4MI8A

Crystal structure of the complex of murine gamma-herpesvirus 68 bcl-2 homolog m11 and a beclin 1 bh3 domain-derived peptide
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
135
structure length
135
Chain Sequence
SHKKSGTYWATLITAFLKTVSKVEELDCVDSAVLVDVSKIITLTQEFRRHYDSVYRADYGPALKNWKRDLSKLFTSLFVDVINSGRIVGFFDVGRYVCEEVLCPGSWTEDHELLNDCMTHFFIENNLMNHFPLED
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.
pubmed doi rcsb
molecule tags Viral protein/apoptosis
source organism Murid herpesvirus 4
molecule keywords Bcl-2 homolog (Gene 16?)
total genus 49
structure length 135
sequence length 135
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15286 Bcl-2_3 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 4mi8A00
2O2FA 1R2IA 3WIXA 2ME8A 4MI8A 4BD2A 4YK9A 4HW4A 1MAZA 2ABOA 4S0OA 4QVXA 2VOFA 4OQ5A 1K3KA 1G5MA 4BD6A 2IMSA 3I1HA 5FDRA 4BPIA 1OHUA 4U2VA 2JCNA 2WH6A 5FC4A 2KBWA 1BXLA 5JSBA 4BD8A 2LR1A 3IHCA 3IIHA 2RODA 2B48A 2M5BA 4QNQA 4HW3A 1WSXA 4ZBFA 2VOGA 5IEZA 3MK8A 4ZBIA 4ZIEA 5C3FA 5KU9A 5C6HA 2MHSA 4G35A 3KJ0A 3MQPA 4K5BC 1YSWA 2YV6A 2XA0A 2K7WA 2ROCA 4B4SA 1R2GA 1G5JA 3IO9A 2W3LA 3ILCA 4BPJA 4BD7A 1PQ1A 1PQ0A 2O2MA 2V6QA 3IHDA 1YSIA 3KZ0A 5KTGA 4ZIGA 2VOHA 1GJHA 2XPXA 2VOIA 1R2DA 1LXLA 3PK1A 2IMTA 3IHEA 3KJ1A 1R2HA 3D7VA 3BL2A 2O2NA 1YSGA 2BIDA 3KJ2A 2NL9A 5FMIA 4ZIIA 3WIYA 4HW2A 2O21A 2JM6B 4YJ4A 4ZIFA 1AF3A 2MEJA 4S0PA 1ZY3A 4U2UA 4ZIHA 2O22A 4OYDA 2A5YA 1DDBA 2PQKA 4BDUA 1R2EA 3CVAX 5FDOA 1O0LA 1TY4A 3IIGA 1MK3A 2VM6A 3DVUA 4WMRA 2KUAA 3QBRA 1F16A 5IF4A 1Q59A 4OQ6A 1YSNA 2BZWA 4ZEQA 2NLAA
chains in the Genus database with same CATH superfamily
2O2FA 1R2IA 3WIXA 2ME8A 4MI8A 4BD2A 4YK9A 2UXEA 4UF2A 4HW4A 1MAZA 4BBDA 2ABOA 4S0OA 4QVXA 4BBBA 2VOFA 4OQ5A 1K3KA 1G5MA 4BD6A 2IMSA 3I1HA 5FDRA 4BPIA 1OHUA 4U2VA 2JCNA 2WH6A 5FC4A 2KBWA 1BXLA 5JSBA 4BD8A 4BBCA 2LR1A 3IHCA 3IIHA 2RODA 4D2MA 2B48A 2M5BA 4UF3A 4QNQA 4HW3A 2K36A 1WSXA 4ZBFA 2VOGA 5IEZA 3MK8A 4ZBIA 4ZIEA 5C3FA 5KU9A 5C6HA 2MHSA 4G35A 3JRVA 2O42A 3KJ0A 2VTYA 3MQPA 4K5BC 1YSWA 2YV6A 2XA0A 2K7WA 2ROCA 4B4SA 1R2GA 1G5JA 3IO9A 2W3LA 3ILCA 4BPJA 4BD7A 1PQ1A 1PQ0A 2O2MA 2V6QA 2VVWA 4M0SA 3IHDA 1YSIA 3KZ0A 5KTGA 4ZIGA 2VOHA 1GJHA 2XPXA 2VOIA 1R2DA 1LXLA 2JBXA 3PK1A 2IMTA 3IHEA 3KJ1A 1R2HA 3D7VA 3BL2A 2O2NA 1YSGA 2BIDA 3KJ2A 2NL9A 5FMIA 4ZIIA 3WIYA 4HW2A 2O21A 2JM6B 4YJ4A 4ZIFA 1AF3A 2MEJA 4S0PA 1ZY3A 4U2UA 4UF1A 4ZIHA 2O22A 4OYDA 2A5YA 1DDBA 2PQKA 4BDUA 1R2EA 3CVAX 5FDOA 1O0LA 1TY4A 2VVYA 3IIGA 1MK3A 2I39A 2VM6A 3DVUA 4WMRA 2KUAA 3QBRA 1F16A 5IF4A 1Q59A 2JBYA 4OQ6A 4LQKA 1YSNA 2BZWA 4ZEQA 2VVXA 4D2LA 2NLAA
