1WOKA

Crystal structure of catalytic domain of human poly(adp-ribose) polymerase complexed with a quinoxaline-type inhibitor
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
350
structure length
350
Chain Sequence
KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors.
pubmed doi rcsb
molecule keywords Poly [ADP-ribose] polymerase-1
molecule tags Transferase
source organism Homo sapiens
total genus 94
structure length 350
sequence length 350
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2004-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00644 PARP Poly(ADP-ribose) polymerase catalytic domain
A PF02877 PARP_reg Poly(ADP-ribose) polymerase, regulatory domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.142.10 Mainly Alpha Up-down Bundle Poly(ADP-ribose) Polymerase; domain 1 Poly(ADP-ribose) polymerase, regulatory domain 1wokA01
3.90.228.10 Alpha Beta Alpha-Beta Complex Phosphoenolpyruvate Carboxykinase; domain 3 Phosphoenolpyruvate Carboxykinase; domain 3 1wokA02
4HLGA 4TJYA 4HLFA 4BFPA 4UVYA 3BLJA 2PAXA 5AL5A 5C5PA 3C4HA 4R5WA 4BS4A 5AL4A 4BUWA 4BUFA 5ADQA 4KZLA 4PNLA 4UVOA 5AEHA 3P0NA 3SMIA 4BUTA 4DVIA 4HYFA 4BUSA 4L0BA 4UXBA 3L3MA 4L7NA 4UI7A 1EFYA 3UH4A 4UVPA 2RF5A 4LI8A 5FPFA 4LI7A 4L7RA 4ZZXA 1GS0A 4OQAC 4UI5A 1UK1A 4L0VA 4BJBA 4L2GA 4BUAA 4W6EA 4PNSA 4BU5A 4L0TA 3L3LA 4F1QA 4UVNA 4N4TA 4W5IA 4PAXA 4M7BA 2RCWA 4TJWA 4OA7A 4KRSA 2RD6A 4R6EA 4L0IA 4L2KA 4L32A 3UDDA 4L10A 4UVUA 4KZUA 4PNRA 4TKIA 4AVUA 4OQBC 4XHUA 3GEYA 4K4EA 4IUEA 5C5RA 4UI4A 4UVVA 4W5SA 3UA9A 4BUVA 5FPGA 2PAWA 5AL1A 4PNMA 4L33A 4UNDA 4HLHA 4MSGA 4L7UA 4BUUA 3MHKA 3GJWA 4UFUA 4L6SA 4L2FA 3KCZA 4PNQA 4J21A 5ETYA 3KR7A 4L6ZA 4LI6A 4HL5A 4AVWA 4BUDA 4F0EA 3P0PA 4BJ9A 3U9HA 4UVTA 4PNNA 5ADRA 4MT9A 4N3RA 1PAXA 4UHGA 4K4FA 3P0QA 4TORA 4HMHA 4BUYA 5AL3A 4L7PA 3CE0A 4TOSA 4GV4A 4J3MA 4J1ZA 1UK0A 4BUXA 4L09A 2PQFA 4L34A 4U6AA 4MSKA 4UVSA 5ECEA 4UVLA 4OPXC 4TK0A 4L31A 3GOYA 4PNTA 3HKVA 4UI6A 4BU3A 4L7OA 4UFYA 5LX6A 5AL2A 5LXPA 4UW1A 5AKWA 4UX4A 3UH2A 4ZZZA 4HLKA 4DQYC 4UVXA 4TK5A 4L0SA 1WOKA 4PJTA 2X5YA 4PMLA 3SE2A 3U9YA 4L70A 3MHJA 5EBTA 4GV2A 4I9IA 5C5QA 5ADSA 4GV7A 4HLMA 3GN7A 4RV6A 4HKNA 4N4VA 5AKUA 5DCZA 4TKGA 3KJDA 4J3LA 4BJCA 3KR8A 3C49A 3FHBA 4L7LA 5ADTA 4HHYA 4F1LA 4TJUA 4UI3A 1A26A 4UVWA 3SMJA 4UUHA 4HKIA 4UVZA 4BU7A 4TVJA 4ZZYA 4KZQA 4PJVA 3W51A 3PAXA 4PY4A 4BU9A 4BU6A 4J22A 4HKKA 4GV0A 4UI8A 4BUIA 4TKFA 4HHZA 4BUEA 5LYHA 4BU8A 5A00A 4X52A
chains in the Genus database with same CATH superfamily
1KHEA 5FH1A 4WIUA 1OS1A 4JNGA 2RK7A 3BLJA 5C5PA 4UVOA 3SMIA 4BUSA 4L0BA 4UXBA 3UH4A 4GNPA 4GNQA 1AYLA 4L2GA 4W6EA 4PNSA 4R43A 4L0TA 4UVNA 4N4TA 4W5IA 1OENA 4KRSA 4L32A 4PNRA 3GEYA 3UA9A 5I67A 2PAWA 2PC9A 4L2FA 3KCZA 3KR7A 4AVWA 4BJ9A 3U9HA 4PNNA 4IJSA 5FH0A 4J1JA 4J3MA 4YWDA 4WPVA 4L34A 4WPTA 4TK0A 4UVLA 4PNTA 4UI6A 4BU3A 1AQ2A 4UW1A 2QZYA 5AKWA 4HLKA 4IDUA 4L70A 5FH3A 4N4VA 5AKUA 3GN7A 4WOUA 4L7LA 5ADTA 4F1LA 4TJUA 1KHBA 4KZQA 4BU9A 4UI8A 3DT7A 4BUIA 5A00A 4BFPA 4UVYA 2QF1A 1II2A 2PAXA 4BUFA 1YLHA 5AL4A 5ADQA 3L3MA 4UI7A 1EFYA 4WIEA 4UVPA 4LI7A 4L7RA 1UK1A 4L0VA 4BJBA 1KHGA 4BU5A 4GMMA 4F1QA 4PAXA 4M7BA 2RCWA 4BHHB 3UDDA 4R6EA 4L0IA 4KZUA 4AVUA 4XHUA 4IUEA 4IDUB 4UI4A 3DTBA 4BUVA 4UNDA 4HLHA 3GJWA 4L6SA 4L6ZA 4HL5A 3P0PA 4WL8A 5ADRA 1PAXA 3MOEA 4TOSA 4J1ZA 4BUXA 4L09A 2PQFA 4U6AA 4L7OA 4GNMA 4DQYC 3ZLAA 4L0SA 4PJTA 3SE2A 2FAFA 4I9IA 2FAHA 4GV7A 2RKAA 4HKNA 4TKGA 4GMZA 1A26A 4UVWA 4UVZA 4HKIA 4TVJA 3PAXA 4PY4A 5FH4A 4J22A 5LYHA 4BUUA 4HLGA 4X52A 1K3CA 3C4HA 4R5WA 4BUWA 4KZLA 5AEHA 3P0NA 4BUTA 4HYFA 4L7NA 4BUAA 3L3LA 4TJWA 1KHFA 4L2KA 2RD6A 2PXZX 3MOFA 4TKIA 4K4EA 5C5RA 4PNMA 2GMVA 4GMWA 4L33A 4MSGA 4J21A 2QEYA 4LI6A 4BUDA 4UVTA 2RKDA 4MT9A 1YVYA 4N3RA 3P0QA 5AL3A 4L7PA 1UK0A 4IDXA 3DT2A 4YW8A 4UVSA 5ECEA 4OPXC 4L31A 4YWBA 4UX4A 4ZZZA 4UVXA 4RCGA 1WOKA 3U9YA 3MHJA 5EBTA 5ADSA 5C5QA 4GV2A 4HLMA 4RV6A 4J3LA 3C49A 4OX2A 4HHYA 4UUHA 4BU7A 4ZZYA 4PJVA 4TKFA 4HHZA 4TJYA 4HLFA 5AL5A 4BS4A 4PNLA 4DVIA 4BGPA 2RF5A 4LI8A 5FPFA 5FH5A 4ZZXA 1GS0A 4OQAC 4UI5A 2QF2A 2QEWA 2RK8A 4OA7A 2OLQA 4L10A 4UVUA 4GNLA 4OQBC 4UVVA 4W5SA 5FPGA 5AL1A 1YGGA 4L7UA 3MHKA 1K3DA 4UFUA 4PNQA 5ETYA 4F0EA 3DT4A 4UHGA 4K4FA 4TORA 4HMHA 4BUYA 4GMUA 3CE0A 4GV4A 1YTMA 4WPUA 4MSKA 3GOYA 3HKVA 2PY7X 4GNOA 4UFYA 1NHXA 5LX6A 5AL2A 5LXPA 3UH2A 1J3BA 2ZCIA 4TK5A 2RKEA 4J1GA 2X5YA 4PMLA 2OLRA 1M51A 5DCZA 3KJDA 4BJCA 3KR8A 3FHBA 3MOHA 1XKVA 4YW9A 4UI3A 5FH2A 3ZL9A 3SMJA 3W51A 4BU6A 4HKKA 4GV0A 4BU8A 4BUEA
chains in the Genus database with same CATH topology
4HLGA 1KHEA 4TJYA 5FH1A 4HLFA 1K3CA 4BFPA 4UVYA 2QF1A 1II2A 4WIUA 1OS1A 2RK7A 3BLJA 2PAXA 5AL5A 5C5PA 3C4HA 4R5WA 4BS4A 1YLHA 5AL4A 4BUWA 4BUFA 5ADQA 4KZLA 4PNLA 4UVOA 5AEHA 3P0NA 3SMIA 4BUTA 4DVIA 4HYFA 4BUSA 4L0BA 4UXBA 3L3MA 4L7NA 4UI7A 1EFYA 4WIEA 3UH4A 4UVPA 2RF5A 4GNPA 4LI8A 4LI7A 4L7RA 4BUIA 5FPFA 4ZZXA 5FH5A 1GS0A 4GNQA 3UDDA 4OQAC 4UI5A 1UK1A 4L0VA 1AYLA 4BJBA 1KHGA 4L2GA 2QF2A 2QEWA 4BUAA 4W6EA 4PNSA 4R43A 4BU5A 4L0TA 3L3LA 4GMMA 4F1QA 4UVNA 2RK8A 4N4TA 4W5IA 4PAXA 4M7BA 2RCWA 1KHFA 4TJWA 4OA7A 1OENA 4KRSA 2RD6A 4R6EA 2OLQA 4L0IA 2PXZX 4L2KA 4L10A 3MOFA 4L32A 4KZUA 4UVUA 4PNRA 4TKIA 4AVUA 4GNLA 4OQBC 4XHUA 3GEYA 4K4EA 4IUEA 5C5RA 4UI4A 4UVVA 4W5SA 3UA9A 5I67A 3DTBA 5ADSA 4BUVA 5FPGA 2PAWA 5AL1A 4PNMA 2GMVA 4GMWA 4L33A 4UNDA 1YGGA 4HLHA 4L7UA 4MSGA 2PC9A 3MHKA 3GJWA 1K3DA 4L6SA 4UFUA 4BUUA 4L2FA 3KCZA 4PNQA 4J21A 2QEYA 3KR7A 4L6ZA 5ETYA 4LI6A 4HL5A 4AVWA 4BUDA 4F0EA 3P0PA 4BJ9A 3U9HA 4UVTA 4YW8A 2RKDA 4WL8A 4PNNA 3DT4A 4MT9A 1YVYA 5FH0A 5ADRA 4N3RA 1PAXA 3MOEA 4UHGA 4K4FA 3P0QA 4TORA 4HMHA 4BUYA 4GMUA 5AL3A 4L7PA 3CE0A 4TOSA 4GV4A 1YTMA 4J3MA 4J1ZA 4WPUA 4TK0A 1UK0A 4BUXA 4YWDA 3DT2A 4L09A 2PQFA 4L34A 4U6AA 4MSKA 4UVSA 4WPTA 4UVLA 4OPXC 4WPVA 5ECEA 4L31A 3GOYA 4PNTA 3HKVA 4UI6A 2PY7X 4BU3A 4YWBA 4L7OA 4GNOA 4UFYA 1NHXA 5LX6A 5AL2A 1AQ2A 5LXPA 4UW1A 2QZYA 4UX4A 4GNMA 5AKWA 4ZZZA 3UH2A 4HLKA 1J3BA 4DQYC 2ZCIA 4UVXA 4RCGA 4TK5A 4L0SA 1WOKA 4PJTA 2RKEA 2X5YA 4PMLA 2FAFA 4L70A 3MHJA 5EBTA 5C5QA 3SE2A 3U9YA 5FH3A 4GV2A 2OLRA 4I9IA 2FAHA 4GV7A 1M51A 