The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
142
|
sequence length |
412
|
structure length |
409
|
Chain Sequence |
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDAARVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFAAAAIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
pubmed rcsb |
| molecule tags |
Oxidoreductase
|
| source organism |
Homo sapiens
|
| molecule keywords |
Isocitrate dehydrogenase [NADP] cytoplasmic
|
| total genus |
142
|
| structure length |
409
|
| sequence length |
412
|
| ec nomenclature |
ec
1.1.1.42: Isocitrate dehydrogenase (NADP(+)). |
| pdb deposition date | 2016-05-28 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00180 | Iso_dh | Isocitrate/isopropylmalate dehydrogenase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 3-Layer(aba) Sandwich | Isopropylmalate Dehydrogenase | Isopropylmalate Dehydrogenase |
#chains in the Genus database with same CATH superfamily 4F7I A; 5GRL A; 4AOV A; 3FLK A; 2AYQ A; 2E5M A; 2Y42 A; 3BLV B; 2HI1 A; 4AJR A; 4L06 A; 1IDD A; 4ICD A; 3TY3 A; 4WUO A; 5J32 A; 1XAB A; 4Y1P A; 5GRL B; 1IDM A; 1DR0 A; 3MAP A; 3AH3 A; 4AJB A; 1PS7 A; 2Y3Z A; 4L04 A; 1IDE A; 4HCX A; 4BNP A; 3U1H A; 1V5B A; 5HN6 A; 1DPZ A; 8ICD A; 5GRF A; 1LWD A; 3UDU A; 1PTM A; 1AI3 A; 5HN4 A; 4XRX A; 1CW1 A; 5GRF B; 3VMJ A; 5I96 A; 5I95 A; 4AJS A; 1PB1 A; 1ZOR A; 2Y40 A; 2G4O A; 2UXR A; 1XAC A; 3UF6 A; 2E0C A; 4AJ3 A; 3WZW A; 3UDO A; 3ASJ A; 5DE1 A; 4I3K A; 1VI1 A; 3VL7 A; 2IV0 A; 3FMX X; 1V53 A; 3WZX A; 3ICD A; 1YXO A; 1OSJ A; 5ICD A; 3VKZ A; 1YCO A; 4AJA A; 2QFY A; 2DHT A; 3INM A; 3US8 A; 4JQP A; 5K10 A; 2Y41 A; 4KZO A; 1XGV A; 4JA8 A; 1OSI A; 4AJC A; 1AI2 A; 5J33 A; 6ICD A; 4ATY A; 5J34 A; 1CW4 A; 1WPW A; 1P8F A; 1XAD A; 2D1C A; 3R8W A; 2ZTW A; 1G2U A; 2UXQ A; 1GC9 A; 3VL2 A; 1HQS A; 3LCB C; 3TSN A; 9ICD A; 2QFV A; 4XS3 A; 2QFX A; 1GRO A; 4UMY A; 5LGE A; 2D4V A; 1XAA A; 5HN3 A; 1A05 A; 4YB4 A; 5L58 A; 1PB3 A; 1CNZ A; 5HN5 A; 5GRI A; 5GRE A; 4IWH A; 4L03 A; 5K11 A; 5L57 A; 1R8K A; 3VML A; 3MAS A; 1V94 A; 1T09 A; 5GRI B; 3VL3 A; 3TY4 A; 1U7N A; 1DR8 A; 3LXY A; 5GRE B; 1ISO A; 4AOY A; 1GC8 A; 3VMK A; 3MAS B; 4P69 C; 4XXV A; 1X0L A; 1IKA A; 7ICD A; 1PS6 A; 1SJS A; 3BLX A; 3TNG A; 1IDF A; 1CW7 A; 1XKD A; 3BLX B; 1VLC A; 1GRP A; 1HEX A; 1T0L A; 4UMX A; 1BL5 A; 1W0D A; 1IPD A; 3VL6 A; 4AOU A; 4I3L A; 3VL4 A; 1HJ6 A; 5GRH A; 3WZY A; 1IDC A; 1TYO A; 1WAL A; 3MAR A; 3DMS A; 1CM7 A; 5GRH B; 3U9E A; 3WZV A; 2QFW A; 3BLV A; #chains in the Genus database with same CATH topology 4F7I A; 5GRL A; 4AOV A; 3FLK A; 2AYQ A; 2E5M A; 2Y42 A; 3BLV B; 2HI1 A; 4AJR A; 4L06 A; 1IDD A; 4ICD A; 3TY3 A; 4WUO A; 5J32 A; 1XAB A; 4Y1P A; 5GRL B; 1IDM A; 1DR0 A; 3MAP A; 3AH3 A; 4AJB A; 1PS7 A; 2Y3Z A; 4L04 A; 1IDE A; 4HCX A; 4BNP A; 3U1H A; 1V5B A; 5HN6 A; 1DPZ A; 8ICD A; 5GRF A; 1LWD A; 3UDU A; 1PTM A; 1AI3 A; 5HN4 A; 4XRX A; 1CW1 A; 5GRF B; 3VMJ A; 5I96 A; 5I95 A; 4AJS A; 1PB1 A; 1ZOR A; 2Y40 A; 2G4O A; 2UXR A; 1XAC A; 3UF6 A; 2E0C A; 4AJ3 A; 3WZW A; 3UDO A; 3ASJ A; 5DE1 A; 4I3K A; 1VI1 A; 3VL7 A; 2IV0 A; 3FMX X; 1V53 A; 3WZX A; 3ICD A; 1YXO A; 1OSJ A; 5ICD A; 3VKZ A; 1YCO A; 4AJA A; 2QFY A; 2DHT A; 3INM A; 3US8 A; 4JQP A; 5K10 A; 2Y41 A; 4KZO A; 1XGV A; 4JA8 A; 1OSI A; 4AJC A; 1AI2 A; 5J33 A; 6ICD A; 4ATY A; 5J34 A; 1CW4 A; 1WPW A; 1P8F A; 1XAD A; 2D1C A; 3R8W A; 2ZTW A; 1G2U A; 2UXQ A; 1GC9 A; 3VL2 A; 1HQS A; 3LCB C; 3TSN A; 9ICD A; 2QFV A; 4XS3 A; 2QFX A; 1GRO A; 4UMY A; 5LGE A; 2D4V A; 1XAA A; 5HN3 A; 1A05 A; 4YB4 A; 5L58 A; 1PB3 A; 1CNZ A; 5HN5 A; 5GRI A; 5GRE A; 4IWH A; 4L03 A; 5K11 A; 5L57 A; 1R8K A; 3VML A; 3MAS A; 1V94 A; 1T09 A; 5GRI B; 3VL3 A; 3TY4 A; 1U7N A; 1DR8 A; 3LXY A; 5GRE B; 1ISO A; 4AOY A; 1GC8 A; 3VMK A; 3MAS B; 4P69 C; 4XXV A; 1X0L A; 1IKA A; 7ICD A; 1PS6 A; 1SJS A; 3BLX A; 3TNG A; 1IDF A; 1CW7 A; 1XKD A; 3BLX B; 1VLC A; 1GRP A; 1HEX A; 1T0L A; 4UMX A; 1BL5 A; 1W0D A; 1IPD A; 3VL6 A; 4AOU A; 4I3L A; 3VL4 A; 1HJ6 A; 5GRH A; 3WZY A; 1IDC A; 1TYO A; 1WAL A; 3MAR A; 3DMS A; 1CM7 A; 5GRH B; 3U9E A; 3WZV A; 2QFW A; 3BLV A; #chains in the Genus database with same CATH homology 4F7I A; 5GRL A; 4AOV A; 3FLK A; 2AYQ A; 2E5M A; 2Y42 A; 3BLV B; 2HI1 A; 4AJR A; 4L06 A; 1IDD A; 4ICD A; 3TY3 A; 4WUO A; 5J32 A; 1XAB A; 4Y1P A; 5GRL B; 1IDM A; 1DR0 A; 3MAP A; 3AH3 A; 4AJB A; 1PS7 A; 2Y3Z A; 4L04 A; 1IDE A; 4HCX A; 4BNP A; 3U1H A; 1V5B A; 5HN6 A; 1DPZ A; 8ICD A; 5GRF A; 1LWD A; 3UDU A; 1PTM A; 1AI3 A; 5HN4 A; 4XRX A; 1CW1 A; 5GRF B; 3VMJ A; 5I96 A; 5I95 A; 4AJS A; 1PB1 A; 1ZOR A; 2Y40 A; 2G4O A; 2UXR A; 1XAC A; 3UF6 A; 2E0C A; 4AJ3 A; 3WZW A; 3UDO A; 3ASJ A; 5DE1 A; 4I3K A; 1VI1 A; 3VL7 A; 2IV0 A; 3FMX X; 1V53 A; 3WZX A; 3ICD A; 1YXO A; 1OSJ A; 5ICD A; 3VKZ A; 1YCO A; 4AJA A; 2QFY A; 2DHT A; 3INM A; 3US8 A; 4JQP A; 5K10 A; 2Y41 A; 4KZO A; 1XGV A; 4JA8 A; 1OSI A; 4AJC A; 1AI2 A; 5J33 A; 6ICD A; 4ATY A; 5J34 A; 1CW4 A; 1WPW A; 1P8F A; 1XAD A; 2D1C A; 3R8W A; 2ZTW A; 1G2U A; 2UXQ A; 1GC9 A; 3VL2 A; 1HQS A; 3LCB C; 3TSN A; 9ICD A; 2QFV A; 4XS3 A; 2QFX A; 1GRO A; 4UMY A; 5LGE A; 2D4V A; 1XAA A; 5HN3 A; 1A05 A; 4YB4 A; 5L58 A; 1PB3 A; 1CNZ A; 5HN5 A; 5GRI A; 5GRE A; 4IWH A; 4L03 A; 5K11 A; 5L57 A; 1R8K A; 3VML A; 3MAS A; 1V94 A; 1T09 A; 5GRI B; 3VL3 A; 3TY4 A; 1U7N A; 1DR8 A; 3LXY A; 5GRE B; 1ISO A; 4AOY A; 1GC8 A; 3VMK A; 3MAS B; 4P69 C; 4XXV A; 1X0L A; 1IKA A; 7ICD A; 1PS6 A; 1SJS A; 3BLX A; 3TNG A; 1IDF A; 1CW7 A; 1XKD A; 3BLX B; 1VLC A; 1GRP A; 1HEX A; 1T0L A; 4UMX A; 1BL5 A; 1W0D A; 1IPD A; 3VL6 A; 4AOU A; 4I3L A; 3VL4 A; 1HJ6 A; 5GRH A; 3WZY A; 1IDC A; 1TYO A; 1WAL A; 3MAR A; 3DMS A; 1CM7 A; 5GRH B; 3U9E A; 3WZV A; 2QFW A; 3BLV A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
