8ICDA

Regulation of an enzyme by phosphorylation at the active site
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
414
structure length
414
Chain Sequence
SKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSAEMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Regulation of an enzyme by phosphorylation at the active site.
pubmed rcsb
molecule tags Oxidoreductase (nad(a)-choh(d))
source organism Escherichia coli
molecule keywords ISOCITRATE DEHYDROGENASE
total genus 138
structure length 414
sequence length 414
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 1990-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 8icdA00
1CW7A 3MAPA 3VL6A 3DMSA 1ISOA 2DHTA 4UMYA 2Y3ZA 3WZYA 3VL7A 2IV0A 1X0LA 1U7NA 4ICDA 1PS7A 5HN4A 2QFYA 5L58A 1CW4A 2Y40A 8ICDA 1TYOA 2UXRA 3MARA 1DPZA 5K11A 3VMJA 1WPWA 3WZXA 4XS3A 3BLXA 5GRHA 1IDFA 1R8KA 4HCXA 2QFWA 4AOUA 1XKDA 3U1HA 4XRXA 3UDOA 3WZWA 4I3LA 1VLCA 3FMXX 5GRLB 1IDEA 1T09A 1V53A 3VL3A 1XABA 3AH3A 4F7IA 3LXYA 1BL5A 4BNPA 1PTMA 1A05A 3UF6A 1GC8A 7ICDA 5J32A 1XAAA 1IPDA 2Y42A 5GRIB 3VMKA 2QFVA 4Y1PA 4AOVA 4AJ3A 1GRPA 4I3KA 1G2UA 5HN5A 6ICDA 3VL4A 2D1CA 5HN6A 4ATYA 3R8WA 4AJSA 4L03A 2Y41A 4XXVA 3ASJA 3INMA 9ICDA 1HQSA 3TSNA 3TY4A 5ICDA 3UDUA 3WZVA 5DE1A 4KZOA 3U9EA 3BLVB 4AJCA 3FLKA 5GREA 1WALA 5J34A 1SJSA 1HEXA 5GRFB 4AOYA 1P8FA 1AI2A 1HJ6A 3BLXB 2E0CA 2AYQA 1VI1A 1DR0A 4IWHA 5I95A 5K10A 2ZTWA 2QFXA 1IDMA 1PS6A 3MASB 4AJAA 3VL2A 1YXOA 4JQPA 2UXQA 4YB4A 4AJRA 3LCBC 1V5BA 1XACA 3TY3A 2E5MA 1OSJA 4JA8A 1IDCA 1XADA 3TNGA 1YCOA 5GRLA 1CM7A 5J33A 5I96A 1CW1A 5HN3A 1IKAA 4WUOA 1GC9A 3US8A 1W0DA 3BLVA 1DR8A 5GRHB 1XGVA 2HI1A 3VKZA 1AI3A 1LWDA 4L06A 1V94A 3VMLA 2D4VA 1T0LA 1CNZA 2G4OA 4P69C 5GRFA 4AJBA 5L57A 5LGEA 1ZORA 4UMXA 1GROA 1OSIA 1PB3A 3ICDA 5GRIA 1IDDA 4L04A 1PB1A 3MASA 5GREB
chains in the Genus database with same CATH superfamily
1CW7A 3MAPA 3VL6A 3DMSA 1ISOA 2DHTA 4UMYA 2Y3ZA 3WZYA 3VL7A 2IV0A 1X0LA 1U7NA 4ICDA 1PS7A 5HN4A 2QFYA 5L58A 1CW4A 2Y40A 8ICDA 1TYOA 2UXRA 3MARA 1DPZA 5K11A 3VMJA 1WPWA 3WZXA 4XS3A 3BLXA 5GRHA 1IDFA 1R8KA 4HCXA 2QFWA 4AOUA 1XKDA 3U1HA 4XRXA 3UDOA 3WZWA 4I3LA 1VLCA 3FMXX 5GRLB 1IDEA 1T09A 1V53A 3VL3A 1XABA 3AH3A 4F7IA 3LXYA 1BL5A 4BNPA 1PTMA 1A05A 3UF6A 1GC8A 7ICDA 5J32A 1XAAA 1IPDA 2Y42A 5GRIB 3VMKA 2QFVA 4Y1PA 4AOVA 4AJ3A 1GRPA 4I3KA 1G2UA 5HN5A 6ICDA 3VL4A 2D1CA 5HN6A 4ATYA 3R8WA 4AJSA 4L03A 2Y41A 4XXVA 3ASJA 3INMA 9ICDA 1HQSA 3TSNA 3TY4A 5ICDA 3UDUA 3WZVA 5DE1A 4KZOA 3U9EA 3BLVB 4AJCA 3FLKA 5GREA 1WALA 5J34A 1SJSA 1HEXA 5GRFB 4AOYA 1P8FA 1AI2A 1HJ6A 3BLXB 2E0CA 2AYQA 1VI1A 1DR0A 4IWHA 5I95A 5K10A 2ZTWA 2QFXA 1IDMA 1PS6A 3MASB 4AJAA 3VL2A 1YXOA 4JQPA 2UXQA 4YB4A 4AJRA 3LCBC 1V5BA 1XACA 3TY3A 2E5MA 1OSJA 4JA8A 1IDCA 1XADA 3TNGA 1YCOA 5GRLA 1CM7A 5J33A 5I96A 1CW1A 5HN3A 1IKAA 4WUOA 1GC9A 3US8A 1W0DA 3BLVA 1DR8A 5GRHB 1XGVA 2HI1A 3VKZA 1AI3A 1LWDA 4L06A 1V94A 3VMLA 2D4VA 1T0LA 1CNZA 2G4OA 4P69C 5GRFA 4AJBA 5L57A 5LGEA 1ZORA 4UMXA 1GROA 1OSIA 1PB3A 3ICDA 5GRIA 1IDDA 4L04A 1PB1A 3MASA 5GREB
chains in the Genus database with same CATH topology
1CW7A 3MAPA 3VL6A 3DMSA 1ISOA 2DHTA 4UMYA 2Y3ZA 3WZYA 3VL7A 2IV0A 1X0LA 1U7NA 4ICDA 1PS7A 5HN4A 2QFYA 5L58A 1CW4A 2Y40A 8ICDA 1TYOA 2UXRA 3MARA 1DPZA 5K11A 3VMJA 1WPWA 3WZXA 4XS3A 3BLXA 5GRHA 1IDFA 1R8KA 4HCXA 2QFWA 4AOUA 1XKDA 3U1HA 4XRXA 3UDOA 3WZWA 4I3LA 1VLCA 3FMXX 5GRLB 1IDEA 1T09A 1V53A 3VL3A 1XABA 3AH3A 4F7IA 3LXYA 1BL5A 4BNPA 1PTMA 1A05A 3UF6A 1GC8A 7ICDA 5J32A 1XAAA 1IPDA 2Y42A 5GRIB 3VMKA 2QFVA 4Y1PA 4AOVA 4AJ3A 1GRPA 4I3KA 1G2UA 5HN5A 6ICDA 3VL4A 2D1CA 5HN6A 4ATYA 3R8WA 4AJSA 4L03A 2Y41A 4XXVA 3ASJA 3INMA 9ICDA 1HQSA 3TSNA 3TY4A 5ICDA 3UDUA 3WZVA 5DE1A 4KZOA 3U9EA 3BLVB 4AJCA 3FLKA 5GREA 1WALA 5J34A 1SJSA 1HEXA 5GRFB 4AOYA 1P8FA 1AI2A 1HJ6A 3BLXB 2E0CA 2AYQA 1VI1A 1DR0A 4IWHA 5I95A 5K10A 2ZTWA 2QFXA 1IDMA 1PS6A 3MASB 4AJAA 3VL2A 1YXOA 4JQPA 2UXQA 4YB4A 4AJRA 3LCBC 1V5BA 1XACA 3TY3A 2E5MA 1OSJA 4JA8A 1IDCA 1XADA 3TNGA 1YCOA 5GRLA 1CM7A 5J33A 5I96A 1CW1A 5HN3A 1IKAA 4WUOA 1GC9A 3US8A 1W0DA 3BLVA 1DR8A 5GRHB 1XGVA 2HI1A 3VKZA 1AI3A 1LWDA 4L06A 1V94A 3VMLA 2D4VA 1T0LA 1CNZA 2G4OA 4P69C 5GRFA 4AJBA 5L57A 5LGEA 1ZORA 4UMXA 1GROA 1OSIA 1PB3A 3ICDA 5GRIA 1IDDA 4L04A 1PB1A 3MASA 5GREB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CW7 A;  3MAP A;  3VL6 A;  3DMS A;  1ISO A;  2DHT A;  4UMY A;  2Y3Z A;  3WZY A;  3VL7 A;  2IV0 A;  1X0L A;  1U7N A;  4ICD A;  1PS7 A;  5HN4 A;  2QFY A;  5L58 A;  1CW4 A;  2Y40 A;  8ICD A;  1TYO A;  2UXR A;  3MAR A;  1DPZ A;  5K11 A;  3VMJ A;  1WPW A;  3WZX A;  4XS3 A;  3BLX A;  5GRH A;  1IDF A;  1R8K A;  4HCX A;  2QFW A;  4AOU A;  1XKD A;  3U1H A;  4XRX A;  3UDO A;  3WZW A;  4I3L A;  1VLC A;  3FMX X;  5GRL B;  1IDE A;  1T09 A;  1V53 A;  3VL3 A;  1XAB A;  3AH3 A;  4F7I A;  3LXY A;  1BL5 A;  4BNP A;  1PTM A;  1A05 A;  3UF6 A;  1GC8 A;  7ICD A;  5J32 A;  1XAA A;  1IPD A;  2Y42 A;  5GRI B;  3VMK A;  2QFV A;  4Y1P A;  4AOV A;  4AJ3 A;  1GRP A;  4I3K A;  1G2U A;  5HN5 A;  6ICD A;  3VL4 A;  2D1C A;  5HN6 A;  4ATY A;  3R8W A;  4AJS A;  4L03 A;  2Y41 A;  4XXV A;  3ASJ A;  3INM A;  9ICD A;  1HQS A;  3TSN A;  3TY4 A;  5ICD A;  3UDU A;  3WZV A;  5DE1 A;  4KZO A;  3U9E A;  3BLV B;  4AJC A;  3FLK A;  5GRE A;  1WAL A;  5J34 A;  1SJS A;  1HEX A;  5GRF B;  4AOY A;  1P8F A;  1AI2 A;  1HJ6 A;  3BLX B;  2E0C A;  2AYQ A;  1VI1 A;  1DR0 A;  4IWH A;  5I95 A;  5K10 A;  2ZTW A;  2QFX A;  1IDM A;  1PS6 A;  3MAS B;  4AJA A;  3VL2 A;  1YXO A;  4JQP A;  2UXQ A;  4YB4 A;  4AJR A;  3LCB C;  1V5B A;  1XAC A;  3TY3 A;  2E5M A;  1OSJ A;  4JA8 A;  1IDC A;  1XAD A;  3TNG A;  1YCO A;  5GRL A;  1CM7 A;  5J33 A;  5I96 A;  1CW1 A;  5HN3 A;  1IKA A;  4WUO A;  1GC9 A;  3US8 A;  1W0D A;  3BLV A;  1DR8 A;  5GRH B;  1XGV A;  2HI1 A;  3VKZ A;  1AI3 A;  1LWD A;  4L06 A;  1V94 A;  3VML A;  2D4V A;  1T0L A;  1CNZ A;  2G4O A;  4P69 C;  5GRF A;  4AJB A;  5L57 A;  5LGE A;  1ZOR A;  4UMX A;  1GRO A;  1OSI A;  1PB3 A;  3ICD A;  5GRI A;  1IDD A;  4L04 A;  1PB1 A;  3MAS A;  5GRE B; 
#chains in the Genus database with same CATH topology
 1CW7 A;  3MAP A;  3VL6 A;  3DMS A;  1ISO A;  2DHT A;  4UMY A;  2Y3Z A;  3WZY A;  3VL7 A;  2IV0 A;  1X0L A;  1U7N A;  4ICD A;  1PS7 A;  5HN4 A;  2QFY A;  5L58 A;  1CW4 A;  2Y40 A;  8ICD A;  1TYO A;  2UXR A;  3MAR A;  1DPZ A;  5K11 A;  3VMJ A;  1WPW A;  3WZX A;  4XS3 A;  3BLX A;  5GRH A;  1IDF A;  1R8K A;  4HCX A;  2QFW A;  4AOU A;  1XKD A;  3U1H A;  4XRX A;  3UDO A;  3WZW A;  4I3L A;  1VLC A;  3FMX X;  5GRL B;  1IDE A;  1T09 A;  1V53 A;  3VL3 A;  1XAB A;  3AH3 A;  4F7I A;  3LXY A;  1BL5 A;  4BNP A;  1PTM A;  1A05 A;  3UF6 A;  1GC8 A;  7ICD A;  5J32 A;  1XAA A;  1IPD A;  2Y42 A;  5GRI B;  3VMK A;  2QFV A;  4Y1P A;  4AOV A;  4AJ3 A;  1GRP A;  4I3K A;  1G2U A;  5HN5 A;  6ICD A;  3VL4 A;  2D1C A;  5HN6 A;  4ATY A;  3R8W A;  4AJS A;  4L03 A;  2Y41 A;  4XXV A;  3ASJ A;  3INM A;  9ICD A;  1HQS A;  3TSN A;  3TY4 A;  5ICD A;  3UDU A;  3WZV A;  5DE1 A;  4KZO A;  3U9E A;  3BLV B;  4AJC A;  3FLK A;  5GRE A;  1WAL A;  5J34 A;  1SJS A;  1HEX A;  5GRF B;  4AOY A;  1P8F A;  1AI2 A;  1HJ6 A;  3BLX B;  2E0C A;  2AYQ A;  1VI1 A;  1DR0 A;  4IWH A;  5I95 A;  5K10 A;  2ZTW A;  2QFX A;  1IDM A;  1PS6 A;  3MAS B;  4AJA A;  3VL2 A;  1YXO A;  4JQP A;  2UXQ A;  4YB4 A;  4AJR A;  3LCB C;  1V5B A;  1XAC A;  3TY3 A;  2E5M A;  1OSJ A;  4JA8 A;  1IDC A;  1XAD A;  3TNG A;  1YCO A;  5GRL A;  1CM7 A;  5J33 A;  5I96 A;  1CW1 A;  5HN3 A;  1IKA A;  4WUO A;  1GC9 A;  3US8 A;  1W0D A;  3BLV A;  1DR8 A;  5GRH B;  1XGV A;  2HI1 A;  3VKZ A;  1AI3 A;  1LWD A;  4L06 A;  1V94 A;  3VML A;  2D4V A;  1T0L A;  1CNZ A;  2G4O A;  4P69 C;  5GRF A;  4AJB A;  5L57 A;  5LGE A;  1ZOR A;  4UMX A;  1GRO A;  1OSI A;  1PB3 A;  3ICD A;  5GRI A;  1IDD A;  4L04 A;  1PB1 A;  3MAS A;  5GRE B; 
#chains in the Genus database with same CATH homology
 1CW7 A;  3MAP A;  3VL6 A;  3DMS A;  1ISO A;  2DHT A;  4UMY A;  2Y3Z A;  3WZY A;  3VL7 A;  2IV0 A;  1X0L A;  1U7N A;  4ICD A;  1PS7 A;  5HN4 A;  2QFY A;  5L58 A;  1CW4 A;  2Y40 A;  8ICD A;  1TYO A;  2UXR A;  3MAR A;  1DPZ A;  5K11 A;  3VMJ A;  1WPW A;  3WZX A;  4XS3 A;  3BLX A;  5GRH A;  1IDF A;  1R8K A;  4HCX A;  2QFW A;  4AOU A;  1XKD A;  3U1H A;  4XRX A;  3UDO A;  3WZW A;  4I3L A;  1VLC A;  3FMX X;  5GRL B;  1IDE A;  1T09 A;  1V53 A;  3VL3 A;  1XAB A;  3AH3 A;  4F7I A;  3LXY A;  1BL5 A;  4BNP A;  1PTM A;  1A05 A;  3UF6 A;  1GC8 A;  7ICD A;  5J32 A;  1XAA A;  1IPD A;  2Y42 A;  5GRI B;  3VMK A;  2QFV A;  4Y1P A;  4AOV A;  4AJ3 A;  1GRP A;  4I3K A;  1G2U A;  5HN5 A;  6ICD A;  3VL4 A;  2D1C A;  5HN6 A;  4ATY A;  3R8W A;  4AJS A;  4L03 A;  2Y41 A;  4XXV A;  3ASJ A;  3INM A;  9ICD A;  1HQS A;  3TSN A;  3TY4 A;  5ICD A;  3UDU A;  3WZV A;  5DE1 A;  4KZO A;  3U9E A;  3BLV B;  4AJC A;  3FLK A;  5GRE A;  1WAL A;  5J34 A;  1SJS A;  1HEX A;  5GRF B;  4AOY A;  1P8F A;  1AI2 A;  1HJ6 A;  3BLX B;  2E0C A;  2AYQ A;  1VI1 A;  1DR0 A;  4IWH A;  5I95 A;  5K10 A;  2ZTW A;  2QFX A;  1IDM A;  1PS6 A;  3MAS B;  4AJA A;  3VL2 A;  1YXO A;  4JQP A;  2UXQ A;  4YB4 A;  4AJR A;  3LCB C;  1V5B A;  1XAC A;  3TY3 A;  2E5M A;  1OSJ A;  4JA8 A;  1IDC A;  1XAD A;  3TNG A;  1YCO A;  5GRL A;  1CM7 A;  5J33 A;  5I96 A;  1CW1 A;  5HN3 A;  1IKA A;  4WUO A;  1GC9 A;  3US8 A;  1W0D A;  3BLV A;  1DR8 A;  5GRH B;  1XGV A;  2HI1 A;  3VKZ A;  1AI3 A;  1LWD A;  4L06 A;  1V94 A;  3VML A;  2D4V A;  1T0L A;  1CNZ A;  2G4O A;  4P69 C;  5GRF A;  4AJB A;  5L57 A;  5LGE A;  1ZOR A;  4UMX A;  1GRO A;  1OSI A;  1PB3 A;  3ICD A;  5GRI A;  1IDD A;  4L04 A;  1PB1 A;  3MAS A;  5GRE B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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