4QNQ | Genus

Total Genus 62

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	62
sequence length	197
structure length	144
Chain Sequence	MSQSNRELVVDFLSYKLSQKGYSWSQFIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGN

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Apoptosis/apoptosis inhibitor
source organism	Rattus norvegicus
publication title	Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263 rcsb
molecule keywords	Bcl-2-like protein 1
total genus	62
structure length	144
sequence length	197
chains with identical sequence	B, C, D, E, F, G, H, I, J, K, L
ec nomenclature
pdb deposition date	2014-06-18

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00452	Bcl-2	Apoptosis regulator proteins, Bcl-2 family
A	PF02180	BH4	Bcl-2 homology region 4

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	4qnqA00

2VOGA 2W3LA 4ZBFA 4U2UA 4ZIGA 2O2MA 1YSGA 1R2HA 3CVAX 3MK8A 5FMIA 1YSIA 1Q59A 2O21A 4ZIFA 4G35A 4HW4A 4OQ5A 4ZEQA 2ABOA 2RODA 3DVUA 4ZIIA 2KUAA 2MHSA 2JCNA 3KJ0A 1YSNA 1PQ0A 2O2FA 1G5JA 3IHCA 1R2IA 3IO9A 1F16A 4BPIA 1R2EA 1MK3A 5IEZA 1WSXA 3KJ2A 2VOFA 1ZY3A 2ME8A 3IHEA 2LR1A 2XPXA 4WMRA 2VOHA 3KZ0A 5KU9A 4S0OA 4BD2A 5FDOA 4OYDA 1BXLA 2IMSA 5C6HA 2M5BA 4OQ6A 1R2DA 2BIDA 4QVXA 2NL9A 3BL2A 4QNQA 1R2GA 5IF4A 3I1HA 3ILCA 2JM6B 5C3FA 3WIXA 4U2VA 2O22A 1LXLA 1MAZA 2PQKA 2A5YA 4BD6A 4ZBIA 5FC4A 4BDUA 3PK1A 3IHDA 2VM6A 1PQ1A 2XA0A 4HW2A 4HW3A 4B4SA 1O0LA 4S0PA 4ZIHA 2B48A 4BD7A 3KJ1A 5KTGA 3MQPA 3QBRA 4MI8A 3IIGA 2MEJA 1AF3A 2NLAA 2O2NA 1TY4A 2YV6A 4ZIEA 4BD8A 5JSBA 4BPJA 2VOIA 4K5BC 2IMTA 1GJHA 4YJ4A 3WIYA 4YK9A 2BZWA 3D7VA 2KBWA 1OHUA 1G5MA 1DDBA 5FDRA 2ROCA 1YSWA 2V6QA 2WH6A 2K7WA 3IIHA 1K3KA
chains in the Genus database with same CATH superfamily

2VOGA 2VVWA 2W3LA 4ZBFA 4U2UA 4ZIGA 2O2MA 1YSGA 1R2HA 3CVAX 3MK8A 5FMIA 1YSIA 4UF2A 1Q59A 2O21A 4ZIFA 4G35A 4HW4A 4OQ5A 4ZEQA 2ABOA 2RODA 3DVUA 2I39A 4ZIIA 4BBBA 2KUAA 2MHSA 2JCNA 3KJ0A 1YSNA 4BBCA 1PQ0A 2O2FA 1G5JA 3IHCA 1R2IA 3IO9A 1F16A 4BPIA 1R2EA 1MK3A 5IEZA 1WSXA 2UXEA 2VVYA 3KJ2A 2VOFA 1ZY3A 2ME8A 3IHEA 2JBYA 2LR1A 2XPXA 4WMRA 2VOHA 3KZ0A 5KU9A 4S0OA 4BD2A 4LQKA 5FDOA 4OYDA 1BXLA 2IMSA 4UF3A 5C6HA 2M5BA 4OQ6A 1R2DA 2BIDA 4QVXA 2NL9A 3BL2A 4QNQA 1R2GA 5IF4A 3I1HA 4D2LA 3ILCA 2JM6B 5C3FA 3WIXA 4U2VA 2O22A 1LXLA 2VTYA 1MAZA 2PQKA 2A5YA 4BD6A 4ZBIA 4M0SA 4D2MA 4UF1A 5FC4A 3JRVA 4BDUA 3PK1A 3IHDA 2VM6A 1PQ1A 2XA0A 4HW2A 4HW3A 2VVXA 4B4SA 2K36A 1O0LA 4S0PA 4ZIHA 2B48A 4BD7A 2O42A 3KJ1A 5KTGA 3MQPA 3QBRA 4MI8A 3IIGA 2MEJA 1AF3A 2NLAA 2O2NA 1TY4A 2YV6A 4ZIEA 4BBDA 5JSBA 4BD8A 4BPJA 2VOIA 4K5BC 2IMTA 1GJHA 4YJ4A 3WIYA 4YK9A 2BZWA 3D7VA 2KBWA 1OHUA 1G5MA 1DDBA 5FDRA 2JBXA 2ROCA 1YSWA 2V6QA 2WH6A 2K7WA 3IIHA 1K3KA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2VOG A;  2W3L A;  4ZBF A;  4U2U A;  4ZIG A;  2O2M A;  1YSG A;  1R2H A;  3CVA X;  3MK8 A;  5FMI A;  1YSI A;  1Q59 A;  2O21 A;  4ZIF A;  4G35 A;  4HW4 A;  4OQ5 A;  4ZEQ A;  2ABO A;  2ROD A;  3DVU A;  4ZII A;  2KUA A;  2MHS A;  2JCN A;  3KJ0 A;  1YSN A;  1PQ0 A;  2O2F A;  1G5J A;  3IHC A;  1R2I A;  3IO9 A;  1F16 A;  4BPI A;  1R2E A;  1MK3 A;  5IEZ A;  1WSX A;  3KJ2 A;  2VOF A;  1ZY3 A;  2ME8 A;  3IHE A;  2LR1 A;  2XPX A;  4WMR A;  2VOH A;  3KZ0 A;  5KU9 A;  4S0O A;  4BD2 A;  5FDO A;  4OYD A;  1BXL A;  2IMS A;  5C6H A;  2M5B A;  4OQ6 A;  1R2D A;  2BID A;  4QVX A;  2NL9 A;  3BL2 A;  4QNQ A;  1R2G A;  5IF4 A;  3I1H A;  3ILC A;  2JM6 B;  5C3F A;  3WIX A;  4U2V A;  2O22 A;  1LXL A;  1MAZ A;  2PQK A;  2A5Y A;  4BD6 A;  4ZBI A;  5FC4 A;  4BDU A;  3PK1 A;  3IHD A;  2VM6 A;  1PQ1 A;  2XA0 A;  4HW2 A;  4HW3 A;  4B4S A;  1O0L A;  4S0P A;  4ZIH A;  2B48 A;  4BD7 A;  3KJ1 A;  5KTG A;  3MQP A;  3QBR A;  4MI8 A;  3IIG A;  2MEJ A;  1AF3 A;  2NLA A;  2O2N A;  1TY4 A;  2YV6 A;  4ZIE A;  4BD8 A;  5JSB A;  4BPJ A;  2VOI A;  4K5B C;  2IMT A;  1GJH A;  4YJ4 A;  3WIY A;  4YK9 A;  2BZW A;  3D7V A;  2KBW A;  1OHU A;  1G5M A;  1DDB A;  5FDR A;  2ROC A;  1YSW A;  2V6Q A;  2WH6 A;  2K7W A;  3IIH A;  1K3K A; 
#chains in the Genus database with same CATH topology
 2VOG A;  2VVW A;  2W3L A;  4ZBF A;  4U2U A;  4ZIG A;  2O2M A;  1YSG A;  1R2H A;  3CVA X;  3MK8 A;  5FMI A;  1YSI A;  4UF2 A;  1Q59 A;  2O21 A;  4ZIF A;  4G35 A;  4HW4 A;  4OQ5 A;  4ZEQ A;  2ABO A;  2ROD A;  3DVU A;  2I39 A;  4ZII A;  4BBB A;  2KUA A;  2MHS A;  2JCN A;  3KJ0 A;  1YSN A;  4BBC A;  1PQ0 A;  2O2F A;  1G5J A;  3IHC A;  1R2I A;  3IO9 A;  1F16 A;  4BPI A;  1R2E A;  1MK3 A;  5IEZ A;  1WSX A;  2UXE A;  2VVY A;  3KJ2 A;  2VOF A;  1ZY3 A;  2ME8 A;  3IHE A;  2JBY A;  2LR1 A;  2XPX A;  4WMR A;  2VOH A;  3KZ0 A;  5KU9 A;  4S0O A;  4BD2 A;  4LQK A;  5FDO A;  4OYD A;  1BXL A;  2IMS A;  4UF3 A;  5C6H A;  2M5B A;  4OQ6 A;  1R2D A;  2BID A;  4QVX A;  2NL9 A;  3BL2 A;  4QNQ A;  1R2G A;  5IF4 A;  3I1H A;  4D2L A;  3ILC A;  2JM6 B;  5C3F A;  3WIX A;  4U2V A;  2O22 A;  1LXL A;  2VTY A;  1MAZ A;  2PQK A;  2A5Y A;  4BD6 A;  4ZBI A;  4M0S A;  4D2M A;  4UF1 A;  5FC4 A;  3JRV A;  4BDU A;  3PK1 A;  3IHD A;  2VM6 A;  1PQ1 A;  2XA0 A;  4HW2 A;  4HW3 A;  2VVX A;  4B4S A;  2K36 A;  1O0L A;  4S0P A;  4ZIH A;  2B48 A;  4BD7 A;  2O42 A;  3KJ1 A;  5KTG A;  3MQP A;  3QBR A;  4MI8 A;  3IIG A;  2MEJ A;  1AF3 A;  2NLA A;  2O2N A;  1TY4 A;  2YV6 A;  4ZIE A;  4BBD A;  5JSB A;  4BD8 A;  4BPJ A;  2VOI A;  4K5B C;  2IMT A;  1GJH A;  4YJ4 A;  3WIY A;  4YK9 A;  2BZW A;  3D7V A;  2KBW A;  1OHU A;  1G5M A;  1DDB A;  5FDR A;  2JBX A;  2ROC A;  1YSW A;  2V6Q A;  2WH6 A;  2K7W A;  3IIH A;  1K3K A; 
#chains in the Genus database with same CATH homology
 2VOG A;  2W3L A;  4ZBF A;  4U2U A;  4ZIG A;  2O2M A;  1YSG A;  1R2H A;  3CVA X;  3MK8 A;  5FMI A;  1YSI A;  1Q59 A;  2O21 A;  4ZIF A;  4G35 A;  4HW4 A;  4OQ5 A;  4ZEQ A;  2ABO A;  2ROD A;  3DVU A;  4ZII A;  2KUA A;  2MHS A;  2JCN A;  3KJ0 A;  1YSN A;  1PQ0 A;  2O2F A;  1G5J A;  3IHC A;  1R2I A;  3IO9 A;  1F16 A;  4BPI A;  1R2E A;  1MK3 A;  5IEZ A;  1WSX A;  3KJ2 A;  2VOF A;  1ZY3 A;  2ME8 A;  3IHE A;  2LR1 A;  2XPX A;  4WMR A;  2VOH A;  3KZ0 A;  5KU9 A;  4S0O A;  4BD2 A;  5FDO A;  4OYD A;  1BXL A;  2IMS A;  5C6H A;  2M5B A;  4OQ6 A;  1R2D A;  2BID A;  4QVX A;  2NL9 A;  3BL2 A;  4QNQ A;  1R2G A;  5IF4 A;  3I1H A;  3ILC A;  2JM6 B;  5C3F A;  3WIX A;  4U2V A;  2O22 A;  1LXL A;  1MAZ A;  2PQK A;  2A5Y A;  4BD6 A;  4ZBI A;  5FC4 A;  4BDU A;  3PK1 A;  3IHD A;  2VM6 A;  1PQ1 A;  2XA0 A;  4HW2 A;  4HW3 A;  4B4S A;  1O0L A;  4S0P A;  4ZIH A;  2B48 A;  4BD7 A;  3KJ1 A;  5KTG A;  3MQP A;  3QBR A;  4MI8 A;  3IIG A;  2MEJ A;  1AF3 A;  2NLA A;  2O2N A;  1TY4 A;  2YV6 A;  4ZIE A;  4BD8 A;  5JSB A;  4BPJ A;  2VOI A;  4K5B C;  2IMT A;  1GJH A;  4YJ4 A;  3WIY A;  4YK9 A;  2BZW A;  3D7V A;  2KBW A;  1OHU A;  1G5M A;  1DDB A;  5FDR A;  2ROC A;  1YSW A;  2V6Q A;  2WH6 A;  2K7W A;  3IIH A;  1K3K A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4QNQA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations