1KHG | Genus

Total Genus 201

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	201
sequence length	613
structure length	603
Chain Sequence	NLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEALGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLVLGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGSTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWDKEVEDIEKYLVDQVNADLPCEIEREILALKQRISQM

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Lyase
source organism	Homo sapiens
publication title	Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. pubmed doi rcsb
molecule keywords	Phosphoenolpyruvate carboxykinase, cytosolic (GTP)
total genus	201
structure length	603
sequence length	613
ec nomenclature	ec 4.1.1.32: Phosphoenolpyruvate carboxykinase (GTP).
pdb deposition date	2001-11-29

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00821	PEPCK_GTP	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain
A	PF17297	PEPCK_N	Phosphoenolpyruvate carboxykinase N-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.170.8.10	Mainly Beta	Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 2	Phosphoenolpyruvate Carboxykinase, domain 2	1khgA02
3.40.449.10	Alpha Beta	3-Layer(aba) Sandwich	Phosphoenolpyruvate Carboxykinase; domain 1	Phosphoenolpyruvate Carboxykinase, domain 1	1khgA01
3.90.228.20	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 3	Phosphoenolpyruvate Carboxykinase; domain 3	1khgA03

1KHEA 1II2A 2QEWA 2PXZX 3DT2A 4WIEA 4GNPA 4WL8A 4GMMA 4GNQA 2RKEA 5FH5A 4WPVA 1XKVA 2PY7X 2ZCIA 1NHXA 2RKDA 2FAHA 5FH1A 2PC9A 3DT7A 5I67A 1YLHA 3MOEA 1KHBA 1K3DA 1YVYA 5FH0A 5FH4A 1OENA 2QZYA 4GMWA 4GMUA 5FH2A 4WOUA 4YWBA 1M51A 2RK8A 4WPUA 4RCGA 4OX2A 1YGGA 2OLRA 4WIUA 4WPTA 5FH3A 1AQ2A 3DTBA 2GMVA 2RK7A 3DT4A 4YWDA 4GNOA 3MOFA 1J3BA 1OS1A 4GNLA 4R43A 4GNMA 4GMZA 1AYLA 1KHGA 2QEYA 1K3CA 2OLQA 4YW9A 3MOHA 4YW8A 2FAFA 2QF1A 1KHFA 2RKAA 2QF2A 1YTMA
chains in the Genus database with same CATH superfamily

