3WZYA

S266a mutant 3-isopropylmalate dehydrogenase from shewanella oneidensis mr-1 at 580mpa - complex with ipm and mg
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
364
structure length
364
Chain Sequence
SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDNHGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHFELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGRQGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACSVLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLASASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQILSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTVQMGDFIADAVKAGV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pressure Adaptation of 3-Isopropylmalate Dehydrogenase from the Extremely Piezophilic Bacterium Shewanella benthica is Attributed to just One Amino Acid Substitution
rcsb
molecule tags Oxidoreductase
source organism Shewanella oneidensis mr-1
molecule keywords 3-isopropylmalate dehydrogenase
total genus 129
structure length 364
sequence length 364
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2014-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 3wzyA00
3LXYA 3BLXB 1CW4A 1U7NA 2E0CA 5GREB 3TY4A 1V94A 1XGVA 2QFYA 3ICDA 3TSNA 2Y41A 1PS7A 2UXQA 3BLXA 3MASB 4JQPA 3VMKA 1PS6A 5GREA 2HI1A 1DPZA 3VL4A 4F7IA 7ICDA 1XKDA 1VLCA 2DHTA 2Y40A 1CW1A 1SJSA 3VMJA 4ATYA 1PB3A 1OSIA 2D1CA 1DR8A 4AJCA 1YCOA 1HEXA 4ICDA 9ICDA 1PTMA 1IDCA 5GRLB 5GRIB 1GROA 3ASJA 2D4VA 1A05A 4I3LA 5DE1A 4JA8A 5GRHA 5I95A 4UMYA 4XS3A 3VL3A 4L04A 4HCXA 4L06A 1R8KA 1YXOA 3US8A 8ICDA 2Y42A 3VMLA 4I3KA 3UDUA 3AH3A 4L03A 1XACA 4IWHA 5HN3A 3MASA 5GRFB 3VL2A 5I96A 1IDDA 1G2UA 3FMXX 5GRFA 1XADA 1ISOA 4UMXA 1WPWA 1IDFA 1X0LA 1DR0A 2QFWA 2G4OA 5L58A 3VL6A 1VI1A 4AJRA 4WUOA 3UDOA 4AOYA 3LCBC 1TYOA 5K10A 3FLKA 3TNGA 5GRLA 6ICDA 5GRIA 1LWDA 1IDEA 1V5BA 3DMSA 4Y1PA 1OSJA 3WZXA 1PB1A 1ZORA 2AYQA 4XXVA 1GC8A 2Y3ZA 1AI2A 1P8FA 3UF6A 5K11A 5J34A 4BNPA 4AJAA 3MARA 5J33A 1IPDA 4P69C 4XRXA 4AJBA 5HN4A 1T0LA 5HN6A 3WZWA 1BL5A 3R8WA 3MAPA 4AOVA 4KZOA 1CNZA 5L57A 1HJ6A 3TY3A 5J32A 3VL7A 1V53A 3U1HA 4AJSA 1HQSA 2IV0A 1IDMA 3WZYA 4AOUA 1CW7A 2QFXA 2QFVA 4YB4A 3INMA 3WZVA 2E5MA 4AJ3A 2UXRA 1GC9A 3BLVB 5HN5A 1XABA 3VKZA 3U9EA 1W0DA 1AI3A 1T09A 1CM7A 1WALA 2ZTWA 3BLVA 5ICDA 1IKAA 1XAAA 5GRHB 5LGEA 1GRPA
chains in the Genus database with same CATH superfamily
3LXYA 3BLXB 1CW4A 1U7NA 2E0CA 5GREB 3TY4A 1V94A 1XGVA 2QFYA 3ICDA 3TSNA 2Y41A 1PS7A 2UXQA 3BLXA 3MASB 4JQPA 3VMKA 1PS6A 5GREA 2HI1A 1DPZA 3VL4A 4F7IA 7ICDA 1XKDA 1VLCA 2DHTA 2Y40A 1CW1A 1SJSA 3VMJA 4ATYA 1PB3A 1OSIA 2D1CA 1DR8A 4AJCA 1YCOA 1HEXA 4ICDA 9ICDA 1PTMA 1IDCA 5GRLB 5GRIB 1GROA 3ASJA 2D4VA 1A05A 4I3LA 5DE1A 4JA8A 5GRHA 5I95A 4UMYA 4XS3A 3VL3A 4L04A 4HCXA 4L06A 1R8KA 1YXOA 3US8A 8ICDA 2Y42A 3VMLA 4I3KA 3UDUA 3AH3A 4L03A 1XACA 4IWHA 5HN3A 3MASA 5GRFB 3VL2A 5I96A 1IDDA 1G2UA 3FMXX 5GRFA 1XADA 1ISOA 4UMXA 1WPWA 1IDFA 1X0LA 1DR0A 2QFWA 2G4OA 5L58A 3VL6A 1VI1A 4AJRA 4WUOA 3UDOA 4AOYA 3LCBC 1TYOA 5K10A 3FLKA 3TNGA 5GRLA 6ICDA 5GRIA 1LWDA 1IDEA 1V5BA 3DMSA 4Y1PA 1OSJA 3WZXA 1PB1A 1ZORA 2AYQA 4XXVA 1GC8A 2Y3ZA 1AI2A 1P8FA 3UF6A 5K11A 5J34A 4BNPA 4AJAA 3MARA 5J33A 1IPDA 4P69C 4XRXA 4AJBA 5HN4A 1T0LA 5HN6A 3WZWA 1BL5A 3R8WA 3MAPA 4AOVA 4KZOA 1CNZA 5L57A 1HJ6A 3TY3A 5J32A 3VL7A 1V53A 3U1HA 4AJSA 1HQSA 2IV0A 1IDMA 3WZYA 4AOUA 1CW7A 2QFXA 2QFVA 4YB4A 3INMA 3WZVA 2E5MA 4AJ3A 2UXRA 1GC9A 3BLVB 5HN5A 1XABA 3VKZA 3U9EA 1W0DA 1AI3A 1T09A 1CM7A 1WALA 2ZTWA 3BLVA 5ICDA 1IKAA 1XAAA 5GRHB 5LGEA 1GRPA
chains in the Genus database with same CATH topology
3LXYA 3BLXB 1CW4A 1U7NA 2E0CA 5GREB 3TY4A 1V94A 1XGVA 2QFYA 3ICDA 3TSNA 2Y41A 1PS7A 2UXQA 3BLXA 3MASB 4JQPA 3VMKA 1PS6A 5GREA 2HI1A 1DPZA 3VL4A 4F7IA 7ICDA 1XKDA 1VLCA 2DHTA 2Y40A 1CW1A 1SJSA 3VMJA 4ATYA 1PB3A 1OSIA 2D1CA 1DR8A 4AJCA 1YCOA 1HEXA 4ICDA 9ICDA 1PTMA 1IDCA 5GRLB 5GRIB 1GROA 3ASJA 2D4VA 1A05A 4I3LA 5DE1A 4JA8A 5GRHA 5I95A 4UMYA 4XS3A 3VL3A 4L04A 4HCXA 4L06A 1R8KA 1YXOA 3US8A 8ICDA 2Y42A 3VMLA 4I3KA 3UDUA 3AH3A 4L03A 1XACA 4IWHA 5HN3A 3MASA 5GRFB 3VL2A 5I96A 1IDDA 1G2UA 3FMXX 5GRFA 1XADA 1ISOA 4UMXA 1WPWA 1IDFA 1X0LA 1DR0A 2QFWA 2G4OA 5L58A 3VL6A 1VI1A 4AJRA 4WUOA 3UDOA 4AOYA 3LCBC 1TYOA 5K10A 3FLKA 3TNGA 5GRLA 6ICDA 5GRIA 1LWDA 1IDEA 1V5BA 3DMSA 4Y1PA 1OSJA 3WZXA 1PB1A 1ZORA 2AYQA 4XXVA 1GC8A 2Y3ZA 1AI2A 1P8FA 3UF6A 5K11A 5J34A 4BNPA 4AJAA 3MARA 5J33A 1IPDA 4P69C 4XRXA 4AJBA 5HN4A 1T0LA 5HN6A 3WZWA 1BL5A 3R8WA 3MAPA 4AOVA 4KZOA 1CNZA 5L57A 1HJ6A 3TY3A 5J32A 3VL7A 1V53A 3U1HA 4AJSA 1HQSA 2IV0A 1IDMA 3WZYA 4AOUA 1CW7A 2QFXA 2QFVA 4YB4A 3INMA 3WZVA 2E5MA 4AJ3A 2UXRA 1GC9A 3BLVB 5HN5A 1XABA 3VKZA 3U9EA 1W0DA 1AI3A 1T09A 1CM7A 1WALA 2ZTWA 3BLVA 5ICDA 1IKAA 1XAAA 5GRHB 5LGEA 1GRPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LXY A;  3BLX B;  1CW4 A;  1U7N A;  2E0C A;  5GRE B;  3TY4 A;  1V94 A;  1XGV A;  2QFY A;  3ICD A;  3TSN A;  2Y41 A;  1PS7 A;  2UXQ A;  3BLX A;  3MAS B;  4JQP A;  3VMK A;  1PS6 A;  5GRE A;  2HI1 A;  1DPZ A;  3VL4 A;  4F7I A;  7ICD A;  1XKD A;  1VLC A;  2DHT A;  2Y40 A;  1CW1 A;  1SJS A;  3VMJ A;  4ATY A;  1PB3 A;  1OSI A;  2D1C A;  1DR8 A;  4AJC A;  1YCO A;  1HEX A;  4ICD A;  9ICD A;  1PTM A;  1IDC A;  5GRL B;  5GRI B;  1GRO A;  3ASJ A;  2D4V A;  1A05 A;  4I3L A;  5DE1 A;  4JA8 A;  5GRH A;  5I95 A;  4UMY A;  4XS3 A;  3VL3 A;  4L04 A;  4HCX A;  4L06 A;  1R8K A;  1YXO A;  3US8 A;  8ICD A;  2Y42 A;  3VML A;  4I3K A;  3UDU A;  3AH3 A;  4L03 A;  1XAC A;  4IWH A;  5HN3 A;  3MAS A;  5GRF B;  3VL2 A;  5I96 A;  1IDD A;  1G2U A;  3FMX X;  5GRF A;  1XAD A;  1ISO A;  4UMX A;  1WPW A;  1IDF A;  1X0L A;  1DR0 A;  2QFW A;  2G4O A;  5L58 A;  3VL6 A;  1VI1 A;  4AJR A;  4WUO A;  3UDO A;  4AOY A;  3LCB C;  1TYO A;  5K10 A;  3FLK A;  3TNG A;  5GRL A;  6ICD A;  5GRI A;  1LWD A;  1IDE A;  1V5B A;  3DMS A;  4Y1P A;  1OSJ A;  3WZX A;  1PB1 A;  1ZOR A;  2AYQ A;  4XXV A;  1GC8 A;  2Y3Z A;  1AI2 A;  1P8F A;  3UF6 A;  5K11 A;  5J34 A;  4BNP A;  4AJA A;  3MAR A;  5J33 A;  1IPD A;  4P69 C;  4XRX A;  4AJB A;  5HN4 A;  1T0L A;  5HN6 A;  3WZW A;  1BL5 A;  3R8W A;  3MAP A;  4AOV A;  4KZO A;  1CNZ A;  5L57 A;  1HJ6 A;  3TY3 A;  5J32 A;  3VL7 A;  1V53 A;  3U1H A;  4AJS A;  1HQS A;  2IV0 A;  1IDM A;  3WZY A;  4AOU A;  1CW7 A;  2QFX A;  2QFV A;  4YB4 A;  3INM A;  3WZV A;  2E5M A;  4AJ3 A;  2UXR A;  1GC9 A;  3BLV B;  5HN5 A;  1XAB A;  3VKZ A;  3U9E A;  1W0D A;  1AI3 A;  1T09 A;  1CM7 A;  1WAL A;  2ZTW A;  3BLV A;  5ICD A;  1IKA A;  1XAA A;  5GRH B;  5LGE A;  1GRP A; 
#chains in the Genus database with same CATH topology
 3LXY A;  3BLX B;  1CW4 A;  1U7N A;  2E0C A;  5GRE B;  3TY4 A;  1V94 A;  1XGV A;  2QFY A;  3ICD A;  3TSN A;  2Y41 A;  1PS7 A;  2UXQ A;  3BLX A;  3MAS B;  4JQP A;  3VMK A;  1PS6 A;  5GRE A;  2HI1 A;  1DPZ A;  3VL4 A;  4F7I A;  7ICD A;  1XKD A;  1VLC A;  2DHT A;  2Y40 A;  1CW1 A;  1SJS A;  3VMJ A;  4ATY A;  1PB3 A;  1OSI A;  2D1C A;  1DR8 A;  4AJC A;  1YCO A;  1HEX A;  4ICD A;  9ICD A;  1PTM A;  1IDC A;  5GRL B;  5GRI B;  1GRO A;  3ASJ A;  2D4V A;  1A05 A;  4I3L A;  5DE1 A;  4JA8 A;  5GRH A;  5I95 A;  4UMY A;  4XS3 A;  3VL3 A;  4L04 A;  4HCX A;  4L06 A;  1R8K A;  1YXO A;  3US8 A;  8ICD A;  2Y42 A;  3VML A;  4I3K A;  3UDU A;  3AH3 A;  4L03 A;  1XAC A;  4IWH A;  5HN3 A;  3MAS A;  5GRF B;  3VL2 A;  5I96 A;  1IDD A;  1G2U A;  3FMX X;  5GRF A;  1XAD A;  1ISO A;  4UMX A;  1WPW A;  1IDF A;  1X0L A;  1DR0 A;  2QFW A;  2G4O A;  5L58 A;  3VL6 A;  1VI1 A;  4AJR A;  4WUO A;  3UDO A;  4AOY A;  3LCB C;  1TYO A;  5K10 A;  3FLK A;  3TNG A;  5GRL A;  6ICD A;  5GRI A;  1LWD A;  1IDE A;  1V5B A;  3DMS A;  4Y1P A;  1OSJ A;  3WZX A;  1PB1 A;  1ZOR A;  2AYQ A;  4XXV A;  1GC8 A;  2Y3Z A;  1AI2 A;  1P8F A;  3UF6 A;  5K11 A;  5J34 A;  4BNP A;  4AJA A;  3MAR A;  5J33 A;  1IPD A;  4P69 C;  4XRX A;  4AJB A;  5HN4 A;  1T0L A;  5HN6 A;  3WZW A;  1BL5 A;  3R8W A;  3MAP A;  4AOV A;  4KZO A;  1CNZ A;  5L57 A;  1HJ6 A;  3TY3 A;  5J32 A;  3VL7 A;  1V53 A;  3U1H A;  4AJS A;  1HQS A;  2IV0 A;  1IDM A;  3WZY A;  4AOU A;  1CW7 A;  2QFX A;  2QFV A;  4YB4 A;  3INM A;  3WZV A;  2E5M A;  4AJ3 A;  2UXR A;  1GC9 A;  3BLV B;  5HN5 A;  1XAB A;  3VKZ A;  3U9E A;  1W0D A;  1AI3 A;  1T09 A;  1CM7 A;  1WAL A;  2ZTW A;  3BLV A;  5ICD A;  1IKA A;  1XAA A;  5GRH B;  5LGE A;  1GRP A; 
#chains in the Genus database with same CATH homology
 3LXY A;  3BLX B;  1CW4 A;  1U7N A;  2E0C A;  5GRE B;  3TY4 A;  1V94 A;  1XGV A;  2QFY A;  3ICD A;  3TSN A;  2Y41 A;  1PS7 A;  2UXQ A;  3BLX A;  3MAS B;  4JQP A;  3VMK A;  1PS6 A;  5GRE A;  2HI1 A;  1DPZ A;  3VL4 A;  4F7I A;  7ICD A;  1XKD A;  1VLC A;  2DHT A;  2Y40 A;  1CW1 A;  1SJS A;  3VMJ A;  4ATY A;  1PB3 A;  1OSI A;  2D1C A;  1DR8 A;  4AJC A;  1YCO A;  1HEX A;  4ICD A;  9ICD A;  1PTM A;  1IDC A;  5GRL B;  5GRI B;  1GRO A;  3ASJ A;  2D4V A;  1A05 A;  4I3L A;  5DE1 A;  4JA8 A;  5GRH A;  5I95 A;  4UMY A;  4XS3 A;  3VL3 A;  4L04 A;  4HCX A;  4L06 A;  1R8K A;  1YXO A;  3US8 A;  8ICD A;  2Y42 A;  3VML A;  4I3K A;  3UDU A;  3AH3 A;  4L03 A;  1XAC A;  4IWH A;  5HN3 A;  3MAS A;  5GRF B;  3VL2 A;  5I96 A;  1IDD A;  1G2U A;  3FMX X;  5GRF A;  1XAD A;  1ISO A;  4UMX A;  1WPW A;  1IDF A;  1X0L A;  1DR0 A;  2QFW A;  2G4O A;  5L58 A;  3VL6 A;  1VI1 A;  4AJR A;  4WUO A;  3UDO A;  4AOY A;  3LCB C;  1TYO A;  5K10 A;  3FLK A;  3TNG A;  5GRL A;  6ICD A;  5GRI A;  1LWD A;  1IDE A;  1V5B A;  3DMS A;  4Y1P A;  1OSJ A;  3WZX A;  1PB1 A;  1ZOR A;  2AYQ A;  4XXV A;  1GC8 A;  2Y3Z A;  1AI2 A;  1P8F A;  3UF6 A;  5K11 A;  5J34 A;  4BNP A;  4AJA A;  3MAR A;  5J33 A;  1IPD A;  4P69 C;  4XRX A;  4AJB A;  5HN4 A;  1T0L A;  5HN6 A;  3WZW A;  1BL5 A;  3R8W A;  3MAP A;  4AOV A;  4KZO A;  1CNZ A;  5L57 A;  1HJ6 A;  3TY3 A;  5J32 A;  3VL7 A;  1V53 A;  3U1H A;  4AJS A;  1HQS A;  2IV0 A;  1IDM A;  3WZY A;  4AOU A;  1CW7 A;  2QFX A;  2QFV A;  4YB4 A;  3INM A;  3WZV A;  2E5M A;  4AJ3 A;  2UXR A;  1GC9 A;  3BLV B;  5HN5 A;  1XAB A;  3VKZ A;  3U9E A;  1W0D A;  1AI3 A;  1T09 A;  1CM7 A;  1WAL A;  2ZTW A;  3BLV A;  5ICD A;  1IKA A;  1XAA A;  5GRH B;  5LGE A;  1GRP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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