3WZXA

S266a mutant 3-isopropylmalate dehydrogenase from shewanella oneidensis mr-1 at 0.1mpa - complex with ipm and mg
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
364
structure length
364
Chain Sequence
SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLASASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pressure Adaptation of 3-Isopropylmalate Dehydrogenase from the Extremely Piezophilic Bacterium Shewanella benthica is Attributed to just One Amino Acid Substitution
rcsb
molecule tags Oxidoreductase
source organism Shewanella oneidensis mr-1
molecule keywords 3-isopropylmalate dehydrogenase
total genus 128
structure length 364
sequence length 364
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 3wzxA00
1ISOA 4BNPA 5K11A 3VMLA 2DHTA 3WZWA 5I95A 3FLKA 3LXYA 1CNZA 1GC8A 2QFYA 3US8A 4YB4A 1CW1A 4XS3A 2QFVA 1IKAA 1PTMA 1PS6A 1DR0A 2QFXA 2Y42A 4I3KA 2QFWA 1G2UA 3WZXA 4AJAA 1CW4A 5HN4A 1DR8A 1YCOA 5GRHB 4IWHA 3U1HA 2IV0A 4F7IA 5GREA 4I3LA 5HN3A 5GRIA 5LGEA 3ASJA 3BLVB 2UXRA 1CW7A 1XACA 4UMYA 4AOUA 2HI1A 5GRLB 1TYOA 3VKZA 3TSNA 4ATYA 1AI2A 4HCXA 3MAPA 3TNGA 3VL7A 1WPWA 8ICDA 3UDUA 1V94A 1XGVA 1YXOA 5DE1A 1P8FA 4AJRA 1SJSA 5L57A 2UXQA 4P69C 3UF6A 9ICDA 1CM7A 7ICDA 1IDCA 1BL5A 1VI1A 5J33A 1ZORA 5J34A 1X0LA 5GREB 1IDDA 2Y41A 4WUOA 3INMA 3MASA 5GRIB 1XAAA 4L03A 5I96A 2E5MA 1T0LA 5GRFA 1T09A 1W0DA 4XRXA 1HEXA 5HN5A 1GC9A 1GROA 1IDMA 3TY4A 4AJ3A 4XXVA 2Y40A 2G4OA 5J32A 3FMXX 1HQSA 5K10A 3R8WA 2ZTWA 2AYQA 3BLXA 4Y1PA 6ICDA 3WZVA 1PB1A 1V5BA 3VL6A 3VMJA 1VLCA 1AI3A 4AJCA 3TY3A 5ICDA 1PS7A 3MASB 4KZOA 1XKDA 3UDOA 4ICDA 5GRFB 3VMKA 1IPDA 1PB3A 4AOYA 3U9EA 1V53A 1XABA 3VL2A 3LCBC 3WZYA 1IDFA 1U7NA 5L58A 3MARA 1HJ6A 3VL4A 4AOVA 4L04A 1OSIA 4UMXA 1IDEA 2Y3ZA 2D4VA 5GRHA 4L06A 1XADA 5HN6A 4AJSA 4JQPA 3VL3A 1GRPA 4AJBA 3BLVA 3BLXB 3ICDA 1OSJA 2D1CA 2E0CA 1A05A 4JA8A 1R8KA 1LWDA 3AH3A 1WALA 3DMSA 5GRLA 1DPZA
chains in the Genus database with same CATH superfamily
1ISOA 4BNPA 5K11A 3VMLA 2DHTA 3WZWA 5I95A 3FLKA 3LXYA 1CNZA 1GC8A 2QFYA 3US8A 4YB4A 1CW1A 4XS3A 2QFVA 1IKAA 1PTMA 1PS6A 1DR0A 2QFXA 2Y42A 4I3KA 2QFWA 1G2UA 3WZXA 4AJAA 1CW4A 5HN4A 1DR8A 1YCOA 5GRHB 4IWHA 3U1HA 2IV0A 4F7IA 5GREA 4I3LA 5HN3A 5GRIA 5LGEA 3ASJA 3BLVB 2UXRA 1CW7A 1XACA 4UMYA 4AOUA 2HI1A 5GRLB 1TYOA 3VKZA 3TSNA 4ATYA 1AI2A 4HCXA 3MAPA 3TNGA 3VL7A 1WPWA 8ICDA 3UDUA 1V94A 1XGVA 1YXOA 5DE1A 1P8FA 4AJRA 1SJSA 5L57A 2UXQA 4P69C 3UF6A 9ICDA 1CM7A 7ICDA 1IDCA 1BL5A 1VI1A 5J33A 1ZORA 5J34A 1X0LA 5GREB 1IDDA 2Y41A 4WUOA 3INMA 3MASA 5GRIB 1XAAA 4L03A 5I96A 2E5MA 1T0LA 5GRFA 1T09A 1W0DA 4XRXA 1HEXA 5HN5A 1GC9A 1GROA 1IDMA 3TY4A 4AJ3A 4XXVA 2Y40A 2G4OA 5J32A 3FMXX 1HQSA 5K10A 3R8WA 2ZTWA 2AYQA 3BLXA 4Y1PA 6ICDA 3WZVA 1PB1A 1V5BA 3VL6A 3VMJA 1VLCA 1AI3A 4AJCA 3TY3A 5ICDA 1PS7A 3MASB 4KZOA 1XKDA 3UDOA 4ICDA 5GRFB 3VMKA 1IPDA 1PB3A 4AOYA 3U9EA 1V53A 1XABA 3VL2A 3LCBC 3WZYA 1IDFA 1U7NA 5L58A 3MARA 1HJ6A 3VL4A 4AOVA 4L04A 1OSIA 4UMXA 1IDEA 2Y3ZA 2D4VA 5GRHA 4L06A 1XADA 5HN6A 4AJSA 4JQPA 3VL3A 1GRPA 4AJBA 3BLVA 3BLXB 3ICDA 1OSJA 2D1CA 2E0CA 1A05A 4JA8A 1R8KA 1LWDA 3AH3A 1WALA 3DMSA 5GRLA 1DPZA
chains in the Genus database with same CATH topology
1ISOA 4BNPA 5K11A 3VMLA 2DHTA 3WZWA 5I95A 3FLKA 3LXYA 1CNZA 1GC8A 2QFYA 3US8A 4YB4A 1CW1A 4XS3A 2QFVA 1IKAA 1PTMA 1PS6A 1DR0A 2QFXA 2Y42A 4I3KA 2QFWA 1G2UA 3WZXA 4AJAA 1CW4A 5HN4A 1DR8A 1YCOA 5GRHB 4IWHA 3U1HA 2IV0A 4F7IA 5GREA 4I3LA 5HN3A 5GRIA 5LGEA 3ASJA 3BLVB 2UXRA 1CW7A 1XACA 4UMYA 4AOUA 2HI1A 5GRLB 1TYOA 3VKZA 3TSNA 4ATYA 1AI2A 4HCXA 3MAPA 3TNGA 3VL7A 1WPWA 8ICDA 3UDUA 1V94A 1XGVA 1YXOA 5DE1A 1P8FA 4AJRA 1SJSA 5L57A 2UXQA 4P69C 3UF6A 9ICDA 1CM7A 7ICDA 1IDCA 1BL5A 1VI1A 5J33A 1ZORA 5J34A 1X0LA 5GREB 1IDDA 2Y41A 4WUOA 3INMA 3MASA 5GRIB 1XAAA 4L03A 5I96A 2E5MA 1T0LA 5GRFA 1T09A 1W0DA 4XRXA 1HEXA 5HN5A 1GC9A 1GROA 1IDMA 3TY4A 4AJ3A 4XXVA 2Y40A 2G4OA 5J32A 3FMXX 1HQSA 5K10A 3R8WA 2ZTWA 2AYQA 3BLXA 4Y1PA 6ICDA 3WZVA 1PB1A 1V5BA 3VL6A 3VMJA 1VLCA 1AI3A 4AJCA 3TY3A 5ICDA 1PS7A 3MASB 4KZOA 1XKDA 3UDOA 4ICDA 5GRFB 3VMKA 1IPDA 1PB3A 4AOYA 3U9EA 1V53A 1XABA 3VL2A 3LCBC 3WZYA 1IDFA 1U7NA 5L58A 3MARA 1HJ6A 3VL4A 4AOVA 4L04A 1OSIA 4UMXA 1IDEA 2Y3ZA 2D4VA 5GRHA 4L06A 1XADA 5HN6A 4AJSA 4JQPA 3VL3A 1GRPA 4AJBA 3BLVA 3BLXB 3ICDA 1OSJA 2D1CA 2E0CA 1A05A 4JA8A 1R8KA 1LWDA 3AH3A 1WALA 3DMSA 5GRLA 1DPZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ISO A;  4BNP A;  5K11 A;  3VML A;  2DHT A;  3WZW A;  5I95 A;  3FLK A;  3LXY A;  1CNZ A;  1GC8 A;  2QFY A;  3US8 A;  4YB4 A;  1CW1 A;  4XS3 A;  2QFV A;  1IKA A;  1PTM A;  1PS6 A;  1DR0 A;  2QFX A;  2Y42 A;  4I3K A;  2QFW A;  1G2U A;  3WZX A;  4AJA A;  1CW4 A;  5HN4 A;  1DR8 A;  1YCO A;  5GRH B;  4IWH A;  3U1H A;  2IV0 A;  4F7I A;  5GRE A;  4I3L A;  5HN3 A;  5GRI A;  5LGE A;  3ASJ A;  3BLV B;  2UXR A;  1CW7 A;  1XAC A;  4UMY A;  4AOU A;  2HI1 A;  5GRL B;  1TYO A;  3VKZ A;  3TSN A;  4ATY A;  1AI2 A;  4HCX A;  3MAP A;  3TNG A;  3VL7 A;  1WPW A;  8ICD A;  3UDU A;  1V94 A;  1XGV A;  1YXO A;  5DE1 A;  1P8F A;  4AJR A;  1SJS A;  5L57 A;  2UXQ A;  4P69 C;  3UF6 A;  9ICD A;  1CM7 A;  7ICD A;  1IDC A;  1BL5 A;  1VI1 A;  5J33 A;  1ZOR A;  5J34 A;  1X0L A;  5GRE B;  1IDD A;  2Y41 A;  4WUO A;  3INM A;  3MAS A;  5GRI B;  1XAA A;  4L03 A;  5I96 A;  2E5M A;  1T0L A;  5GRF A;  1T09 A;  1W0D A;  4XRX A;  1HEX A;  5HN5 A;  1GC9 A;  1GRO A;  1IDM A;  3TY4 A;  4AJ3 A;  4XXV A;  2Y40 A;  2G4O A;  5J32 A;  3FMX X;  1HQS A;  5K10 A;  3R8W A;  2ZTW A;  2AYQ A;  3BLX A;  4Y1P A;  6ICD A;  3WZV A;  1PB1 A;  1V5B A;  3VL6 A;  3VMJ A;  1VLC A;  1AI3 A;  4AJC A;  3TY3 A;  5ICD A;  1PS7 A;  3MAS B;  4KZO A;  1XKD A;  3UDO A;  4ICD A;  5GRF B;  3VMK A;  1IPD A;  1PB3 A;  4AOY A;  3U9E A;  1V53 A;  1XAB A;  3VL2 A;  3LCB C;  3WZY A;  1IDF A;  1U7N A;  5L58 A;  3MAR A;  1HJ6 A;  3VL4 A;  4AOV A;  4L04 A;  1OSI A;  4UMX A;  1IDE A;  2Y3Z A;  2D4V A;  5GRH A;  4L06 A;  1XAD A;  5HN6 A;  4AJS A;  4JQP A;  3VL3 A;  1GRP A;  4AJB A;  3BLV A;  3BLX B;  3ICD A;  1OSJ A;  2D1C A;  2E0C A;  1A05 A;  4JA8 A;  1R8K A;  1LWD A;  3AH3 A;  1WAL A;  3DMS A;  5GRL A;  1DPZ A; 
#chains in the Genus database with same CATH topology
 1ISO A;  4BNP A;  5K11 A;  3VML A;  2DHT A;  3WZW A;  5I95 A;  3FLK A;  3LXY A;  1CNZ A;  1GC8 A;  2QFY A;  3US8 A;  4YB4 A;  1CW1 A;  4XS3 A;  2QFV A;  1IKA A;  1PTM A;  1PS6 A;  1DR0 A;  2QFX A;  2Y42 A;  4I3K A;  2QFW A;  1G2U A;  3WZX A;  4AJA A;  1CW4 A;  5HN4 A;  1DR8 A;  1YCO A;  5GRH B;  4IWH A;  3U1H A;  2IV0 A;  4F7I A;  5GRE A;  4I3L A;  5HN3 A;  5GRI A;  5LGE A;  3ASJ A;  3BLV B;  2UXR A;  1CW7 A;  1XAC A;  4UMY A;  4AOU A;  2HI1 A;  5GRL B;  1TYO A;  3VKZ A;  3TSN A;  4ATY A;  1AI2 A;  4HCX A;  3MAP A;  3TNG A;  3VL7 A;  1WPW A;  8ICD A;  3UDU A;  1V94 A;  1XGV A;  1YXO A;  5DE1 A;  1P8F A;  4AJR A;  1SJS A;  5L57 A;  2UXQ A;  4P69 C;  3UF6 A;  9ICD A;  1CM7 A;  7ICD A;  1IDC A;  1BL5 A;  1VI1 A;  5J33 A;  1ZOR A;  5J34 A;  1X0L A;  5GRE B;  1IDD A;  2Y41 A;  4WUO A;  3INM A;  3MAS A;  5GRI B;  1XAA A;  4L03 A;  5I96 A;  2E5M A;  1T0L A;  5GRF A;  1T09 A;  1W0D A;  4XRX A;  1HEX A;  5HN5 A;  1GC9 A;  1GRO A;  1IDM A;  3TY4 A;  4AJ3 A;  4XXV A;  2Y40 A;  2G4O A;  5J32 A;  3FMX X;  1HQS A;  5K10 A;  3R8W A;  2ZTW A;  2AYQ A;  3BLX A;  4Y1P A;  6ICD A;  3WZV A;  1PB1 A;  1V5B A;  3VL6 A;  3VMJ A;  1VLC A;  1AI3 A;  4AJC A;  3TY3 A;  5ICD A;  1PS7 A;  3MAS B;  4KZO A;  1XKD A;  3UDO A;  4ICD A;  5GRF B;  3VMK A;  1IPD A;  1PB3 A;  4AOY A;  3U9E A;  1V53 A;  1XAB A;  3VL2 A;  3LCB C;  3WZY A;  1IDF A;  1U7N A;  5L58 A;  3MAR A;  1HJ6 A;  3VL4 A;  4AOV A;  4L04 A;  1OSI A;  4UMX A;  1IDE A;  2Y3Z A;  2D4V A;  5GRH A;  4L06 A;  1XAD A;  5HN6 A;  4AJS A;  4JQP A;  3VL3 A;  1GRP A;  4AJB A;  3BLV A;  3BLX B;  3ICD A;  1OSJ A;  2D1C A;  2E0C A;  1A05 A;  4JA8 A;  1R8K A;  1LWD A;  3AH3 A;  1WAL A;  3DMS A;  5GRL A;  1DPZ A; 
#chains in the Genus database with same CATH homology
 1ISO A;  4BNP A;  5K11 A;  3VML A;  2DHT A;  3WZW A;  5I95 A;  3FLK A;  3LXY A;  1CNZ A;  1GC8 A;  2QFY A;  3US8 A;  4YB4 A;  1CW1 A;  4XS3 A;  2QFV A;  1IKA A;  1PTM A;  1PS6 A;  1DR0 A;  2QFX A;  2Y42 A;  4I3K A;  2QFW A;  1G2U A;  3WZX A;  4AJA A;  1CW4 A;  5HN4 A;  1DR8 A;  1YCO A;  5GRH B;  4IWH A;  3U1H A;  2IV0 A;  4F7I A;  5GRE A;  4I3L A;  5HN3 A;  5GRI A;  5LGE A;  3ASJ A;  3BLV B;  2UXR A;  1CW7 A;  1XAC A;  4UMY A;  4AOU A;  2HI1 A;  5GRL B;  1TYO A;  3VKZ A;  3TSN A;  4ATY A;  1AI2 A;  4HCX A;  3MAP A;  3TNG A;  3VL7 A;  1WPW A;  8ICD A;  3UDU A;  1V94 A;  1XGV A;  1YXO A;  5DE1 A;  1P8F A;  4AJR A;  1SJS A;  5L57 A;  2UXQ A;  4P69 C;  3UF6 A;  9ICD A;  1CM7 A;  7ICD A;  1IDC A;  1BL5 A;  1VI1 A;  5J33 A;  1ZOR A;  5J34 A;  1X0L A;  5GRE B;  1IDD A;  2Y41 A;  4WUO A;  3INM A;  3MAS A;  5GRI B;  1XAA A;  4L03 A;  5I96 A;  2E5M A;  1T0L A;  5GRF A;  1T09 A;  1W0D A;  4XRX A;  1HEX A;  5HN5 A;  1GC9 A;  1GRO A;  1IDM A;  3TY4 A;  4AJ3 A;  4XXV A;  2Y40 A;  2G4O A;  5J32 A;  3FMX X;  1HQS A;  5K10 A;  3R8W A;  2ZTW A;  2AYQ A;  3BLX A;  4Y1P A;  6ICD A;  3WZV A;  1PB1 A;  1V5B A;  3VL6 A;  3VMJ A;  1VLC A;  1AI3 A;  4AJC A;  3TY3 A;  5ICD A;  1PS7 A;  3MAS B;  4KZO A;  1XKD A;  3UDO A;  4ICD A;  5GRF B;  3VMK A;  1IPD A;  1PB3 A;  4AOY A;  3U9E A;  1V53 A;  1XAB A;  3VL2 A;  3LCB C;  3WZY A;  1IDF A;  1U7N A;  5L58 A;  3MAR A;  1HJ6 A;  3VL4 A;  4AOV A;  4L04 A;  1OSI A;  4UMX A;  1IDE A;  2Y3Z A;  2D4V A;  5GRH A;  4L06 A;  1XAD A;  5HN6 A;  4AJS A;  4JQP A;  3VL3 A;  1GRP A;  4AJB A;  3BLV A;  3BLX B;  3ICD A;  1OSJ A;  2D1C A;  2E0C A;  1A05 A;  4JA8 A;  1R8K A;  1LWD A;  3AH3 A;  1WAL A;  3DMS A;  5GRL A;  1DPZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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