3INM | Genus

Total Genus 152

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	152
sequence length	407
structure length	407
Chain Sequence	KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLA

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NADP] cytoplasmic
molecule tags	Oxidoreductase
source organism	Homo sapiens
total genus	152
structure length	407
sequence length	407
chains with identical sequence	B, C
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	2009-08-12

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	3inmA00

5I96A 1CM7A 1IDCA 2ZTWA 5LGEA 3BLXB 4AJBA 1ZORA 4JA8A 3TY3A 4AJCA 5J33A 4I3LA 3MAPA 2AYQA 2E5MA 3TNGA 1U7NA 2Y41A 4I3KA 4ICDA 5GRLA 1SJSA 1HJ6A 3AH3A 3MARA 5GREA 5J32A 2HI1A 1OSJA 3TSNA 1XACA 1XAAA 1XKDA 3ICDA 5HN4A 3WZXA 4AJRA 4AJSA 1DR8A 1AI3A 4IWHA 9ICDA 1PB3A 4Y1PA 1PS6A 4AOYA 1IDFA 3MASB 3WZYA 3VMKA 1IDEA 3FLKA 3FMXX 1OSIA 2QFVA 3BLVA 4AJ3A 3VL6A 1VLCA 2QFWA 1W0DA 1CW1A 4L06A 1PS7A 4P69C 1V94A 3UF6A 1LWDA 1R8KA 3VL3A 5HN3A 3U9EA 4AOUA 5ICDA 1YCOA 3LXYA 1GC9A 4L04A 4L03A 1PB1A 1AI2A 1CNZA 1VI1A 5DE1A 2UXQA 1T0LA 6ICDA 1GROA 2DHTA 4AOVA 2Y40A 2D1CA 5GRFA 1T09A 3VKZA 5L57A 5GRLB 5GREB 1P8FA 3ASJA 1YXOA 3VMLA 1XABA 4JQPA 1V5BA 1XGVA 4UMXA 5GRHA 1ISOA 2UXRA 2IV0A 3VL4A 3BLVB 5GRIA 5J34A 1WPWA 2G4OA 3WZVA 3BLXA 1IDDA 1IDMA 4UMYA 3TY4A 1DPZA 2Y42A 3LCBC 3U1HA 4WUOA 1DR0A 4F7IA 1HEXA 3VL7A 5L58A 4KZOA 1TYOA 1XADA 3VL2A 3R8WA 2QFYA 4HCXA 4YB4A 7ICDA 3MASA 1CW7A 5K10A 3DMSA 1A05A 2Y3ZA 3UDOA 1WALA 5GRFB 8ICDA 1G2UA 1BL5A 2E0CA 1V53A 5K11A 1GRPA 4AJAA 1HQSA 1X0LA 3UDUA 1CW4A 5HN6A 4XS3A 1GC8A 3US8A 5I95A 1IPDA 3VMJA 4BNPA 3WZWA 1PTMA 3INMA 4XXVA 5GRHB 4ATYA 4XRXA 5HN5A 1IKAA 2D4VA 5GRIB 2QFXA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 5I96 A;  1CM7 A;  1IDC A;  2ZTW A;  5LGE A;  3BLX B;  4AJB A;  1ZOR A;  4JA8 A;  3TY3 A;  4AJC A;  5J33 A;  4I3L A;  3MAP A;  2AYQ A;  2E5M A;  3TNG A;  1U7N A;  2Y41 A;  4I3K A;  4ICD A;  5GRL A;  1SJS A;  1HJ6 A;  3AH3 A;  3MAR A;  5GRE A;  5J32 A;  2HI1 A;  1OSJ A;  3TSN A;  1XAC A;  1XAA A;  1XKD A;  3ICD A;  5HN4 A;  3WZX A;  4AJR A;  4AJS A;  1DR8 A;  1AI3 A;  4IWH A;  9ICD A;  1PB3 A;  4Y1P A;  1PS6 A;  4AOY A;  1IDF A;  3MAS B;  3WZY A;  3VMK A;  1IDE A;  3FLK A;  3FMX X;  1OSI A;  2QFV A;  3BLV A;  4AJ3 A;  3VL6 A;  1VLC A;  2QFW A;  1W0D A;  1CW1 A;  4L06 A;  1PS7 A;  4P69 C;  1V94 A;  3UF6 A;  1LWD A;  1R8K A;  3VL3 A;  5HN3 A;  3U9E A;  4AOU A;  5ICD A;  1YCO A;  3LXY A;  1GC9 A;  4L04 A;  4L03 A;  1PB1 A;  1AI2 A;  1CNZ A;  1VI1 A;  5DE1 A;  2UXQ A;  1T0L A;  6ICD A;  1GRO A;  2DHT A;  4AOV A;  2Y40 A;  2D1C A;  5GRF A;  1T09 A;  3VKZ A;  5L57 A;  5GRL B;  5GRE B;  1P8F A;  3ASJ A;  1YXO A;  3VML A;  1XAB A;  4JQP A;  1V5B A;  1XGV A;  4UMX A;  5GRH A;  1ISO A;  2UXR A;  2IV0 A;  3VL4 A;  3BLV B;  5GRI A;  5J34 A;  1WPW A;  2G4O A;  3WZV A;  3BLX A;  1IDD A;  1IDM A;  4UMY A;  3TY4 A;  1DPZ A;  2Y42 A;  3LCB C;  3U1H A;  4WUO A;  1DR0 A;  4F7I A;  1HEX A;  3VL7 A;  5L58 A;  4KZO A;  1TYO A;  1XAD A;  3VL2 A;  3R8W A;  2QFY A;  4HCX A;  4YB4 A;  7ICD A;  3MAS A;  1CW7 A;  5K10 A;  3DMS A;  1A05 A;  2Y3Z A;  3UDO A;  1WAL A;  5GRF B;  8ICD A;  1G2U A;  1BL5 A;  2E0C A;  1V53 A;  5K11 A;  1GRP A;  4AJA A;  1HQS A;  1X0L A;  3UDU A;  1CW4 A;  5HN6 A;  4XS3 A;  1GC8 A;  3US8 A;  5I95 A;  1IPD A;  3VMJ A;  4BNP A;  3WZW A;  1PTM A;  3INM A;  4XXV A;  5GRH B;  4ATY A;  4XRX A;  5HN5 A;  1IKA A;  2D4V A;  5GRI B;  2QFX A; 
#chains in the Genus database with same CATH topology
 5I96 A;  1CM7 A;  1IDC A;  2ZTW A;  5LGE A;  3BLX B;  4AJB A;  1ZOR A;  4JA8 A;  3TY3 A;  4AJC A;  5J33 A;  4I3L A;  3MAP A;  2AYQ A;  2E5M A;  3TNG A;  1U7N A;  2Y41 A;  4I3K A;  4ICD A;  5GRL A;  1SJS A;  1HJ6 A;  3AH3 A;  3MAR A;  5GRE A;  5J32 A;  2HI1 A;  1OSJ A;  3TSN A;  1XAC A;  1XAA A;  1XKD A;  3ICD A;  5HN4 A;  3WZX A;  4AJR A;  4AJS A;  1DR8 A;  1AI3 A;  4IWH A;  9ICD A;  1PB3 A;  4Y1P A;  1PS6 A;  4AOY A;  1IDF A;  3MAS B;  3WZY A;  3VMK A;  1IDE A;  3FLK A;  3FMX X;  1OSI A;  2QFV A;  3BLV A;  4AJ3 A;  3VL6 A;  1VLC A;  2QFW A;  1W0D A;  1CW1 A;  4L06 A;  1PS7 A;  4P69 C;  1V94 A;  3UF6 A;  1LWD A;  1R8K A;  3VL3 A;  5HN3 A;  3U9E A;  4AOU A;  5ICD A;  1YCO A;  3LXY A;  1GC9 A;  4L04 A;  4L03 A;  1PB1 A;  1AI2 A;  1CNZ A;  1VI1 A;  5DE1 A;  2UXQ A;  1T0L A;  6ICD A;  1GRO A;  2DHT A;  4AOV A;  2Y40 A;  2D1C A;  5GRF A;  1T09 A;  3VKZ A;  5L57 A;  5GRL B;  5GRE B;  1P8F A;  3ASJ A;  1YXO A;  3VML A;  1XAB A;  4JQP A;  1V5B A;  1XGV A;  4UMX A;  5GRH A;  1ISO A;  2UXR A;  2IV0 A;  3VL4 A;  3BLV B;  5GRI A;  5J34 A;  1WPW A;  2G4O A;  3WZV A;  3BLX A;  1IDD A;  1IDM A;  4UMY A;  3TY4 A;  1DPZ A;  2Y42 A;  3LCB C;  3U1H A;  4WUO A;  1DR0 A;  4F7I A;  