4IWHA

Crystal structure of a 3-isopropylmalate dehydrogenase from burkholderia pseudomallei
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
358
structure length
358
Chain Sequence
HHHMKIAVLPGDGIGPEIVNEAVKVLNALDEKFELEHAPVGGAGYEASGHPLPDATLALAKEADAILFGAVGDWKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVAGLDILIVRELNGDIYFGQPRGVRAAPDGPFAGEREGFDTMRYSEPEVRRIAHVAFQAAQKRAKKLLSVDKSNVLETSQFWRDVMIDVSKEYADVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEASMLTGSIGMLPSASLDKNNKGLYEPSHGSAPDIAGKGIANPLATILSAAMLLRYSLNRAEQADRIERAVKTVLEQGYRTGDIATPGCRQVGTAAMGDAVVAAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of a 3-isopropylmalate dehydrogenase from Burkholderia pseudomallei
rcsb
molecule tags Oxidoreductase
source organism Burkholderia thailandensis
molecule keywords 3-isopropylmalate dehydrogenase
total genus 124
structure length 358
sequence length 358
chains with identical sequence B
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2013-01-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4iwhA00
1LWDA 3VL2A 1G2UA 8ICDA 1CNZA 4UMYA 2IV0A 4I3LA 1CM7A 1PB3A 1ISOA 3ICDA 1P8FA 3WZVA 1XABA 5GRFB 1HJ6A 1WPWA 1XACA 1R8KA 2D4VA 5DE1A 1CW7A 1IPDA 3UDUA 1OSJA 4I3KA 3VL7A 3US8A 1PTMA 2DHTA 4JQPA 5I95A 5HN5A 3VMLA 3FLKA 1DR8A 3TNGA 5J34A 1V53A 2HI1A 5GREA 4XXVA 1IDFA 1TYOA 3VL4A 1IDEA 3VMKA 3INMA 5HN6A 3AH3A 2QFXA 5J33A 1VI1A 3BLVA 4IWHA 3LXYA 3WZYA 1IDDA 1W0DA 3BLVB 2G4OA 4AJBA 5GRFA 3VL6A 2QFYA 4KZOA 1XAAA 3VL3A 4L04A 1BL5A 3BLXB 3MAPA 2D1CA 3UDOA 1PS6A 3DMSA 5LGEA 4ICDA 5GRHA 5HN3A 3MARA 5GRHB 3U9EA 5J32A 4AJ3A 4F7IA 3ASJA 3WZXA 3TY3A 1X0LA 1DR0A 2Y3ZA 3LCBC 2AYQA 3TY4A 1SJSA 9ICDA 4XRXA 1U7NA 4AJRA 4AJAA 3BLXA 4AOYA 4AJCA 1AI2A 5GRIB 4P69C 1HQSA 2Y41A 4JA8A 1IKAA 3R8WA 4AOUA 1AI3A 1CW1A 1PS7A 5L57A 2UXRA 3MASB 2E5MA 1CW4A 1WALA 1VLCA 1OSIA 1ZORA 5GRLA 2ZTWA 5ICDA 5GRLB 3VMJA 1GC9A 6ICDA 1T0LA 1IDCA 4L06A 4Y1PA 1IDMA 4WUOA 5K11A 1YXOA 1A05A 1XGVA 1PB1A 1V94A 1GROA 7ICDA 5GRIA 3UF6A 2Y40A 5L58A 1DPZA 3WZWA 1XADA 4L03A 3VKZA 4AJSA 1GRPA 3FMXX 4HCXA 5HN4A 1GC8A 2Y42A 4ATYA 4YB4A 5K10A 1V5BA 1HEXA 2E0CA 3U1HA 3MASA 5GREB 2QFWA 4AOVA 1YCOA 4UMXA 2UXQA 5I96A 1XKDA 4BNPA 2QFVA 3TSNA 1T09A 4XS3A
chains in the Genus database with same CATH superfamily
1LWDA 3VL2A 1G2UA 8ICDA 1CNZA 4UMYA 2IV0A 4I3LA 1CM7A 1PB3A 1ISOA 3ICDA 1P8FA 3WZVA 1XABA 5GRFB 1HJ6A 1WPWA 1XACA 1R8KA 2D4VA 5DE1A 1CW7A 1IPDA 3UDUA 1OSJA 4I3KA 3VL7A 3US8A 1PTMA 2DHTA 4JQPA 5I95A 5HN5A 3VMLA 3FLKA 1DR8A 3TNGA 5J34A 1V53A 2HI1A 5GREA 4XXVA 1IDFA 1TYOA 3VL4A 1IDEA 3VMKA 3INMA 5HN6A 3AH3A 2QFXA 5J33A 1VI1A 3BLVA 4IWHA 3LXYA 3WZYA 1IDDA 1W0DA 3BLVB 2G4OA 4AJBA 5GRFA 3VL6A 2QFYA 4KZOA 1XAAA 3VL3A 4L04A 1BL5A 3BLXB 3MAPA 2D1CA 3UDOA 1PS6A 3DMSA 5LGEA 4ICDA 5GRHA 5HN3A 3MARA 5GRHB 3U9EA 5J32A 4AJ3A 4F7IA 3ASJA 3WZXA 3TY3A 1X0LA 1DR0A 2Y3ZA 3LCBC 2AYQA 3TY4A 1SJSA 9ICDA 4XRXA 1U7NA 4AJRA 4AJAA 3BLXA 4AOYA 4AJCA 1AI2A 5GRIB 4P69C 1HQSA 2Y41A 4JA8A 1IKAA 3R8WA 4AOUA 1AI3A 1CW1A 1PS7A 5L57A 2UXRA 3MASB 2E5MA 1CW4A 1WALA 1VLCA 1OSIA 1ZORA 5GRLA 2ZTWA 5ICDA 5GRLB 3VMJA 1GC9A 6ICDA 1T0LA 1IDCA 4L06A 4Y1PA 1IDMA 4WUOA 5K11A 1YXOA 1A05A 1XGVA 1PB1A 1V94A 1GROA 7ICDA 5GRIA 3UF6A 2Y40A 5L58A 1DPZA 3WZWA 1XADA 4L03A 3VKZA 4AJSA 1GRPA 3FMXX 4HCXA 5HN4A 1GC8A 2Y42A 4ATYA 4YB4A 5K10A 1V5BA 1HEXA 2E0CA 3U1HA 3MASA 5GREB 2QFWA 4AOVA 1YCOA 4UMXA 2UXQA 5I96A 1XKDA 4BNPA 2QFVA 3TSNA 1T09A 4XS3A
chains in the Genus database with same CATH topology
1LWDA 3VL2A 1G2UA 8ICDA 1CNZA 4UMYA 2IV0A 4I3LA 1CM7A 1PB3A 1ISOA 3ICDA 1P8FA 3WZVA 1XABA 5GRFB 1HJ6A 1WPWA 1XACA 1R8KA 2D4VA 5DE1A 1CW7A 1IPDA 3UDUA 1OSJA 4I3KA 3VL7A 3US8A 1PTMA 2DHTA 4JQPA 5I95A 5HN5A 3VMLA 3FLKA 1DR8A 3TNGA 5J34A 1V53A 2HI1A 5GREA 4XXVA 1IDFA 1TYOA 3VL4A 1IDEA 3VMKA 3INMA 5HN6A 3AH3A 2QFXA 5J33A 1VI1A 3BLVA 4IWHA 3LXYA 3WZYA 1IDDA 1W0DA 3BLVB 2G4OA 4AJBA 5GRFA 3VL6A 2QFYA 4KZOA 1XAAA 3VL3A 4L04A 1BL5A 3BLXB 3MAPA 2D1CA 3UDOA 1PS6A 3DMSA 5LGEA 4ICDA 5GRHA 5HN3A 3MARA 5GRHB 3U9EA 5J32A 4AJ3A 4F7IA 3ASJA 3WZXA 3TY3A 1X0LA 1DR0A 2Y3ZA 3LCBC 2AYQA 3TY4A 1SJSA 9ICDA 4XRXA 1U7NA 4AJRA 4AJAA 3BLXA 4AOYA 4AJCA 1AI2A 5GRIB 4P69C 1HQSA 2Y41A 4JA8A 1IKAA 3R8WA 4AOUA 1AI3A 1CW1A 1PS7A 5L57A 2UXRA 3MASB 2E5MA 1CW4A 1WALA 1VLCA 1OSIA 1ZORA 5GRLA 2ZTWA 5ICDA 5GRLB 3VMJA 1GC9A 6ICDA 1T0LA 1IDCA 4L06A 4Y1PA 1IDMA 4WUOA 5K11A 1YXOA 1A05A 1XGVA 1PB1A 1V94A 1GROA 7ICDA 5GRIA 3UF6A 2Y40A 5L58A 1DPZA 3WZWA 1XADA 4L03A 3VKZA 4AJSA 1GRPA 3FMXX 4HCXA 5HN4A 1GC8A 2Y42A 4ATYA 4YB4A 5K10A 1V5BA 1HEXA 2E0CA 3U1HA 3MASA 5GREB 2QFWA 4AOVA 1YCOA 4UMXA 2UXQA 5I96A 1XKDA 4BNPA 2QFVA 3TSNA 1T09A 4XS3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LWD A;  3VL2 A;  1G2U A;  8ICD A;  1CNZ A;  4UMY A;  2IV0 A;  4I3L A;  1CM7 A;  1PB3 A;  1ISO A;  3ICD A;  1P8F A;  3WZV A;  1XAB A;  5GRF B;  1HJ6 A;  1WPW A;  1XAC A;  1R8K A;  2D4V A;  5DE1 A;  1CW7 A;  1IPD A;  3UDU A;  1OSJ A;  4I3K A;  3VL7 A;  3US8 A;  1PTM A;  2DHT A;  4JQP A;  5I95 A;  5HN5 A;  3VML A;  3FLK A;  1DR8 A;  3TNG A;  5J34 A;  1V53 A;  2HI1 A;  5GRE A;  4XXV A;  1IDF A;  1TYO A;  3VL4 A;  1IDE A;  3VMK A;  3INM A;  5HN6 A;  3AH3 A;  2QFX A;  5J33 A;  1VI1 A;  3BLV A;  4IWH A;  3LXY A;  3WZY A;  1IDD A;  1W0D A;  3BLV B;  2G4O A;  4AJB A;  5GRF A;  3VL6 A;  2QFY A;  4KZO A;  1XAA A;  3VL3 A;  4L04 A;  1BL5 A;  3BLX B;  3MAP A;  2D1C A;  3UDO A;  1PS6 A;  3DMS A;  5LGE A;  4ICD A;  5GRH A;  5HN3 A;  3MAR A;  5GRH B;  3U9E A;  5J32 A;  4AJ3 A;  4F7I A;  3ASJ A;  3WZX A;  3TY3 A;  1X0L A;  1DR0 A;  2Y3Z A;  3LCB C;  2AYQ A;  3TY4 A;  1SJS A;  9ICD A;  4XRX A;  1U7N A;  4AJR A;  4AJA A;  3BLX A;  4AOY A;  4AJC A;  1AI2 A;  5GRI B;  4P69 C;  1HQS A;  2Y41 A;  4JA8 A;  1IKA A;  3R8W A;  4AOU A;  1AI3 A;  1CW1 A;  1PS7 A;  5L57 A;  2UXR A;  3MAS B;  2E5M A;  1CW4 A;  1WAL A;  1VLC A;  1OSI A;  1ZOR A;  5GRL A;  2ZTW A;  5ICD A;  5GRL B;  3VMJ A;  1GC9 A;  6ICD A;  1T0L A;  1IDC A;  4L06 A;  4Y1P A;  1IDM A;  4WUO A;  5K11 A;  1YXO A;  1A05 A;  1XGV A;  1PB1 A;  1V94 A;  1GRO A;  7ICD A;  5GRI A;  3UF6 A;  2Y40 A;  5L58 A;  1DPZ A;  3WZW A;  1XAD A;  4L03 A;  3VKZ A;  4AJS A;  1GRP A;  3FMX X;  4HCX A;  5HN4 A;  1GC8 A;  2Y42 A;  4ATY A;  4YB4 A;  5K10 A;  1V5B A;  1HEX A;  2E0C A;  3U1H A;  3MAS A;  5GRE B;  2QFW A;  4AOV A;  1YCO A;  4UMX A;  2UXQ A;  5I96 A;  1XKD A;  4BNP A;  2QFV A;  3TSN A;  1T09 A;  4XS3 A; 
#chains in the Genus database with same CATH topology
 1LWD A;  3VL2 A;  1G2U A;  8ICD A;  1CNZ A;  4UMY A;  2IV0 A;  4I3L A;  1CM7 A;  1PB3 A;  1ISO A;  3ICD A;  1P8F A;  3WZV A;  1XAB A;  5GRF B;  1HJ6 A;  1WPW A;  1XAC A;  1R8K A;  2D4V A;  5DE1 A;  1CW7 A;  1IPD A;  3UDU A;  1OSJ A;  4I3K A;  3VL7 A;  3US8 A;  1PTM A;  2DHT A;  4JQP A;  5I95 A;  5HN5 A;  3VML A;  3FLK A;  1DR8 A;  3TNG A;  5J34 A;  1V53 A;  2HI1 A;  5GRE A;  4XXV A;  1IDF A;  1TYO A;  3VL4 A;  1IDE A;  3VMK A;  3INM A;  5HN6 A;  3AH3 A;  2QFX A;  5J33 A;  1VI1 A;  3BLV A;  4IWH A;  3LXY A;  3WZY A;  1IDD A;  1W0D A;  3BLV B;  2G4O A;  4AJB A;  5GRF A;  3VL6 A;  2QFY A;  4KZO A;  1XAA A;  3VL3 A;  4L04 A;  1BL5 A;  3BLX B;  3MAP A;  2D1C A;  3UDO A;  1PS6 A;  3DMS A;  5LGE A;  4ICD A;  5GRH A;  5HN3 A;  3MAR A;  5GRH B;  3U9E A;  5J32 A;  4AJ3 A;  4F7I A;  3ASJ A;  3WZX A;  3TY3 A;  1X0L A;  1DR0 A;  2Y3Z A;  3LCB C;  2AYQ A;  3TY4 A;  1SJS A;  9ICD A;  4XRX A;  1U7N A;  4AJR A;  4AJA A;  3BLX A;  4AOY A;  4AJC A;  1AI2 A;  5GRI B;  4P69 C;  1HQS A;  2Y41 A;  4JA8 A;  1IKA A;  3R8W A;  4AOU A;  1AI3 A;  1CW1 A;  1PS7 A;  5L57 A;  2UXR A;  3MAS B;  2E5M A;  1CW4 A;  1WAL A;  1VLC A;  1OSI A;  1ZOR A;  5GRL A;  2ZTW A;  5ICD A;  5GRL B;  3VMJ A;  1GC9 A;  6ICD A;  1T0L A;  1IDC A;  4L06 A;  4Y1P A;  1IDM A;  4WUO A;  5K11 A;  1YXO A;  1A05 A;  1XGV A;  1PB1 A;  1V94 A;  1GRO A;  7ICD A;  5GRI A;  3UF6 A;  2Y40 A;  5L58 A;  1DPZ A;  3WZW A;  1XAD A;  4L03 A;  3VKZ A;  4AJS A;  1GRP A;  3FMX X;  4HCX A;  5HN4 A;  1GC8 A;  2Y42 A;  4ATY A;  4YB4 A;  5K10 A;  1V5B A;  1HEX A;  2E0C A;  3U1H A;  3MAS A;  5GRE B;  2QFW A;  4AOV A;  1YCO A;  4UMX A;  2UXQ A;  5I96 A;  1XKD A;  4BNP A;  2QFV A;  3TSN A;  1T09 A;  4XS3 A; 
#chains in the Genus database with same CATH homology
 1LWD A;  3VL2 A;  1G2U A;  8ICD A;  1CNZ A;  4UMY A;  2IV0 A;  4I3L A;  1CM7 A;  1PB3 A;  1ISO A;  3ICD A;  1P8F A;  3WZV A;  1XAB A;  5GRF B;  1HJ6 A;  1WPW A;  1XAC A;  1R8K A;  2D4V A;  5DE1 A;  1CW7 A;  1IPD A;  3UDU A;  1OSJ A;  4I3K A;  3VL7 A;  3US8 A;  1PTM A;  2DHT A;  4JQP A;  5I95 A;  5HN5 A;  3VML A;  3FLK A;  1DR8 A;  3TNG A;  5J34 A;  1V53 A;  2HI1 A;  5GRE A;  4XXV A;  1IDF A;  1TYO A;  3VL4 A;  1IDE A;  3VMK A;  3INM A;  5HN6 A;  3AH3 A;  2QFX A;  5J33 A;  1VI1 A;  3BLV A;  4IWH A;  3LXY A;  3WZY A;  1IDD A;  1W0D A;  3BLV B;  2G4O A;  4AJB A;  5GRF A;  3VL6 A;  2QFY A;  4KZO A;  1XAA A;  3VL3 A;  4L04 A;  1BL5 A;  3BLX B;  3MAP A;  2D1C A;  3UDO A;  1PS6 A;  3DMS A;  5LGE A;  4ICD A;  5GRH A;  5HN3 A;  3MAR A;  5GRH B;  3U9E A;  5J32 A;  4AJ3 A;  4F7I A;  3ASJ A;  3WZX A;  3TY3 A;  1X0L A;  1DR0 A;  2Y3Z A;  3LCB C;  2AYQ A;  3TY4 A;  1SJS A;  9ICD A;  4XRX A;  1U7N A;  4AJR A;  4AJA A;  3BLX A;  4AOY A;  4AJC A;  1AI2 A;  5GRI B;  4P69 C;  1HQS A;  2Y41 A;  4JA8 A;  1IKA A;  3R8W A;  4AOU A;  1AI3 A;  1CW1 A;  1PS7 A;  5L57 A;  2UXR A;  3MAS B;  2E5M A;  1CW4 A;  1WAL A;  1VLC A;  1OSI A;  1ZOR A;  5GRL A;  2ZTW A;  5ICD A;  5GRL B;  3VMJ A;  1GC9 A;  6ICD A;  1T0L A;  1IDC A;  4L06 A;  4Y1P A;  1IDM A;  4WUO A;  5K11 A;  1YXO A;  1A05 A;  1XGV A;  1PB1 A;  1V94 A;  1GRO A;  7ICD A;  5GRI A;  3UF6 A;  2Y40 A;  5L58 A;  1DPZ A;  3WZW A;  1XAD A;  4L03 A;  3VKZ A;  4AJS A;  1GRP A;  3FMX X;  4HCX A;  5HN4 A;  1GC8 A;  2Y42 A;  4ATY A;  4YB4 A;  5K10 A;  1V5B A;  1HEX A;  2E0C A;  3U1H A;  3MAS A;  5GRE B;  2QFW A;  4AOV A;  1YCO A;  4UMX A;  2UXQ A;  5I96 A;  1XKD A;  4BNP A;  2QFV A;  3TSN A;  1T09 A;  4XS3 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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