4E5LA

Crystal structure of avian influenza virus pan bound to compound 6
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
179
structure length
179
Chain Sequence
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDGGSKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHTYYLEKANKIKSEETHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease.
pubmed doi rcsb
molecule tags Viral protein, transcription
source organism Influenza a virus
molecule keywords Polymerase protein PA
total genus 68
structure length 179
sequence length 179
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2012-03-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.91.90 Alpha Beta 3-Layer(aba) Sandwich Restriction Endonuclease Restriction Endonuclease 4e5lA00
5CL0A 3HW5A 3EBJA 5FDDA 4E5GA 4AWKA 5I13A 5D9JA 5D8UA 5JHVA 5D4GA 3HW4A 4AWGA 4E5IA 5DBSA 5CCYA 5CZNA 5DEBA 5D42A 5EGAA 4AVGA 4ZI0A 3HW6A 4E5EA 4ZHZA 4E5LA 4AVQA 4E5FA 5CGVA 4E5JA 4YYLA 3HW3A 4E5HA 4AWFA 5D2OA 4AWMA 4CGSA 4ZQQA 5FDGA 4AWHA 4NFZA 4AVLA 4CHCA 4CGXA 5JHTA 5DESA
chains in the Genus database with same CATH superfamily
5CL0A 3BM3A 3MQ6A 1FZRA 4E5IA 2P14A 5EGAA 4F0QA 4ZI0A 3A4KA 4ZHZA 4E5LA 1M0DA 3HW3A 1DFMA 4AWHA 2EWFA 5JHTA 4CGXA 3BAMA 3MQYA 3EBJA 3N7BA 4AWKA 5I13A 5D9JA 5D8UA 5D4GA 1D2IA 3N78A 3HW4A 4AWGA 1FOKA 5DEBA 2XI5A 4AVGA 3HW6A 3V21A 3DPGA 4E5EA 3WVPA 4E5JA 4AWFA 2GB7A 4AWMA 4ZQQA 5FDGA 1ESGA 4AVLA 3ODHA 2XI7A 4F0PA 5DESA 3CAEA 3V20A 4OC8A 3HW5A 5FDDA 2FOKA 3WVIA 3WVHA 2FQZA 3WVGA 2BAMA 5CZNA 3WVKA 4AVQA 3DVOA 1BHMA 1KNVA 4YYLA 1CFRA 5D2OA 1BAMA 4CGSA 4NFZA 4E5GA 2PFJA 4R28A 5JHVA 2P0JA 1M0IA 5DBSA 5CCYA 1SDOA 5D42A 1VRRA 3V1ZA 4E5FA 5CGVA 2E52A 4E5HA 1DC1A 4CHCA 3DW9A 1ES8A
chains in the Genus database with same CATH topology
5CL0A 3BM3A 3MQ6A 1FZRA 4E5IA 2P14A 5EGAA 4F0QA 4ZI0A 3A4KA 4ZHZA 4E5LA 1M0DA 3HW3A 1DFMA 4AWHA 2EWFA 5JHTA 4CGXA 3BAMA 3MQYA 3EBJA 3N7BA 4AWKA 5I13A 5D9JA 5D8UA 5D4GA 1D2IA 3N78A 3HW4A 4AWGA 1FOKA 5DEBA 2XI5A 4AVGA 3HW6A 3V21A 3DPGA 4E5EA 3WVPA 4E5JA 4AWFA 2GB7A 4AWMA 4ZQQA 5FDGA 1ESGA 4AVLA 3ODHA 2XI7A 4F0PA 5DESA 3CAEA 3V20A 4OC8A 3HW5A 5FDDA 2FOKA 3WVIA 3WVHA 2FQZA 3WVGA 2BAMA 5CZNA 3WVKA 4AVQA 3DVOA 1BHMA 1KNVA 4YYLA 1CFRA 5D2OA 1BAMA 4CGSA 4NFZA 4E5GA 2PFJA 4R28A 5JHVA 2P0JA 1M0IA 5DBSA 5CCYA 1SDOA 5D42A 1VRRA 3V1ZA 4E5FA 5CGVA 2E52A 4E5HA 1DC1A 4CHCA 3DW9A 1ES8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CL0 A;  3HW5 A;  3EBJ A;  5FDD A;  4E5G A;  4AWK A;  5I13 A;  5D9J A;  5D8U A;  5JHV A;  5D4G A;  3HW4 A;  4AWG A;  4E5I A;  5DBS A;  5CCY A;  5CZN A;  5DEB A;  5D42 A;  5EGA A;  4AVG A;  4ZI0 A;  3HW6 A;  4E5E A;  4ZHZ A;  4E5L A;  4AVQ A;  4E5F A;  5CGV A;  4E5J A;  4YYL A;  3HW3 A;  4E5H A;  4AWF A;  5D2O A;  4AWM A;  4CGS A;  4ZQQ A;  5FDG A;  4AWH A;  4NFZ A;  4AVL A;  4CHC A;  4CGX A;  5JHT A;  5DES A; 
#chains in the Genus database with same CATH topology
 5CL0 A;  3BM3 A;  3MQ6 A;  1FZR A;  4E5I A;  2P14 A;  5EGA A;  4F0Q A;  4ZI0 A;  3A4K A;  4ZHZ A;  4E5L A;  1M0D A;  3HW3 A;  1DFM A;  4AWH A;  2EWF A;  5JHT A;  4CGX A;  3BAM A;  3MQY A;  3EBJ A;  3N7B A;  4AWK A;  5I13 A;  5D9J A;  5D8U A;  5D4G A;  1D2I A;  3N78 A;  3HW4 A;  4AWG A;  1FOK A;  5DEB A;  2XI5 A;  4AVG A;  3HW6 A;  3V21 A;  3DPG A;  4E5E A;  3WVP A;  4E5J A;  4AWF A;  2GB7 A;  4AWM A;  4ZQQ A;  5FDG A;  1ESG A;  4AVL A;  3ODH A;  2XI7 A;  4F0P A;  5DES A;  3CAE A;  3V20 A;  4OC8 A;  3HW5 A;  5FDD A;  2FOK A;  3WVI A;  3WVH A;  2FQZ A;  3WVG A;  2BAM A;  5CZN A;  3WVK A;  4AVQ A;  3DVO A;  1BHM A;  1KNV A;  4YYL A;  1CFR A;  5D2O A;  1BAM A;  4CGS A;  4NFZ A;  4E5G A;  2PFJ A;  4R28 A;  5JHV A;  2P0J A;  1M0I A;  5DBS A;  5CCY A;  1SDO A;  5D42 A;  1VRR A;  3V1Z A;  4E5F A;  5CGV A;  2E52 A;  4E5H A;  1DC1 A;  4CHC A;  3DW9 A;  1ES8 A; 
#chains in the Genus database with same CATH homology
 5CL0 A;  3BM3 A;  3MQ6 A;  1FZR A;  4E5I A;  2P14 A;  5EGA A;  4F0Q A;  4ZI0 A;  3A4K A;  4ZHZ A;  4E5L A;  1M0D A;  3HW3 A;  1DFM A;  4AWH A;  2EWF A;  5JHT A;  4CGX A;  3BAM A;  3MQY A;  3EBJ A;  3N7B A;  4AWK A;  5I13 A;  5D9J A;  5D8U A;  5D4G A;  1D2I A;  3N78 A;  3HW4 A;  4AWG A;  1FOK A;  5DEB A;  2XI5 A;  4AVG A;  3HW6 A;  3V21 A;  3DPG A;  4E5E A;  3WVP A;  4E5J A;  4AWF A;  2GB7 A;  4AWM A;  4ZQQ A;  5FDG A;  1ESG A;  4AVL A;  3ODH A;  2XI7 A;  4F0P A;  5DES A;  3CAE A;  3V20 A;  4OC8 A;  3HW5 A;  5FDD A;  2FOK A;  3WVI A;  3WVH A;  2FQZ A;  3WVG A;  2BAM A;  5CZN A;  3WVK A;  4AVQ A;  3DVO A;  1BHM A;  1KNV A;  4YYL A;  1CFR A;  5D2O A;  1BAM A;  4CGS A;  4NFZ A;  4E5G A;  2PFJ A;  4R28 A;  5JHV A;  2P0J A;  1M0I A;  5DBS A;  5CCY A;  1SDO A;  5D42 A;  1VRR A;  3V1Z A;  4E5F A;  5CGV A;  2E52 A;  4E5H A;  1DC1 A;  4CHC A;  3DW9 A;  1ES8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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