5I95 | Genus

Total Genus 155

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	155
sequence length	413
structure length	413
Chain Sequence	DKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIQNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Oxidoreductase
source organism	Homo sapiens
publication title	AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NADP], mitochondrial
total genus	155
structure length	413
sequence length	413
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	2016-02-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	5i95A00

3TY3A 5GREA 5LGEA 3BLXA 1BL5A 1R8KA 9ICDA 2Y40A 1OSJA 1XGVA 4AJ3A 3ASJA 2Y3ZA 1IPDA 4XRXA 1AI2A 3MARA 5GREB 4P69C 3BLXB 1GRPA 1W0DA 1XAAA 4UMYA 1CM7A 1TYOA 4Y1PA 2G4OA 4ICDA 3R8WA 2QFYA 3MASA 2HI1A 4AOVA 1LWDA 5I95A 5L57A 3BLVA 3MAPA 5HN6A 8ICDA 1VLCA 4ATYA 5GRFA 4YB4A 4AJBA 1G2UA 3MASB 1GROA 1HQSA 1XADA 2E0CA 1U7NA 5GRIA 4AJAA 5ICDA 1GC9A 1T09A 1PS7A 2E5MA 5GRFB 4JA8A 4L06A 3WZYA 1CW1A 2D1CA 5GRLA 3UDUA 1XKDA 2ZTWA 3DMSA 4AJSA 1GC8A 1WALA 3VMJA 1XACA 3AH3A 3LXYA 5GRIB 4I3LA 3TNGA 2UXQA 2UXRA 5GRHA 1CW7A 1IDEA 1PB1A 1ISOA 1XABA 3VL6A 4WUOA 3WZVA 4AJCA 6ICDA 5HN3A 3U9EA 5I96A 1IDMA 2QFWA 4I3KA 5J33A 3FMXX 3UDOA 1V53A 2D4VA 5J32A 1OSIA 4HCXA 1IDDA 3ICDA 3WZXA 2QFXA 4F7IA 1A05A 2Y41A 3BLVB 4AOUA 1HEXA 3VL4A 5K11A 2DHTA 7ICDA 3LCBC 2AYQA 1IKAA 4BNPA 4IWHA 1DPZA 1DR8A 1P8FA 1PTMA 1HJ6A 1CNZA 3US8A 4KZOA 3VKZA 3VMLA 1PS6A 3VMKA 5GRLB 3TSNA 3VL2A 3VL7A 1X0LA 5DE1A 5K10A 3VL3A 4AOYA 1ZORA 1VI1A 4L04A 2QFVA 3FLKA 4JQPA 1CW4A 5GRHB 5HN5A 1V94A 4XS3A 3WZWA 1AI3A 1T0LA 2IV0A 3U1HA 3INMA 1YXOA 1SJSA 1V5BA 5HN4A 4XXVA 1PB3A 3UF6A 4AJRA 1IDCA 5L58A 2Y42A 1DR0A 3TY4A 1IDFA 4L03A 1YCOA 4UMXA 5J34A 1WPWA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3TY3 A;  5GRE A;  5LGE A;  3BLX A;  1BL5 A;  1R8K A;  9ICD A;  2Y40 A;  1OSJ A;  1XGV A;  4AJ3 A;  3ASJ A;  2Y3Z A;  1IPD A;  4XRX A;  1AI2 A;  3MAR A;  5GRE B;  4P69 C;  3BLX B;  1GRP A;  1W0D A;  1XAA A;  4UMY A;  1CM7 A;  1TYO A;  4Y1P A;  2G4O A;  4ICD A;  3R8W A;  2QFY A;  3MAS A;  2HI1 A;  4AOV A;  1LWD A;  5I95 A;  5L57 A;  3BLV A;  3MAP A;  5HN6 A;  8ICD A;  1VLC A;  4ATY A;  5GRF A;  4YB4 A;  4AJB A;  1G2U A;  3MAS B;  1GRO A;  1HQS A;  1XAD A;  2E0C A;  1U7N A;  5GRI A;  4AJA A;  5ICD A;  1GC9 A;  1T09 A;  1PS7 A;  2E5M A;  5GRF B;  4JA8 A;  4L06 A;  3WZY A;  