5DE1A

Crystal structure of human idh1 in complex with gsk321a
Total Genus 142
50100150200250300350020406080100120140
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
sequence length
412
structure length
399
Chain Sequence
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
50100150200250300350300200100
020406080100120140Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (5-14)TI1 (31-34)AH2 (46-52)AH1 (17-31)S3 (69-72)S2 (35-43)3H3 (383-385)TIV1 (88-91)TI'1 (52-55)AH3 (55-67)EMPTYTIV4 (284-287)3H2 (288-290)S13 (291-296)AH4 (80-86)TI8 (297-300)TIV5 (299-302)TI7 (279-282)S4 (106-111)S5 (128-132)AH6 (186-203)AH11 (350-369)TI3 (114-117)TVIII1 (119-122)S11 (246-250)AH8 (251-260)S6 (143-146)3H1 (282-284)S10 (207-211)TI6 (212-215)TIV2 (213-216)AH7 (217-242)S12 (265-269)S14 (303-307)AH9 (313-321)3H4 (388-390)AH12 (374-381)AH13 (394-413)AH5 (95-103)TI4 (121-124)TVIII2 (172-175)S8 (165-172)TI5 (158-161)S7 (150-156)AH10 (329-347)S9 (177-180)Updating...
connected with : NaN
molecule tags Oxidoreductase/oxidoreductase inhibitor
source organism Homo sapiens
publication title New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
pubmed doi rcsb
molecule keywords Isocitrate dehydrogenase [NADP] cytoplasmic
total genus 142
structure length 399
sequence length 412
chains with identical sequence B
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2015-08-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 5de1A00
1PB3A 3BLXA 4AJBA 2HI1A 1DR8A 1GC9A 1IDMA 3AH3A 3U1HA 1CW7A 1AI3A 2QFYA 1LWDA 1V53A 1HJ6A 3FLKA 1WALA 4P69C 4WUOA 1XGVA 1SJSA 2E0CA 2UXQA 3LCBC 1V5BA 4XXVA 4AJCA 6ICDA 3BLVA 1CW4A 1W0DA 5J32A 2Y42A 1OSJA 4AOUA 3MASB 4BNPA 1YXOA 1X0LA 2Y3ZA 4I3LA 3UDOA 3WZXA 5HN5A 5HN6A 1BL5A 1T09A 1GC8A 3FMXX 2Y40A 2AYQA 5GRFA 1ISOA 4XS3A 3VKZA 2QFWA 1A05A 4AOVA 5I96A 1CNZA 1G2UA 2UXRA 4ICDA 5K11A 3VL2A 1DR0A 3ASJA 1HEXA 1PS7A 1XKDA 3WZVA 3MAPA 3VMJA 2IV0A 5K10A 1YCOA 1V94A 5GREA 2D1CA 1CW1A 4L06A 5GRHB 2QFXA 3VMLA 1VLCA 4AJ3A 1T0LA 1U7NA 5GRLB 4UMXA 3VMKA 3BLXB 5L57A 2G4OA 3VL6A 8ICDA 5I95A 5GRLA 1CM7A 1HQSA 1DPZA 1GROA 2ZTWA 3VL3A 4AOYA 1ZORA 5HN3A 4XRXA 4AJRA 1XACA 5ICDA 3LXYA 4JA8A 1XADA 5LGEA 3INMA 4AJSA 4Y1PA 3MARA 1IKAA 1GRPA 3BLVB 4L03A 5J33A 4UMYA 3ICDA 3UF6A 3VL4A 1P8FA 1WPWA 5DE1A 2QFVA 5GRIA 1IDDA 4HCXA 3VL7A 3TSNA 3TY3A 1AI2A 5L58A 1OSIA 9ICDA 3UDUA 4IWHA 1PB1A 5HN4A 4JQPA 4KZOA 1IDCA 5GRFB 4L04A 3WZYA 1PS6A 1PTMA 2DHTA 1XABA 7ICDA 2E5MA 2D4VA 1R8KA 4YB4A 5J34A 3TY4A 1TYOA 1XAAA 3DMSA 3WZWA 3R8WA 1IPDA 3U9EA 3TNGA 4ATYA 1IDEA 1VI1A 4I3KA 5GRHA 5GREB 3MASA 5GRIB 3US8A 1IDFA 4AJAA 2Y41A 4F7IA
chains in the Genus database with same CATH superfamily
1PB3A 3BLXA 4AJBA 2HI1A 1DR8A 1GC9A 1IDMA 3AH3A 3U1HA 1CW7A 1AI3A 2QFYA 1LWDA 1V53A 1HJ6A 3FLKA 1WALA 4P69C 4WUOA 1XGVA 1SJSA 2E0CA 2UXQA 3LCBC 1V5BA 4XXVA 4AJCA 6ICDA 3BLVA 1CW4A 1W0DA 5J32A 2Y42A 1OSJA 4AOUA 3MASB 4BNPA 1YXOA 1X0LA 2Y3ZA 4I3LA 3UDOA 3WZXA 5HN5A 5HN6A 1BL5A 1T09A 1GC8A 3FMXX 2Y40A 2AYQA 5GRFA 1ISOA 4XS3A 3VKZA 2QFWA 1A05A 4AOVA 5I96A 1CNZA 1G2UA 2UXRA 4ICDA 5K11A 3VL2A 1DR0A 3ASJA 1HEXA 1PS7A 1XKDA 3WZVA 3MAPA 3VMJA 2IV0A 5K10A 1YCOA 1V94A 5GREA 2D1CA 1CW1A 4L06A 5GRHB 2QFXA 3VMLA 1VLCA 4AJ3A 1T0LA 1U7NA 5GRLB 4UMXA 3VMKA 3BLXB 5L57A 2G4OA 3VL6A 8ICDA 5I95A 5GRLA 1CM7A 1HQSA 1DPZA 1GROA 2ZTWA 3VL3A 4AOYA 1ZORA 5HN3A 4XRXA 4AJRA 1XACA 5ICDA 3LXYA 4JA8A 1XADA 5LGEA 3INMA 4AJSA 4Y1PA 3MARA 1IKAA 1GRPA 3BLVB 4L03A 5J33A 4UMYA 3ICDA 3UF6A 3VL4A 1P8FA 1WPWA 5DE1A 2QFVA 5GRIA 1IDDA 4HCXA 3VL7A 3TSNA 3TY3A 1AI2A 5L58A 1OSIA 9ICDA 3UDUA 4IWHA 1PB1A 5HN4A 4JQPA 4KZOA 1IDCA 5GRFB 4L04A 3WZYA 1PS6A 1PTMA 2DHTA 1XABA 7ICDA 2E5MA 2D4VA 1R8KA 4YB4A 5J34A 3TY4A 1TYOA 1XAAA 3DMSA 3WZWA 3R8WA 1IPDA 3U9EA 3TNGA 4ATYA 1IDEA 1VI1A 4I3KA 5GRHA 5GREB 3MASA 5GRIB 3US8A 1IDFA 4AJAA 2Y41A 4F7IA
chains in the Genus database with same CATH topology
1PB3A 3BLXA 4AJBA 2HI1A 1DR8A 1GC9A 1IDMA 3AH3A 3U1HA 1CW7A 1AI3A 2QFYA 1LWDA 1V53A 1HJ6A 3FLKA 1WALA 4P69C 4WUOA 1XGVA 1SJSA 2E0CA 2UXQA 3LCBC 1V5BA 4XXVA 4AJCA 6ICDA 3BLVA 1CW4A 1W0DA 5J32A 2Y42A 1OSJA 4AOUA 3MASB 4BNPA 1YXOA 1X0LA 2Y3ZA 4I3LA 3UDOA 3WZXA 5HN5A 5HN6A 1BL5A 1T09A 1GC8A 3FMXX 2Y40A 2AYQA 5GRFA 1ISOA 4XS3A 3VKZA 2QFWA 1A05A 4AOVA 5I96A 1CNZA 1G2UA 2UXRA 4ICDA 5K11A 3VL2A 1DR0A 3ASJA 1HEXA 1PS7A 1XKDA 3WZVA 3MAPA 3VMJA 2IV0A 5K10A 1YCOA 1V94A 5GREA 2D1CA 1CW1A 4L06A 5GRHB 2QFXA 3VMLA 1VLCA 4AJ3A 1T0LA 1U7NA 5GRLB 4UMXA 3VMKA 3BLXB 5L57A 2G4OA 3VL6A 8ICDA 5I95A 5GRLA 1CM7A 1HQSA 1DPZA 1GROA 2ZTWA 3VL3A 4AOYA 1ZORA 5HN3A 4XRXA 4AJRA 1XACA 5ICDA 3LXYA 4JA8A 1XADA 5LGEA 3INMA 4AJSA 4Y1PA 3MARA 1IKAA 1GRPA 3BLVB 4L03A 5J33A 4UMYA 3ICDA 3UF6A 3VL4A 1P8FA 1WPWA 5DE1A 2QFVA 5GRIA 1IDDA 4HCXA 3VL7A 3TSNA 3TY3A 1AI2A 5L58A 1OSIA 9ICDA 3UDUA 4IWHA 1PB1A 5HN4A 4JQPA 4KZOA 1IDCA 5GRFB 4L04A 3WZYA 1PS6A 1PTMA 2DHTA 1XABA 7ICDA 2E5MA 2D4VA 1R8KA 4YB4A 5J34A 3TY4A 1TYOA 1XAAA 3DMSA 3WZWA 3R8WA 1IPDA 3U9EA 3TNGA 4ATYA 1IDEA 1VI1A 4I3KA 5GRHA 5GREB 3MASA 5GRIB 3US8A 1IDFA 4AJAA 2Y41A 4F7IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PB3 A;  3BLX A;  4AJB A;  2HI1 A;  1DR8 A;  1GC9 A;  1IDM A;  3AH3 A;  3U1H A;  1CW7 A;  1AI3 A;  2QFY A;  1LWD A;  1V53 A;  1HJ6 A;  3FLK A;  1WAL A;  4P69 C;  4WUO A;  1XGV A;  1SJS A;  2E0C A;  2UXQ A;  3LCB C;  1V5B A;  4XXV A;  4AJC A;  6ICD A;  3BLV A;  1CW4 A;  1W0D A;  5J32 A;  2Y42 A;  1OSJ A;  4AOU A;  3MAS B;  4BNP A;  1YXO A;  1X0L A;  2Y3Z A;  4I3L A;  3UDO A;  3WZX A;  5HN5 A;  5HN6 A;  1BL5 A;  1T09 A;  1GC8 A;  3FMX X;  2Y40 A;  2AYQ A;  5GRF A;  1ISO A;  4XS3 A;  3VKZ A;  2QFW A;  1A05 A;  4AOV A;  5I96 A;  1CNZ A;  1G2U A;  2UXR A;  4ICD A;  5K11 A;  3VL2 A;  1DR0 A;  3ASJ A;  1HEX A;  1PS7 A;  1XKD A;  3WZV A;  3MAP A;  3VMJ A;  2IV0 A;  5K10 A;  1YCO A;  1V94 A;  5GRE A;  2D1C A;  1CW1 A;  4L06 A;  5GRH B;  2QFX A;  3VML A;  1VLC A;  4AJ3 A;  1T0L A;  1U7N A;  5GRL B;  4UMX A;  3VMK A;  3BLX B;  5L57 A;  2G4O A;  3VL6 A;  8ICD A;  5I95 A;  5GRL A;  1CM7 A;  1HQS A;  1DPZ A;  1GRO A;  2ZTW A;  3VL3 A;  4AOY A;  1ZOR A;  5HN3 A;  4XRX A;  4AJR A;  1XAC A;  5ICD A;  3LXY A;  4JA8 A;  1XAD A;  5LGE A;  3INM A;  4AJS A;  4Y1P A;  3MAR A;  1IKA A;  1GRP A;  3BLV B;  4L03 A;  5J33 A;  4UMY A;  3ICD A;  3UF6 A;  3VL4 A;  1P8F A;  1WPW A;  5DE1 A;  2QFV A;  5GRI A;  1IDD A;  4HCX A;  3VL7 A;  3TSN A;  3TY3 A;  1AI2 A;  5L58 A;  1OSI A;  9ICD A;  3UDU A;  4IWH A;  1PB1 A;  5HN4 A;  4JQP A;  4KZO A;  1IDC A;  5GRF B;  4L04 A;  3WZY A;  1PS6 A;  1PTM A;  2DHT A;  1XAB A;  7ICD A;  2E5M A;  2D4V A;  1R8K A;  4YB4 A;  5J34 A;  3TY4 A;  1TYO A;  1XAA A;  3DMS A;  3WZW A;  3R8W A;  1IPD A;  3U9E A;  3TNG A;  4ATY A;  1IDE A;  1VI1 A;  4I3K A;  5GRH A;  5GRE B;  3MAS A;  5GRI B;  3US8 A;  1IDF A;  4AJA A;  2Y41 A;  4F7I A; 
#chains in the Genus database with same CATH topology
 1PB3 A;  3BLX A;  4AJB A;  2HI1 A;  1DR8 A;  1GC9 A;  1IDM A;  3AH3 A;  3U1H A;  1CW7 A;  1AI3 A;  2QFY A;  1LWD A;  1V53 A;  1HJ6 A;  3FLK A;  1WAL A;  4P69 C;  4WUO A;  1XGV A;  1SJS A;  2E0C A;  2UXQ A;  3LCB C;  1V5B A;  4XXV A;  4AJC A;  6ICD A;  3BLV A;  1CW4 A;  1W0D A;  5J32 A;  2Y42 A;  1OSJ A;  4AOU A;  3MAS B;  4BNP A;  1YXO A;  1X0L A;  2Y3Z A;  4I3L A;  3UDO A;  3WZX A;  5HN5 A;  5HN6 A;  1BL5 A;  1T09 A;  1GC8 A;  3FMX X;  2Y40 A;  2AYQ A;  5GRF A;  1ISO A;  4XS3 A;  3VKZ A;  2QFW A;  1A05 A;  4AOV A;  5I96 A;  1CNZ A;  1G2U A;  2UXR A;  4ICD A;  5K11 A;  3VL2 A;  1DR0 A;  3ASJ A;  1HEX A;  1PS7 A;  1XKD A;  3WZV A;  3MAP A;  3VMJ A;  2IV0 A;  5K10 A;  1YCO A;  1V94 A;  5GRE A;  2D1C A;  1CW1 A;  4L06 A;  5GRH B;  2QFX A;  3VML A;  1VLC A;  4AJ3 A;  1T0L A;  1U7N A;  5GRL B;  4UMX A;  3VMK A;  3BLX B;  5L57 A;  2G4O A;  3VL6 A;  8ICD A;  5I95 A;  5GRL A;  1CM7 A;  1HQS A;  1DPZ A;  1GRO A;  2ZTW A;  3VL3 A;  4AOY A;  1ZOR A;  5HN3 A;  4XRX A;  4AJR A;  1XAC A;  5ICD A;  3LXY A;  4JA8 A;  1XAD A;  5LGE A;  3INM A;  4AJS A;  4Y1P A;  3MAR A;  1IKA A;  1GRP A;  3BLV B;  4L03 A;  5J33 A;  4UMY A;  3ICD A;  3UF6 A;  3VL4 A;  1P8F A;  1WPW A;  5DE1 A;  2QFV A;  5GRI A;  1IDD A;  4HCX A;  3VL7 A;  3TSN A;  3TY3 A;  1AI2 A;  5L58 A;  1OSI A;  9ICD A;  3UDU A;  4IWH A;  1PB1 A;  5HN4 A;  4JQP A;  4KZO A;  1IDC A;  5GRF B;  4L04 A;  3WZY A;  1PS6 A;  1PTM A;  2DHT A;  1XAB A;  7ICD A;  2E5M A;  2D4V A;  1R8K A;  4YB4 A;  5J34 A;  3TY4 A;  1TYO A;  1XAA A;  3DMS A;  3WZW A;  3R8W A;  1IPD A;  3U9E A;  3TNG A;  4ATY A;  1IDE A;  1VI1 A;  4I3K A;  5GRH A;  5GRE B;  3MAS A;  5GRI B;  3US8 A;  1IDF A;  4AJA A;  2Y41 A;  4F7I A; 
#chains in the Genus database with same CATH homology
 1PB3 A;  3BLX A;  4AJB A;  2HI1 A;  1DR8 A;  1GC9 A;  1IDM A;  3AH3 A;  3U1H A;  1CW7 A;  1AI3 A;  2QFY A;  1LWD A;  1V53 A;  1HJ6 A;  3FLK A;  1WAL A;  4P69 C;  4WUO A;  1XGV A;  1SJS A;  2E0C A;  2UXQ A;  3LCB C;  1V5B A;  4XXV A;  4AJC A;  6ICD A;  3BLV A;  1CW4 A;  1W0D A;  5J32 A;  2Y42 A;  1OSJ A;  4AOU A;  3MAS B;  4BNP A;  1YXO A;  1X0L A;  2Y3Z A;  4I3L A;  3UDO A;  3WZX A;  5HN5 A;  5HN6 A;  1BL5 A;  1T09 A;  1GC8 A;  3FMX X;  2Y40 A;  2AYQ A;  5GRF A;  1ISO A;  4XS3 A;  3VKZ A;  2QFW A;  1A05 A;  4AOV A;  5I96 A;  1CNZ A;  1G2U A;  2UXR A;  4ICD A;  5K11 A;  3VL2 A;  1DR0 A;  3ASJ A;  1HEX A;  1PS7 A;  1XKD A;  3WZV A;  3MAP A;  3VMJ A;  2IV0 A;  5K10 A;  1YCO A;  1V94 A;  5GRE A;  2D1C A;  1CW1 A;  4L06 A;  5GRH B;  2QFX A;  3VML A;  1VLC A;  4AJ3 A;  1T0L A;  1U7N A;  5GRL B;  4UMX A;  3VMK A;  3BLX B;  5L57 A;  2G4O A;  3VL6 A;  8ICD A;  5I95 A;  5GRL A;  1CM7 A;  1HQS A;  1DPZ A;  1GRO A;  2ZTW A;  3VL3 A;  4AOY A;  1ZOR A;  5HN3 A;  4XRX A;  4AJR A;  1XAC A;  5ICD A;  3LXY A;  4JA8 A;  1XAD A;  5LGE A;  3INM A;  4AJS A;  4Y1P A;  3MAR A;  1IKA A;  1GRP A;  3BLV B;  4L03 A;  5J33 A;  4UMY A;  3ICD A;  3UF6 A;  3VL4 A;  1P8F A;  1WPW A;  5DE1 A;  2QFV A;  5GRI A;  1IDD A;  4HCX A;  3VL7 A;  3TSN A;  3TY3 A;  1AI2 A;  5L58 A;  1OSI A;  9ICD A;  3UDU A;  4IWH A;  1PB1 A;  5HN4 A;  4JQP A;  4KZO A;  1IDC A;  5GRF B;  4L04 A;  3WZY A;  1PS6 A;  1PTM A;  2DHT A;  1XAB A;  7ICD A;  2E5M A;  2D4V A;  1R8K A;  4YB4 A;  5J34 A;  3TY4 A;  1TYO A;  1XAA A;  3DMS A;  3WZW A;  3R8W A;  1IPD A;  3U9E A;  3TNG A;  4ATY A;  1IDE A;  1VI1 A;  4I3K A;  5GRH A;  5GRE B;  3MAS A;  5GRI B;  3US8 A;  1IDF A;  4AJA A;  2Y41 A;  4F7I A; 
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