3GN7A 4RV6A 2RKAA 4HKNA 4HLMA 4N4VA 4TKGA 5AKUA 3KJDA 5DCZA 4J3LA 4BJCA 3KR8A 3C49A 4GMZA 4WOUA 3FHBA 3MOHA 1XKVA 4OX2A 4L7LA 4YW9A 5ADTA 4HHYA 4F1LA 4TJUA 4UI3A 1A26A 5FH2A 4UVWA 3SMJA 4UUHA 4HKIA 4UVZA 4BU7A 4TVJA 4ZZYA 1KHBA 4PJVA 4KZQA 3PAXA 4PY4A 5FH4A 3W51A 4BU9A 4BU6A 4J22A 4HKKA 4GV0A 4UI8A 3DT7A 4TKFA 4HHZA 4BUEA 5LYHA 4BU8A 5A00A 4X52A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HLG A;  4TJY A;  4HLF A;  4BFP A;  4UVY A;  3BLJ A;  2PAX A;  5AL5 A;  5C5P A;  3C4H A;  4R5W A;  4BS4 A;  5AL4 A;  4BUW A;  4BUF A;  5ADQ A;  4KZL A;  4PNL A;  4UVO A;  5AEH A;  3P0N A;  3SMI A;  4BUT A;  4DVI A;  4HYF A;  4BUS A;  4L0B A;  4UXB A;  3L3M A;  4L7N A;  4UI7 A;  1EFY A;  3UH4 A;  4UVP A;  2RF5 A;  4LI8 A;  5FPF A;  4LI7 A;  4L7R A;  4ZZX A;  1GS0 A;  4OQA C;  4UI5 A;  1UK1 A;  4L0V A;  4BJB A;  4L2G A;  4BUA A;  4W6E A;  4PNS A;  4BU5 A;  4L0T A;  3L3L A;  4F1Q A;  4UVN A;  4N4T A;  4W5I A;  4PAX A;  4M7B A;  2RCW A;  4TJW A;  4OA7 A;  4KRS A;  2RD6 A;  4R6E A;  4L0I A;  4L2K A;  4L32 A;  3UDD A;  4L10 A;  4UVU A;  4KZU A;  4PNR A;  4TKI A;  4AVU A;  4OQB C;  4XHU A;  3GEY A;  4K4E A;  4IUE A;  5C5R A;  4UI4 A;  4UVV A;  4W5S A;  3UA9 A;  4BUV A;  5FPG A;  2PAW A;  5AL1 A;  4PNM A;  4L33 A;  4UND A;  4HLH A;  4MSG A;  4L7U A;  4BUU A;  3MHK A;  3GJW A;  4UFU A;  4L6S A;  4L2F A;  3KCZ A;  4PNQ A;  4J21 A;  5ETY A;  3KR7 A;  4L6Z A;  4LI6 A;  4HL5 A;  4AVW A;  4BUD A;  4F0E A;  3P0P A;  4BJ9 A;  3U9H A;  4UVT A;  4PNN A;  5ADR A;  4MT9 A;  4N3R A;  1PAX A;  4UHG A;  4K4F A;  3P0Q A;  4TOR A;  4HMH A;  4BUY A;  5AL3 A;  4L7P A;  3CE0 A;  4TOS A;  4GV4 A;  4J3M A;  4J1Z A;  1UK0 A;  4BUX A;  4L09 A;  2PQF A;  4L34 A;  4U6A A;  4MSK A;  4UVS A;  5ECE A;  4UVL A;  4OPX C;  4TK0 A;  4L31 A;  3GOY A;  4PNT A;  3HKV A;  4UI6 A;  4BU3 A;  4L7O A;  4UFY A;  5LX6 A;  5AL2 A;  5LXP A;  4UW1 A;  5AKW A;  4UX4 A;  3UH2 A;  4ZZZ A;  4HLK A;  4DQY C;  4UVX A;  4TK5 A;  4L0S A;  1WOK A;  4PJT A;  2X5Y A;  4PML A;  3SE2 A;  3U9Y