4F7IA

Structure of isopropylmalate dehydrogenase from thermus thermophilus in complex with ipm, mn and nadh
Total Genus 125

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
350
structure length
350
Chain Sequence
SMKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFEAARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLAAAAL
5010015020025030030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (11-30)TI9 (276-279)TII4 (279-282)3H1 (75-77)AH2 (42-49)TII1 (77-80)AH3 (55-63)TIV1 (51-54)EMPTY3H2 (82-84)AH4 (86-97)TIV3 (133-136)S4 (101-107)AH9 (237-248)S5 (127-133)TII2 (109-112)AH5 (120-123)TII3 (123-126)TII'1 (136-139)TI2 (138-141)S6 (145-147)TI1 (137-140)AH6 (159-175)TIV5 (204-207)TI5 (206-209)S8 (179-184)AH7 (190-204)TI4 (185-188)S9 (210-215)AH8 (216-226)TIV4 (186-189)3H4 (227-229)TI7 (253-256)TIV6 (248-251)TI8 (254-257)3H5 (325-327)AH10 (287-302)S11 (259-262)S12 (268-270)TI10 (277-280)AH11 (305-321)S1 (1-8)S2 (34-38)3H3 (113-115)S7 (150-152)TI3 (147-150)S10 (232-235)S3 (66-71)AH12 (333-348)Updating...
connected with : NaN
publication title Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Thermus thermophilus
molecule keywords 3-isopropylmalate dehydrogenase
total genus 125
structure length 350
sequence length 350
chains with identical sequence B, C, D
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2012-05-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4f7iA00
2HI1A 3R8WA 4JA8A 3WZYA 1CNZA 1CW7A 3BLXB 1VI1A 5J32A 5LGEA 3AH3A 1G2UA 4IWHA 4AJSA 1PS7A 2QFWA 3WZWA 5HN5A 2AYQA 8ICDA 1ZORA 2QFXA 1XGVA 5J34A 1P8FA 2IV0A 4XS3A 1OSJA 1WPWA 3VL7A 1VLCA 1TYOA 1IPDA 5GRLA 5I96A 3UDUA 3US8A 1PB1A 4AOYA 4AJ3A 1A05A 1XAAA 2DHTA 1PS6A 2ZTWA 5GRIA 1V5BA 3WZVA 2E5MA 3BLVA 4KZOA 1CW1A 1DR8A 1GROA 5K11A 3VMJA 4HCXA 1R8KA 1U7NA 5L57A 3TSNA 5L58A 1CW4A 5J33A 1GRPA 3MASB 3UF6A 1HJ6A 5GRLB 1CM7A 2G4OA 3MARA 3VKZA 4BNPA 1IDMA 3INMA 4AJRA 4AOUA 3U9EA 1HEXA 1IKAA 3MASA 5GRIB 1ISOA 1WALA 1YCOA 3LCBC 4Y1PA 1V53A 3BLVB 4I3KA 4WUOA 4ICDA 3LXYA 5HN6A 6ICDA 4XXVA 1GC9A 