4O1VA

Spop promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
141
structure length
141
Chain Sequence
SGKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Speckle-type POZ protein
total genus 28
structure length 141
sequence length 141
ec nomenclature
pdb deposition date 2013-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 4o1vA01
5E1TA 1D00A 1CZYA 2GKWA 1L0AA 3HQMA 1KZZA 1F3VB 4I7CA 4M4EA 2FOPA 4I7BA 2FOJA 1CA9A 1YY6A 1K2FA 1YZEA 3MQRA 4Z8MA 5H9MA 3IVQA 3MQSC 2AN6A 1RF3A 4GWMA 2XXNA 1QSCA 4O1VA 4C9ZA 2CR2A 4GWNA 3HQLA 4I7DA 2F1XA 4K8UA 3IVVA 3HQHA 4KG9A 2F1ZA 2F1YA 2FOOA 1FLKA 3HSVA 1D0JA 2A25A 4GHUA 2F1WA 3ZJBA 1LB4A 1ZMSA 1LB5A 1D01A 3IVBA 4JJQA 4X3GA 4CA1A 4GJHA 1D0AA 1LB6A 1CA4A 1CZZA 3HQIA 3HU6A 1FLLA 4YSIA
chains in the Genus database with same CATH superfamily
5E1TA 1D00A 1CZYA 2GKWA 1L0AA 3HQMA 1KZZA 1F3VB 4I7CA 4M4EA 2FOPA 4I7BA 2FOJA 1CA9A 1YY6A 1K2FA 1YZEA 3MQRA 4Z8MA 5H9MA 3IVQA 3MQSC 2AN6A 1RF3A 4GWMA 2XXNA 1QSCA 4O1VA 4C9ZA 2CR2A 4GWNA 3HQLA 4I7DA 2F1XA 4K8UA 3IVVA 3HQHA 4KG9A 2F1ZA 2F1YA 2FOOA 1FLKA 3HSVA 1D0JA 2A25A 4GHUA 2F1WA 3ZJBA 1LB4A 1ZMSA 1LB5A 1D01A 3IVBA 4JJQA 4X3GA 4CA1A 4GJHA 1D0AA 1LB6A 1CA4A 1CZZA 3HQIA 3HU6A 1FLLA 4YSIA
chains in the Genus database with same CATH topology
5E1TA 1D00A 1CZYA 2GKWA 1L0AA 3HQMA 1KZZA 1F3VB 4I7CA 4M4EA 2FOPA 4I7BA 2FOJA 1CA9A 1YY6A 1K2FA 1YZEA 3MQRA 4Z8MA 5H9MA 3IVQA 3MQSC 2AN6A 1RF3A 4GWMA 2XXNA 1QSCA 4O1VA 4C9ZA 2CR2A 4GWNA 3HQLA 4I7DA 2F1XA 4K8UA 3IVVA 3HQHA 4KG9A 2F1ZA 2F1YA 2FOOA 1FLKA 3HSVA 1D0JA 2A25A 4GHUA 2F1WA 3ZJBA 1LB4A 1ZMSA 1LB5A 1D01A 3IVBA 4JJQA 4X3GA 4CA1A 4GJHA 1D0AA 1LB6A 1CA4A 1CZZA 3HQIA 3HU6A 1FLLA 4YSIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E1T A;  1D00 A;  1CZY A;  2GKW A;  1L0A A;  3HQM A;  1KZZ A;  1F3V B;  4I7C A;  4M4E A;  2FOP A;  4I7B A;  2FOJ A;  1CA9 A;  1YY6 A;  1K2F A;  1YZE A;  3MQR A;  4Z8M A;  5H9M A;  3IVQ A;  3MQS C;  2AN6 A;  1RF3 A;  4GWM A;  2XXN A;  1QSC A;  4O1V A;  4C9Z A;  2CR2 A;  4GWN A;  3HQL A;  4I7D A;  2F1X A;  4K8U A;  3IVV A;  3HQH A;  4KG9 A;  2F1Z A;  2F1Y A;  2FOO A;  1FLK A;  3HSV A;  1D0J A;  2A25 A;  4GHU A;  2F1W A;  3ZJB A;  1LB4 A;  1ZMS A;  1LB5 A;  1D01 A;  3IVB A;  4JJQ A;  4X3G A;  4CA1 A;  4GJH A;  1D0A A;  1LB6 A;  1CA4 A;  1CZZ A;  3HQI A;  3HU6 A;  1FLL A;  4YSI A; 
#chains in the Genus database with same CATH topology
 5E1T A;  1D00 A;  1CZY A;  2GKW A;  1L0A A;  3HQM A;  1KZZ A;  1F3V B;  4I7C A;  4M4E A;  2FOP A;  4I7B A;  2FOJ A;  1CA9 A;  1YY6 A;  1K2F A;  1YZE A;  3MQR A;  4Z8M A;  5H9M A;  3IVQ A;  3MQS C;  2AN6 A;  1RF3 A;  4GWM A;  2XXN A;  1QSC A;  4O1V A;  4C9Z A;  2CR2 A;  4GWN A;  3HQL A;  4I7D A;  2F1X A;  4K8U A;  3IVV A;  3HQH A;  4KG9 A;  2F1Z A;  2F1Y A;  2FOO A;  1FLK A;  3HSV A;  1D0J A;  2A25 A;  4GHU A;  2F1W A;  3ZJB A;  1LB4 A;  1ZMS A;  1LB5 A;  1D01 A;  3IVB A;  4JJQ A;  4X3G A;  4CA1 A;  4GJH A;  1D0A A;  1LB6 A;  1CA4 A;  1CZZ A;  3HQI A;  3HU6 A;  1FLL A;  4YSI A; 
#chains in the Genus database with same CATH homology
 5E1T A;  1D00 A;  1CZY A;  2GKW A;  1L0A A;  3HQM A;  1KZZ A;  1F3V B;  4I7C A;  4M4E A;  2FOP A;  4I7B A;  2FOJ A;  1CA9 A;  1YY6 A;  1K2F A;  1YZE A;  3MQR A;  4Z8M A;  5H9M A;  3IVQ A;  3MQS C;  2AN6 A;  1RF3 A;  4GWM A;  2XXN A;  1QSC A;  4O1V A;  4C9Z A;  2CR2 A;  4GWN A;  3HQL A;  4I7D A;  2F1X A;  4K8U A;  3IVV A;  3HQH A;  4KG9 A;  2F1Z A;  2F1Y A;  2FOO A;  1FLK A;  3HSV A;  1D0J A;  2A25 A;  4GHU A;  2F1W A;  3ZJB A;  1LB4 A;  1ZMS A;  1LB5 A;  1D01 A;  3IVB A;  4JJQ A;  4X3G A;  4CA1 A;  4GJH A;  1D0A A;  1LB6 A;  1CA4 A;  1CZZ A;  3HQI A;  3HU6 A;  1FLL A;  4YSI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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