5D8UA

2009 h1n1 pa endonuclease mutant e119d in complex with l-742,001
Total Genus 66
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
179
structure length
179
Chain Sequence
GSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIDIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Influenza a virus
molecule keywords Polymerase acidic protein
total genus 66
structure length 179
sequence length 179
ec nomenclature
pdb deposition date 2015-08-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.91.90 Alpha Beta 3-Layer(aba) Sandwich Restriction Endonuclease Restriction Endonuclease 5d8uA00
5CL0A 4ZI0A 4AWMA 3HW4A 4CGXA 4AVLA 4YYLA 4AWFA 4E5LA 5FDGA 3HW6A 4AWHA 4CGSA 4E5GA 5D8UA 5D42A 3HW3A 5EGAA 5I13A 5CZNA 4ZQQA 4E5IA 4ZHZA 5FDDA 5D4GA 5DESA 4AWKA 3EBJA 4E5JA 5CCYA 4E5FA 4CHCA 5D2OA 5DBSA 5JHTA 4E5EA 5JHVA 4AVGA 4NFZA 4AWGA 4E5HA 4AVQA 5DEBA 5D9JA 5CGVA 3HW5A
chains in the Genus database with same CATH superfamily
3N7BA 4ZI0A 3V20A 4AWMA 1M0IA 4CGXA 4AWFA 3V21A 1DC1A 2EWFA 4E5GA 4F0PA 2FOKA 5D8UA 1ESGA 5CZNA 4ZQQA 4AWKA 1DFMA 3MQ6A 4CHCA 2XI7A 4NFZA 3DW9A 4AVQA 3WVPA 5FDDA 4E5JA 5CL0A 1FOKA 3V1ZA 4YYLA 2XI5A 2P14A 4OC8A 3WVKA 1BAMA 5I13A 3DVOA 5D4GA 3CAEA 4E5FA 3MQYA 2BAMA 5JHTA 3A4KA 4AVGA 5CGVA 3DPGA 3ODHA 4AVLA 3HW6A 3WVHA 1ES8A 3HW3A 1KNVA 4ZHZA 3EBJA 3WVGA 4E5EA 4R28A 4E5HA 5DEBA 2FQZA 1CFRA 1SDOA 1FZRA 3HW4A 1D2IA 1VRRA 4E5LA 5FDGA 2PFJA 4AWHA 3WVIA 4CGSA 5D42A 5EGAA 2E52A 1BHMA 1M0DA 4E5IA 2GB7A 5DESA 3N78A 3BM3A 3BAMA 5CCYA 5D2OA 5DBSA 2P0JA 4F0QA 5JHVA 4AWGA 5D9JA 3HW5A
chains in the Genus database with same CATH topology
3N7BA 4ZI0A 3V20A 4AWMA 1M0IA 4CGXA 4AWFA 3V21A 1DC1A 2EWFA 4E5GA 4F0PA 2FOKA 5D8UA 1ESGA 5CZNA 4ZQQA 4AWKA 1DFMA 3MQ6A 4CHCA 2XI7A 4NFZA 3DW9A 4AVQA 3WVPA 5FDDA 4E5JA 5CL0A 1FOKA 3V1ZA 4YYLA 2XI5A 2P14A 4OC8A 3WVKA 1BAMA 5I13A 3DVOA 5D4GA 3CAEA 4E5FA 3MQYA 2BAMA 5JHTA 3A4KA 4AVGA 5CGVA 3DPGA 3ODHA 4AVLA 3HW6A 3WVHA 1ES8A 3HW3A 1KNVA 4ZHZA 3EBJA 3WVGA 4E5EA 4R28A 4E5HA 5DEBA 2FQZA 1CFRA 1SDOA 1FZRA 3HW4A 1D2IA 1VRRA 4E5LA 5FDGA 2PFJA 4AWHA 3WVIA 4CGSA 5D42A 5EGAA 2E52A 1BHMA 1M0DA 4E5IA 2GB7A 5DESA 3N78A 3BM3A 3BAMA 5CCYA 5D2OA 5DBSA 2P0JA 4F0QA 5JHVA 4AWGA 5D9JA 3HW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CL0 A;  4ZI0 A;  4AWM A;  3HW4 A;  4CGX A;  4AVL A;  4YYL A;  4AWF A;  4E5L A;  5FDG A;  3HW6 A;  4AWH A;  4CGS A;  4E5G A;  5D8U A;  5D42 A;  3HW3 A;  5EGA A;  5I13 A;  5CZN A;  4ZQQ A;  4E5I A;  4ZHZ A;  5FDD A;  5D4G A;  5DES A;  4AWK A;  3EBJ A;  4E5J A;  5CCY A;  4E5F A;  4CHC A;  5D2O A;  5DBS A;  5JHT A;  4E5E A;  5JHV A;  4AVG A;  4NFZ A;  4AWG A;  4E5H A;  4AVQ A;  5DEB A;  5D9J A;  5CGV A;  3HW5 A; 
#chains in the Genus database with same CATH topology
 3N7B A;  4ZI0 A;  3V20 A;  4AWM A;  1M0I A;  4CGX A;  4AWF A;  3V21 A;  1DC1 A;  2EWF A;  4E5G A;  4F0P A;  2FOK A;  5D8U A;  1ESG A;  5CZN A;  4ZQQ A;  4AWK A;  1DFM A;  3MQ6 A;  4CHC A;  2XI7 A;  4NFZ A;  3DW9 A;  4AVQ A;  3WVP A;  5FDD A;  4E5J A;  5CL0 A;  1FOK A;  3V1Z A;  4YYL A;  2XI5 A;  2P14 A;  4OC8 A;  3WVK A;  1BAM A;  5I13 A;  3DVO A;  5D4G A;  3CAE A;  4E5F A;  3MQY A;  2BAM A;  5JHT A;  3A4K A;  4AVG A;  5CGV A;  3DPG A;  3ODH A;  4AVL A;  3HW6 A;  3WVH A;  1ES8 A;  3HW3 A;  1KNV A;  4ZHZ A;  3EBJ A;  3WVG A;  4E5E A;  4R28 A;  4E5H A;  5DEB A;  2FQZ A;  1CFR A;  1SDO A;  1FZR A;  3HW4 A;  1D2I A;  1VRR A;  4E5L A;  5FDG A;  2PFJ A;  4AWH A;  3WVI A;  4CGS A;  5D42 A;  5EGA A;  2E52 A;  1BHM A;  1M0D A;  4E5I A;  2GB7 A;  5DES A;  3N78 A;  3BM3 A;  3BAM A;  5CCY A;  5D2O A;  5DBS A;  2P0J A;  4F0Q A;  5JHV A;  4AWG A;  5D9J A;  3HW5 A; 
#chains in the Genus database with same CATH homology
 3N7B A;  4ZI0 A;  3V20 A;  4AWM A;  1M0I A;  4CGX A;  4AWF A;  3V21 A;  1DC1 A;  2EWF A;  4E5G A;  4F0P A;  2FOK A;  5D8U A;  1ESG A;  5CZN A;  4ZQQ A;  4AWK A;  1DFM A;  3MQ6 A;  4CHC A;  2XI7 A;  4NFZ A;  3DW9 A;  4AVQ A;  3WVP A;  5FDD A;  4E5J A;  5CL0 A;  1FOK A;  3V1Z A;  4YYL A;  2XI5 A;  2P14 A;  4OC8 A;  3WVK A;  1BAM A;  5I13 A;  3DVO A;  5D4G A;  3CAE A;  4E5F A;  3MQY A;  2BAM A;  5JHT A;  3A4K A;  4AVG A;  5CGV A;  3DPG A;  3ODH A;  4AVL A;  3HW6 A;  3WVH A;  1ES8 A;  3HW3 A;  1KNV A;  4ZHZ A;  3EBJ A;  3WVG A;  4E5E A;  4R28 A;  4E5H A;  5DEB A;  2FQZ A;  1CFR A;  1SDO A;  1FZR A;  3HW4 A;  1D2I A;  1VRR A;  4E5L A;  5FDG A;  2PFJ A;  4AWH A;  3WVI A;  4CGS A;  5D42 A;  5EGA A;  2E52 A;  1BHM A;  1M0D A;  4E5I A;  2GB7 A;  5DES A;  3N78 A;  3BM3 A;  3BAM A;  5CCY A;  5D2O A;  5DBS A;  2P0J A;  4F0Q A;  5JHV A;  4AWG A;  5D9J A;  3HW5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...