1T0LA 3DMSA 4AOVA 1GC8A 1SJSA 3FLKA 2UXRA 5K10A 1AI2A 3VL2A 1LWDA 1DPZA 5HN4A 4XRXA 4L06A 2UXQA 2E0CA 3ASJA 4JQPA 3UDOA 2D4VA 2QFVA 3VL3A 5GRHA 4AJAA 3TNGA 3VMKA 1W0DA 5HN3A 4UMXA 3MAPA 7ICDA 1T09A 1IDDA 1X0LA 1YXOA 5GRFA 3WZXA 4I3LA 5I95A 1DR0A 3TY4A 3VMLA 5DE1A 3VL6A 1XADA 4F7IA 2Y3ZA 1XKDA 4L04A 5GRHB 2D1CA 4YB4A 3VL4A 4AJCA 1BL5A 3U1HA 1XABA 3BLXA 4P69C 1AI3A 1V94A 5GRFB 5GREB 1HQSA 3ICDA 4L03A 2Y42A 1IDEA 3TY3A 1PB3A 9ICDA 5ICDA 1XACA 2QFYA 2Y41A 1PTMA 2Y40A 1IDCA 4AJBA 1IDFA 5GREA 4UMYA 1OSIA 4ATYA 3FMXX
chains in the Genus database with same CATH superfamily
2HI1A 3R8WA 4JA8A 3WZYA 1CNZA 1CW7A 3BLXB 1VI1A 5J32A 5LGEA 3AH3A 1G2UA 4IWHA 4AJSA 1PS7A 2QFWA 3WZWA 5HN5A 2AYQA 8ICDA 1ZORA 2QFXA 1XGVA 5J34A 1P8FA 2IV0A 4XS3A 1OSJA 1WPWA 3VL7A 1VLCA 1TYOA 1IPDA 5GRLA 5I96A 3UDUA 3US8A 1PB1A 4AOYA 4AJ3A 1A05A 1XAAA 2DHTA 1PS6A 2ZTWA 5GRIA 1V5BA 3WZVA 2E5MA 3BLVA 4KZOA 1CW1A 1DR8A 1GROA 5K11A 3VMJA 4HCXA 1R8KA 1U7NA 5L57A 3TSNA 5L58A 1CW4A 5J33A 1GRPA 3MASB 3UF6A 1HJ6A 5GRLB 1CM7A 2G4OA 3MARA 3VKZA 4BNPA 1IDMA 3INMA 4AJRA 4AOUA 3U9EA 1HEXA 1IKAA 3MASA 5GRIB 1ISOA 1WALA 1YCOA 3LCBC 4Y1PA 1V53A 3BLVB 4I3KA 4WUOA 4ICDA 3LXYA 5HN6A 6ICDA 4XXVA 1GC9A 1T0LA 3DMSA 4AOVA 1GC8A 1SJSA 3FLKA 2UXRA 5K10A 1AI2A 3VL2A 1LWDA 1DPZA 5HN4A 4XRXA 4L06A 2UXQA 2E0CA 3ASJA 4JQPA 3UDOA 2D4VA 2QFVA 3VL3A 5GRHA 4AJAA 3TNGA 3VMKA 1W0DA 5HN3A 4UMXA 3MAPA 7ICDA 1T09A 1IDDA 1X0LA 1YXOA 5GRFA 3WZXA 4I3LA 5I95A 1DR0A 3TY4A 3VMLA 5DE1A 3VL6A 1XADA 4F7IA 2Y3ZA 1XKDA 4L04A 5GRHB 2D1CA 4YB4A 3VL4A 4AJCA 1BL5A 3U1HA 1XABA 3BLXA 4P69C 1AI3A 1V94A 5GRFB 5GREB 1HQSA 3ICDA 4L03A 2Y42A 1IDEA 3TY3A 1PB3A 9ICDA 5ICDA 1XACA 2QFYA 2Y41A 1PTMA 2Y40A 1IDCA 4AJBA 1IDFA 5GREA 4UMYA 1OSIA 4ATYA 3FMXX
chains in the Genus database with same CATH topology
2HI1A 3R8WA 4JA8A 3WZYA 1CNZA 1CW7A 3BLXB 1VI1A 5J32A 5LGEA 3AH3A 1G2UA 4IWHA 4AJSA 1PS7A 2QFWA 3WZWA 5HN5A 2AYQA 8ICDA 1ZORA 2QFXA 1XGVA 5J34A 1P8FA 2IV0A 4XS3A 1OSJA 1WPWA 3VL7A 1VLCA 1TYOA 1IPDA 5GRLA 5I96A 3UDUA 3US8A 1PB1A 4AOYA 4AJ3A 1A05A 1XAAA 2DHTA 1PS6A 2ZTWA 5GRIA 1V5BA 3WZVA 2E5MA 3BLVA 4KZOA 1CW1A 1DR8A 1GROA 5K11A 3VMJA 4HCXA 1R8KA 1U7NA 5L57A 3TSNA 5L58A 1CW4A 5J33A 1GRPA 3MASB 3UF6A 1HJ6A 5GRLB 1CM7A 2G4OA 3MARA 3VKZA 4BNPA 1IDMA 3INMA 4AJRA 4AOUA 3U9EA 1HEXA 1IKAA 3MASA 5GRIB 1ISOA 1WALA 1YCOA 3LCBC 4Y1PA 1V53A 3BLVB 4I3KA 4WUOA 4ICDA 3LXYA 5HN6A 6ICDA 4XXVA 1GC9A 1T0LA 3DMSA 4AOVA 1GC8A 1SJSA 3FLKA 2UXRA 5K10A 1AI2A 3VL2A 1LWDA 1DPZA 5HN4A 4XRXA 4L06A 2UXQA 2E0CA 3ASJA 4JQPA 3UDOA 2D4VA 2QFVA 3VL3A 5GRHA 4AJAA 3TNGA 3VMKA 1W0DA 5HN3A 4UMXA 3MAPA 7ICDA 1T09A 1IDDA 1X0LA 1YXOA 5GRFA 3WZXA 4I3LA 5I95A 1DR0A 3TY4A 3VMLA 5DE1A 3VL6A 1XADA 4F7IA 2Y3ZA 1XKDA 4L04A 5GRHB 2D1CA 4YB4A 3VL4A 4AJCA 1BL5A 3U1HA 1XABA 3BLXA 4P69C 1AI3A 1V94A 5GRFB 5GREB 1HQSA 3ICDA 4L03A 2Y42A 1IDEA 3TY3A 1PB3A 9ICDA 5ICDA 1XACA 2QFYA 2Y41A 1PTMA 2Y40A 1IDCA 4AJBA 1IDFA 5GREA 4UMYA 1OSIA 4ATYA 3FMXX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HI1 A;  3R8W A;  4JA8 A;  3WZY A;  1CNZ A;  1CW7 A;  3BLX B;  1VI1 A;  5J32 A;  5LGE A;  3AH3 A;  1G2U A;  4IWH A;  4AJS A;  1PS7 A;  2QFW A;  3WZW A;  5HN5 A;  2AYQ A;  8ICD A;  1ZOR A;  2QFX A;  1XGV A;  5J34 A;  1P8F A;  2IV0 A;  4XS3 A;  1OSJ A;  1WPW A;  3VL7 A;  1VLC A;  1TYO A;  1IPD A;  5GRL A;  5I96 A;  3UDU A;  3US8 A;  1PB1 A;  4AOY A;  4AJ3 A;  1A05 A;  1XAA A;  2DHT A;  1PS6 A;  2ZTW A;  5GRI A;  1V5B A;  3WZV A;  2E5M A;  3BLV A;  4KZO A;  1CW1 A;  1DR8 A;  1GRO A;  5K11 A;  3VMJ A;  4HCX A;  1R8K A;  1U7N A;  5L57 A;  3TSN A;  5L58 A;  1CW4 A;  5J33 A;  1GRP A;  3MAS B;  3UF6 A;  1HJ6 A;  5GRL B;  1CM7 A;  2G4O A;  3MAR A;  3VKZ A;  4BNP A;  1IDM A;  3INM A;  4AJR A;  4AOU A;  3U9E A;  1HEX A;  1IKA A;  3MAS A;  5GRI B;  1ISO A;  1WAL A;  1YCO A;  3LCB C;  4Y1P A;  1V53 A;  3BLV B;  4I3K A;  4WUO A;  4ICD A;  3LXY A;  5HN6 A;  6ICD A;  4XXV A;  1GC9 A;  1T0L A;  3DMS A;  4AOV A;  1GC8 A;  1SJS A;  3FLK A;  2UXR A;  5K10 A;  1AI2 A;  3VL2 A;  1LWD A;  1DPZ A;  5HN4 A;  4XRX A;  4L06 A;  2UXQ A;  2E0C A;  3ASJ A;  4JQP A;  3UDO A;  2D4V A;  2QFV A;  3VL3 A;  5GRH A;  4AJA A;  3TNG A;  3VMK A;  1W0D A;  5HN3 A;  4UMX A;  3MAP A;  7ICD A;  1T09 A;  1IDD A;  1X0L A;  1YXO A;  5GRF A;  3WZX A;  4I3L A;  5I95 A;  1DR0 A;  3TY4 A;  3VML A;  5DE1 A;  3VL6 A;  1XAD A;  4F7I A;  2Y3Z A;  1XKD A;  4L04 A;  5GRH B;  2D1C A;  4YB4 A;  3VL4 A;  4AJC A;  1BL5 A;  3U1H A;  1XAB A;  3BLX A;  4P69 C;  1AI3 A;  1V94 A;  5GRF B;  5GRE B;  1HQS A;  3ICD A;  4L03 A;  2Y42 A;  1IDE A;  3TY3 A;  1PB3 A;  9ICD A;  5ICD A;  1XAC A;  2QFY A;  2Y41 A;  1PTM A;  2Y40 A;  1IDC A;  4AJB A;  1IDF A;  5GRE A;  4UMY A;  1OSI A;  4ATY A;  3FMX X; 
#chains in the Genus database with same CATH topology
 2HI1 A;  3R8W A;  4JA8 A;  3WZY A;  1CNZ A;  1CW7 A;  3BLX B;  1VI1 A;  5J32 A;  5LGE A;  3AH3 A;  1G2U A;  4IWH A;  4AJS A;  1PS7 A;  2QFW A;  3WZW A;  5HN5 A;  2AYQ A;  8ICD A;  1ZOR A;  2QFX A;  1XGV A;  5J34 A;  1P8F A;  2IV0 A;  4XS3 A;  1OSJ A;  1WPW A;  3VL7 A;  1VLC A;  1TYO A;  1IPD A;  5GRL A;  5I96 A;  3UDU A;  3US8 A;  1PB1 A;  4AOY A;  4AJ3 A;  1A05 A;  1XAA A;  2DHT A;  1PS6 A;  2ZTW A;  5GRI A;  1V5B A;  3WZV A;  2E5M A;  3BLV A;  4KZO A;  1CW1 A;  1DR8 A;  1GRO A;  5K11 A;  3VMJ A;  4HCX A;  1R8K A;  1U7N A;  5L57 A;  3TSN A;  5L58 A;  1CW4 A;  5J33 A;  1GRP A;  3MAS B;  3UF6 A;  1HJ6 A;  5GRL B;  1CM7 A;  2G4O A;  3MAR A;  3VKZ A;  4BNP A;  1IDM A;  3INM A;  4AJR A;  4AOU A;  3U9E A;  1HEX A;  1IKA A;  3MAS A;  5GRI B;  1ISO A;  1WAL A;  1YCO A;  3LCB C;  4Y1P A;  1V53 A;  3BLV B;  4I3K A;  4WUO A;  4ICD A;  3LXY A;  5HN6 A;  6ICD A;  4XXV A;  1GC9 A;  1T0L A;  3DMS A;  4AOV A;  1GC8 A;  1SJS A;  3FLK A;  2UXR A;  5K10 A;  1AI2 A;  3VL2 A;  1LWD A;  1DPZ A;  5HN4 A;  4XRX A;  4L06 A;  2UXQ A;  2E0C A;  3ASJ A;  4JQP A;  3UDO A;  2D4V A;  2QFV A;  3VL3 A;  5GRH A;  4AJA A;  3TNG A;  3VMK A;  1W0D A;  5HN3 A;  4UMX A;  3MAP A;  7ICD A;  1T09 A;  1IDD A;  1X0L A;  1YXO A;  5GRF A;  3WZX A;  4I3L A;  5I95 A;  1DR0 A;  3TY4 A;  3VML A;  5DE1 A;  3VL6 A;  1XAD A;  4F7I A;  2Y3Z A;  1XKD A;  4L04 A;  5GRH B;  2D1C A;  4YB4 A;  3VL4 A;  4AJC A;  1BL5 A;  3U1H A;  1XAB A;  3BLX A;  4P69 C;  1AI3 A;  1V94 A;  5GRF B;  5GRE B;  1HQS A;  3ICD A;  4L03 A;  2Y42 A;  1IDE A;  3TY3 A;  1PB3 A;  9ICD A;  5ICD A;  1XAC A;  2QFY A;  2Y41 A;  1PTM A;  2Y40 A;  1IDC A;  4AJB A;  1IDF A;  5GRE A;  4UMY A;  1OSI A;  4ATY A;  3FMX X; 
#chains in the Genus database with same CATH homology
 2HI1 A;  3R8W A;  4JA8 A;  3WZY A;  1CNZ A;  1CW7 A;  3BLX B;  1VI1 A;  5J32 A;  5LGE A;  3AH3 A;  1G2U A;  4IWH A;  4AJS A;  1PS7 A;  2QFW A;  3WZW A;  5HN5 A;  2AYQ A;  8ICD A;  1ZOR A;  2QFX A;  1XGV A;  5J34 A;  1P8F A;  2IV0 A;  4XS3 A;  1OSJ A;  1WPW A;  3VL7 A;  1VLC A;  1TYO A;  1IPD A;  5GRL A;  5I96 A;  3UDU A;  3US8 A;  1PB1 A;  4AOY A;  4AJ3 A;  1A05 A;  1XAA A;  2DHT A;  1PS6 A;  2ZTW A;  5GRI A;  1V5B A;  3WZV A;  2E5M A;  3BLV A;  4KZO A;  1CW1 A;  1DR8 A;  1GRO A;  5K11 A;  3VMJ A;  4HCX A;  1R8K A;  1U7N A;  5L57 A;  3TSN A;  5L58 A;  1CW4 A;  5J33 A;  1GRP A;  3MAS B;  3UF6 A;  1HJ6 A;  5GRL B;  1CM7 A;  2G4O A;  3MAR A;  3VKZ A;  4BNP A;  1IDM A;  3INM A;  4AJR A;  4AOU A;  3U9E A;  1HEX A;  1IKA A;  3MAS A;  5GRI B;  1ISO A;  1WAL A;  1YCO A;  3LCB C;  4Y1P A;  1V53 A;  3BLV B;  4I3K A;  4WUO A;  4ICD A;  3LXY A;  5HN6 A;  6ICD A;  4XXV A;  1GC9 A;  1T0L A;  3DMS A;  4AOV A;  1GC8 A;  1SJS A;  3FLK A;  2UXR A;  5K10 A;  1AI2 A;  3VL2 A;  1LWD A;  1DPZ A;  5HN4 A;  4XRX A;  4L06 A;  2UXQ A;  2E0C A;  3ASJ A;  4JQP A;  3UDO A;  2D4V A;  2QFV A;  3VL3 A;  5GRH A;  4AJA A;  3TNG A;  3VMK A;  1W0D A;  5HN3 A;  4UMX A;  3MAP A;  7ICD A;  1T09 A;  1IDD A;  1X0L A;  1YXO A;  5GRF A;  3WZX A;  4I3L A;  5I95 A;  1DR0 A;  3TY4 A;  3VML A;  5DE1 A;  3VL6 A;  1XAD A;  4F7I A;  2Y3Z A;  1XKD A;  4L04 A;  5GRH B;  2D1C A;  4YB4 A;  3VL4 A;  4AJC A;  1BL5 A;  3U1H A;  1XAB A;  3BLX A;  4P69 C;  1AI3 A;  1V94 A;  5GRF B;  5GRE B;  1HQS A;  3ICD A;  4L03 A;  2Y42 A;  1IDE A;  3TY3 A;  1PB3 A;  9ICD A;  5ICD A;  1XAC A;  2QFY A;  2Y41 A;  1PTM A;  2Y40 A;  1IDC A;  4AJB A;  1IDF A;  5GRE A;  4UMY A;  1OSI A;  4ATY A;  3FMX X; 
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