5GRE | Genus

Total Genus 113

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	113
sequence length	333
structure length	333
Chain Sequence	RHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIRVI

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Molecular mechanism of the allosteric regulation of the alpha gamma heterodimer of human NAD-dependent isocitrate dehydrogenase. pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
molecule tags	Oxidoreductase
source organism	Homo sapiens
total genus	113
structure length	333
sequence length	333
ec nomenclature
pdb deposition date	2016-08-11

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
B	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	5greB00

3TY3A 3WZYA 4XS3A 3VMLA 3VL3A 3BLXB 4AJRA 1CW4A 5GRIA 2DHTA 2QFVA 1ZORA 3MAPA 1GRPA 2AYQA 3DMSA 1AI3A 5HN4A 4UMXA 5K10A 1CW1A 5K11A 2E5MA 5HN3A 1PB1A 1T0LA 5J34A 3VL6A 1XACA 1GC8A 1VLCA 4XXVA 5DE1A 1A05A 4YB4A 5L58A 3BLXA 3U1HA 1V53A 2Y40A 3BLVA 3VMJA 4P69C 4AJCA 7ICDA 2Y41A 1T09A 4I3KA 5I95A 5J32A 3VL7A 3TSNA 2UXQA 3AH3A 5HN6A 1G2UA 5J33A 1HEXA 1IKAA 1BL5A 1IDCA 1HJ6A 8ICDA 1XADA 1CW7A 4Y1PA 4BNPA 4XRXA 1AI2A 1WPWA 1YCOA 4KZOA 2Y3ZA 4ICDA 4JQPA 3U9EA 3UF6A 1IPDA 3VL4A 4AJSA 2G4OA 5GRFB 1P8FA 2HI1A 3R8WA 5ICDA 1LWDA 1YXOA 5GRLB 1U7NA 1ISOA 1V94A 1IDFA 1XKDA 5GRHB 1OSJA 3VKZA 4ATYA 3LCBC 3WZWA 2QFYA 1PB3A 1V5BA 4AOVA 5GREB 3UDUA 5GRFA 1IDMA 1XGVA 3ASJA 1DPZA 5L57A 2IV0A 5GRLA 4F7IA 3US8A 1PS7A 5GRHA 5HN5A 5I96A 3MARA 3ICDA 3WZXA 1CM7A 1IDDA 1GC9A 3MASB 1OSIA 4L03A 1PTMA 4JA8A 1XAAA 3TY4A 1CNZA 5GREA 3LXYA 1PS6A 3INMA 9ICDA 2Y42A 4AJBA 4L06A 4HCXA 4I3LA 3UDOA 2ZTWA 2UXRA 3FMXX 4AOUA 1R8KA 2QFWA 1WALA 4IWHA 3BLVB 1IDEA 3MASA 2E0CA 4L04A 3VMKA 1DR8A 1SJSA 4AJ3A 1HQSA 1TYOA 3VL2A 4UMYA 2QFXA 1DR0A 4AOYA 3TNGA 1W0DA 2D1CA 3FLKA 1VI1A 1XABA 5LGEA 5GRIB 2D4VA 1X0LA 3WZVA 6ICDA 4AJAA 4WUOA 1GROA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3TY3 A;  3WZY A;  4XS3 A;  3VML A;  3VL3 A;  3BLX B;  4AJR A;  1CW4 A;  5GRI A;  2DHT A;  2QFV A;  1ZOR A;  3MAP A;  1GRP A;  2AYQ A;  3DMS A;  1AI3 A;  5HN4 A;  4UMX A;  5K10 A;  1CW1 A;  5K11 A;  2E5M A;  5HN3 A;  1PB1 A;  1T0L A;  5J34 A;  3VL6 A;  1XAC A;  1GC8 A;  1VLC A;  4XXV A;  5DE1 A;  1A05 A;  4YB4 A;  5L58 A;  3BLX A;  3U1H A;  1V53 A;  2Y40 A;  3BLV A;  3VMJ A;  4P69 C;  4AJC A;  7ICD A;  2Y41 A;  1T09 A;  4I3K A;  5I95 A;  5J32 A;  3VL7 A;  3TSN A;  2UXQ A;  3AH3 A;  5HN6 A;  1G2U A;  5J33 A;  1HEX A;  1IKA A;  1BL5 A;  1IDC A;  1HJ6 A;  8ICD A;  1XAD A;  1CW7 A;  4Y1P A;  4BNP A;  4XRX A;  1AI2 A;  1WPW A;  1YCO A;  4KZO A;  2Y3Z A;  4ICD A;  4JQP A;  3U9E A;  3UF6 A;  1IPD A;  3VL4 A;  4AJS A;  2G4O A;  5GRF B;  1P8F A;  2HI1 A;  3R8W A;  5ICD A;  1LWD A;  1YXO A;  5GRL B;  1U7N A;  1ISO A;  1V94 A;  1IDF A;  1XKD A;  5GRH B;  1OSJ A;  3VKZ A;  4ATY A;  3LCB C;  3WZW A;  2QFY A;  1PB3 A;  1V5B A;  4AOV A;  5GRE B;  3UDU A;  5GRF A;  1IDM A;  1XGV A;  3ASJ A;  1DPZ A;  5L57 A;  2IV0 A;  5GRL A;  4F7I A;  3US8 A;  1PS7 A;  5GRH A;  5HN5 A;  5I96 A;  3MAR A;  3ICD A;  3WZX A;  1CM7 A;  1IDD A;  1GC9 A;  3MAS B;  1OSI A;  4L03 A;  1PTM A;  4JA8 A;  1XAA A;  3TY4 A;  1CNZ A;  5GRE A;  3LXY A;  1PS6 A;  3INM A;  9ICD A;  2Y42 A;  4AJB A;  4L06 A;  4HCX A;  4I3L A;  3UDO A;  2ZTW A;  2UXR A;  3FMX X;  4AOU A;  1R8K A;  2QFW A;  1WAL A;  4IWH A;  3BLV B;  1IDE A;  3MAS A;  2E0C A;  4L04 A;  3VMK A;  1DR8 A;  1SJS A;  4AJ3 A;  1HQS A;  1TYO A;  3VL2 A;  4UMY A;  2QFX A;  1DR0 A;  4AOY A;  3TNG A;  1W0D A;  2D1C A;  3FLK A;  1VI1 A;  1XAB A;  5LGE A;  5GRI B;  2D4V A;  1X0L A;  3WZV A;  6ICD A;  4AJA A;  4WUO A;  1GRO A; 
#chains in the Genus database with same CATH topology
 3TY3 A;  3WZY A;  4XS3 A;  3VML A;  3VL3 A;  3BLX B;  4AJR A;  1CW4 A;  5GRI A;  2DHT A;  2QFV A;  1ZOR A;  3MAP A;  1GRP A;  2AYQ A;  3DMS A;  1AI3 A;  5HN4 A;  4UMX A;  5K10 A;  1CW1 A;  5K11 A;  2E5M A;  5HN3 A;  1PB1 A;  1T0L A;  5J34 A;  3VL6 A;  1XAC A;  1GC8 A;  1VLC A;  4XXV A;  5DE1 A;  1A05 A;  4YB4 A;  5L58 A;  3BLX A;  3U1H A;  1V53 A;  2Y40 A;  3BLV A;  3VMJ A;  4P69 C;  4AJC A;  7ICD A;  2Y41 A;  1T09 A;  4I3K A;  5I95 A;  5J32 A;  3VL7 A;  3TSN A;  2UXQ A;  3AH3 A;  5HN6 A;  1G2U A;  5J33 A;  1HEX A;  1IKA A;  1BL5 A;  1IDC A;  1HJ6 A;  8ICD A;  1XAD A;  1CW7 A;  4Y1P A;  4BNP A;  4XRX A;  1AI2 A;  1WPW A;  1YCO A;  4KZO A;  2Y3Z A;  4ICD A;  4JQP A;  3U9E A;  3UF6 A;  1IPD A;  3VL4 A;  4AJS A;  2G4O A;  5GRF B;  1P8F A;  2HI1 A;  3R8W A;  5ICD A;  1LWD A;  1YXO A;  5GRL B;  1U7N A;  1ISO A;  1V94 A;  1IDF A;  1XKD A;  5GRH B;  1OSJ A;  3VKZ A;  4ATY A;  3LCB C;  3WZW A;  2QFY A;  1PB3 A;  1V5B A;  4AOV A;  5GRE B;  3UDU A;  5GRF A;  1IDM A;  1XGV A;  3ASJ A;  1DPZ A;  5L57 A;  2IV0 A;  5GRL A;  4F7I A;  3US8 A;  1PS7 A;  5GRH A;  5HN5 A;  5I96 A;  3MAR A;  3ICD A;  3WZX A;  1CM7 A;  1IDD A;  1GC9 A;  3MAS B;  1OSI A;  4L03 A;  1PTM A;  4JA8 A;  1XAA A;  3TY4 A;  1CNZ A;  5GRE A;  3LXY A;  1PS6 A;  3INM A;  9ICD A;  2Y42 A;  4AJB A;  4L06 A;  4HCX A;  4I3L A;  3UDO A;  2ZTW A;  2UXR A;  3FMX X;  4AOU A;  1R8K A;  2QFW A;  1WAL A;  4IWH A;  3BLV B;  1IDE A;  3MAS A;  2E0C A;  4L04 A;  3VMK A;  1DR8 A;  1SJS A;  4AJ3 A;  1HQS A;  1TYO A;  3VL2 A;  4UMY A;  2QFX A;  1DR0 A;  4AOY A;  3TNG A;  1W0D A;  2D1C A;  3FLK A;  1VI1 A;  1XAB A;  5LGE A;  5GRI B;  2D4V A;  1X0L A;  3WZV A;  6ICD A;  4AJA A;  4WUO A;  1GRO A; 
#chains in the Genus database with same CATH homology
 3TY3 A;  3WZY A;  4XS3 A;  3VML A;  3VL3 A;  3BLX B;  4AJR A;  1CW4 A;  5GRI A;  2DHT A;  2QFV A;  1ZOR A;  3MAP A;  1GRP A;  2AYQ A;  3DMS A;  1AI3 A;  5HN4 A;  4UMX A;  5K10 A;  1CW1 A;  5K11 A;  2E5M A;  5HN3 A;  1PB1 A;  1T0L A;  5J34 A;  3VL6 A;  1XAC A;  1GC8 A;  1VLC A;  4XXV A;  5DE1 A;  1A05 A;  4YB4 A;  5L58 A;  3BLX A;  3U1H A;  1V53 A;  2Y40 A;  3BLV A;  3VMJ A;  4P69 C;  4AJC A;  7ICD A;  2Y41 A;  1T09 A;  4I3K A;  5I95 A;  5J32 A;  3VL7 A;  3TSN A;  2UXQ A;  3AH3 A;  5HN6 A;  1G2U A;  5J33 A;  1HEX A;  1IKA A;  1BL5 A;  1IDC A;  1HJ6 A;  8ICD A;  1XAD A;  1CW7 A;  4Y1P A;  4BNP A;  4XRX A;  1AI2 A;  1WPW A;  1YCO A;  4KZO A;  2Y3Z A;  4ICD A;  4JQP A;  3U9E A;  3UF6 A;  1IPD A;  3VL4 A;  4AJS A;  2G4O A;  5GRF B;  1P8F A;  2HI1 A;  3R8W A;  5ICD A;  1LWD A;  1YXO A;  5GRL B;  1U7N A;  1ISO A;  1V94 A;  1IDF A;  1XKD A;  5GRH B;  1OSJ A;  3VKZ A;  4ATY A;  3LCB C;  3WZW A;  2QFY A;  1PB3 A;  1V5B A;  4AOV A;  5GRE B;  3UDU A;  5GRF A;  1IDM A;  1XGV A;  3ASJ A;  1DPZ A;  5L57 A;  2IV0 A;  5GRL A;  4F7I A;  3US8 A;  1PS7 A;  5GRH A;  5HN5 A;  5I96 A;  3MAR A;  3ICD A;  3WZX A;  1CM7 A;  1IDD A;  1GC9 A;  3MAS B;  1OSI A;  4L03 A;  1PTM A;  4JA8 A;  1XAA A;  3TY4 A;  1CNZ A;  5GRE A;  3LXY A;  1PS6 A;  3INM A;  9ICD A;  2Y42 A;  4AJB A;  4L06 A;  4HCX A;  4I3L A;  3UDO A;  2ZTW A;  2UXR A;  3FMX X;  4AOU A;  1R8K A;  2QFW A;  1WAL A;  4IWH A;  3BLV B;  1IDE A;  3MAS A;  2E0C A;  4L04 A;  3VMK A;  1DR8 A;  1SJS A;  4AJ3 A;  1HQS A;  1TYO A;  3VL2 A;  4UMY A;  2QFX A;  1DR0 A;  4AOY A;  3TNG A;  1W0D A;  2D1C A;  3FLK A;  1VI1 A;  1XAB A;  5LGE A;  5GRI B;  2D4V A;  1X0L A;  3WZV A;  6ICD A;  4AJA A;  4WUO A;  1GRO A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5GREB

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations