ0 A; 2NL9 A; 3KJ1 A; 4YK9 A; 1R2E A; 4ZEQ A; 3IIH A; 2A5Y A; 1GJH A; 2O2N A; #chains in the Genus database with same CATH topology 4B4S A; 4BPJ A; 4OYD A; 4K5B C; 4D2L A; 2B48 A; 5C3F A; 2K36 A; 3JRV A; 2VVW A; 3D7V A; 1OHU A; 2VOF A; 5FDO A; 5JSB A; 1R2D A; 1R2I A; 1AF3 A; 4QNQ A; 3IO9 A; 2JCN A; 2NLA A; 3QBR A; 1LXL A; 2KBW A; 4YJ4 A; 1ZY3 A; 2O21 A; 4M0S A; 3CVA X; 2MHS A; 4WMR A; 4BBC A; 2XPX A; 4ZIF A; 3BL2 A; 2JM6 B; 3IHE A; 3KJ2 A; 4HW2 A; 3WIY A; 1G5J A; 2VOI A; 3WIX A; 4UF3 A; 2UXE A; 2I39 A; 1Q59 A; 3I1H A; 4UF1 A; 3IHC A; 2O2F A; 4G35 A; 1TY4 A; 3DVU A; 4QVX A; 2K7W A; 2MEJ A; 2O42 A; 5IEZ A; 5KU9 A; 5IF4 A; 4BBD A; 2O22 A; 2VOH A; 1K3K A; 3ILC A; 2BZW A; 4S0P A; 4OQ5 A; 4U2V A; 2BID A; 2ME8 A; 4BDU A; 1O0L A; 2VVX A; 5FC4 A; 2WH6 A; 1F16 A; 4ZII A; 2M5B A; 3MQP A; 2VM6 A; 1MK3 A; 2IMT A; 2LR1 A; 2ROC A; 3IHD A; 4S0O A; 2ABO A; 4BD7 A; 5KTG A; 4LQK A; 1WSX A; 2O2M A; 1R2G A; 4MI8 A; 2YV6 A; 2PQK A; 4OQ6 A; 4D2M A; 5C6H A; 3IIG A; 1YSG A; 4HW4 A; 4BBB A; 4HW3 A; 4BD6 A; 4BD2 A; 1PQ1 A; 1G5M A; 2JBX A; 4BD8 A; 1YSI A; 4ZIH A; 4UF2 A; 1PQ0 A; 1MAZ A; 3MK8 A; 5FMI A; 3KJ0 A; 4BPI A; 2W3L A; 2VTY A; 2ROD A; 2VVY A; 1YSN A; 2VOG A; 4ZBF A; 1YSW A; 4U2U A; 1R2H A; 4ZIG A; 2KUA A; 2JBY A; 2IMS A; 1DDB A; 4ZIE A; 2V6Q A; 2XA0 A; 4ZBI A; 3PK1 A; 1BXL A; 5FDR A; 3KZ0 A; 2NL9 A; 3KJ1 A; 4YK9 A; 1R2E A; 4ZEQ A; 3IIH A; 2A5Y A; 1GJH A; 2O2N A; #chains in the Genus database with same CATH homology 4B4S A; 4BPJ A; 4OYD A; 4K5B C; 5C3F A; 2B48 A; 3D7V A; 1OHU A; 2VOF A; 5FDO A; 5JSB A; 1R2D A; 1R2I A; 1AF3 A; 4QNQ A; 3IO9 A; 2JCN A; 2NLA A; 3QBR A; 1LXL A; 2KBW A; 4YJ4 A; 1ZY3 A; 2O21 A; 3CVA X; 2MHS A; 4WMR A; 2XPX A; 4ZIF A; 3BL2 A; 3IHE A; 2JM6 B; 3KJ2 A; 4HW2 A; 3WIY A; 1G5J A; 2VOI A; 3WIX A; 3I1H A; 1Q59 A; 3IHC A; 2O2F A; 4G35 A; 1TY4 A; 3DVU A; 4QVX A; 2K7W A; 2MEJ A; 5IEZ A; 5KU9 A; 5IF4 A; 2O22 A; 2VOH A; 1K3K A; 3ILC A; 2BZW A; 4S0P A; 4OQ5 A; 4U2V A; 2BID A; 2ME8 A; 4BDU A; 1O0L A; 5FC4 A; 2WH6 A; 1F16 A; 4ZII A; 2M5B A; 3MQP A; 2VM6 A; 1MK3 A; 2IMT A; 2LR1 A; 2ROC A; 3IHD A; 4S0O A; 2ABO A; 4BD7 A; 5KTG A; 1WSX A; 2O2M A; 1R2G A; 4MI8 A; 2YV6 A; 2PQK A; 4OQ6 A; 5C6H A; 3IIG A; 1YSG A; 4HW4 A; 4HW3 A; 4BD6 A; 4BD2 A; 1PQ1 A; 1G5M A; 4BD8 A; 1YSI A; 4ZIH A; 1PQ0 A; 1MAZ A; 3MK8 A; 5FMI A; 3KJ0 A; 4BPI A; 2W3L A; 2ROD A; 1YSN A; 2VOG A; 4ZBF A; 1YSW A; 4U2U A; 1R2H A; 4ZIG A; 2KUA A; 2IMS A; 1DDB A; 4ZIE A; 2V6Q A; 2XA0 A; 4ZBI A; 3PK1 A; 1BXL A; 5FDR A; 3KZ0 A; 2NL9 A; 3KJ1 A; 4YK9 A; 1R2E A; 4ZEQ A; 3IIH A; 2A5Y A; 1GJH A; 2O2N A;
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