4E5LA

Crystal structure of avian influenza virus pan bound to compound 6
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
179
structure length
179
Chain Sequence
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDGGSKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.
pubmed doi rcsb
molecule tags Viral protein, transcription
source organism Influenza a virus
molecule keywords Polymerase protein PA
total genus 68
structure length 179
sequence length 179
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-03-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.91.90 Alpha Beta 3-Layer(aba) Sandwich Restriction Endonuclease Restriction Endonuclease 4e5lA00
5D42A 4E5JA 4E5EA 3EBJA 4AWFA 5FDGA 4CGXA 5DBSA 3HW4A 5D8UA 4AWHA 4E5LA 5D2OA 5D4GA 5I13A 4ZQQA 4AWMA 5CGVA 5DEBA 4YYLA 4AWGA 4AVLA 4E5HA 5JHTA 5CL0A 5FDDA 5CCYA 5CZNA 3HW6A 3HW3A 4E5GA 4CHCA 5D9JA 4AVQA 4CGSA 4ZI0A 5JHVA 5EGAA 4AVGA 4AWKA 5DESA 4NFZA 4E5FA 4ZHZA 4E5IA 3HW5A
chains in the Genus database with same CATH superfamily
3MQYA 3V1ZA 2FQZA 5FDGA 1ES8A 3V21A 4AWHA 1CFRA 4ZQQA 5CGVA 3V20A 1FZRA 4AWGA 2BAMA 1DFMA 2P0JA 5FDDA 3HW6A 3WVIA 5JHVA 1BAMA 3BM3A 3WVGA 5DESA 2PFJA 3HW5A 1BHMA 2P14A 4E5EA 4AWFA 1KNVA 4AWMA 4YYLA 4AVLA 4F0QA 5JHTA 5CL0A 1VRRA 4E5GA 4CHCA 1ESGA 2XI7A 1M0IA 3N7BA 2E52A 4AVGA 4NFZA 2EWFA 2FOKA 5D42A 4E5JA 3WVKA 3CAEA 3EBJA 3BAMA 4OC8A 5DBSA 3HW4A 5I13A 5DEBA 3A4KA 1FOKA 3DVOA 5CCYA 3HW3A 5D9JA 4AVQA 4ZI0A 3ODHA 5EGAA 3MQ6A 2XI5A 4ZHZA 4E5IA 4R28A 3WVHA 1M0DA 4CGXA 3N78A 5D8UA 4E5LA 5D2OA 5D4GA 1DC1A 4F0PA 4E5HA 2GB7A 5CZNA 1SDOA 3DW9A 4CGSA 3DPGA 3WVPA 1D2IA 4AWKA 4E5FA
chains in the Genus database with same CATH topology
3MQYA 3V1ZA 2FQZA 5FDGA 1ES8A 3V21A 4AWHA 1CFRA 4ZQQA 5CGVA 3V20A 1FZRA 4AWGA 2BAMA 1DFMA 2P0JA 5FDDA 3HW6A 3WVIA 5JHVA 1BAMA 3BM3A 3WVGA 5DESA 2PFJA 3HW5A 1BHMA 2P14A 4E5EA 4AWFA 1KNVA 4AWMA 4YYLA 4AVLA 4F0QA 5JHTA 5CL0A 1VRRA 4E5GA 4CHCA 1ESGA 2XI7A 1M0IA 3N7BA 2E52A 4AVGA 4NFZA 2EWFA 2FOKA 5D42A 4E5JA 3WVKA 3CAEA 3EBJA 3BAMA 4OC8A 5DBSA 3HW4A 5I13A 5DEBA 3A4KA 1FOKA 3DVOA 5CCYA 3HW3A 5D9JA 4AVQA 4ZI0A 3ODHA 5EGAA 3MQ6A 2XI5A 4ZHZA 4E5IA 4R28A 3WVHA 1M0DA 4CGXA 3N78A 5D8UA 4E5LA 5D2OA 5D4GA 1DC1A 4F0PA 4E5HA 2GB7A 5CZNA 1SDOA 3DW9A 4CGSA 3DPGA 3WVPA 1D2IA 4AWKA 4E5FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D42 A;  4E5J A;  4E5E A;  3EBJ A;  4AWF A;  5FDG A;  4CGX A;  5DBS A;  3HW4 A;  5D8U A;  4AWH A;  4E5L A;  5D2O A;  5D4G A;  5I13 A;  4ZQQ A;  4AWM A;  5CGV A;  5DEB A;  4YYL A;  4AWG A;  4AVL A;  4E5H A;  5JHT A;  5CL0 A;  5FDD A;  5CCY A;  5CZN A;  3HW6 A;  3HW3 A;  4E5G A;  4CHC A;  5D9J A;  4AVQ A;  4CGS A;  4ZI0 A;  5JHV A;  5EGA A;  4AVG A;  4AWK A;  5DES A;  4NFZ A;  4E5F A;  4ZHZ A;  4E5I A;  3HW5 A; 
#chains in the Genus database with same CATH topology
 3MQY A;  3V1Z A;  2FQZ A;  5FDG A;  1ES8 A;  3V21 A;  4AWH A;  1CFR A;  4ZQQ A;  5CGV A;  3V20 A;  1FZR A;  4AWG A;  2BAM A;  1DFM A;  2P0J A;  5FDD A;  3HW6 A;  3WVI A;  5JHV A;  1BAM A;  3BM3 A;  3WVG A;  5DES A;  2PFJ A;  3HW5 A;  1BHM A;  2P14 A;  4E5E A;  4AWF A;  1KNV A;  4AWM A;  4YYL A;  4AVL A;  4F0Q A;  5JHT A;  5CL0 A;  1VRR A;  4E5G A;  4CHC A;  1ESG A;  2XI7 A;  1M0I A;  3N7B A;  2E52 A;  4AVG A;  4NFZ A;  2EWF A;  2FOK A;  5D42 A;  4E5J A;  3WVK A;  3CAE A;  3EBJ A;  3BAM A;  4OC8 A;  5DBS A;  3HW4 A;  5I13 A;  5DEB A;  3A4K A;  1FOK A;  3DVO A;  5CCY A;  3HW3 A;  5D9J A;  4AVQ A;  4ZI0 A;  3ODH A;  5EGA A;  3MQ6 A;  2XI5 A;  4ZHZ A;  4E5I A;  4R28 A;  3WVH A;  1M0D A;  4CGX A;  3N78 A;  5D8U A;  4E5L A;  5D2O A;  5D4G A;  1DC1 A;  4F0P A;  4E5H A;  2GB7 A;  5CZN A;  1SDO A;  3DW9 A;  4CGS A;  3DPG A;  3WVP A;  1D2I A;  4AWK A;  4E5F A; 
#chains in the Genus database with same CATH homology
 3MQY A;  3V1Z A;  2FQZ A;  5FDG A;  1ES8 A;  3V21 A;  4AWH A;  1CFR A;  4ZQQ A;  5CGV A;  3V20 A;  1FZR A;  4AWG A;  2BAM A;  1DFM A;  2P0J A;  5FDD A;  3HW6 A;  3WVI A;  5JHV A;  1BAM A;  3BM3 A;  3WVG A;  5DES A;  2PFJ A;  3HW5 A;  1BHM A;  2P14 A;  4E5E A;  4AWF A;  1KNV A;  4AWM A;  4YYL A;  4AVL A;  4F0Q A;  5JHT A;  5CL0 A;  1VRR A;  4E5G A;  4CHC A;  1ESG A;  2XI7 A;  1M0I A;  3N7B A;  2E52 A;  4AVG A;  4NFZ A;  2EWF A;  2FOK A;  5D42 A;  4E5J A;  3WVK A;  3CAE A;  3EBJ A;  3BAM A;  4OC8 A;  5DBS A;  3HW4 A;  5I13 A;  5DEB A;  3A4K A;  1FOK A;  3DVO A;  5CCY A;  3HW3 A;  5D9J A;  4AVQ A;  4ZI0 A;  3ODH A;  5EGA A;  3MQ6 A;  2XI5 A;  4ZHZ A;  4E5I A;  4R28 A;  3WVH A;  1M0D A;  4CGX A;  3N78 A;  5D8U A;  4E5L A;  5D2O A;  5D4G A;  1DC1 A;  4F0P A;  4E5H A;  2GB7 A;  5CZN A;  1SDO A;  3DW9 A;  4CGS A;  3DPG A;  3WVP A;  1D2I A;  4AWK A;  4E5F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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