1HEX A;  3VL7 A;  5L58 A;  4KZO A;  1TYO A;  1XAD A;  3VL2 A;  3R8W A;  2QFY A;  4HCX A;  4YB4 A;  7ICD A;  3MAS A;  1CW7 A;  5K10 A;  3DMS A;  1A05 A;  2Y3Z A;  3UDO A;  1WAL A;  5GRF B;  8ICD A;  1G2U A;  1BL5 A;  2E0C A;  1V53 A;  5K11 A;  1GRP A;  4AJA A;  1HQS A;  1X0L A;  3UDU A;  1CW4 A;  5HN6 A;  4XS3 A;  1GC8 A;  3US8 A;  5I95 A;  1IPD A;  3VMJ A;  4BNP A;  3WZW A;  1PTM A;  3INM A;  4XXV A;  5GRH B;  4ATY A;  4XRX A;  5HN5 A;  1IKA A;  2D4V A;  5GRI B;  2QFX A; 
#chains in the Genus database with same CATH homology
 5I96 A;  1CM7 A;  1IDC A;  2ZTW A;  5LGE A;  3BLX B;  4AJB A;  1ZOR A;  4JA8 A;  3TY3 A;  4AJC A;  5J33 A;  4I3L A;  3MAP A;  2AYQ A;  2E5M A;  3TNG A;  1U7N A;  2Y41 A;  4I3K A;  4ICD A;  5GRL A;  1SJS A;  1HJ6 A;  3AH3 A;  3MAR A;  5GRE A;  5J32 A;  2HI1 A;  1OSJ A;  3TSN A;  1XAC A;  1XAA A;  1XKD A;  3ICD A;  5HN4 A;  3WZX A;  4AJR A;  4AJS A;  1DR8 A;  1AI3 A;  4IWH A;  9ICD A;  1PB3 A;  4Y1P A;  1PS6 A;  4AOY A;  1IDF A;  3MAS B;  3WZY A;  3VMK A;  1IDE A;  3FLK A;  3FMX X;  1OSI A;  2QFV A;  3BLV A;  4AJ3 A;  3VL6 A;  1VLC A;  2QFW A;  1W0D A;  1CW1 A;  4L06 A;  1PS7 A;  4P69 C;  1V94 A;  3UF6 A;  1LWD A;  1R8K A;  3VL3 A;  5HN3 A;  3U9E A;  4AOU A;  5ICD A;  1YCO A;  3LXY A;  1GC9 A;  4L04 A;  4L03 A;  1PB1 A;  1AI2 A;  1CNZ A;  1VI1 A;  5DE1 A;  2UXQ A;  1T0L A;  6ICD A;  1GRO A;  2DHT A;  4AOV A;  2Y40 A;  2D1C A;  5GRF A;  1T09 A;  3VKZ A;  5L57 A;  5GRL B;  5GRE B;  1P8F A;  3ASJ A;  1YXO A;  3VML A;  1XAB A;  4JQP A;  1V5B A;  1XGV A;  4UMX A;  5GRH A;  1ISO A;  2UXR A;  2IV0 A;  3VL4 A;  3BLV B;  5GRI A;  5J34 A;  1WPW A;  2G4O A;  3WZV A;  3BLX A;  1IDD A;  1IDM A;  4UMY A;  3TY4 A;  1DPZ A;  2Y42 A;  3LCB C;  3U1H A;  4WUO A;  1DR0 A;  4F7I A;  1HEX A;  3VL7 A;  5L58 A;  4KZO A;  1TYO A;  1XAD A;  3VL2 A;  3R8W A;  2QFY A;  4HCX A;  4YB4 A;  7ICD A;  3MAS A;  1CW7 A;  5K10 A;  3DMS A;  1A05 A;  2Y3Z A;  3UDO A;  1WAL A;  5GRF B;  8ICD A;  1G2U A;  1BL5 A;  2E0C A;  1V53 A;  5K11 A;  1GRP A;  4AJA A;  1HQS A;  1X0L A;  3UDU A;  1CW4 A;  5HN6 A;  4XS3 A;  1GC8 A;  3US8 A;  5I95 A;  1IPD A;  3VMJ A;  4BNP A;  3WZW A;  1PTM A;  3INM A;  4XXV A;  5GRH B;  4ATY A;  4XRX A;  5HN5 A;  1IKA A;  2D4V A;  5GRI B;  2QFX A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3INMA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations