4YB4 | Genus

Total Genus 115

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	115
sequence length	333
structure length	333
Chain Sequence	AYRICLIEGDGIGHEVIPAARRVLEATGLPLEFVEAEAGWETFERRGTSVPEETVEKILSCHATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSRPVPGSRPGVDLVIVRENTEGLYVEQERRYLDVAIADAVISKKASERIGRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDTTAVFEPVHGSAPDIAGKGIANPTAAILSAAMMLDYLGEKEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALKSL

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Thermus thermophilus hb27
publication title	Structure of homoisocitrate dehydrogenase from Thermus thermophilus in complex with homoisocitrate, magnesium(II) and NADH rcsb
molecule keywords	Homoisocitrate dehydrogenase
total genus	115
structure length	333
sequence length	333
chains with identical sequence	B, C, D
ec nomenclature	ec 1.1.1.87: Homoisocitrate dehydrogenase.
pdb deposition date	2015-02-18

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	4yb4A00

1YCOA 4ICDA 3VMJA 4UMXA 5GRHB 2ZTWA 1DR8A 1SJSA 5I96A 3TY3A 4AJSA 3VL3A 1GROA 1IDCA 3LXYA 1T0LA 2E0CA 4XRXA 3ICDA 1VI1A 2Y40A 1HEXA 1WPWA 4JA8A 3U1HA 5I95A 1IDMA 1PTMA 1R8KA 1V53A 4XS3A 4L06A 3VL4A 3AH3A 3DMSA 3WZYA 5GRHA 4HCXA 1P8FA 1CW7A 1PB3A 4AOYA 1LWDA 4AJ3A 7ICDA 2QFYA 1CM7A 3VL6A 3US8A 1XAAA 1GC8A 2DHTA 2IV0A 1ZORA 2UXQA 5GRLA 1CW4A 3MARA 1OSJA 5GREA 1A05A 2AYQA 3UDUA 4IWHA 2Y3ZA 5L57A 1XADA 1CNZA 1G2UA 3WZXA 3R8WA 5GRLB 1IKAA 5GREB 4AJRA 1V5BA 4AJCA 4KZOA 5HN3A 3TY4A 3VKZA 1GC9A 1IDEA 4AJBA 1HJ6A 1GRPA 5HN5A 1HQSA 3U9EA 3ASJA 5GRIB 1DR0A 1BL5A 2QFWA 4AJAA 1IDDA 4P69C 4ATYA 2Y42A 1IPDA 1X0LA 1IDFA 9ICDA 5J33A 1TYOA 8ICDA 2UXRA 3VL2A 3MASB 3BLXB 3VMKA 1XACA 5LGEA 4I3KA 4BNPA 1AI2A 1PB1A 3BLVA 2E5MA 4L04A 3WZVA 2QFVA 3VMLA 1PS7A 5K10A 5GRIA 1XGVA 1T09A 3FMXX 2Y41A 3BLVB 3TNGA 5K11A 5J34A 5J32A 1AI3A 3INMA 5GRFA 1YXOA 2QFXA 1V94A 5HN4A 4UMYA 3MASA 3BLXA 4I3LA 5ICDA 2HI1A 3TSNA 5L58A 6ICDA 5GRFB 3FLKA 1ISOA 3MAPA 2G4OA 1XABA 4Y1PA 5DE1A 1OSIA 4YB4A 4XXVA 1VLCA 1PS6A 1W0DA 4WUOA 1DPZA 3UF6A 4L03A 5HN6A 3LCBC 1U7NA 3VL7A 4AOVA 1CW1A 2D1CA 4JQPA 4F7IA 3UDOA 2D4VA 4AOUA 3WZWA 1XKDA 1WALA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1YCO A;  4ICD A;  3VMJ A;  4UMX A;  5GRH B;  2ZTW A;  1DR8 A;  1SJS A;  5I96 A;  3TY3 A;  4AJS A;  3VL3 A;  1GRO A;  1IDC A;  3LXY A;  1T0L A;  2E0C A;  4XRX A;  3ICD A;  1VI1 A;  2Y40 A;  1HEX A;  1WPW A;  4JA8 A;  3U1H A;  5I95 A;  1IDM A;  1PTM A;  1R8K A;  1V53 A;  4XS3 A;  4L06 A;  3VL4 A;  3AH3 A;  3DMS A;  3WZY A;  5GRH A;  4HCX A;  1P8F A;  1CW7 A;  1PB3 A;  4AOY A;  1LWD A;  4AJ3 A;  7ICD A;  2QFY A;  1CM7 A;  3VL6 A;  3US8 A;  1XAA A;  1GC8 A;  2DHT A;  2IV0 A;  1ZOR A;  2UXQ A;  5GRL A;  1CW4 A;  3MAR A;  1OSJ A;  5GRE A;  1A05 A;  2AYQ A;  3UDU A;  4IWH A;  2Y3Z A;  5L57 A;  1XAD A;  1CNZ A;  1G2U A;  3WZX A;  3R8W A;  5GRL B;  1IKA A;  5GRE B;  4AJR A;  1V5B A;  4AJC A;  4KZO A;  5HN3 A;  3TY4 A;  3VKZ A;  1GC9 A;  1IDE A;  4AJB A;  1HJ6 A;  1GRP A;  5HN5 A;  1HQS A;  3U9E A;  3ASJ A;  5GRI B;  1DR0 A;  1BL5 A;  2QFW A;  4AJA A;  1IDD A;  4P69 C;  4ATY A;  2Y42 A;  1IPD A;  1X0L A;  1IDF A;  9ICD A;  5J33 A;  1TYO A;  8ICD A;  2UXR A;  3VL2 A;  3MAS B;  3BLX B;  3VMK A;  1XAC A;  5LGE A;  4I3K A;  4BNP A;  1AI2 A;  1PB1 A;  3BLV A;  2E5M A;  4L04 A;  3WZV A;  2QFV A;  3VML A;  1PS7 A;  5K10 A;  5GRI A;  1XGV A;  1T09 A;  3FMX X;  2Y41 A;  3BLV B;  3TNG A;  5K11 A;  5J34 A;  5J32 A;  1AI3 A;  3INM A;  5GRF A;  1YXO A;  2QFX A;  1V94 A;  5HN4 A;  4UMY A;  3MAS A;  3BLX A;  4I3L A;  5ICD A;  2HI1 A;  3TSN A;  5L58 A;  6ICD A;  5GRF B;  3FLK A;  1ISO A;  3MAP A;  2G4O A;  1XAB A;  4Y1P A;  5DE1 A;  1OSI A;  4YB4 A;  4XXV A;  1VLC A;  1PS6 A;  1W0D A;  4WUO A;  1DPZ A;  3UF6 A;  4L03 A;  5HN6 A;  3LCB C;  1U7N A;  3VL7 A;  4AOV A;  1CW1 A;  2D1C A;  4JQP A;  4F7I A;  3UDO A;  2D4V A;  4AOU A;  3WZW A;  1XKD A;  1WAL A; 
#chains in the Genus database with same CATH topology
 1YCO A;  4ICD A;  3VMJ A;  4UMX A;  5GRH B;  2ZTW A;  1DR8 A;  1SJS A;  5I96 A;  3TY3 A;  4AJS A;  3VL3 A;  1GRO A;  1IDC A;  3LXY A;  1T0L A;  2E0C A;  4XRX A;  3ICD A;  1VI1 A;  2Y40 A;  1HEX A;  1WPW A;  4JA8 A;  3U1H A;  5I95 A;  1IDM A;  1PTM A;  1R8K A;  1V53 A;  4XS3 A;  4L06 A;  3VL4 A;  3AH3 A;  3DMS A;  3WZY A;  5GRH A;  4HCX A;  1P8F A;  1CW7 A;  1PB3 A;  4AOY A;  1LWD A;  4AJ3 A;  7ICD A;  2QFY A;  1CM7 A;  3VL6 A;  3US8 A;  1XAA A;  1GC8 A;  2DHT A;  2IV0 A;  1ZOR A;  2UXQ A;  5GRL A;  1CW4 A;  3MAR A;  1OSJ A;  5GRE A;  1A05 A;  2AYQ A;  3UDU A;  4IWH A;  2Y3Z A;  5L57 A;  1XAD A;  1CNZ A;  1G2U A;  3WZX A;  3R8W A;  5GRL B;  1IKA A;  5GRE B;  4AJR A;  1V5B A;  4AJC A;  4KZO A;  5HN3 A;  3TY4 A;  3VKZ A;  1GC9 A;  1IDE A;  4AJB A;  1HJ6 A;  1GRP A;  5HN5 A;  1HQS A;  3U9E A;  3ASJ A;  5GRI B;  1DR0 A;  1BL5 A;  2QFW A;  4AJA A;  1IDD A;  4P69 C;  4ATY A;  2Y42 A;  1IPD A;  1X0L A;  1IDF A;  9ICD A;  5J33 A;  1TYO A;  8ICD A;  2UXR A;  3VL2 A;  3MAS B;  3BLX B;  3VMK A;  1XAC A;  5LGE A;  4I3K A;  4BNP A;  1AI2 A;  1PB1 A;  3BLV A;  2E5M A;  4L04 A;  3WZV A;  2QFV A;  3VML A;  1PS7 A;  5K10 A;  5GRI A;  1XGV A;  1T09 A;  3FMX X;  2Y41 A;  3BLV B;  3TNG A;  5K11 A;  5J34 A;  5J32 A;  1AI3 A;  3INM A;  5GRF A;  1YXO A;  2QFX A;  1V94 A;  5HN4 A;  4UMY A;  3MAS A;  3BLX A;  4I3L A;  5ICD A;  2HI1 A;  3TSN A;  5L58 A;  6ICD A;  5GRF B;  3FLK A;  1ISO A;  3MAP A;  2G4O A;  1XAB A;  4Y1P A;  5DE1 A;  1OSI A;  4YB4 A;  4XXV A;  1VLC A;  1PS6 A;  1W0D A;  4WUO A;  1DPZ A;  3UF6 A;  4L03 A;  5HN6 A;  3LCB C;  1U7N A;  3VL7 A;  4AOV A;  1CW1 A;  2D1C A;  4JQP A;  4F7I A;  3UDO A;  2D4V A;  4AOU A;  3WZW A;  1XKD A;  1WAL A; 
#chains in the Genus database with same CATH homology
 1YCO A;  4ICD A;  3VMJ A;  4UMX A;  5GRH B;  2ZTW A;  1DR8 A;  1SJS A;  5I96 A;  3TY3 A;  4AJS A;  3VL3 A;  1GRO A;  1IDC A;  3LXY A;  1T0L A;  2E0C A;  4XRX A;  3ICD A;  1VI1 A;  2Y40 A;  1HEX A;  1WPW A;  4JA8 A;  3U1H A;  5I95 A;  1IDM A;  1PTM A;  1R8K A;  1V53 A;  4XS3 A;  4L06 A;  3VL4 A;  3AH3 A;  3DMS A;  3WZY A;  5GRH A;  4HCX A;  1P8F A;  1CW7 A;  1PB3 A;  4AOY A;  1LWD A;  4AJ3 A;  7ICD A;  2QFY A;  1CM7 A;  3VL6 A;  3US8 A;  1XAA A;  1GC8 A;  2DHT A;  2IV0 A;  1ZOR A;  2UXQ A;  5GRL A;  1CW4 A;  3MAR A;  1OSJ A;  5GRE A;  1A05 A;  2AYQ A;  3UDU A;  4IWH A;  2Y3Z A;  5L57 A;  1XAD A;  1CNZ A;  1G2U A;  3WZX A;  3R8W A;  5GRL B;  1IKA A;  5GRE B;  4AJR A;  1V5B A;  4AJC A;  4KZO A;  5HN3 A;  3TY4 A;  3VKZ A;  1GC9 A;  1IDE A;  4AJB A;  1HJ6 A;  1GRP A;  5HN5 A;  1HQS A;  3U9E A;  3ASJ A;  5GRI B;  1DR0 A;  1BL5 A;  2QFW A;  4AJA A;  1IDD A;  4P69 C;  4ATY A;  2Y42 A;  1IPD A;  1X0L A;  1IDF A;  9ICD A;  5J33 A;  1TYO A;  8ICD A;  2UXR A;  3VL2 A;  3MAS B;  3BLX B;  3VMK A;  1XAC A;  5LGE A;  4I3K A;  4BNP A;  1AI2 A;  1PB1 A;  3BLV A;  2E5M A;  4L04 A;  3WZV A;  2QFV A;  3VML A;  1PS7 A;  5K10 A;  5GRI A;  1XGV A;  1T09 A;  3FMX X;  2Y41 A;  3BLV B;  3TNG A;  5K11 A;  5J34 A;  5J32 A;  1AI3 A;  3INM A;  5GRF A;  1YXO A;  2QFX A;  1V94 A;  5HN4 A;  4UMY A;  3MAS A;  3BLX A;  4I3L A;  5ICD A;  2HI1 A;  3TSN A;  5L58 A;  6ICD A;  5GRF B;  3FLK A;  1ISO A;  3MAP A;  2G4O A;  1XAB A;  4Y1P A;  5DE1 A;  1OSI A;  4YB4 A;  4XXV A;  1VLC A;  1PS6 A;  1W0D A;  4WUO A;  1DPZ A;  3UF6 A;  4L03 A;  5HN6 A;  3LCB C;  1U7N A;  3VL7 A;  4AOV A;  1CW1 A;  2D1C A;  4JQP A;  4F7I A;  3UDO A;  2D4V A;  4AOU A;  3WZW A;  1XKD A;  1WAL A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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4YB4A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations