4O1VA

Spop promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
141
structure length
141
Chain Sequence
SGKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Speckle-type POZ protein
total genus 28
structure length 141
sequence length 141
ec nomenclature
pdb deposition date 2013-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 4o1vA01
4I7DA 3MQSC 2FOOA 1CZZA 1D01A 2A25A 4GJHA 4CA1A 2F1XA 1YZEA 2F1ZA 3IVVA 3MQRA 1FLLA 3ZJBA 1D0JA 1RF3A 1D0AA 3HSVA 1CA9A 4GWNA 4C9ZA 4GHUA 2F1YA 3HQIA 1ZMSA 4I7BA 4Z8MA 4KG9A 4JJQA 1KZZA 2GKWA 5E1TA 1LB6A 3IVBA 1QSCA 2CR2A 3HQMA 3HU6A 1F3VB 3IVQA 4X3GA 1FLKA 4K8UA 1LB4A 2F1WA 3HQHA 1CA4A 2AN6A 1LB5A 4I7CA 4GWMA 1CZYA 4M4EA 4O1VA 1D00A 3HQLA 2FOJA 2FOPA 1K2FA 1L0AA 2XXNA 4YSIA 5H9MA 1YY6A
chains in the Genus database with same CATH superfamily
4I7DA 3MQSC 2FOOA 1CZZA 1D01A 2A25A 4GJHA 4CA1A 2F1XA 1YZEA 2F1ZA 3IVVA 3MQRA 1FLLA 3ZJBA 1D0JA 1RF3A 1D0AA 3HSVA 1CA9A 4GWNA 4C9ZA 4GHUA 2F1YA 3HQIA 1ZMSA 4I7BA 4Z8MA 4KG9A 4JJQA 1KZZA 2GKWA 5E1TA 1LB6A 3IVBA 1QSCA 2CR2A 3HQMA 3HU6A 1F3VB 3IVQA 4X3GA 1FLKA 4K8UA 1LB4A 2F1WA 3HQHA 1CA4A 2AN6A 1LB5A 4I7CA 4GWMA 1CZYA 4M4EA 4O1VA 1D00A 3HQLA 2FOJA 2FOPA 1K2FA 1L0AA 2XXNA 4YSIA 5H9MA 1YY6A
chains in the Genus database with same CATH topology
4I7DA 3MQSC 2FOOA 1CZZA 1D01A 2A25A 4GJHA 4CA1A 2F1XA 1YZEA 2F1ZA 3IVVA 3MQRA 1FLLA 3ZJBA 1D0JA 1RF3A 1D0AA 3HSVA 1CA9A 4GWNA 4C9ZA 4GHUA 2F1YA 3HQIA 1ZMSA 4I7BA 4Z8MA 4KG9A 4JJQA 1KZZA 2GKWA 5E1TA 1LB6A 3IVBA 1QSCA 2CR2A 3HQMA 3HU6A 1F3VB 3IVQA 4X3GA 1FLKA 4K8UA 1LB4A 2F1WA 3HQHA 1CA4A 2AN6A 1LB5A 4I7CA 4GWMA 1CZYA 4M4EA 4O1VA 1D00A 3HQLA 2FOJA 2FOPA 1K2FA 1L0AA 2XXNA 4YSIA 5H9MA 1YY6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I7D A;  3MQS C;  2FOO A;  1CZZ A;  1D01 A;  2A25 A;  4GJH A;  4CA1 A;  2F1X A;  1YZE A;  2F1Z A;  3IVV A;  3MQR A;  1FLL A;  3ZJB A;  1D0J A;  1RF3 A;  1D0A A;  3HSV A;  1CA9 A;  4GWN A;  4C9Z A;  4GHU A;  2F1Y A;  3HQI A;  1ZMS A;  4I7B A;  4Z8M A;  4KG9 A;  4JJQ A;  1KZZ A;  2GKW A;  5E1T A;  1LB6 A;  3IVB A;  1QSC A;  2CR2 A;  3HQM A;  3HU6 A;  1F3V B;  3IVQ A;  4X3G A;  1FLK A;  4K8U A;  1LB4 A;  2F1W A;  3HQH A;  1CA4 A;  2AN6 A;  1LB5 A;  4I7C A;  4GWM A;  1CZY A;  4M4E A;  4O1V A;  1D00 A;  3HQL A;  2FOJ A;  2FOP A;  1K2F A;  1L0A A;  2XXN A;  4YSI A;  5H9M A;  1YY6 A; 
#chains in the Genus database with same CATH topology
 4I7D A;  3MQS C;  2FOO A;  1CZZ A;  1D01 A;  2A25 A;  4GJH A;  4CA1 A;  2F1X A;  1YZE A;  2F1Z A;  3IVV A;  3MQR A;  1FLL A;  3ZJB A;  1D0J A;  1RF3 A;  1D0A A;  3HSV A;  1CA9 A;  4GWN A;  4C9Z A;  4GHU A;  2F1Y A;  3HQI A;  1ZMS A;  4I7B A;  4Z8M A;  4KG9 A;  4JJQ A;  1KZZ A;  2GKW A;  5E1T A;  1LB6 A;  3IVB A;  1QSC A;  2CR2 A;  3HQM A;  3HU6 A;  1F3V B;  3IVQ A;  4X3G A;  1FLK A;  4K8U A;  1LB4 A;  2F1W A;  3HQH A;  1CA4 A;  2AN6 A;  1LB5 A;  4I7C A;  4GWM A;  1CZY A;  4M4E A;  4O1V A;  1D00 A;  3HQL A;  2FOJ A;  2FOP A;  1K2F A;  1L0A A;  2XXN A;  4YSI A;  5H9M A;  1YY6 A; 
#chains in the Genus database with same CATH homology
 4I7D A;  3MQS C;  2FOO A;  1CZZ A;  1D01 A;  2A25 A;  4GJH A;  4CA1 A;  2F1X A;  1YZE A;  2F1Z A;  3IVV A;  3MQR A;  1FLL A;  3ZJB A;  1D0J A;  1RF3 A;  1D0A A;  3HSV A;  1CA9 A;  4GWN A;  4C9Z A;  4GHU A;  2F1Y A;  3HQI A;  1ZMS A;  4I7B A;  4Z8M A;  4KG9 A;  4JJQ A;  1KZZ A;  2GKW A;  5E1T A;  1LB6 A;  3IVB A;  1QSC A;  2CR2 A;  3HQM A;  3HU6 A;  1F3V B;  3IVQ A;  4X3G A;  1FLK A;  4K8U A;  1LB4 A;  2F1W A;  3HQH A;  1CA4 A;  2AN6 A;  1LB5 A;  4I7C A;  4GWM A;  1CZY A;  4M4E A;  4O1V A;  1D00 A;  3HQL A;  2FOJ A;  2FOP A;  1K2F A;  1L0A A;  2XXN A;  4YSI A;  5H9M A;  1YY6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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