1CW1 A;  2D1C A;  5GRL A;  3UDU A;  1XKD A;  2ZTW A;  3DMS A;  4AJS A;  1GC8 A;  1WAL A;  3VMJ A;  1XAC A;  3AH3 A;  3LXY A;  5GRI B;  4I3L A;  3TNG A;  2UXQ A;  2UXR A;  5GRH A;  1CW7 A;  1IDE A;  1PB1 A;  1ISO A;  1XAB A;  3VL6 A;  4WUO A;  3WZV A;  4AJC A;  6ICD A;  5HN3 A;  3U9E A;  5I96 A;  1IDM A;  2QFW A;  4I3K A;  5J33 A;  3FMX X;  3UDO A;  1V53 A;  2D4V A;  5J32 A;  1OSI A;  4HCX A;  1IDD A;  3ICD A;  3WZX A;  2QFX A;  4F7I A;  1A05 A;  2Y41 A;  3BLV B;  4AOU A;  1HEX A;  3VL4 A;  5K11 A;  2DHT A;  7ICD A;  3LCB C;  2AYQ A;  1IKA A;  4BNP A;  4IWH A;  1DPZ A;  1DR8 A;  1P8F A;  1PTM A;  1HJ6 A;  1CNZ A;  3US8 A;  4KZO A;  3VKZ A;  3VML A;  1PS6 A;  3VMK A;  5GRL B;  3TSN A;  3VL2 A;  3VL7 A;  1X0L A;  5DE1 A;  5K10 A;  3VL3 A;  4AOY A;  1ZOR A;  1VI1 A;  4L04 A;  2QFV A;  3FLK A;  4JQP A;  1CW4 A;  5GRH B;  5HN5 A;  1V94 A;  4XS3 A;  3WZW A;  1AI3 A;  1T0L A;  2IV0 A;  3U1H A;  3INM A;  1YXO A;  1SJS A;  1V5B A;  5HN4 A;  4XXV A;  1PB3 A;  3UF6 A;  4AJR A;  1IDC A;  5L58 A;  2Y42 A;  1DR0 A;  3TY4 A;  1IDF A;  4L03 A;  1YCO A;  4UMX A;  5J34 A;  1WPW A; 
#chains in the Genus database with same CATH topology
 3TY3 A;  5GRE A;  5LGE A;  3BLX A;  1BL5 A;  1R8K A;  9ICD A;  2Y40 A;  1OSJ A;  1XGV A;  4AJ3 A;  3ASJ A;  2Y3Z A;  1IPD A;  4XRX A;  1AI2 A;  3MAR A;  5GRE B;  4P69 C;  3BLX B;  1GRP A;  1W0D A;  1XAA A;  4UMY A;  1CM7 A;  1TYO A;  4Y1P A;  2G4O A;  4ICD A;  3R8W A;  2QFY A;  3MAS A;  2HI1 A;  4AOV A;  1LWD A;  5I95 A;  5L57 A;  3BLV A;  3MAP A;  5HN6 A;  8ICD A;  1VLC A;  4ATY A;  5GRF A;  4YB4 A;  4AJB A;  1G2U A;  3MAS B;  1GRO A;  1HQS A;  1XAD A;  2E0C A;  1U7N A;  5GRI A;  4AJA A;  5ICD A;  1GC9 A;  1T09 A;  1PS7 A;  2E5M A;  5GRF B;  4JA8 A;  4L06 A;  3WZY A;  1CW1 A;  2D1C A;  5GRL A;  3UDU A;  1XKD A;  2ZTW A;  3DMS A;  4AJS A;  1GC8 A;  1WAL A;  3VMJ A;  1XAC A;  3AH3 A;  3LXY A;  5GRI B;  4I3L A;  3TNG A;  2UXQ A;  2UXR A;  5GRH A;  1CW7 A;  1IDE A;  1PB1 A;  1ISO A;  1XAB A;  3VL6 A;  4WUO A;  3WZV A;  4AJC A;  6ICD A;  5HN3 A;  3U9E A;  5I96 A;  1IDM A;  2QFW A;  4I3K A;  5J33 A;  3FMX X;  3UDO A;  1V53 A;  2D4V A;  5J32 A;  1OSI A;  4HCX A;  1IDD A;  3ICD A;  3WZX A;  2QFX A;  4F7I A;  1A05 A;  2Y41 A;  3BLV B;  4AOU A;  1HEX A;  3VL4 A;  5K11 A;  2DHT A;  7ICD A;  3LCB C;  2AYQ A;  1IKA A;  4BNP A;  4IWH A;  1DPZ A;  1DR8 A;  1P8F A;  1PTM A;  1HJ6 A;  1CNZ A;  3US8 A;  4KZO A;  3VKZ A;  3VML A;  1PS6 A;  3VMK A;  5GRL B;  3TSN A;  3VL2 A;  3VL7 A;  1X0L A;  5DE1 A;  5K10 A;  3VL3 A;  4AOY A;  1ZOR A;  1VI1 A;  4L04 A;  2QFV A;  3FLK A;  4JQP A;  1CW4 A;  5GRH B;  5HN5 A;  1V94 A;  4XS3 A;  3WZW A;  1AI3 A;  1T0L A;  2IV0 A;  3U1H A;  3INM A;  1YXO A;  1SJS A;  1V5B A;  5HN4 A;  4XXV A;  1PB3 A;  3UF6 A;  4AJR A;  1IDC A;  5L58 A;  2Y42 A;  1DR0 A;  3TY4 A;  1IDF A;  4L03 A;  1YCO A;  4UMX A;  5J34 A;  1WPW A; 
#chains in the Genus database with same CATH homology
 3TY3 A;  5GRE A;  5LGE A;  3BLX A;  1BL5 A;  1R8K A;  9ICD A;  2Y40 A;  1OSJ A;  1XGV A;  4AJ3 A;  3ASJ A;  2Y3Z A;  1IPD A;  4XRX A;  1AI2 A;  3MAR A;  5GRE B;  4P69 C;  3BLX B;  1GRP A;  1W0D A;  1XAA A;  4UMY A;  1CM7 A;  1TYO A;  4Y1P A;  2G4O A;  4ICD A;  3R8W A;  2QFY A;  3MAS A;  2HI1 A;  4AOV A;  1LWD A;  5I95 A;  5L57 A;  3BLV A;  3MAP A;  5HN6 A;  8ICD A;  1VLC A;  4ATY A;  5GRF A;  4YB4 A;  4AJB A;  1G2U A;  3MAS B;  1GRO A;  1HQS A;  1XAD A;  2E0C A;  1U7N A;  5GRI A;  4AJA A;  5ICD A;  1GC9 A;  1T09 A;  1PS7 A;  2E5M A;  5GRF B;  4JA8 A;  4L06 A;  3WZY A;  1CW1 A;  2D1C A;  5GRL A;  3UDU A;  1XKD A;  2ZTW A;  3DMS A;  4AJS A;  1GC8 A;  1WAL A;  3VMJ A;  1XAC A;  3AH3 A;  3LXY A;  5GRI B;  4I3L A;  3TNG A;  2UXQ A;  2UXR A;  5GRH A;  1CW7 A;  1IDE A;  1PB1 A;  1ISO A;  1XAB A;  3VL6 A;  4WUO A;  3WZV A;  4AJC A;  6ICD A;  5HN3 A;  3U9E A;  5I96 A;  1IDM A;  2QFW A;  4I3K A;  5J33 A;  3FMX X;  3UDO A;  1V53 A;  2D4V A;  5J32 A;  1OSI A;  4HCX A;  1IDD A;  3ICD A;  3WZX A;  2QFX A;  4F7I A;  1A05 A;  2Y41 A;  3BLV B;  4AOU A;  1HEX A;  3VL4 A;  5K11 A;  2DHT A;  7ICD A;  3LCB C;  2AYQ A;  1IKA A;  4BNP A;  4IWH A;  1DPZ A;  1DR8 A;  1P8F A;  1PTM A;  1HJ6 A;  1CNZ A;  3US8 A;  4KZO A;  3VKZ A;  3VML A;  1PS6 A;  3VMK A;  5GRL B;  3TSN A;  3VL2 A;  3VL7 A;  1X0L A;  5DE1 A;  5K10 A;  3VL3 A;  4AOY A;  1ZOR A;  1VI1 A;  4L04 A;  2QFV A;  3FLK A;  4JQP A;  1CW4 A;  5GRH B;  5HN5 A;  1V94 A;  4XS3 A;  3WZW A;  1AI3 A;  1T0L A;  2IV0 A;  3U1H A;  3INM A;  1YXO A;  1SJS A;  1V5B A;  5HN4 A;  4XXV A;  1PB3 A;  3UF6 A;  4AJR A;  1IDC A;  5L58 A;  2Y42 A;  1DR0 A;  3TY4 A;  1IDF A;  4L03 A;  1YCO A;  4UMX A;  5J34 A;  1WPW A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5I95A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations