4O1VA

Spop promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
141
structure length
141
Chain Sequence
SGKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Speckle-type POZ protein
total genus 28
structure length 141
sequence length 141
ec nomenclature
pdb deposition date 2013-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00917 MATH MATH domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.210.10 Mainly Beta Sandwich Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A 4o1vA01
1YY6A 2FOJA 5H9MA 1CZYA 2CR2A 3IVVA 4GJHA 4O1VA 2F1ZA 1FLKA 1K2FA 3MQSC 3IVQA 3HQLA 4I7BA 4GWMA 3ZJBA 1YZEA 4GWNA 2F1XA 1CA9A 1D0JA 1CA4A 2GKWA 2FOPA 1KZZA 3HU6A 1D0AA 4KG9A 4CA1A 1LB6A 2F1YA 1ZMSA 4I7CA 1L0AA 1F3VB 2FOOA 1QSCA 4JJQA 2F1WA 4M4EA 4C9ZA 3HQHA 3HQIA 3IVBA 4I7DA 1LB5A 4X3GA 3HSVA 3HQMA 1LB4A 4YSIA 4Z8MA 1CZZA 4K8UA 1RF3A 2AN6A 3MQRA 5E1TA 4GHUA 1FLLA 2XXNA 1D01A 2A25A 1D00A
chains in the Genus database with same CATH superfamily
1YY6A 2FOJA 5H9MA 1CZYA 2CR2A 3IVVA 4GJHA 4O1VA 2F1ZA 1FLKA 1K2FA 3MQSC 3IVQA 3HQLA 4I7BA 4GWMA 3ZJBA 1YZEA 4GWNA 2F1XA 1CA9A 1D0JA 1CA4A 2GKWA 2FOPA 1KZZA 3HU6A 1D0AA 4KG9A 4CA1A 1LB6A 2F1YA 1ZMSA 4I7CA 1L0AA 1F3VB 2FOOA 1QSCA 4JJQA 2F1WA 4M4EA 4C9ZA 3HQHA 3HQIA 3IVBA 4I7DA 1LB5A 4X3GA 3HSVA 3HQMA 1LB4A 4YSIA 4Z8MA 1CZZA 4K8UA 1RF3A 2AN6A 3MQRA 5E1TA 4GHUA 1FLLA 2XXNA 1D01A 2A25A 1D00A
chains in the Genus database with same CATH topology
1YY6A 2FOJA 5H9MA 1CZYA 2CR2A 3IVVA 4GJHA 4O1VA 2F1ZA 1FLKA 1K2FA 3MQSC 3IVQA 3HQLA 4I7BA 4GWMA 3ZJBA 1YZEA 4GWNA 2F1XA 1CA9A 1D0JA 1CA4A 2GKWA 2FOPA 1KZZA 3HU6A 1D0AA 4KG9A 4CA1A 1LB6A 2F1YA 1ZMSA 4I7CA 1L0AA 1F3VB 2FOOA 1QSCA 4JJQA 2F1WA 4M4EA 4C9ZA 3HQHA 3HQIA 3IVBA 4I7DA 1LB5A 4X3GA 3HSVA 3HQMA 1LB4A 4YSIA 4Z8MA 1CZZA 4K8UA 1RF3A 2AN6A 3MQRA 5E1TA 4GHUA 1FLLA 2XXNA 1D01A 2A25A 1D00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YY6 A;  2FOJ A;  5H9M A;  1CZY A;  2CR2 A;  3IVV A;  4GJH A;  4O1V A;  2F1Z A;  1FLK A;  1K2F A;  3MQS C;  3IVQ A;  3HQL A;  4I7B A;  4GWM A;  3ZJB A;  1YZE A;  4GWN A;  2F1X A;  1CA9 A;  1D0J A;  1CA4 A;  2GKW A;  2FOP A;  1KZZ A;  3HU6 A;  1D0A A;  4KG9 A;  4CA1 A;  1LB6 A;  2F1Y A;  1ZMS A;  4I7C A;  1L0A A;  1F3V B;  2FOO A;  1QSC A;  4JJQ A;  2F1W A;  4M4E A;  4C9Z A;  3HQH A;  3HQI A;  3IVB A;  4I7D A;  1LB5 A;  4X3G A;  3HSV A;  3HQM A;  1LB4 A;  4YSI A;  4Z8M A;  1CZZ A;  4K8U A;  1RF3 A;  2AN6 A;  3MQR A;  5E1T A;  4GHU A;  1FLL A;  2XXN A;  1D01 A;  2A25 A;  1D00 A; 
#chains in the Genus database with same CATH topology
 1YY6 A;  2FOJ A;  5H9M A;  1CZY A;  2CR2 A;  3IVV A;  4GJH A;  4O1V A;  2F1Z A;  1FLK A;  1K2F A;  3MQS C;  3IVQ A;  3HQL A;  4I7B A;  4GWM A;  3ZJB A;  1YZE A;  4GWN A;  2F1X A;  1CA9 A;  1D0J A;  1CA4 A;  2GKW A;  2FOP A;  1KZZ A;  3HU6 A;  1D0A A;  4KG9 A;  4CA1 A;  1LB6 A;  2F1Y A;  1ZMS A;  4I7C A;  1L0A A;  1F3V B;  2FOO A;  1QSC A;  4JJQ A;  2F1W A;  4M4E A;  4C9Z A;  3HQH A;  3HQI A;  3IVB A;  4I7D A;  1LB5 A;  4X3G A;  3HSV A;  3HQM A;  1LB4 A;  4YSI A;  4Z8M A;  1CZZ A;  4K8U A;  1RF3 A;  2AN6 A;  3MQR A;  5E1T A;  4GHU A;  1FLL A;  2XXN A;  1D01 A;  2A25 A;  1D00 A; 
#chains in the Genus database with same CATH homology
 1YY6 A;  2FOJ A;  5H9M A;  1CZY A;  2CR2 A;  3IVV A;  4GJH A;  4O1V A;  2F1Z A;  1FLK A;  1K2F A;  3MQS C;  3IVQ A;  3HQL A;  4I7B A;  4GWM A;  3ZJB A;  1YZE A;  4GWN A;  2F1X A;  1CA9 A;  1D0J A;  1CA4 A;  2GKW A;  2FOP A;  1KZZ A;  3HU6 A;  1D0A A;  4KG9 A;  4CA1 A;  1LB6 A;  2F1Y A;  1ZMS A;  4I7C A;  1L0A A;  1F3V B;  2FOO A;  1QSC A;  4JJQ A;  2F1W A;  4M4E A;  4C9Z A;  3HQH A;  3HQI A;  3IVB A;  4I7D A;  1LB5 A;  4X3G A;  3HSV A;  3HQM A;  1LB4 A;  4YSI A;  4Z8M A;  1CZZ A;  4K8U A;  1RF3 A;  2AN6 A;  3MQR A;  5E1T A;  4GHU A;  1FLL A;  2XXN A;  1D01 A;  2A25 A;  1D00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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