The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
59
|
sequence length |
152
|
structure length |
152
|
Chain Sequence |
GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
pubmed doi rcsb |
| molecule keywords |
Induced myeloid leukemia cell differentiation protein Mcl-1
|
| molecule tags |
Apoptosis/apoptosis inhibitor
|
| source organism |
Homo sapiens
|
| total genus |
59
|
| structure length |
152
|
| sequence length |
152
|
| chains with identical sequence |
B, C, D, E, F, G, H, I, J, K, L
|
| ec nomenclature | |
| pdb deposition date | 2015-04-14 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00452 | Bcl-2 | Apoptosis regulator proteins, Bcl-2 family |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Apoptosis Regulator Bcl-x | Blc2-like |
#chains in the Genus database with same CATH superfamily 3QBR A; 2ME8 A; 2O22 A; 2VOI A; 4ZEQ A; 3IHC A; 3D7V A; 1TY4 A; 1LXL A; 4YJ4 A; 4ZIF A; 5C6H A; 5IEZ A; 2O2N A; 2JM6 B; 3WIY A; 4HW3 A; 2XPX A; 2VOG A; 3PK1 A; 4ZBF A; 1F16 A; 1G5M A; 4BPI A; 1DDB A; 5FDR A; 3IIG A; 2JCN A; 1PQ1 A; 2BZW A; 2VOF A; 1YSW A; 2B48 A; 3I1H A; 2IMS A; 3KZ0 A; 1AF3 A; 4MI8 A; 2NLA A; 4HW4 A; 2O2M A; 3KJ0 A; 2YV6 A; 1GJH A; 3DVU A; 2W3L A; 4OYD A; 4BD6 A; 4ZBI A; 1YSG A; 1PQ0 A; 3MK8 A; 5IF4 A; 3IHE A; 1R2H A; 2WH6 A; 1BXL A; 4QNQ A; 5FDO A; 4G35 A; 3WIX A; 2XA0 A; 2MEJ A; 3KJ2 A; 1ZY3 A; 3ILC A; 1Q59 A; 1MAZ A; 1R2D A; 1MK3 A; 5FC4 A; 3BL2 A; 2VOH A; 4ZIG A; 1G5J A; 1R2E A; 4OQ5 A; 2K7W A; 1K3K A; 1YSI A; 2ROC A; 2V6Q A; 2M5B A; 2ABO A; 4U2V A; 5JSB A; 4BD7 A; 4QVX A; 2NL9 A; 5KU9 A; 3IO9 A; 4YK9 A; 4BD8 A; 1O0L A; 4BPJ A; 2MHS A; 4HW2 A; 1R2I A; 2O2F A; 2KBW A; 1WSX A; 2KUA A; 4BD2 A; 1R2G A; 2A5Y A; 4S0P A; 3KJ1 A; 4K5B C; 5KTG A; 2PQK A; 2BID A; 4B4S A; 2IMT A; 4S0O A; 4OQ6 A; 1YSN A; 4U2U A; 4WMR A; 4BDU A; 5FMI A; 3MQP A; 3CVA X; 2O21 A; 4ZIE A; 2LR1 A; 2ROD A; 3IHD A; 5C3F A; 4ZII A; 2VM6 A; 3IIH A; 1OHU A; 4ZIH A; #chains in the Genus database with same CATH topology 3QBR A; 2ME8 A; 2O22 A; 2VOI A; 4ZEQ A; 3IHC A; 3D7V A; 1TY4 A; 1LXL A; 4YJ4 A; 4ZIF A; 5C6H A; 5IEZ A; 2O2N A; 2JM6 B; 2JBX A; 3WIY A; 4HW3 A; 2XPX A; 2VOG A; 3PK1 A; 4ZBF A; 1F16 A; 1G5M A; 4BPI A; 1DDB A; 5FDR A; 2I39 A; 4D2M A; 3IIG A; 2JCN A; 1PQ1 A; 2BZW A; 2VOF A; 1YSW A; 2B48 A; 3I1H A; 2IMS A; 3KZ0 A; 1AF3 A; 4MI8 A; 2NLA A; 4HW4 A; 2O2M A; 3KJ0 A; 2YV6 A; 1GJH A; 3DVU A; 2W3L A; 3JRV A; 4OYD A; 4ZBI A; 4BD6 A; 1YSG A; 1PQ0 A; 3MK8 A; 5IF4 A; 3IHE A; 1R2H A; 4UF3 A; 2O42 A; 2WH6 A; 1BXL A; 4QNQ A; 5FDO A; 4G35 A; 3WIX A; 2XA0 A; 2MEJ A; 3KJ2 A; 1ZY3 A; 3ILC A; 1Q59 A; 1MAZ A; 1R2D A; 1MK3 A; 4UF1 A; 5FC4 A; 3BL2 A; 2VOH A; 4ZIG A; 1G5J A; 1R2E A; 4OQ5 A; 2K7W A; 1K3K A; 1YSI A; 2UXE A; 2ROC A; 2JBY A; 2V6Q A; 2M5B A; 2ABO A; 4U2V A; 5JSB A; 4BD7 A; 4QVX A; 2NL9 A; 4M0S A; 5KU9 A; 4UF2 A; 3IO9 A; 4YK9 A; 4BD8 A; 2VTY A; 1O0L A; 4BPJ A; 2MHS A; 4HW2 A; 1R2I A; 2O2F A; 2KBW A; 2K36 A; 2VVW A; 1WSX A; 2KUA A; 4BD2 A; 1R2G A; 2A5Y A; 4S0P A; 4BBC A; 3KJ1 A; 4K5B C; 5KTG A; 2PQK A; 2BID A; 4B4S A; 2IMT A; 4S0O A; 4LQK A; 4OQ6 A; 1YSN A; 2VVX A; 4U2U A; 4WMR A; 4BBD A; 4BDU A; 5FMI A; 3MQP A; 3CVA X; 2O21 A; 4BBB A; 4ZIE A; 2LR1 A; 4D2L A; 2ROD A; 3IHD A; 5C3F A; 4ZII A; 2VM6 A; 2VVY A; 3IIH A; 1OHU A; 4ZIH A; #chains in the Genus database with same CATH homology 3QBR A; 2ME8 A; 2O22 A; 2VOI A; 4ZEQ A; 3IHC A; 3D7V A; 1TY4 A; 1LXL A; 4YJ4 A; 4ZIF A; 5C6H A; 5IEZ A; 2O2N A; 2JM6 B; 3WIY A; 4HW3 A; 2XPX A; 2VOG A; 3PK1 A; 4ZBF A; 1F16 A; 1G5M A; 4BPI A; 1DDB A; 5FDR A; 3IIG A; 2JCN A; 1PQ1 A; 2BZW A; 2VOF A; 1YSW A; 2B48 A; 3I1H A; 2IMS A; 3KZ0 A; 1AF3 A; 4MI8 A; 2NLA A; 4HW4 A; 2O2M A; 3KJ0 A; 2YV6 A; 1GJH A; 3DVU A; 2W3L A; 4OYD A; 4BD6 A; 4ZBI A; 1YSG A; 1PQ0 A; 3MK8 A; 5IF4 A; 3IHE A; 1R2H A; 2WH6 A; 1BXL A; 4QNQ A; 5FDO A; 4G35 A; 3WIX A; 2XA0 A; 2MEJ A; 3KJ2 A; 1ZY3 A; 3ILC A; 1Q59 A; 1MAZ A; 1R2D A; 1MK3 A; 5FC4 A; 3BL2 A; 2VOH A; 4ZIG A; 1G5J A; 1R2E A; 4OQ5 A; 2K7W A; 1K3K A; 1YSI A; 2ROC A; 2V6Q A; 2M5B A; 2ABO A; 4U2V A; 5JSB A; 4BD7 A; 4QVX A; 2NL9 A; 5KU9 A; 3IO9 A; 4YK9 A; 4BD8 A; 1O0L A; 4BPJ A; 2MHS A; 4HW2 A; 1R2I A; 2O2F A; 2KBW A; 1WSX A; 2KUA A; 4BD2 A; 1R2G A; 2A5Y A; 4S0P A; 3KJ1 A; 4K5B C; 5KTG A; 2PQK A; 2BID A; 4B4S A; 2IMT A; 4S0O A; 4OQ6 A; 1YSN A; 4U2U A; 4WMR A; 4BDU A; 5FMI A; 3MQP A; 3CVA X; 2O21 A; 4ZIE A; 2LR1 A; 2ROD A; 3IHD A; 5C3F A; 4ZII A; 2VM6 A; 3IIH A; 1OHU A; 4ZIH A;
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