chains in the Genus database with same CATH topology
2O2FA 1R2IA 3WIXA 2ME8A 4MI8A 4BD2A 4YK9A 4HW4A 1MAZA 2ABOA 4S0OA 4QVXA 2VOFA 4OQ5A 1K3KA 1G5MA 4BD6A 2IMSA 3I1HA 5FDRA 4BPIA 1OHUA 4U2VA 2JCNA 2WH6A 5FC4A 2KBWA 1BXLA 5JSBA 4BD8A 2LR1A 3IHCA 3IIHA 2RODA 2B48A 2M5BA 4QNQA 4HW3A 1WSXA 4ZBFA 2VOGA 5IEZA 3MK8A 4ZBIA 4ZIEA 5C3FA 5KU9A 5C6HA 2MHSA 4G35A 3KJ0A 3MQPA 4K5BC 1YSWA 2YV6A 2XA0A 2K7WA 2ROCA 4B4SA 1R2GA 1G5JA 3IO9A 2W3LA 3ILCA 4BPJA 4BD7A 1PQ1A 1PQ0A 2O2MA 2V6QA 3IHDA 1YSIA 3KZ0A 5KTGA 4ZIGA 2VOHA 1GJHA 2XPXA 2VOIA 1R2DA 1LXLA 3PK1A 2IMTA 3IHEA 3KJ1A 1R2HA 3D7VA 3BL2A 2O2NA 1YSGA 2BIDA 3KJ2A 2NL9A 5FMIA 4ZIIA 3WIYA 4HW2A 2O21A 2JM6B 4YJ4A 4ZIFA 1AF3A 2MEJA 4S0PA 1ZY3A 4U2UA 4ZIHA 2O22A 4OYDA 2A5YA 1DDBA 2PQKA 4BDUA 1R2EA 3CVAX 5FDOA 1O0LA 1TY4A 3IIGA 1MK3A 2VM6A 3DVUA 4WMRA 2KUAA 3QBRA 1F16A 5IF4A 1Q59A 4OQ6A 1YSNA 2BZWA 4ZEQA 2NLAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O2F A;  1R2I A;  3WIX A;  2ME8 A;  4MI8 A;  4BD2 A;  4YK9 A;  4HW4 A;  1MAZ A;  2ABO A;  4S0O A;  4QVX A;  2VOF A;  4OQ5 A;  1K3K A;  1G5M A;  4BD6 A;  2IMS A;  3I1H A;  5FDR A;  4BPI A;  1OHU A;  4U2V A;  2JCN A;  2WH6 A;  5FC4 A;  2KBW A;  1BXL A;  5JSB A;  4BD8 A;  2LR1 A;  3IHC A;  3IIH A;  2ROD A;  2B48 A;  2M5B A;  4QNQ A;  4HW3 A;  1WSX A;  4ZBF A;  2VOG A;  5IEZ A;  3MK8 A;  4ZBI A;  4ZIE A;  5C3F A;  5KU9 A;  5C6H A;  2MHS A;  4G35 A;  3KJ0 A;  3MQP A;  4K5B C;  1YSW A;  2YV6 A;  2XA0 A;  2K7W A;  2ROC A;  4B4S A;  1R2G A;  1G5J A;  3IO9 A;  2W3L A;  3ILC A;  4BPJ A;  4BD7 A;  1PQ1 A;  1PQ0 A;  2O2M A;  2V6Q A;  3IHD A;  1YSI A;  3KZ0 A;  5KTG A;  4ZIG A;  2VOH A;  1GJH A;  2XPX A;  2VOI A;  1R2D A;  1LXL A;  3PK1 A;  2IMT A;  3IHE A;  3KJ1 A;  1R2H A;  3D7V A;  3BL2 A;  2O2N A;  1YSG A;  2BID A;  3KJ2 A;  2NL9 A;  5FMI A;  4ZII A;  3WIY A;  4HW2 A;  2O21 A;  2JM6 B;  4YJ4 A;  4ZIF A;  1AF3 A;  2MEJ A;  4S0P A;  1ZY3 A;  4U2U A;  4ZIH A;  2O22 A;  4OYD A;  2A5Y A;  1DDB A;  2PQK A;  4BDU A;  1R2E A;  3CVA X;  5FDO A;  1O0L A;  1TY4 A;  3IIG A;  1MK3 A;  2VM6 A;  3DVU A;  4WMR A;  2KUA A;  3QBR A;  1F16 A;  5IF4 A;  1Q59 A;  4OQ6 A;  1YSN A;  2BZW A;  4ZEQ A;  2NLA A; 
#chains in the Genus database with same CATH topology
 2O2F A;  1R2I A;  3WIX A;  2ME8 A;  4MI8 A;  4BD2 A;  4YK9 A;  2UXE A;  4UF2 A;  4HW4 A;  1MAZ A;  4BBD A;  2ABO A;  4S0O A;  4QVX A;  4BBB A;  2VOF A;  4OQ5 A;  1K3K A;  1G5M A;  4BD6 A;  2IMS A;  3I1H A;  5FDR A;  4BPI A;  1OHU A;  4U2V A;  2JCN A;  2WH6 A;  5FC4 A;  2KBW A;  1BXL A;  5JSB A;  4BD8 A;  4BBC A;  2LR1 A;  3IHC A;  3IIH A;  2ROD A;  4D2M A;  2B48 A;  2M5B A;  4UF3 A;  4QNQ A;  4HW3 A;  2K36 A;  1WSX A;  4ZBF A;  2VOG A;  5IEZ A;  3MK8 A;  4ZBI A;  4ZIE A;  5C3F A;  5KU9 A;  5C6H A;  2MHS A;  4G35 A;  3JRV A;  2O42 A;  3KJ0 A;  2VTY A;  3MQP A;  4K5B C;  1YSW A;  2YV6 A;  2XA0 A;  2K7W A;  2ROC A;  4B4S A;  1R2G A;  1G5J A;  3IO9 A;  2W3L A;  3ILC A;  4BPJ A;  4BD7 A;  1PQ1 A;  1PQ0 A;  2O2M A;  2V6Q A;  2VVW A;  4M0S A;  3IHD A;  1YSI A;  3KZ0 A;  5KTG A;  4ZIG A;  2VOH A;  1GJH A;  2XPX A;  2VOI A;  1R2D A;  1LXL A;  2JBX A;  3PK1 A;  2IMT A;  3IHE A;  3KJ1 A;  1R2H A;  3D7V A;  3BL2 A;  2O2N A;  1YSG A;  2BID A;  3KJ2 A;  2NL9 A;  5FMI A;  4ZII A;  3WIY A;  4HW2 A;  2O21 A;  2JM6 B;  4YJ4 A;  4ZIF A;  1AF3 A;  2MEJ A;  4S0P A;  1ZY3 A;  4U2U A;  4UF1 A;  4ZIH A;  2O22 A;  4OYD A;  2A5Y A;  1DDB A;  2PQK A;  4BDU A;  1R2E A;  3CVA X;  5FDO A;  1O0L A;  1TY4 A;  2VVY A;  3IIG A;  1MK3 A;  2I39 A;  2VM6 A;  3DVU A;  4WMR A;  2KUA A;  3QBR A;  1F16 A;  5IF4 A;  1Q59 A;  2JBY A;  4OQ6 A;  4LQK A;  1YSN A;  2BZW A;  4ZEQ A;  2VVX A;  4D2L A;  2NLA A; 
#chains in the Genus database with same CATH homology
 2O2F A;  1R2I A;  3WIX A;  2ME8 A;  4MI8 A;  4BD2 A;  4YK9 A;  4HW4 A;  1MAZ A;  2ABO A;  4S0O A;  4QVX A;  2VOF A;  4OQ5 A;  1K3K A;  1G5M A;  4BD6 A;  2IMS A;  3I1H A;  5FDR A;  4BPI A;  1OHU A;  4U2V A;  2JCN A;  2WH6 A;  5FC4 A;  2KBW A;  1BXL A;  5JSB A;  4BD8 A;  2LR1 A;  3IHC A;  3IIH A;  2ROD A;  2B48 A;  2M5B A;  4QNQ A;  4HW3 A;  1WSX A;  4ZBF A;  2VOG A;  5IEZ A;  3MK8 A;  4ZBI A;  4ZIE A;  5C3F A;  5KU9 A;  5C6H A;  2MHS A;  4G35 A;  3KJ0 A;  3MQP A;  4K5B C;  1YSW A;  2YV6 A;  2XA0 A;  2K7W A;  2ROC A;  4B4S A;  1R2G A;  1G5J A;  3IO9 A;  2W3L A;  3ILC A;  4BPJ A;  4BD7 A;  1PQ1 A;  1PQ0 A;  2O2M A;  2V6Q A;  3IHD A;  1YSI A;  3KZ0 A;  5KTG A;  4ZIG A;  2VOH A;  1GJH A;  2XPX A;  2VOI A;  1R2D A;  1LXL A;  3PK1 A;  2IMT A;  3IHE A;  3KJ1 A;  1R2H A;  3D7V A;  3BL2 A;  2O2N A;  1YSG A;  2BID A;  3KJ2 A;  2NL9 A;  5FMI A;  4ZII A;  3WIY A;  4HW2 A;  2O21 A;  2JM6 B;  4YJ4 A;  4ZIF A;  1AF3 A;  2MEJ A;  4S0P A;  1ZY3 A;  4U2U A;  4ZIH A;  2O22 A;  4OYD A;  2A5Y A;  1DDB A;  2PQK A;  4BDU A;  1R2E A;  3CVA X;  5FDO A;  1O0L A;  1TY4 A;  3IIG A;  1MK3 A;  2VM6 A;  3DVU A;  4WMR A;  2KUA A;  3QBR A;  1F16 A;  5IF4 A;  1Q59 A;  4OQ6 A;  1YSN A;  2BZW A;  4ZEQ A;  2NLA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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