5K10 | Genus

Total Genus 98

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	98
sequence length	411
structure length	397
Chain Sequence	KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAK

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. pubmed doi rcsb
molecule keywords	Isocitrate dehydrogenase [NADP] cytoplasmic
molecule tags	Oxidoreductase
source organism	Homo sapiens
total genus	98
structure length	397
sequence length	411
chains with identical sequence	B
ec nomenclature	ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date	2016-05-17

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00180	Iso_dh	Isocitrate/isopropylmalate dehydrogenase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.718.10	Alpha Beta	3-Layer(aba) Sandwich	Isopropylmalate Dehydrogenase	Isopropylmalate Dehydrogenase	5k10A00

1IDFA 4BNPA 4AJCA 1ISOA 3VL4A 5GREA 4JA8A 1PB3A 5GRIB 2QFXA 4AOVA 4ATYA 1HQSA 1U7NA 6ICDA 1IDMA 5K10A 3VL7A 4YB4A 1GROA 3MAPA 5J34A 1CW4A 1PS7A 1IDCA 2AYQA 5GREB 5K11A 5LGEA 4KZOA 4AOYA 1HJ6A 5HN4A 3FLKA 1VI1A 2Y3ZA 2D1CA 2Y41A 1V53A 1G2UA 3WZWA 4JQPA 1XABA 3BLXA 7ICDA 3VMLA 2UXQA 3FMXX 5I96A 1ZORA 1AI2A 3TY3A 2E0CA 5GRHA 4ICDA 3AH3A 3VL3A 2QFYA 1V94A 4L06A 1IDEA 2UXRA 2G4OA 4XS3A 3WZVA 4XRXA 9ICDA 3R8WA 1P8FA 5HN3A 4F7IA 1A05A 2Y40A 3TSNA 5L58A 1V5BA 5J33A 5HN5A 1BL5A 3BLVA 1IKAA 1XADA 4AOUA 5L57A 1SJSA 4AJRA 4HCXA 2D4VA 2E5MA 1CW7A 1PB1A 1YXOA 3US8A 1PTMA 3VL6A 4I3LA 1T09A 1AI3A 2IV0A 3VMKA 5J32A 1OSJA 5GRLA 4P69C 5GRFA 4AJAA 1DR8A 1XACA 4AJ3A 3MASA 3BLVB 1TYOA 1XKDA 3VL2A 1GRPA 2QFVA 3ASJA 1GC8A 1IDDA 3DMSA 1T0LA 3MARA 4L04A 1CNZA 5GRIA 3BLXB 1X0LA 1DPZA 3UDUA 1GC9A 3UF6A 1XGVA 2DHTA 1CW1A 5GRHB 4XXVA 1DR0A 3WZYA 1HEXA 2Y42A 2QFWA 4AJBA 4AJSA 5I95A 1R8KA 1IPDA 2ZTWA 4L03A 4IWHA 3TNGA 3LXYA 4UMXA 4I3KA 4Y1PA 5ICDA 1XAAA 3WZXA 8ICDA 3U9EA 1WALA 3U1HA 1CM7A 3VKZA 3LCBC 1LWDA 5GRLB 1WPWA 2HI1A 3INMA 5DE1A 5GRFB 5HN6A 3UDOA 1W0DA 1YCOA 3TY4A 1VLCA 1OSIA 1PS6A 3MASB 4UMYA 4WUOA 3VMJA 3ICDA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1IDF A;  4BNP A;  4AJC A;  1ISO A;  3VL4 A;  5GRE A;  4JA8 A;  1PB3 A;  5GRI B;  2QFX A;  4AOV A;  4ATY A;  1HQS A;  1U7N A;  6ICD A;  1IDM A;  5K10 A;  3VL7 A;  4YB4 A;  1GRO A;  3MAP A;  5J34 A;  1CW4 A;  1PS7 A;  1IDC A;  2AYQ A;  5GRE B;  5K11 A;  5LGE A;  4KZO A;  4AOY A;  1HJ6 A;  5HN4 A;  3FLK A;  1VI1 A;  2Y3Z A;  2D1C A;  2Y41 A;  1V53 A;  1G2U A;  3WZW A;  4JQP A;  1XAB A;  3BLX A;  7ICD A;  3VML A;  2UXQ A;  3FMX X;  5I96 A;  1ZOR A;  1AI2 A;  3TY3 A;  2E0C A;  5GRH A;  4ICD A;  3AH3 A;  3VL3 A;  2QFY A;  1V94 A;  4L06 A;  1IDE A;  2UXR A;  2G4O A;  4XS3 A;  3WZV A;  4XRX A;  9ICD A;  3R8W A;  1P8F A;  5HN3 A;  4F7I A;  1A05 A;  2Y40 A;  3TSN A;  5L58 A;  1V5B A;  5J33 A;  5HN5 A;  1BL5 A;  3BLV A;  1IKA A;  1XAD A;  4AOU A;  5L57 A;  1SJS A;  4AJR A;  4HCX A;  2D4V A;  2E5M A;  1CW7 A;  1PB1 A;  1YXO A;  3US8 A;  1PTM A;  3VL6 A;  4I3L A;  1T09 A;  1AI3 A;  2IV0 A;  3VMK A;  5J32 A;  1OSJ A;  5GRL A;  4P69 C;  5GRF A;  4AJA A;  1DR8 A;  1XAC A;  4AJ3 A;  3MAS A;  3BLV B;  1TYO A;  1XKD A;  3VL2 A;  1GRP A;  2QFV A;  3ASJ A;  1GC8 A;  1IDD A;  3DMS A;  1T0L A;  3MAR A;  4L04 A;  1CNZ A;  5GRI A;  3BLX B;  1X0L A;  1DPZ A;  3UDU A;  1GC9 A;  3UF6 A;  1XGV A;  2DHT A;  1CW1 A;  5GRH B;  4XXV A;  1DR0 A;  3WZY A;  1HEX A;  2Y42 A;  2QFW A;  4AJB A;  4AJS A;  5I95 A;  1R8K A;  1IPD A;  2ZTW A;  4L03 A;  4IWH A;  3TNG A;  3LXY A;  4UMX A;  4I3K A;  4Y1P A;  5ICD A;  1XAA A;  3WZX A;  8ICD A;  3U9E A;  1WAL A;  3U1H A;  1CM7 A;  3VKZ A;  3LCB C;  1LWD A;  5GRL B;  1WPW A;  2HI1 A;  3INM A;  5DE1 A;  5GRF B;  5HN6 A;  3UDO A;  1W0D A;  1YCO A;  3TY4 A;  1VLC A;  1OSI A;  1PS6 A;  3MAS B;  4UMY A;  4WUO A;  3VMJ A;  3ICD A; 
#chains in the Genus database with same CATH topology
 1IDF A;  4BNP A;  4AJC A;  1ISO A;  3VL4 A;  5GRE A;  4JA8 A;  1PB3 A;  5GRI B;  2QFX A;  4AOV A;  4ATY A;  1HQS A;  1U7N A;  6ICD A;  1IDM A;  5K10 A;  3VL7 A;  4YB4 A;  1GRO A;  3MAP A;  5J34 A;  1CW4 A;  1PS7 A;  1IDC A;  2AYQ A;  5GRE B;  5K11 A;  5LGE A;  4KZO A;  4AOY A;  1HJ6 A;  5HN4 A;  3FLK A;  1VI1 A;  2Y3Z A;  2D1C A;  2Y41 A;  1V53 A;  1G2U A;  3WZW A;  4JQP A;  1XAB A;  3BLX A;  7ICD A;  3VML A;  2UXQ A;  3FMX X;  5I96 A;  1ZOR A;  1AI2 A;  3TY3 A;  2E0C A;  5GRH A;  4ICD A;  3AH3 A;  3VL3 A;  2QFY A;  1V94 A;  4L06 A;  1IDE A;  2UXR A;  2G4O A;  4XS3 A;  3WZV A;  4XRX A;  9ICD A;  3R8W A;  1P8F A;  5HN3 A;  4F7I A;  1A05 A;  2Y40 A;  3TSN A;  5L58 A;  1V5B A;  5J33 A;  5HN5 A;  1BL5 A;  3BLV A;  1IKA A;  1XAD A;  4AOU A;  5L57 A;  1SJS A;  4AJR A;  4HCX A;  2D4V A;  2E5M A;  1CW7 A;  1PB1 A;  1YXO A;  3US8 A;  1PTM A;  3VL6 A;  4I3L A;  1T09 A;  1AI3 A;  2IV0 A;  3VMK A;  5J32 A;  1OSJ A;  5GRL A;  4P69 C;  5GRF A;  4AJA A;  1DR8 A;  1XAC A;  4AJ3 A;  3MAS A;  3BLV B;  1TYO A;  1XKD A;  3VL2 A;  1GRP A;  2QFV A;  3ASJ A;  1GC8 A;  1IDD A;  3DMS A;  1T0L A;  3MAR A;  4L04 A;  1CNZ A;  5GRI A;  3BLX B;  1X0L A;  1DPZ A;  3UDU A;  1GC9 A;  3UF6 A;  1XGV A;  2DHT A;  1CW1 A;  5GRH B;  4XXV A;  1DR0 A;  3WZY A;  1HEX A;  2Y42 A;  2QFW A;  4AJB A;  4AJS A;  5I95 A;  1R8K A;  1IPD A;  2ZTW A;  4L03 A;  4IWH A;  3TNG A;  3LXY A;  4UMX A;  4I3K A;  4Y1P A;  5ICD A;  1XAA A;  3WZX A;  8ICD A;  3U9E A;  1WAL A;  3U1H A;  1CM7 A;  3VKZ A;  3LCB C;  1LWD A;  5GRL B;  1WPW A;  2HI1 A;  3INM A;  5DE1 A;  5GRF B;  5HN6 A;  3UDO A;  1W0D A;  1YCO A;  3TY4 A;  1VLC A;  1OSI A;  1PS6 A;  3MAS B;  4UMY A;  4WUO A;  3VMJ A;  3ICD A; 
#chains in the Genus database with same CATH homology
 1IDF A;  4BNP A;  4AJC A;  1ISO A;  3VL4 A;  5GRE A;  4JA8 A;  1PB3 A;  5GRI B;  2QFX A;  4AOV A;  4ATY A;  1HQS A;  1U7N A;  6ICD A;  1IDM A;  5K10 A;  3VL7 A;  4YB4 A;  1GRO A;  3MAP A;  5J34 A;  1CW4 A;  1PS7 A;  1IDC A;  2AYQ A;  5GRE B;  5K11 A;  5LGE A;  4KZO A;  4AOY A;  1HJ6 A;  5HN4 A;  3FLK A;  1VI1 A;  2Y3Z A;  2D1C A;  2Y41 A;  1V53 A;  1G2U A;  3WZW A;  4JQP A;  1XAB A;  3BLX A;  7ICD A;  3VML A;  2UXQ A;  3FMX X;  5I96 A;  1ZOR A;  1AI2 A;  3TY3 A;  2E0C A;  5GRH A;  4ICD A;  3AH3 A;  3VL3 A;  2QFY A;  1V94 A;  4L06 A;  1IDE A;  2UXR A;  2G4O A;  4XS3 A;  3WZV A;  4XRX A;  9ICD A;  3R8W A;  1P8F A;  5HN3 A;  4F7I A;  1A05 A;  2Y40 A;  3TSN A;  5L58 A;  1V5B A;  5J33 A;  5HN5 A;  1BL5 A;  3BLV A;  1IKA A;  1XAD A;  4AOU A;  5L57 A;  1SJS A;  4AJR A;  4HCX A;  2D4V A;  2E5M A;  1CW7 A;  1PB1 A;  1YXO A;  3US8 A;  1PTM A;  3VL6 A;  4I3L A;  1T09 A;  1AI3 A;  2IV0 A;  3VMK A;  5J32 A;  1OSJ A;  5GRL A;  4P69 C;  5GRF A;  4AJA A;  1DR8 A;  1XAC A;  4AJ3 A;  3MAS A;  3BLV B;  1TYO A;  1XKD A;  3VL2 A;  1GRP A;  2QFV A;  3ASJ A;  1GC8 A;  1IDD A;  3DMS A;  1T0L A;  3MAR A;  4L04 A;  1CNZ A;  5GRI A;  3BLX B;  1X0L A;  1DPZ A;  3UDU A;  1GC9 A;  3UF6 A;  1XGV A;  2DHT A;  1CW1 A;  5GRH B;  4XXV A;  1DR0 A;  3WZY A;  1HEX A;  2Y42 A;  2QFW A;  4AJB A;  4AJS A;  5I95 A;  1R8K A;  1IPD A;  2ZTW A;  4L03 A;  4IWH A;  3TNG A;  3LXY A;  4UMX A;  4I3K A;  4Y1P A;  5ICD A;  1XAA A;  3WZX A;  8ICD A;  3U9E A;  1WAL A;  3U1H A;  1CM7 A;  3VKZ A;  3LCB C;  1LWD A;  5GRL B;  1WPW A;  2HI1 A;  3INM A;  5DE1 A;  5GRF B;  5HN6 A;  3UDO A;  1W0D A;  1YCO A;  3TY4 A;  1VLC A;  1OSI A;  1PS6 A;  3MAS B;  4UMY A;  4WUO A;  3VMJ A;  3ICD A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5K10A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations