5J33A

Isopropylmalate dehydrogenase in complex with nad+
Total Genus 121
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
360
structure length
360
Chain Sequence
KRYTITLLPGDGIGPEVVSIAKNVLQQAGSLEGVEFNFREMPIGGAALDLVGVPLPEETISAAKESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARKRRGKLCSVDKANVLEASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRTGDIYSAGTKLVGCKEMGEEVLKSVDSQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure and Mechanism of Isopropylmalate Dehydrogenase from Arabidopsis thaliana: INSIGHTS ON LEUCINE AND ALIPHATIC GLUCOSINOLATE BIOSYNTHESIS.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Arabidopsis thaliana
molecule keywords 3-isopropylmalate dehydrogenase 2, chloroplastic
total genus 121
structure length 360
sequence length 360
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 1.1.1.85: 3-isopropylmalate dehydrogenase.
pdb deposition date 2016-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 5j33A00
5HN4A 1WPWA 1XADA 2UXRA 1WALA 3R8WA 4XRXA 4L03A 3AH3A 1YXOA 3TY4A 5K11A 1PB3A 1XKDA 2Y40A 1HEXA 3VL4A 5J32A 4I3LA 4AJ3A 3INMA 2QFXA 1ZORA 3UF6A 3US8A 5GRLB 3ASJA 4AJAA 1R8KA 4JQPA 4P69C 5GRFA 4YB4A 1PS6A 1YCOA 3BLXB 1BL5A 3BLVA 3LCBC 3VL7A 1DR8A 2Y42A 3WZYA 5GRHA 5I95A 1HJ6A 1T0LA 1HQSA 3UDOA 4WUOA 3U1HA 3WZXA 1SJSA 3VMJA 5DE1A 2E0CA 4I3KA 5L57A 5GRIA 5GRFB 4XXVA 4JA8A 5GREA 7ICDA 3VKZA 1GROA 3BLVB 5I96A 5HN6A 3VMLA 3TY3A 4UMYA 1IDDA 1CW7A 2DHTA 1XGVA 8ICDA 3MASA 1G2UA 1V94A 4AJSA 4F7IA 4UMXA 1CW4A 1XABA 4AJBA 1GC9A 4BNPA 1PB1A 5GRIB 1X0LA 1IDFA 4ATYA 4AJCA 4HCXA 3TNGA 1CNZA 3VMKA 1AI2A 1T09A 1TYOA 3DMSA 3WZVA 1PTMA 1XACA 4KZOA 4AJRA 5ICDA 3VL3A 5J33A 3VL6A 2AYQA 3U9EA 2D1CA 1AI3A 2QFVA 3MAPA 2D4VA 2IV0A 5GRLA 1W0DA 1DPZA 4AOYA 1IDMA 1IKAA 5GRHB 9ICDA 1A05A 1V5BA 3BLXA 3MARA 1LWDA 1GC8A 4Y1PA 3ICDA 4AOUA 6ICDA 5J34A 1VI1A 3TSNA 2UXQA 2ZTWA 4XS3A 1P8FA 3WZWA 2E5MA 1OSJA 5GREB 2QFYA 5L58A 3FLKA 4L04A 1IDCA 1IDEA 1VLCA 1V53A 1CM7A 2HI1A 4L06A 4ICDA 2Y41A 1DR0A 1PS7A 3UDUA 3VL2A 5HN3A 3FMXX 1GRPA 3MASB 2Y3ZA 2G4OA 1U7NA 1CW1A 4IWHA 3LXYA 4AOVA 5K10A 5LGEA 1OSIA 1XAAA 5HN5A 2QFWA 1ISOA 1IPDA
chains in the Genus database with same CATH superfamily
5HN4A 1WPWA 1XADA 2UXRA 1WALA 3R8WA 4XRXA 4L03A 3AH3A 1YXOA 3TY4A 5K11A 1PB3A 1XKDA 2Y40A 1HEXA 3VL4A 5J32A 4I3LA 4AJ3A 3INMA 2QFXA 1ZORA 3UF6A 3US8A 5GRLB 3ASJA 4AJAA 1R8KA 4JQPA 4P69C 5GRFA 4YB4A 1PS6A 1YCOA 3BLXB 1BL5A 3BLVA 3LCBC 3VL7A 1DR8A 2Y42A 3WZYA 5GRHA 5I95A 1HJ6A 1T0LA 1HQSA 3UDOA 4WUOA 3U1HA 3WZXA 1SJSA 3VMJA 5DE1A 2E0CA 4I3KA 5L57A 5GRIA 5GRFB 4XXVA 4JA8A 5GREA 7ICDA 3VKZA 1GROA 3BLVB 5I96A 5HN6A 3VMLA 3TY3A 4UMYA 1IDDA 1CW7A 2DHTA 1XGVA 8ICDA 3MASA 1G2UA 1V94A 4AJSA 4F7IA 4UMXA 1CW4A 1XABA 4AJBA 1GC9A 4BNPA 1PB1A 5GRIB 1X0LA 1IDFA 4ATYA 4AJCA 4HCXA 3TNGA 1CNZA 3VMKA 1AI2A 1T09A 1TYOA 3DMSA 3WZVA 1PTMA 1XACA 4KZOA 4AJRA 5ICDA 3VL3A 5J33A 3VL6A 2AYQA 3U9EA 2D1CA 1AI3A 2QFVA 3MAPA 2D4VA 2IV0A 5GRLA 1W0DA 1DPZA 4AOYA 1IDMA 1IKAA 5GRHB 9ICDA 1A05A 1V5BA 3BLXA 3MARA 1LWDA 1GC8A 4Y1PA 3ICDA 4AOUA 6ICDA 5J34A 1VI1A 3TSNA 2UXQA 2ZTWA 4XS3A 1P8FA 3WZWA 2E5MA 1OSJA 5GREB 2QFYA 5L58A 3FLKA 4L04A 1IDCA 1IDEA 1VLCA 1V53A 1CM7A 2HI1A 4L06A 4ICDA 2Y41A 1DR0A 1PS7A 3UDUA 3VL2A 5HN3A 3FMXX 1GRPA 3MASB 2Y3ZA 2G4OA 1U7NA 1CW1A 4IWHA 3LXYA 4AOVA 5K10A 5LGEA 1OSIA 1XAAA 5HN5A 2QFWA 1ISOA 1IPDA
chains in the Genus database with same CATH topology
5HN4A 1WPWA 1XADA 2UXRA 1WALA 3R8WA 4XRXA 4L03A 3AH3A 1YXOA 3TY4A 5K11A 1PB3A 1XKDA 2Y40A 1HEXA 3VL4A 5J32A 4I3LA 4AJ3A 3INMA 2QFXA 1ZORA 3UF6A 3US8A 5GRLB 3ASJA 4AJAA 1R8KA 4JQPA 4P69C 5GRFA 4YB4A 1PS6A 1YCOA 3BLXB 1BL5A 3BLVA 3LCBC 3VL7A 1DR8A 2Y42A 3WZYA 5GRHA 5I95A 1HJ6A 1T0LA 1HQSA 3UDOA 4WUOA 3U1HA 3WZXA 1SJSA 3VMJA 5DE1A 2E0CA 4I3KA 5L57A 5GRIA 5GRFB 4XXVA 4JA8A 5GREA 7ICDA 3VKZA 1GROA 3BLVB 5I96A 5HN6A 3VMLA 3TY3A 4UMYA 1IDDA 1CW7A 2DHTA 1XGVA 8ICDA 3MASA 1G2UA 1V94A 4AJSA 4F7IA 4UMXA 1CW4A 1XABA 4AJBA 1GC9A 4BNPA 1PB1A 5GRIB 1X0LA 1IDFA 4ATYA 4AJCA 4HCXA 3TNGA 1CNZA 3VMKA 1AI2A 1T09A 1TYOA 3DMSA 3WZVA 1PTMA 1XACA 4KZOA 4AJRA 5ICDA 3VL3A 5J33A 3VL6A 2AYQA 3U9EA 2D1CA 1AI3A 2QFVA 3MAPA 2D4VA 2IV0A 5GRLA 1W0DA 1DPZA 4AOYA 1IDMA 1IKAA 5GRHB 9ICDA 1A05A 1V5BA 3BLXA 3MARA 1LWDA 1GC8A 4Y1PA 3ICDA 4AOUA 6ICDA 5J34A 1VI1A 3TSNA 2UXQA 2ZTWA 4XS3A 1P8FA 3WZWA 2E5MA 1OSJA 5GREB 2QFYA 5L58A 3FLKA 4L04A 1IDCA 1IDEA 1VLCA 1V53A 1CM7A 2HI1A 4L06A 4ICDA 2Y41A 1DR0A 1PS7A 3UDUA 3VL2A 5HN3A 3FMXX 1GRPA 3MASB 2Y3ZA 2G4OA 1U7NA 1CW1A 4IWHA 3LXYA 4AOVA 5K10A 5LGEA 1OSIA 1XAAA 5HN5A 2QFWA 1ISOA 1IPDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HN4 A;  1WPW A;  1XAD A;  2UXR A;  1WAL A;  3R8W A;  4XRX A;  4L03 A;  3AH3 A;  1YXO A;  3TY4 A;  5K11 A;  1PB3 A;  1XKD A;  2Y40 A;  1HEX A;  3VL4 A;  5J32 A;  4I3L A;  4AJ3 A;  3INM A;  2QFX A;  1ZOR A;  3UF6 A;  3US8 A;  5GRL B;  3ASJ A;  4AJA A;  1R8K A;  4JQP A;  4P69 C;  5GRF A;  4YB4 A;  1PS6 A;  1YCO A;  3BLX B;  1BL5 A;  3BLV A;  3LCB C;  3VL7 A;  1DR8 A;  2Y42 A;  3WZY A;  5GRH A;  5I95 A;  1HJ6 A;  1T0L A;  1HQS A;  3UDO A;  4WUO A;  3U1H A;  3WZX A;  1SJS A;  3VMJ A;  5DE1 A;  2E0C A;  4I3K A;  5L57 A;  5GRI A;  5GRF B;  4XXV A;  4JA8 A;  5GRE A;  7ICD A;  3VKZ A;  1GRO A;  3BLV B;  5I96 A;  5HN6 A;  3VML A;  3TY3 A;  4UMY A;  1IDD A;  1CW7 A;  2DHT A;  1XGV A;  8ICD A;  3MAS A;  1G2U A;  1V94 A;  4AJS A;  4F7I A;  4UMX A;  1CW4 A;  1XAB A;  4AJB A;  1GC9 A;  4BNP A;  1PB1 A;  5GRI B;  1X0L A;  1IDF A;  4ATY A;  4AJC A;  4HCX A;  3TNG A;  1CNZ A;  3VMK A;  1AI2 A;  1T09 A;  1TYO A;  3DMS A;  3WZV A;  1PTM A;  1XAC A;  4KZO A;  4AJR A;  5ICD A;  3VL3 A;  5J33 A;  3VL6 A;  2AYQ A;  3U9E A;  2D1C A;  1AI3 A;  2QFV A;  3MAP A;  2D4V A;  2IV0 A;  5GRL A;  1W0D A;  1DPZ A;  4AOY A;  1IDM A;  1IKA A;  5GRH B;  9ICD A;  1A05 A;  1V5B A;  3BLX A;  3MAR A;  1LWD A;  1GC8 A;  4Y1P A;  3ICD A;  4AOU A;  6ICD A;  5J34 A;  1VI1 A;  3TSN A;  2UXQ A;  2ZTW A;  4XS3 A;  1P8F A;  3WZW A;  2E5M A;  1OSJ A;  5GRE B;  2QFY A;  5L58 A;  3FLK A;  4L04 A;  1IDC A;  1IDE A;  1VLC A;  1V53 A;  1CM7 A;  2HI1 A;  4L06 A;  4ICD A;  2Y41 A;  1DR0 A;  1PS7 A;  3UDU A;  3VL2 A;  5HN3 A;  3FMX X;  1GRP A;  3MAS B;  2Y3Z A;  2G4O A;  1U7N A;  1CW1 A;  4IWH A;  3LXY A;  4AOV A;  5K10 A;  5LGE A;  1OSI A;  1XAA A;  5HN5 A;  2QFW A;  1ISO A;  1IPD A; 
#chains in the Genus database with same CATH topology
 5HN4 A;  1WPW A;  1XAD A;  2UXR A;  1WAL A;  3R8W A;  4XRX A;  4L03 A;  3AH3 A;  1YXO A;  3TY4 A;  5K11 A;  1PB3 A;  1XKD A;  2Y40 A;  1HEX A;  3VL4 A;  5J32 A;  4I3L A;  4AJ3 A;  3INM A;  2QFX A;  1ZOR A;  3UF6 A;  3US8 A;  5GRL B;  3ASJ A;  4AJA A;  1R8K A;  4JQP A;  4P69 C;  5GRF A;  4YB4 A;  1PS6 A;  1YCO A;  3BLX B;  1BL5 A;  3BLV A;  3LCB C;  3VL7 A;  1DR8 A;  2Y42 A;  3WZY A;  5GRH A;  5I95 A;  1HJ6 A;  1T0L A;  1HQS A;  3UDO A;  4WUO A;  3U1H A;  3WZX A;  1SJS A;  3VMJ A;  5DE1 A;  2E0C A;  4I3K A;  5L57 A;  5GRI A;  5GRF B;  4XXV A;  4JA8 A;  5GRE A;  7ICD A;  3VKZ A;  1GRO A;  3BLV B;  5I96 A;  5HN6 A;  3VML A;  3TY3 A;  4UMY A;  1IDD A;  1CW7 A;  2DHT A;  1XGV A;  8ICD A;  3MAS A;  1G2U A;  1V94 A;  4AJS A;  4F7I A;  4UMX A;  1CW4 A;  1XAB A;  4AJB A;  1GC9 A;  4BNP A;  1PB1 A;  5GRI B;  1X0L A;  1IDF A;  4ATY A;  4AJC A;  4HCX A;  3TNG A;  1CNZ A;  3VMK A;  1AI2 A;  1T09 A;  1TYO A;  3DMS A;  3WZV A;  1PTM A;  1XAC A;  4KZO A;  4AJR A;  5ICD A;  3VL3 A;  5J33 A;  3VL6 A;  2AYQ A;  3U9E A;  2D1C A;  1AI3 A;  2QFV A;  3MAP A;  2D4V A;  2IV0 A;  5GRL A;  1W0D A;  1DPZ A;  4AOY A;  1IDM A;  1IKA A;  5GRH B;  9ICD A;  1A05 A;  1V5B A;  3BLX A;  3MAR A;  1LWD A;  1GC8 A;  4Y1P A;  3ICD A;  4AOU A;  6ICD A;  5J34 A;  1VI1 A;  3TSN A;  2UXQ A;  2ZTW A;  4XS3 A;  1P8F A;  3WZW A;  2E5M A;  1OSJ A;  5GRE B;  2QFY A;  5L58 A;  3FLK A;  4L04 A;  1IDC A;  1IDE A;  1VLC A;  1V53 A;  1CM7 A;  2HI1 A;  4L06 A;  4ICD A;  2Y41 A;  1DR0 A;  1PS7 A;  3UDU A;  3VL2 A;  5HN3 A;  3FMX X;  1GRP A;  3MAS B;  2Y3Z A;  2G4O A;  1U7N A;  1CW1 A;  4IWH A;  3LXY A;  4AOV A;  5K10 A;  5LGE A;  1OSI A;  1XAA A;  5HN5 A;  2QFW A;  1ISO A;  1IPD A; 
#chains in the Genus database with same CATH homology
 5HN4 A;  1WPW A;  1XAD A;  2UXR A;  1WAL A;  3R8W A;  4XRX A;  4L03 A;  3AH3 A;  1YXO A;  3TY4 A;  5K11 A;  1PB3 A;  1XKD A;  2Y40 A;  1HEX A;  3VL4 A;  5J32 A;  4I3L A;  4AJ3 A;  3INM A;  2QFX A;  1ZOR A;  3UF6 A;  3US8 A;  5GRL B;  3ASJ A;  4AJA A;  1R8K A;  4JQP A;  4P69 C;  5GRF A;  4YB4 A;  1PS6 A;  1YCO A;  3BLX B;  1BL5 A;  3BLV A;  3LCB C;  3VL7 A;  1DR8 A;  2Y42 A;  3WZY A;  5GRH A;  5I95 A;  1HJ6 A;  1T0L A;  1HQS A;  3UDO A;  4WUO A;  3U1H A;  3WZX A;  1SJS A;  3VMJ A;  5DE1 A;  2E0C A;  4I3K A;  5L57 A;  5GRI A;  5GRF B;  4XXV A;  4JA8 A;  5GRE A;  7ICD A;  3VKZ A;  1GRO A;  3BLV B;  5I96 A;  5HN6 A;  3VML A;  3TY3 A;  4UMY A;  1IDD A;  1CW7 A;  2DHT A;  1XGV A;  8ICD A;  3MAS A;  1G2U A;  1V94 A;  4AJS A;  4F7I A;  4UMX A;  1CW4 A;  1XAB A;  4AJB A;  1GC9 A;  4BNP A;  1PB1 A;  5GRI B;  1X0L A;  1IDF A;  4ATY A;  4AJC A;  4HCX A;  3TNG A;  1CNZ A;  3VMK A;  1AI2 A;  1T09 A;  1TYO A;  3DMS A;  3WZV A;  1PTM A;  1XAC A;  4KZO A;  4AJR A;  5ICD A;  3VL3 A;  5J33 A;  3VL6 A;  2AYQ A;  3U9E A;  2D1C A;  1AI3 A;  2QFV A;  3MAP A;  2D4V A;  2IV0 A;  5GRL A;  1W0D A;  1DPZ A;  4AOY A;  1IDM A;  1IKA A;  5GRH B;  9ICD A;  1A05 A;  1V5B A;  3BLX A;  3MAR A;  1LWD A;  1GC8 A;  4Y1P A;  3ICD A;  4AOU A;  6ICD A;  5J34 A;  1VI1 A;  3TSN A;  2UXQ A;  2ZTW A;  4XS3 A;  1P8F A;  3WZW A;  2E5M A;  1OSJ A;  5GRE B;  2QFY A;  5L58 A;  3FLK A;  4L04 A;  1IDC A;  1IDE A;  1VLC A;  1V53 A;  1CM7 A;  2HI1 A;  4L06 A;  4ICD A;  2Y41 A;  1DR0 A;  1PS7 A;  3UDU A;  3VL2 A;  5HN3 A;  3FMX X;  1GRP A;  3MAS B;  2Y3Z A;  2G4O A;  1U7N A;  1CW1 A;  4IWH A;  3LXY A;  4AOV A;  5K10 A;  5LGE A;  1OSI A;  1XAA A;  5HN5 A;  2QFW A;  1ISO A;  1IPD A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...