4I3K | Genus

Total Genus 125

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	125
sequence length	408
structure length	367
Chain Sequence	KISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNPIIIGHHATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVGFIWACKNLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQ

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase/oxidoreductase inhibitor
source organism	Homo sapiens
publication title	Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NADP] cytoplasmic
total genus	125
structure length	367
sequence length	408
chains with identical sequence	B
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	2012-11-26

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	4i3kA00

1U7NA 4Y1PA 4AJSA 1HQSA 3VL7A 5I96A 1GRPA 3VL6A 1HJ6A 2Y41A 4AOUA 4ATYA 1XACA 5K10A 4KZOA 1CW1A 3ASJA 3DMSA 2E5MA 5J33A 3VMLA 4HCXA 3VMJA 3INMA 3WZXA 2UXRA 4XXVA 4AJBA 2Y42A 3VMKA 1XABA 9ICDA 2Y3ZA 4ICDA 1IDCA 3TY3A 1PB1A 2ZTWA 1TYOA 3UF6A 4JA8A 2UXQA 4AJCA 5K11A 2QFXA 2QFYA 4YB4A 8ICDA 5GRIA 1GROA 3MARA 1IDDA 1P8FA 2Y40A 4AJ3A 3BLVB 1BL5A 1HEXA 1XGVA 4BNPA 2D1CA 3TNGA 3MASB 4P69C 1ZORA 3UDUA 1OSIA 3US8A 1PB3A 4AOVA 1CW4A 5I95A 1VLCA 1OSJA 5GRIB 1PS6A 4I3LA 5GRFA 3BLVA 5GRHB 2DHTA 3LCBC 1YXOA 1LWDA 2QFVA 3MASA 4AJAA 1DR8A 4XS3A 2D4VA 1XAAA 1V53A 1R8KA 1W0DA 6ICDA 3R8WA 7ICDA 5GRHA 1WALA 3ICDA 4L06A 5GRFB 1ISOA 1CW7A 5ICDA 1WPWA 4AOYA 3WZVA 3WZYA 1XKDA 3VL3A 4L04A 1IDFA 4WUOA 1T0LA 1GC9A 5HN4A 1T09A 4JQPA 5GREB 5GRLB 3TSNA 4AJRA 3VKZA 4UMXA 1XADA 3UDOA 1G2UA 5HN3A 2E0CA 2IV0A 5J32A 3VL4A 2QFWA 2HI1A 3U9EA 3AH3A 4I3KA 5GREA 3TY4A 3U1HA 5GRLA 1IDMA 1PTMA 1A05A 1DPZA 2G4OA 3WZWA 1YCOA 5L57A 5HN6A 1IPDA 5LGEA 4F7IA 1CM7A 3FLKA 3VL2A 3BLXB 4XRXA 5J34A 1DR0A 1PS7A 3FMXX 1V5BA 1IDEA 1SJSA 1X0LA 1VI1A 4UMYA 3LXYA 1AI2A 1CNZA 5HN5A 1IKAA 2AYQA 4IWHA 5L58A 4L03A 1GC8A 1V94A 3MAPA 1AI3A 3BLXA 5DE1A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1U7N A;  4Y1P A;  4AJS A;  1HQS A;  3VL7 A;  5I96 A;  1GRP A;  3VL6 A;  1HJ6 A;  2Y41 A;  4AOU A;  4ATY A;  1XAC A;  5K10 A;  4KZO A;  1CW1 A;  3ASJ A;  3DMS A;  2E5M A;  5J33 A;  3VML A;  4HCX A;  3VMJ A;  3INM A;  3WZX A;  2UXR A;  4XXV A;  4AJB A;  2Y42 A;  3VMK A;  1XAB A;  9ICD A;  2Y3Z A;  4ICD A;  1IDC A;  3TY3 A;  1PB1 A;  2ZTW A;  1TYO A;  3UF6 A;  4JA8 A;  2UXQ A;  4AJC A;  5K11 A;  2QFX A;  2QFY A;  4YB4 A;  8ICD A;  5GRI A;  1GRO A;  3MAR A;  1IDD A;  1P8F A;  2Y40 A;  4AJ3 A;  3BLV B;  1BL5 A;  1HEX A;  1XGV A;  4BNP A;  2D1C A;  3TNG A;  3MAS B;  4P69 C;  1ZOR A;  3UDU A;  1OSI A;  3US8 A;  1PB3 A;  4AOV A;  1CW4 A;  5I95 A;  1VLC A;  1OSJ A;  5GRI B;  1PS6 A;  4I3L A;  5GRF A;  3BLV A;  5GRH B;  2DHT A;  3LCB C;  1YXO A;  1LWD A;  2QFV A;  3MAS A;  4AJA A;  1DR8 A;  4XS3 A;  2D4V A;  1XAA A;  1V53 A;  1R8K A;  1W0D A;  6ICD A;  3R8W A;  7ICD A;  5GRH A;  1WAL A;  3ICD A;  4L06 A;  5GRF B;  1ISO A;  1CW7 A;  5ICD A;  1WPW A;  4AOY A;  3WZV A;  3WZY A;  1XKD A;  3VL3 A;  4L04 A;  1IDF A;  4WUO A;  1T0L A;  1GC9 A;  5HN4 A;  1T09 A;  4JQP A;  5GRE B;  5GRL B;  3TSN A;  4AJR A;  3VKZ A;  4UMX A;  1XAD A;  3UDO A;  1G2U A;  5HN3 A;  2E0C A;  2IV0 A;  5J32 A;  3VL4 A;  2QFW A;  2HI1 A;  3U9E A;  3AH3 A;  4I3K A;  5GRE A;  3TY4 A;  3U1H A;  5GRL A;  1IDM A;  1PTM A;  1A05 A;  1DPZ A;  2G4O A;  3WZW A;  1YCO A;  5L57 A;  5HN6 A;  1IPD A;  5LGE A;  4F7I A;  1CM7 A;  3FLK A;  3VL2 A;  3BLX B;  4XRX A;  5J34 A;  1DR0 A;  1PS7 A;  3FMX X;  1V5B A;  1IDE A;  1SJS A;  1X0L A;  1VI1 A;  4UMY A;  3LXY A;  1AI2 A;  1CNZ A;  5HN5 A;  1IKA A;  2AYQ A;  4IWH A;  5L58 A;  4L03 A;  1GC8 A;  1V94 A;  3MAP A;  1AI3 A;  3BLX A;  5DE1 A; 
#chains in the Genus database with same CATH topology
 1U7N A;  4Y1P A;  4AJS A;  1HQS A;  3VL7 A;  5I96 A;  1GRP A;  3VL6 A;  1HJ6 A;  2Y41 A;  4AOU A;  4ATY A;  1XAC A;  5K10 A;  4KZO A;  1CW1 A;  3ASJ A;  3DMS A;  2E5M A;  5J33 A;  3VML A;  4HCX A;  3VMJ A;  3INM A;  3WZX A;  2UXR A;  4XXV A;  4AJB A;  2Y42 A;  3VMK A;  1XAB A;  9ICD A;  2Y3Z A;  4ICD A;  1IDC A;  3TY3 A;  1PB1 A;  2ZTW A;  1TYO A;  3UF6 A;  4JA8 A;  2UXQ A;  4AJC A;  5K11 A;  2QFX A;  2QFY A;  4YB4 A;  8ICD A;  5GRI A;  1GRO A;  3MAR A;  1IDD A;  1P8F A;  2Y40 A;  4AJ3 A;  3BLV B;  1BL5 A;  1HEX A;  1XGV A;  4BNP A;  2D1C A;  3TNG A;  3MAS B;  4P69 C;  1ZOR A;  3UDU A;  1OSI A;  3US8 A;  1PB3 A;  4AOV A;  1CW4 A;  5I95 A;  1VLC A;  1OSJ A;  5GRI B;  1PS6 A;  4I3L A;  5GRF A;  3BLV A;  5GRH B;  2DHT A;  3LCB C;  1YXO A;  1LWD A;  2QFV A;  3MAS A;  4AJA A;  1DR8 A;  4XS3 A;  2D4V A;  1XAA A;  1V53 A;  1R8K A;  1W0D A;  6ICD A;  3R8W A;  7ICD A;  5GRH A;  1WAL A;  3ICD A;  4L06 A;  5GRF B;  1ISO A;  1CW7 A;  5ICD A;  1WPW A;  4AOY A;  3WZV A;  3WZY A;  1XKD A;  3VL3 A;  4L04 A;  1IDF A;  4WUO A;  1T0L A;  1GC9 A;  5HN4 A;  1T09 A;  4JQP A;  5GRE B;  5GRL B;  3TSN A;  4AJR A;  3VKZ A;  4UMX A;  1XAD A;  3UDO A;  1G2U A;  5HN3 A;  2E0C A;  2IV0 A;  5J32 A;  3VL4 A;  2QFW A;  2HI1 A;  3U9E A;  3AH3 A;  4I3K A;  5GRE A;  3TY4 A;  3U1H A;  5GRL A;  1IDM A;  1PTM A;  1A05 A;  1DPZ A;  2G4O A;  3WZW A;  1YCO A;  5L57 A;  5HN6 A;  1IPD A;  5LGE A;  4F7I A;  1CM7 A;  3FLK A;  3VL2 A;  3BLX B;  4XRX A;  5J34 A;  1DR0 A;  1PS7 A;  3FMX X;  1V5B A;  1IDE A;  1SJS A;  1X0L A;  1VI1 A;  4UMY A;  3LXY A;  1AI2 A;  1CNZ A;  5HN5 A;  1IKA A;  2AYQ A;  4IWH A;  5L58 A;  4L03 A;  1GC8 A;  1V94 A;  3MAP A;  1AI3 A;  3BLX A;  5DE1 A; 
#chains in the Genus database with same CATH homology
 1U7N A;  4Y1P A;  4AJS A;  1HQS A;  3VL7 A;  5I96 A;  1GRP A;  3VL6 A;  1HJ6 A;  2Y41 A;  4AOU A;  4ATY A;  1XAC A;  5K10 A;  4KZO A;  1CW1 A;  3ASJ A;  3DMS A;  2E5M A;  5J33 A;  3VML A;  4HCX A;  3VMJ A;  3INM A;  3WZX A;  2UXR A;  4XXV A;  4AJB A;  2Y42 A;  3VMK A;  1XAB A;  9ICD A;  2Y3Z A;  4ICD A;  1IDC A;  3TY3 A;  1PB1 A;  2ZTW A;  1TYO A;  3UF6 A;  4JA8 A;  2UXQ A;  4AJC A;  5K11 A;  2QFX A;  2QFY A;  4YB4 A;  8ICD A;  5GRI A;  1GRO A;  3MAR A;  1IDD A;  1P8F A;  2Y40 A;  4AJ3 A;  3BLV B;  1BL5 A;  1HEX A;  1XGV A;  4BNP A;  2D1C A;  3TNG A;  3MAS B;  4P69 C;  1ZOR A;  3UDU A;  1OSI A;  3US8 A;  1PB3 A;  4AOV A;  1CW4 A;  5I95 A;  1VLC A;  1OSJ A;  5GRI B;  1PS6 A;  4I3L A;  5GRF A;  3BLV A;  5GRH B;  2DHT A;  3LCB C;  1YXO A;  1LWD A;  2QFV A;  3MAS A;  4AJA A;  1DR8 A;  4XS3 A;  2D4V A;  1XAA A;  1V53 A;  1R8K A;  1W0D A;  6ICD A;  3R8W A;  7ICD A;  5GRH A;  1WAL A;  3ICD A;  4L06 A;  5GRF B;  1ISO A;  1CW7 A;  5ICD A;  1WPW A;  4AOY A;  3WZV A;  3WZY A;  1XKD A;  3VL3 A;  4L04 A;  1IDF A;  4WUO A;  1T0L A;  1GC9 A;  5HN4 A;  1T09 A;  4JQP A;  5GRE B;  5GRL B;  3TSN A;  4AJR A;  3VKZ A;  4UMX A;  1XAD A;  3UDO A;  1G2U A;  5HN3 A;  2E0C A;  2IV0 A;  5J32 A;  3VL4 A;  2QFW A;  2HI1 A;  3U9E A;  3AH3 A;  4I3K A;  5GRE A;  3TY4 A;  3U1H A;  5GRL A;  1IDM A;  1PTM A;  1A05 A;  1DPZ A;  2G4O A;  3WZW A;  1YCO A;  5L57 A;  5HN6 A;  1IPD A;  5LGE A;  4F7I A;  1CM7 A;  3FLK A;  3VL2 A;  3BLX B;  4XRX A;  5J34 A;  1DR0 A;  1PS7 A;  3FMX X;  1V5B A;  1IDE A;  1SJS A;  1X0L A;  1VI1 A;  4UMY A;  3LXY A;  1AI2 A;  1CNZ A;  5HN5 A;  1IKA A;  2AYQ A;  4IWH A;  5L58 A;  4L03 A;  1GC8 A;  1V94 A;  3MAP A;  1AI3 A;  3BLX A;  5DE1 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4I3KA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations