4S0PA

Crystal structure of the autoinhibited dimer of pro-apoptotic bax (ii)
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
179
structure length
174
Chain Sequence
TSSEQIMKTGALLLQGFIQDRAEAPELALDPVPQDASTKKLSECLKRIRDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.
pubmed doi rcsb
molecule tags Apoptosis
source organism Homo sapiens
molecule keywords Apoptosis regulator BAX
total genus 63
structure length 174
sequence length 179
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-01-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 4s0pA00
1ZY3A 3IHDA 4WMRA 4BD8A 1G5MA 2B48A 1PQ1A 1AF3A 3KZ0A 1YSNA 4HW3A 2NL9A 1R2GA 2NLAA 4OQ6A 4HW2A 4BD7A 2JM6B 2MHSA 4YJ4A 3D7VA 2VOGA 4K5BC 2O2NA 5JSBA 3KJ1A 4B4SA 2RODA 1MK3A 4QNQA 1GJHA 1DDBA 2O22A 4S0OA 1OHUA 5FMIA 2KBWA 3I1HA 5C6HA 2O21A 4OYDA 4MI8A 1WSXA 1O0LA 2JCNA 3IHCA 1G5JA 4BD6A 4OQ5A 5KTGA 3IO9A 2BIDA 5IF4A 2ABOA 1F16A 3WIYA 4G35A 4ZEQA 3IHEA 3MQPA 1LXLA 4S0PA 2PQKA 4HW4A 1R2IA 2XA0A 2ME8A 4ZIGA 1R2HA 2XPXA 2W3LA 2KUAA 4ZIFA 1R2DA 5FDRA 5C3FA 3BL2A 2V6QA 2WH6A 2BZWA 3MK8A 3DVUA 5FDOA 3CVAX 4ZIIA 5IEZA 2VOIA 4BDUA 4ZIEA 4BPJA 2O2FA 1PQ0A 3KJ0A 2VOHA 3PK1A 4ZBIA 4BPIA 2LR1A 3WIXA 1K3KA 2IMTA 2K7WA 4U2VA 1R2EA 4YK9A 1YSWA 1Q59A 4ZIHA 1YSIA 1BXLA 5KU9A 3IIGA 1MAZA 3IIHA 2M5BA 3QBRA 4BD2A 2O2MA 5FC4A 4U2UA 3KJ2A 2MEJA 1TY4A 2ROCA 4ZBFA 3ILCA 1YSGA 2A5YA 2IMSA 2YV6A 4QVXA 2VM6A 2VOFA
chains in the Genus database with same CATH superfamily
1ZY3A 3IHDA 4WMRA 4BD8A 1G5MA 2B48A 1PQ1A 1AF3A 3KZ0A 1YSNA 4HW3A 2NL9A 1R2GA 4M0SA 2NLAA 4OQ6A 4HW2A 4BD7A 2JM6B 2MHSA 4YJ4A 3D7VA 2VOGA 4K5BC 2O2NA 5JSBA 3KJ1A 4B4SA 2RODA 1MK3A 4QNQA 1GJHA 1DDBA 2O22A 4S0OA 1OHUA 5FMIA 2KBWA 3I1HA 5C6HA 2O21A 4OYDA 4BBBA 4MI8A 1WSXA 1O0LA 2JCNA 3IHCA 4UF1A 2K36A 1G5JA 4BD6A 4OQ5A 5KTGA 3IO9A 2O42A 2BIDA 5IF4A 2ABOA 1F16A 3WIYA 4G35A 4ZEQA 2VTYA 3IHEA 3MQPA 1LXLA 4D2LA 4S0PA 2UXEA 2PQKA 4HW4A 1R2IA 4D2MA 2XA0A 2ME8A 4ZIGA 1R2HA 2XPXA 2W3LA 2KUAA 4BBCA 4ZIFA 1R2DA 5FDRA 2JBXA 2VVWA 5C3FA 3BL2A 2V6QA 2VVXA 2WH6A 4LQKA 2BZWA 3MK8A 3DVUA 5FDOA 3CVAX 4ZIIA 5IEZA 2VOIA 4BDUA 4ZIEA 4BPJA 2I39A 2O2FA 4BBDA 1PQ0A 3KJ0A 4UF2A 2VOHA 3PK1A 4ZBIA 4UF3A 4BPIA 2LR1A 3WIXA 1K3KA 2IMTA 2K7WA 4U2VA 2JBYA 1R2EA 4YK9A 1YSWA 1Q59A 4ZIHA 1YSIA 1BXLA 5KU9A 3IIGA 1MAZA 3IIHA 2M5BA 3QBRA 4BD2A 2O2MA 2VVYA 5FC4A 4U2UA 3KJ2A 2MEJA 1TY4A 2ROCA 3JRVA 4ZBFA 3ILCA 1YSGA 2A5YA 2IMSA 2YV6A 4QVXA 2VM6A 2VOFA
chains in the Genus database with same CATH topology