1KHEA 3BLJA 1II2A 4HLMA 4BUWA 2PXZX 4WIEA 4F0EA 4OQBC 4WPVA 3UH4A 1XKVA 4L31A 1NHXA 3C4HA 1A26A 2PC9A 4UI8A 4HL5A 4PY4A 4UVTA 3UDDA 4W6EA 4UVVA 3PAXA 1YVYA 3KR7A 5FH4A 2QZYA 4TJYA 4BU5A 4YWBA 4UXBA 4L7UA 5AKWA 4TK0A 4OA7A 4OX2A 4TK5A 2OLRA 4HKKA 4XHUA 2GMVA 4L32A 5DCZA 4YWDA 3SMJA 4GNOA 3U9HA 3MHJA 4HLFA 4J1ZA 4J21A 4PNMA 4UVNA 4GNMA 4PNTA 2QEYA 4J3MA 2RD6A 4N4VA 4BU6A 4ZZYA 4I9IA 2PY7X 1KHFA 2PQFA 4R5WA 4MSKA 5LYHA 3UH2A 4L0TA 5ADRA 3FHBA 4BUIA 2QEWA 4BUYA 3DT2A 4IUEA 4TKFA 5AL4A 5ETYA 4PNQA 3UA9A 2PAWA 4R6EA 4ZZXA 1PAXA 4L2FA 4BU7A 4K4EA 2ZCIA 4LI7A 4BJBA 4BUEA 5FH1A 4DVIA 4L33A 4KZUA 5AEHA 4BUXA 3MOEA 4F1QA 3KCZA 4GV2A 4N4TA 4HLGA 4UVZA 5A00A 4BJCA 4W5SA 4PNRA 4L0VA 4UFYA 5FPFA 2RK8A 4TOSA 5LXPA 5AL5A 4BU9A 4F1LA 4L7OA 4UW1A 3L3LA 1YGGA 4M7BA 4BS4A 5FH3A 1AQ2A 4BU8A 3DTBA 3DT4A 4GV7A 3GOYA 3SE2A 4LI8A 1WOKA 4UX4A 4GNLA 4MT9A 4GMZA 4HLKA 4L34A 4UNDA 3SMIA 1K3CA 4GV4A 4PNNA 5AKUA 4BUSA 2OLQA 2QF1A 4YW8A 3L3MA 4L70A 4X52A 5AL3A 1YTMA 4BUUA 3P0QA 3HKVA 4HLHA 4L7RA 4MSGA 4KRSA 4U6AA 4ZZZA 4W5IA 1UK1A 4L6SA 4GNQA 3C49A 2RKEA 2X5YA 5FH5A 5FPGA 4TKGA 5I67A 2RKDA 4K4FA 4UVLA 4L7NA 4UVPA 4BFPA 4HKNA 1UK0A 5AL1A 4OPXC 4TJWA 4L10A 4GMWA 4L09A 4TVJA 4UVYA 4WOUA 3U9YA 4J3LA 4RCGA 3P0PA 4HHYA 4WIUA 5EBTA 5C5RA 2RF5A 4UI7A 4L0SA 2PAXA 4R43A 4TORA 4UUHA 1KHGA 4OQAC 4UI5A 5C5QA 3KJDA 4YW9A 4UHGA 2FAFA 3MOFA 3MOHA 4GMUA 2RKAA 4HMHA 2QF2A 4TKIA 4L0BA 5ADTA 4UI3A 1EFYA 4UI4A 4HKIA 4L6ZA 5ECEA 4PNSA 4WL8A 4BU3A 4RV6A 4GNPA 4GMMA 4BUVA 4L0IA 3CE0A 4N3RA 4BJ9A 4PJVA 2FAHA 4PMLA 4BUAA 3DT7A 4BUDA 5ADSA 1YLHA 4LI6A 1KHBA 4KZQA 4UVOA 1K3DA 4UVXA 3GJWA 3P0NA 5ADQA 5FH0A 1OENA 5FH2A 3KR8A 3GN7A 4L7PA 1M51A 4WPUA 4PJTA 4TJUA 4UVUA 4HYFA 2RCWA 4HHZA 4KZLA 4GV0A 4WPTA 4L2GA 5C5PA 3MHKA 4L2KA 4BUTA 4DQYC 4J22A 4AVWA 4PNLA 3W51A 4PAXA 4BUFA 4UI6A 5AL2A 1J3BA 1OS1A 4UVWA 4AVUA 1AYLA 4UVSA 4UFUA 1GS0A 2RK7A 5LX6A 4L7LA 3GEYA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1KHE A;  1II2 A;  2QEW A;  2PXZ X;  3DT2 A;  4WIE A;  4GNP A;  4WL8 A;  4GMM A;  4GNQ A;  2RKE A;  5FH5 A;  4WPV A;  1XKV A;  2PY7 X;  2ZCI A;  1NHX A;  2RKD A;  2FAH A;  5FH1 A;  2PC9 A;  3DT7 A;  5I67 A;  1YLH A;  3MOE A;  1KHB A;  1K3D A;  1YVY A;  5FH0 A;  5FH4 A;  1OEN A;  2QZY A;  4GMW A;  4GMU A;  5FH2 A;  4WOU A;  4YWB A;  1M51 A;  2RK8 A;  4WPU A;  4RCG A;  4OX2 A;  1YGG A;  2OLR A;  4WIU A;  4WPT A;  5FH3 A;  1AQ2 A;  3DTB A;  2GMV A;  2RK7 A;  3DT4 A;  4YWD A;  4GNO A;  3MOF A;  1J3B A;  1OS1 A;  4GNL A;  4R43 A;  4GNM A;  4GMZ A;  1AYL A;  1KHG A;  2QEY A;  1K3C A;  2OLQ A;  4YW9 A;  3MOH A;  4YW8 A;  2FAF A;  2QF1 A;  1KHF A;  2RKA A;  2QF2 A;  1YTM A; 
#chains in the Genus database with same CATH topology
 1KHE A;  3BLJ A;  1II2 A;  4HLM A;  4BUW A;  2PXZ X;  4WIE A;  4F0E A;  4OQB C;  4WPV A;  3UH4 A;  1XKV A;  4L31 A;  1NHX A;  3C4H A;  1A26 A;  2PC9 A;  4UI8 A;  4HL5 A;  4PY4 A;  4UVT A;  3UDD A;  4W6E A;  4UVV A;  3PAX A;  1YVY A;  3KR7 A;  5FH4 A;  2QZY A;  4TJY A;  4BU5 A;  4YWB A;  4UXB A;  4L7U A;  5AKW A;  4TK0 A;  4OA7 A;  4OX2 A;  4TK5 A;  2OLR A;  4HKK A;  4XHU A;  2GMV A;  4L32 A;  5DCZ A;  4YWD A;  3SMJ A;  4GNO A;  3U9H A;  3MHJ A;  4HLF A;  4J1Z A;  4J21 A;  4PNM A;  4UVN A;  4GNM A;  4PNT A;  2QEY A;  4J3M A;  2RD6 A;  4N4V A;  4BU6 A;  4ZZY A;  4I9I A;  2PY7 X;  1KHF A;  2PQF A;  4R5W A;  4MSK A;  5LYH A;  3UH2 A;  4L0T A;  5ADR A;  3FHB A;  4BUI A;  2QEW A;  4BUY A;  3DT2 A;  4IUE A;  4TKF A;  5AL4 A;  5ETY A;  4PNQ A;  3UA9 A;  2PAW A;  4R6E A;  4ZZX A;  1PAX A;  4L2F A;  4BU7 A;  4K4E A;  2ZCI A;  4LI7 A;  4BJB A;  4BUE A;  5FH1 A;  4DVI A;  4L33 A;  4KZU A;  5AEH A;  4BUX A;  3MOE A;  4F1Q A;  3KCZ A;  4GV2 A;  4N4T A;  4HLG A;  4UVZ A;  5A00 A;  4BJC A;  4W5S A;  4PNR A;  4L0V A;  4UFY A;  5FPF A;  2RK8 A;  4TOS A;  5LXP A;  5AL5 A;  4BU9 A;  4F1L A;  4L7O A;  4UW1 A;  3L3L A;  1YGG A;  4M7B A;  4BS4 A;  5FH3 A;  1AQ2 A;  4BU8 A;  3DTB A;  3DT4 A;  4GV7 A;  3GOY A;  3SE2 A;  4LI8 A;  1WOK A;  4UX4 A;  4GNL A;  4MT9 A;  4GMZ A;  4HLK A;  4L34 A;  4UND A;  3SMI A;  1K3C A;  4GV4 A;  4PNN A;  5AKU A;  4BUS A;  2OLQ A;  2QF1 A;  4YW8 A;  3L3M A;  4L70 A;  4X52 A;  5AL3 A;  1YTM A;  4BUU A;  3P0Q A;  3HKV A;  4HLH A;  4L7R A;  4MSG A;  4KRS A;  4U6A A;  4ZZZ A;  4W5I A;  1UK1 A;  4L6S A;  4GNQ A;  3C49 A;  2RKE A;  2X5Y A;  5FH5 A;  5FPG A;  4TKG A;  5I67 A;  2RKD A;  4K4F A;  4UVL A;  4L7N A;  4UVP A;  4BFP A;  4HKN A;  1UK0 A;  5AL1 A;  4OPX C;  4TJW A;  4L10 A;  4GMW A;  4L09 A;  4TVJ A;  4UVY A;  4WOU A;  3U9Y A;  4J3L A;  4RCG A;  3P0P A;  4HHY A;  4WIU A;  5EBT A;  5C5R A;  2RF5 A;  4UI7 A;  4L0S A;  2PAX A;  4R43 A;  4TOR A;  4UUH A;  1KHG A;  4OQA C;  4UI5 A;  5C5Q A;  3KJD A;  4YW9 A;  4UHG A;  2FAF A;  3MOF A;  3MOH A;  4GMU A;  2RKA A;  4HMH A;  2QF2 A;  4TKI A;  4L0B A;  5ADT A;  4UI3 A;  1EFY A;  4UI4 A;  4HKI A;  4L6Z A;  5ECE A;  4PNS A;  4WL8 A;  4BU3 A;  4RV6 A;  4GNP A;  4GMM A;  4BUV A;  4L0I A;  3CE0 A;  4N3R A;  4BJ9 A;  4PJV A;  2FAH A;  4PML A;  4BUA A;  3DT7 A;  4BUD A;  5ADS A;  1YLH A;  4LI6 A;  1KHB A;  4KZQ A;  4UVO A;  1K3D A;  4UVX A;  3GJW A;  3P0N A;  5ADQ A;  5FH0 A;  1OEN A;  5FH2 A;  3KR8 A;  3GN7 A;  4L7P A;  1M51 A;  4WPU A;  4PJT A;  4TJU A;  4UVU A;  4HYF A;  2RCW A;  4HHZ A;  4KZL A;  4GV0 A;  4WPT A;  4L2G A;  5C5P A;  3MHK A;  4L2K A;  4BUT A;  4DQY C;  4J22 A;  4AVW A;  4PNL A;  3W51 A;  4PAX A;  4BUF A;  4UI6 A;  5AL2 A;  1J3B A;  1OS1 A;  4UVW A;  4AVU A;  1AYL A;  4UVS A;  4UFU A;  1GS0 A;  2RK7 A;  5LX6 A;  4L7L A;  3GEY A; 
#chains in the Genus database with same CATH homology
 1KHE A;  3BLJ A;  1II2 A;  4HLM A;  4BUW A;  2PXZ X;  4WIE A;  4F0E A;  4OQB C;  4WPV A;  3UH4 A;  1XKV A;  4L31 A;  1NHX A;  3C4H A;  1A26 A;  2PC9 A;  4UI8 A;  4HL5 A;  4PY4 A;  4UVT A;  3UDD A;  4W6E A;  4UVV A;  3PAX A;  1YVY A;  3KR7 A;  5FH4 A;  2QZY A;  4TJY A;  4BU5 A;  4YWB A;  4UXB A;  4L7U A;  5AKW A;  4TK0 A;  4OA7 A;  4OX2 A;  4TK5 A;  2OLR A;  4HKK A;  4XHU A;  2GMV A;  4L32 A;  5DCZ A;  4YWD A;  3SMJ A;  4GNO A;  3U9H A;  3MHJ A;  4HLF A;  4J1Z A;  4J21 A;  4PNM A;  4UVN A;  4GNM A;  4PNT A;  2QEY A;  4J3M A;  2RD6 A;  4N4V A;  4BU6 A;  4ZZY A;  4I9I A;  2PY7 X;  1KHF A;  2PQF A;  4R5W A;  4MSK A;  5LYH A;  3UH2 A;  4L0T A;  5ADR A;  3FHB A;  4BUI A;  2QEW A;  4BUY A;  3DT2 A;  4IUE A;  4TKF A;  5AL4 A;  5ETY A;  4PNQ A;  3UA9 A;  2PAW A;  4R6E A;  4ZZX A;  1PAX A;  4L2F A;  4BU7 A;  4K4E A;  2ZCI A;  4LI7 A;  4BJB A;  4BUE A;  5FH1 A;  4DVI A;  4L33 A;  4KZU A;  5AEH A;  4BUX A;  3MOE A;  4F1Q A;  3KCZ A;  4GV2 A;  4N4T A;  4HLG A;  4UVZ A;  5A00 A;  4BJC A;  4W5S A;  4PNR A;  4L0V A;  4UFY A;  5FPF A;  2RK8 A;  4TOS A;  5LXP A;  5AL5 A;  4BU9 A;  4F1L A;  4L7O A;  4UW1 A;  3L3L A;  1YGG A;  4M7B A;  4BS4 A;  5FH3 A;  1AQ2 A;  4BU8 A;  3DTB A;  3DT4 A;  4GV7 A;  3GOY A;  3SE2 A;  4LI8 A;  1WOK A;  4UX4 A;  4GNL A;  4MT9 A;  4GMZ A;  4HLK A;  4L34 A;  4UND A;  3SMI A;  1K3C A;  4GV4 A;  4PNN A;  5AKU A;  4BUS A;  2OLQ A;  2QF1 A;  4YW8 A;  3L3M A;  4L70 A;  4X52 A;  5AL3 A;  1YTM A;  4BUU A;  3P0Q A;  3HKV A;  4HLH A;  4L7R A;  4MSG A;  4KRS A;  4U6A A;  4ZZZ A;  4W5I A;  1UK1 A;  4L6S A;  4GNQ A;  3C49 A;  2RKE A;  2X5Y A;  5FH5 A;  5FPG A;  4TKG A;  5I67 A;  2RKD A;  4K4F A;  4UVL A;  4L7N A;  4UVP A;  4BFP A;  4HKN A;  1UK0 A;  5AL1 A;  4OPX C;  4TJW A;  4L10 A;  4GMW A;  4L09 A;  4TVJ A;  4UVY A;  4WOU A;  3U9Y A;  4J3L A;  4RCG A;  3P0P A;  4HHY A;  4WIU A;  5EBT A;  5C5R A;  2RF5 A;  4UI7 A;  4L0S A;  2PAX A;  4R43 A;  4TOR A;  4UUH A;  1KHG A;  4OQA C;  4UI5 A;  5C5Q A;  3KJD A;  4YW9 A;  4UHG A;  2FAF A;  3MOF A;  3MOH A;  4GMU A;  2RKA A;  4HMH A;  2QF2 A;  4TKI A;  4L0B A;  5ADT A;  4UI3 A;  1EFY A;  4UI4 A;  4HKI A;  4L6Z A;  5ECE A;  4PNS A;  4WL8 A;  4BU3 A;  4RV6 A;  4GNP A;  4GMM A;  4BUV A;  4L0I A;  3CE0 A;  4N3R A;  4BJ9 A;  4PJV A;  2FAH A;  4PML A;  4BUA A;  3DT7 A;  4BUD A;  5ADS A;  1YLH A;  4LI6 A;  1KHB A;  4KZQ A;  4UVO A;  1K3D A;  4UVX A;  3GJW A;  3P0N A;  5ADQ A;  5FH0 A;  1OEN A;  5FH2 A;  3KR8 A;  3GN7 A;  4L7P A;  1M51 A;  4WPU A;  4PJT A;  4TJU A;  4UVU A;  4HYF A;  2RCW A;  4HHZ A;  4KZL A;  4GV0 A;  4WPT A;  4L2G A;  5C5P A;  3MHK A;  4L2K A;  4BUT A;  4DQY C;  4J22 A;  4AVW A;  4PNL A;  3W51 A;  4PAX A;  4BUF A;  4UI6 A;  5AL2 A;  1J3B A;  1OS1 A;  4UVW A;  4AVU A;  1AYL A;  4UVS A;  4UFU A;  1GS0 A;  2RK7 A;  5LX6 A;  4L7L A;  3GEY A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1KHGA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations