4B4SA

Crystal structure of a pro-survival bcl-2:bim bh3 complex
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
163
structure length
148
Chain Sequence
DPLRERTELLLADYLGYSAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTAGDVARDSQRLVALLSSRLMGQHRAWLQAQGGWDGFSHFFRTPFP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords BCL-2-LIKE PROTEIN 10
total genus 51
structure length 148
sequence length 163
ec nomenclature
pdb deposition date 2012-08-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 4b4sA01
2VM6A 3IO9A 1YSNA 4OQ5A 1F16A 1R2IA 5C6HA 2BIDA 3DVUA 3IHCA 5KU9A 4B4SA 2VOHA 1YSGA 2NL9A 2PQKA 4WMRA 3KJ1A 2NLAA 1YSIA 2JM6B 2MEJA 1MK3A 5FDRA 4BPJA 4BD6A 3QBRA 4YJ4A 1K3KA 1G5JA 2JCNA 2LR1A 1GJHA 2IMSA 2O21A 2MHSA 4BD8A 5FDOA 3KZ0A 4BD2A 4ZIFA 4OQ6A 1ZY3A 4MI8A 1WSXA 1Q59A 2VOFA 3IIGA 5IF4A 3IIHA 5FC4A 2RODA 1G5MA 4ZBIA 4BPIA 2K7WA 1DDBA 4U2UA 3WIYA 2BZWA 5JSBA 3CVAX 4YK9A 4HW4A 4HW3A 2WH6A 1PQ1A 3MQPA 1O0LA 4G35A 5C3FA 2IMTA 2VOIA 4ZIIA 1BXLA 4U2VA 3PK1A 2KUAA 4QNQA 2O22A 2B48A 4BD7A 3IHDA 2XA0A 1YSWA 4ZIEA 1AF3A 1R2HA 2O2FA 1R2DA 2M5BA 1R2EA 1TY4A 4ZIHA 4ZIGA 3WIXA 2VOGA 4QVXA 2W3LA 1OHUA 2O2MA 4HW2A 5KTGA 2YV6A 3KJ0A 2KBWA 2O2NA 4BDUA 5FMIA 4S0OA 1R2GA 4K5BC 1MAZA 3MK8A 1LXLA 3ILCA 2A5YA 4ZEQA 5IEZA 3KJ2A 2ME8A 3D7VA 2ROCA 4S0PA 2XPXA 1PQ0A 4ZBFA 4OYDA 3I1HA 3BL2A 2V6QA 3IHEA 2ABOA
chains in the Genus database with same CATH superfamily
2VM6A 3IO9A 1YSNA 4D2MA 4OQ5A 1F16A 1R2IA 5C6HA 2BIDA 3DVUA 3IHCA 5KU9A 4B4SA 2VOHA 1YSGA 2NL9A 2PQKA 4WMRA 3KJ1A 4UF3A 2NLAA 1YSIA 2JBXA 4BBCA 2VVWA 3IHEA 2JM6B 2MEJA 1MK3A 5FDRA 2VVYA 4BPJA 4BD6A 3QBRA 4YJ4A 1K3KA 1G5JA 2I39A 4BBBA 2JCNA 2LR1A 4UF2A 1GJHA 2IMSA 2O21A 2MHSA 4BD8A 5FDOA 3KZ0A 2O42A 4BD2A 4ZIFA 4OQ6A 1ZY3A 2UXEA 4LQKA 4MI8A 4M0SA 1WSXA 1Q59A 2VOFA 3IIGA 5IF4A 3IIHA 5FC4A 4ZBIA 1G5MA 4BPIA 2K7WA 1DDBA 2VVXA 4U2UA 3WIYA 2BZWA 5JSBA 3CVAX 4D2LA 4YK9A 2K36A 4HW4A 4HW3A 2WH6A 1PQ1A 3MQPA 1O0LA 3JRVA 4G35A 5C3FA 2IMTA 2VOIA 4ZIIA 1BXLA 4U2VA 3PK1A 2KUAA 4QNQA 2O22A 2B48A 4BD7A 3IHDA 2XA0A 1YSWA 4ZIEA 1AF3A 1R2HA 2O2FA 1R2DA 2M5BA 1R2EA 1TY4A 4ZIHA 4ZIGA 3WIXA 2VOGA 4QVXA 2VTYA 2W3LA 4BBDA 1OHUA 2O2MA 4HW2A 5KTGA 2YV6A 3KJ0A 2KBWA 2O2NA 4BDUA 5FMIA 4S0OA 1R2GA 2JBYA 1MAZA 4K5BC 3MK8A 1LXLA 3ILCA 2A5YA 4ZEQA 4UF1A 5IEZA 3KJ2A 2ME8A 3D7VA 2ROCA 4S0PA 2XPXA 1PQ0A 4ZBFA 4OYDA 3I1HA 3BL2A 2V6QA 2RODA 2ABOA
chains in the Genus database with same CATH topology
2VM6A 3IO9A 1YSNA 4OQ5A 1F16A 1R2IA 5C6HA 2BIDA 3DVUA 3IHCA 5KU9A 4B4SA 2VOHA 1YSGA 2NL9A 2PQKA 4WMRA 3KJ1A 2NLAA 1YSIA 2JM6B 2MEJA 1MK3A 5FDRA 4BPJA 4BD6A 3QBRA 4YJ4A 1K3KA 1G5JA 2JCNA 2LR1A 1GJHA 2IMSA 2O21A 2MHSA 4BD8A 5FDOA 3KZ0A 4BD2A 4ZIFA 4OQ6A 1ZY3A 4MI8A 1WSXA 1Q59A 2VOFA 3IIGA 5IF4A 3IIHA 5FC4A 2RODA 1G5MA 4ZBIA 4BPIA 2K7WA 1DDBA 4U2UA 3WIYA 2BZWA 5JSBA 3CVAX 4YK9A 4HW4A 4HW3A 2WH6A 1PQ1A 3MQPA 1O0LA 4G35A 5C3FA 2IMTA 2VOIA 4ZIIA 1BXLA 4U2VA 3PK1A 2KUAA 4QNQA 2O22A 2B48A 4BD7A 3IHDA 2XA0A 1YSWA 4ZIEA 1AF3A 1R2HA 2O2FA 1R2DA 2M5BA 1R2EA 1TY4A 4ZIHA 4ZIGA 3WIXA 2VOGA 4QVXA 2W3LA 1OHUA 2O2MA 4HW2A 5KTGA 2YV6A 3KJ0A 2KBWA 2O2NA 4BDUA 5FMIA 4S0OA 1R2GA 4K5BC 1MAZA 3MK8A 1LXLA 3ILCA 2A5YA 4ZEQA 5IEZA 3KJ2A 2ME8A 3D7VA 2ROCA 4S0PA 2XPXA 1PQ0A 4ZBFA 4OYDA 3I1HA 3BL2A 2V6QA 3IHEA 2ABOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VM6 A;  3IO9 A;  1YSN A;  4OQ5 A;  1F16 A;  1R2I A;  5C6H A;  2BID A;  3DVU A;  3IHC A;  5KU9 A;  4B4S A;  2VOH A;  1YSG A;  2NL9 A;  2PQK A;  4WMR A;  3KJ1 A;  2NLA A;  1YSI A;  2JM6 B;  2MEJ A;  1MK3 A;  5FDR A;  4BPJ A;  4BD6 A;  3QBR A;  4YJ4 A;  1K3K A;  1G5J A;  2JCN A;  2LR1 A;  1GJH A;  2IMS A;  2O21 A;  2MHS A;  4BD8 A;  5FDO A;  3KZ0 A;  4BD2 A;  4ZIF A;  4OQ6 A;  1ZY3 A;  4MI8 A;  1WSX A;  1Q59 A;  2VOF A;  3IIG A;  5IF4 A;  3IIH A;  5FC4 A;  2ROD A;  1G5M A;  4ZBI A;  4BPI A;  2K7W A;  1DDB A;  4U2U A;  3WIY A;  2BZW A;  5JSB A;  3CVA X;  4YK9 A;  4HW4 A;  4HW3 A;  2WH6 A;  1PQ1 A;  3MQP A;  1O0L A;  4G35 A;  5C3F A;  2IMT A;  2VOI A;  4ZII A;  1BXL A;  4U2V A;  3PK1 A;  2KUA A;  4QNQ A;  2O22 A;  2B48 A;  4BD7 A;  3IHD A;  2XA0 A;  1YSW A;  4ZIE A;  1AF3 A;  1R2H A;  2O2F A;  1R2D A;  2M5B A;  1R2E A;  1TY4 A;  4ZIH A;  4ZIG A;  3WIX A;  2VOG A;  4QVX A;  2W3L A;  1OHU A;  2O2M A;  4HW2 A;  5KTG A;  2YV6 A;  3KJ0 A;  2KBW A;  2O2N A;  4BDU A;  5FMI A;  4S0O A;  1R2G A;  4K5B C;  1MAZ A;  3MK8 A;  1LXL A;  3ILC A;  2A5Y A;  4ZEQ A;  5IEZ A;  3KJ2 A;  2ME8 A;  3D7V A;  2ROC A;  4S0P A;  2XPX A;  1PQ0 A;  4ZBF A;  4OYD A;  3I1H A;  3BL2 A;  2V6Q A;  3IHE A;  2ABO A; 
#chains in the Genus database with same CATH topology
 2VM6 A;  3IO9 A;  1YSN A;  4D2M A;  4OQ5 A;  1F16 A;  1R2I A;  5C6H A;  2BID A;  3DVU A;  3IHC A;  5KU9 A;  4B4S A;  2VOH A;  1YSG A;  2NL9 A;  2PQK A;  4WMR A;  3KJ1 A;  4UF3 A;  2NLA A;  1YSI A;  2JBX A;  4BBC A;  2VVW A;  3IHE A;  2JM6 B;  2MEJ A;  1MK3 A;  5FDR A;  2VVY A;  4BPJ A;  4BD6 A;  3QBR A;  4YJ4 A;  1K3K A;  1G5J A;  2I39 A;  4BBB A;  2JCN A;  2LR1 A;  4UF2 A;  1GJH A;  2IMS A;  2O21 A;  2MHS A;  4BD8 A;  5FDO A;  3KZ0 A;  2O42 A;  4BD2 A;  4ZIF A;  4OQ6 A;  1ZY3 A;  2UXE A;  4LQK A;  4MI8 A;  4M0S A;  1WSX A;  1Q59 A;  2VOF A;  3IIG A;  5IF4 A;  3IIH A;  5FC4 A;  4ZBI A;  1G5M A;  4BPI A;  2K7W A;  1DDB A;  2VVX A;  4U2U A;  3WIY A;  2BZW A;  5JSB A;  3CVA X;  4D2L A;  4YK9 A;  2K36 A;  4HW4 A;  4HW3 A;  2WH6 A;  1PQ1 A;  3MQP A;  1O0L A;  3JRV A;  4G35 A;  5C3F A;  2IMT A;  2VOI A;  4ZII A;  1BXL A;  4U2V A;  3PK1 A;  2KUA A;  4QNQ A;  2O22 A;  2B48 A;  4BD7 A;  3IHD A;  2XA0 A;  1YSW A;  4ZIE A;  1AF3 A;  1R2H A;  2O2F A;  1R2D A;  2M5B A;  1R2E A;  1TY4 A;  4ZIH A;  4ZIG A;  3WIX A;  2VOG A;  4QVX A;  2VTY A;  2W3L A;  4BBD A;  1OHU A;  2O2M A;  4HW2 A;  5KTG A;  2YV6 A;  3KJ0 A;  2KBW A;  2O2N A;  4BDU A;  5FMI A;  4S0O A;  1R2G A;  2JBY A;  1MAZ A;  4K5B C;  3MK8 A;  1LXL A;  3ILC A;  2A5Y A;  4ZEQ A;  4UF1 A;  5IEZ A;  3KJ2 A;  2ME8 A;  3D7V A;  2ROC A;  4S0P A;  2XPX A;  1PQ0 A;  4ZBF A;  4OYD A;  3I1H A;  3BL2 A;  2V6Q A;  2ROD A;  2ABO A; 
#chains in the Genus database with same CATH homology
 2VM6 A;  3IO9 A;  1YSN A;  4OQ5 A;  1F16 A;  1R2I A;  5C6H A;  2BID A;  3DVU A;  3IHC A;  5KU9 A;  4B4S A;  2VOH A;  1YSG A;  2NL9 A;  2PQK A;  4WMR A;  3KJ1 A;  2NLA A;  1YSI A;  2JM6 B;  2MEJ A;  1MK3 A;  5FDR A;  4BPJ A;  4BD6 A;  3QBR A;  4YJ4 A;  1K3K A;  1G5J A;  2JCN A;  2LR1 A;  1GJH A;  2IMS A;  2O21 A;  2MHS A;  4BD8 A;  5FDO A;  3KZ0 A;  4BD2 A;  4ZIF A;  4OQ6 A;  1ZY3 A;  4MI8 A;  1WSX A;  1Q59 A;  2VOF A;  3IIG A;  5IF4 A;  3IIH A;  5FC4 A;  2ROD A;  1G5M A;  4ZBI A;  4BPI A;  2K7W A;  1DDB A;  4U2U A;  3WIY A;  2BZW A;  5JSB A;  3CVA X;  4YK9 A;  4HW4 A;  4HW3 A;  2WH6 A;  1PQ1 A;  3MQP A;  1O0L A;  4G35 A;  5C3F A;  2IMT A;  2VOI A;  4ZII A;  1BXL A;  4U2V A;  3PK1 A;  2KUA A;  4QNQ A;  2O22 A;  2B48 A;  4BD7 A;  3IHD A;  2XA0 A;  1YSW A;  4ZIE A;  1AF3 A;  1R2H A;  2O2F A;  1R2D A;  2M5B A;  1R2E A;  1TY4 A;  4ZIH A;  4ZIG A;  3WIX A;  2VOG A;  4QVX A;  2W3L A;  1OHU A;  2O2M A;  4HW2 A;  5KTG A;  2YV6 A;  3KJ0 A;  2KBW A;  2O2N A;  4BDU A;  5FMI A;  4S0O A;  1R2G A;  4K5B C;  1MAZ A;  3MK8 A;  1LXL A;  3ILC A;  2A5Y A;  4ZEQ A;  5IEZ A;  3KJ2 A;  2ME8 A;  3D7V A;  2ROC A;  4S0P A;  2XPX A;  1PQ0 A;  4ZBF A;  4OYD A;  3I1H A;  3BL2 A;  2V6Q A;  3IHE A;  2ABO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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