1ZY3A 3IHDA 4WMRA 4BD8A 1G5MA 2B48A 1PQ1A 1AF3A 3KZ0A 1YSNA 4HW3A 2NL9A 1R2GA 2NLAA 4OQ6A 4HW2A 4BD7A 2JM6B 2MHSA 4YJ4A 3D7VA 2VOGA 4K5BC 2O2NA 5JSBA 3KJ1A 4B4SA 2RODA 1MK3A 4QNQA 1GJHA 1DDBA 2O22A 4S0OA 1OHUA 5FMIA 2KBWA 3I1HA 5C6HA 2O21A 4OYDA 4MI8A 1WSXA 1O0LA 2JCNA 3IHCA 1G5JA 4BD6A 4OQ5A 5KTGA 3IO9A 2BIDA 5IF4A 2ABOA 1F16A 3WIYA 4G35A 4ZEQA 3IHEA 3MQPA 1LXLA 4S0PA 2PQKA 4HW4A 1R2IA 2XA0A 2ME8A 4ZIGA 1R2HA 2XPXA 2W3LA 2KUAA 4ZIFA 1R2DA 5FDRA 5C3FA 3BL2A 2V6QA 2WH6A 2BZWA 3MK8A 3DVUA 5FDOA 3CVAX 4ZIIA 5IEZA 2VOIA 4BDUA 4ZIEA 4BPJA 2O2FA 1PQ0A 3KJ0A 2VOHA 3PK1A 4ZBIA 4BPIA 2LR1A 3WIXA 1K3KA 2IMTA 2K7WA 4U2VA 1R2EA 4YK9A 1YSWA 1Q59A 4ZIHA 1YSIA 1BXLA 5KU9A 3IIGA 1MAZA 3IIHA 2M5BA 3QBRA 4BD2A 2O2MA 5FC4A 4U2UA 3KJ2A 2MEJA 1TY4A 2ROCA 4ZBFA 3ILCA 1YSGA 2A5YA 2IMSA 2YV6A 4QVXA 2VM6A 2VOFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZY3 A;  3IHD A;  4WMR A;  4BD8 A;  1G5M A;  2B48 A;  1PQ1 A;  1AF3 A;  3KZ0 A;  1YSN A;  4HW3 A;  2NL9 A;  1R2G A;  2NLA A;  4OQ6 A;  4HW2 A;  4BD7 A;  2JM6 B;  2MHS A;  4YJ4 A;  3D7V A;  2VOG A;  4K5B C;  2O2N A;  5JSB A;  3KJ1 A;  4B4S A;  2ROD A;  1MK3 A;  4QNQ A;  1GJH A;  1DDB A;  2O22 A;  4S0O A;  1OHU A;  5FMI A;  2KBW A;  3I1H A;  5C6H A;  2O21 A;  4OYD A;  4MI8 A;  1WSX A;  1O0L A;  2JCN A;  3IHC A;  1G5J A;  4BD6 A;  4OQ5 A;  5KTG A;  3IO9 A;  2BID A;  5IF4 A;  2ABO A;  1F16 A;  3WIY A;  4G35 A;  4ZEQ A;  3IHE A;  3MQP A;  1LXL A;  4S0P A;  2PQK A;  4HW4 A;  1R2I A;  2XA0 A;  2ME8 A;  4ZIG A;  1R2H A;  2XPX A;  2W3L A;  2KUA A;  4ZIF A;  1R2D A;  5FDR A;  5C3F A;  3BL2 A;  2V6Q A;  2WH6 A;  2BZW A;  3MK8 A;  3DVU A;  5FDO A;  3CVA X;  4ZII A;  5IEZ A;  2VOI A;  4BDU A;  4ZIE A;  4BPJ A;  2O2F A;  1PQ0 A;  3KJ0 A;  2VOH A;  3PK1 A;  4ZBI A;  4BPI A;  2LR1 A;  3WIX A;  1K3K A;  2IMT A;  2K7W A;  4U2V A;  1R2E A;  4YK9 A;  1YSW A;  1Q59 A;  4ZIH A;  1YSI A;  1BXL A;  5KU9 A;  3IIG A;  1MAZ A;  3IIH A;  2M5B A;  3QBR A;  4BD2 A;  2O2M A;  5FC4 A;  4U2U A;  3KJ2 A;  2MEJ A;  1TY4 A;  2ROC A;  4ZBF A;  3ILC A;  1YSG A;  2A5Y A;  2IMS A;  2YV6 A;  4QVX A;  2VM6 A;  2VOF A; 
#chains in the Genus database with same CATH topology
 1ZY3 A;  3IHD A;  4WMR A;  4BD8 A;  1G5M A;  2B48 A;  1PQ1 A;  1AF3 A;  3KZ0 A;  1YSN A;  4HW3 A;  2NL9 A;  1R2G A;  4M0S A;  2NLA A;  4OQ6 A;  4HW2 A;  4BD7 A;  2JM6 B;  2MHS A;  4YJ4 A;  3D7V A;  2VOG A;  4K5B C;  2O2N A;  5JSB A;  3KJ1 A;  4B4S A;  2ROD A;  1MK3 A;  4QNQ A;  1GJH A;  1DDB A;  2O22 A;  4S0O A;  1OHU A;  5FMI A;  2KBW A;  3I1H A;  5C6H A;  2O21 A;  4OYD A;  4BBB A;  4MI8 A;  1WSX A;  1O0L A;  2JCN A;  3IHC A;  4UF1 A;  2K36 A;  1G5J A;  4BD6 A;  4OQ5 A;  5KTG A;  3IO9 A;  2O42 A;  2BID A;  5IF4 A;  2ABO A;  1F16 A;  3WIY A;  4G35 A;  4ZEQ A;  2VTY A;  3IHE A;  3MQP A;  1LXL A;  4D2L A;  4S0P A;  2UXE A;  2PQK A;  4HW4 A;  1R2I A;  4D2M A;  2XA0 A;  2ME8 A;  4ZIG A;  1R2H A;  2XPX A;  2W3L A;  2KUA A;  4BBC A;  4ZIF A;  1R2D A;  5FDR A;  2JBX A;  2VVW A;  5C3F A;  3BL2 A;  2V6Q A;  2VVX A;  2WH6 A;  4LQK A;  2BZW A;  3MK8 A;  3DVU A;  5FDO A;  3CVA X;  4ZII A;  5IEZ A;  2VOI A;  4BDU A;  4ZIE A;  4BPJ A;  2I39 A;  2O2F A;  4BBD A;  1PQ0 A;  3KJ0 A;  4UF2 A;  2VOH A;  3PK1 A;  4ZBI A;  4UF3 A;  4BPI A;  2LR1 A;  3WIX A;  1K3K A;  2IMT A;  2K7W A;  4U2V A;  2JBY A;  1R2E A;  4YK9 A;  1YSW A;  1Q59 A;  4ZIH A;  1YSI A;  1BXL A;  5KU9 A;  3IIG A;  1MAZ A;  3IIH A;  2M5B A;  3QBR A;  4BD2 A;  2O2M A;  2VVY A;  5FC4 A;  4U2U A;  3KJ2 A;  2MEJ A;  1TY4 A;  2ROC A;  3JRV A;  4ZBF A;  3ILC A;  1YSG A;  2A5Y A;  2IMS A;  2YV6 A;  4QVX A;  2VM6 A;  2VOF A; 
#chains in the Genus database with same CATH homology
 1ZY3 A;  3IHD A;  4WMR A;  4BD8 A;  1G5M A;  2B48 A;  1PQ1 A;  1AF3 A;  3KZ0 A;  1YSN A;  4HW3 A;  2NL9 A;  1R2G A;  2NLA A;  4OQ6 A;  4HW2 A;  4BD7 A;  2JM6 B;  2MHS A;  4YJ4 A;  3D7V A;  2VOG A;  4K5B C;  2O2N A;  5JSB A;  3KJ1 A;  4B4S A;  2ROD A;  1MK3 A;  4QNQ A;  1GJH A;  1DDB A;  2O22 A;  4S0O A;  1OHU A;  5FMI A;  2KBW A;  3I1H A;  5C6H A;  2O21 A;  4OYD A;  4MI8 A;  1WSX A;  1O0L A;  2JCN A;  3IHC A;  1G5J A;  4BD6 A;  4OQ5 A;  5KTG A;  3IO9 A;  2BID A;  5IF4 A;  2ABO A;  1F16 A;  3WIY A;  4G35 A;  4ZEQ A;  3IHE A;  3MQP A;  1LXL A;  4S0P A;  2PQK A;  4HW4 A;  1R2I A;  2XA0 A;  2ME8 A;  4ZIG A;  1R2H A;  2XPX A;  2W3L A;  2KUA A;  4ZIF A;  1R2D A;  5FDR A;  5C3F A;  3BL2 A;  2V6Q A;  2WH6 A;  2BZW A;  3MK8 A;  3DVU A;  5FDO A;  3CVA X;  4ZII A;  5IEZ A;  2VOI A;  4BDU A;  4ZIE A;  4BPJ A;  2O2F A;  1PQ0 A;  3KJ0 A;  2VOH A;  3PK1 A;  4ZBI A;  4BPI A;  2LR1 A;  3WIX A;  1K3K A;  2IMT A;  2K7W A;  4U2V A;  1R2E A;  4YK9 A;  1YSW A;  1Q59 A;  4ZIH A;  1YSI A;  1BXL A;  5KU9 A;  3IIG A;  1MAZ A;  3IIH A;  2M5B A;  3QBR A;  4BD2 A;  2O2M A;  5FC4 A;  4U2U A;  3KJ2 A;  2MEJ A;  1TY4 A;  2ROC A;  4ZBF A;  3ILC A;  1YSG A;  2A5Y A;  2IMS A;  2YV6 A;  4QVX A;  2VM6 A;  2VOF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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