A;  4L70 A;  3MHJ A;  5EBT A;  4GV2 A;  4I9I A;  5C5Q A;  5ADS A;  4GV7 A;  4HLM A;  3GN7 A;  4RV6 A;  4HKN A;  4N4V A;  5AKU A;  5DCZ A;  4TKG A;  3KJD A;  4J3L A;  4BJC A;  3KR8 A;  3C49 A;  3FHB A;  4L7L A;  5ADT A;  4HHY A;  4F1L A;  4TJU A;  4UI3 A;  1A26 A;  4UVW A;  3SMJ A;  4UUH A;  4HKI A;  4UVZ A;  4BU7 A;  4TVJ A;  4ZZY A;  4KZQ A;  4PJV A;  3W51 A;  3PAX A;  4PY4 A;  4BU9 A;  4BU6 A;  4J22 A;  4HKK A;  4GV0 A;  4UI8 A;  4BUI A;  4TKF A;  4HHZ A;  4BUE A;  5LYH A;  4BU8 A;  5A00 A;  4X52 A; 
#chains in the Genus database with same CATH topology
 1KHE A;  5FH1 A;  4WIU A;  1OS1 A;  4JNG A;  2RK7 A;  3BLJ A;  5C5P A;  4UVO A;  3SMI A;  4BUS A;  4L0B A;  4UXB A;  3UH4 A;  4GNP A;  4GNQ A;  1AYL A;  4L2G A;  4W6E A;  4PNS A;  4R43 A;  4L0T A;  4UVN A;  4N4T A;  4W5I A;  1OEN A;  4KRS A;  4L32 A;  4PNR A;  3GEY A;  3UA9 A;  5I67 A;  2PAW A;  2PC9 A;  4L2F A;  3KCZ A;  3KR7 A;  4AVW A;  4BJ9 A;  3U9H A;  4PNN A;  4IJS A;  5FH0 A;  4J1J A;  4J3M A;  4YWD A;  4WPV A;  4L34 A;  4WPT A;  4TK0 A;  4UVL A;  4PNT A;  4UI6 A;  4BU3 A;  1AQ2 A;  4UW1 A;  2QZY A;  5AKW A;  4HLK A;  4IDU A;  4L70 A;  5FH3 A;  4N4V A;  5AKU A;  3GN7 A;  4WOU A;  4L7L A;  5ADT A;  4F1L A;  4TJU A;  1KHB A;  4KZQ A;  4BU9 A;  4UI8 A;  3DT7 A;  4BUI A;  5A00 A;  4BFP A;  4UVY A;  2QF1 A;  1II2 A;  2PAX A;  4BUF A;  1YLH A;  5AL4 A;  5ADQ A;  3L3M A;  4UI7 A;  1EFY A;  4WIE A;  4UVP A;  4LI7 A;  4L7R A;  1UK1 A;  4L0V A;  4BJB A;  1KHG A;  4BU5 A;  4GMM A;  4F1Q A;  4PAX A;  4M7B A;  2RCW A;  4BHH B;  3UDD A;  4R6E A;  4L0I A;  4KZU A;  4AVU A;  4XHU A;  4IUE A;  4IDU B;  4UI4 A;  3DTB A;  4BUV A;  4UND A;  4HLH A;  3GJW A;  4L6S A;  4L6Z A;  4HL5 A;  3P0P A;  4WL8 A;  5ADR A;  1PAX A;  3MOE A;  4TOS A;  4J1Z A;  4BUX A;  4L09 A;  2PQF A;  4U6A A;  4L7O A;  4GNM A;  4DQY C;  3ZLA A;  4L0S A;  4PJT A;  3SE2 A;  2FAF A;  4I9I A;  2FAH A;  4GV7 A;  2RKA A;  4HKN A;  4TKG A;  4GMZ A;  1A26 A;  4UVW A;  4UVZ A;  4HKI A;  4TVJ A;  3PAX A;  4PY4 A;  5FH4 A;  4J22 A;  5LYH A;  4BUU A;  4HLG A;  4X52 A;  1K3C A;  3C4H A;  4R5W A;  4BUW A;  4KZL A;  5AEH A;  3P0N A;  4BUT A;  4HYF A;  4L7N A;  4BUA A;  3L3L A;  4TJW A;  1KHF A;  4L2K A;  2RD6 A;  2PXZ X;  3MOF A;  4TKI A;  4K4E A;  5C5R A;  4PNM A;  2GMV A;  4GMW A;  4L33 A;  4MSG A;  4J21 A;  2QEY A;  4LI6 A;  4BUD A;  4UVT A;  2RKD A;  4MT9 A;  1YVY A;  4N3R A;  3P0Q A;  5AL3 A;  4L7P A;  1UK0 A;  4IDX A;  3DT2 A;  4YW8 A;  4UVS A;  5ECE A;  4OPX C;  4L31 A;  4YWB A;  4UX4 A;  4ZZZ A;  4UVX A;  4RCG A;  1WOK A;  3U9Y A;  3MHJ A;  5EBT A;  5ADS A;  5C5Q A;  4GV2 A;  4HLM A;  4RV6 A;  4J3L A;  3C49 A;  4OX2 A;  4HHY A;  4UUH A;  4BU7 A;  4ZZY A;  4PJV A;  4TKF A;  4HHZ A;  4TJY A;  4HLF A;  5AL5 A;  4BS4 A;  4PNL A;  4DVI A;  4BGP A;  2RF5 A;  4LI8 A;  5FPF A;  5FH5 A;  4ZZX A;  1GS0 A;  4OQA C;  4UI5 A;  2QF2 A;  2QEW A;  2RK8 A;  4OA7 A;  2OLQ A;  4L10 A;  4UVU A;  4GNL A;  4OQB C;  4UVV A;  4W5S A;  5FPG A;  5AL1 A;  1YGG A;  4L7U A;  3MHK A;  1K3D A;  4UFU A;  4PNQ A;  5ETY A;  4F0E A;  3DT4 A;  4UHG A;  4K4F A;  4TOR A;  4HMH A;  4BUY A;  4GMU A;  3CE0 A;  4GV4 A;  1YTM A;  4WPU A;  4MSK A;  3GOY A;  3HKV A;  2PY7 X;  4GNO A;  4UFY A;  1NHX A;  5LX6 A;  5AL2 A;  5LXP A;  3UH2 A;  1J3B A;  2ZCI A;  4TK5 A;  2RKE A;  4J1G A;  2X5Y A;  4PML A;  2OLR A;  1M51 A;  5DCZ A;  3KJD A;  4BJC A;  3KR8 A;  3FHB A;  3MOH A;  1XKV A;  4YW9 A;  4UI3 A;  5FH2 A;  3ZL9 A;  3SMJ A;  3W51 A;  4BU6 A;  4HKK A;  4GV0 A;  4BU8 A;  4BUE A; 
#chains in the Genus database with same CATH homology
 4HLG A;  1KHE A;  4TJY A;  5FH1 A;  4HLF A;  1K3C A;  4BFP A;  4UVY A;  2QF1 A;  1II2 A;  4WIU A;  1OS1 A;  2RK7 A;  3BLJ A;  2PAX A;  5AL5 A;  5C5P A;  3C4H A;  4R5W A;  4BS4 A;  1YLH A;  5AL4 A;  4BUW A;  4BUF A;  5ADQ A;  4KZL A;  4PNL A;  4UVO A;  5AEH A;  3P0N A;  3SMI A;  4BUT A;  4DVI A;  4HYF A;  4BUS A;  4L0B A;  4UXB A;  3L3M A;  4L7N A;  4UI7 A;  1EFY A;  4WIE A;  3UH4 A;  4UVP A;  2RF5 A;  4GNP A;  4LI8 A;  4LI7 A;  4L7R A;  4BUI A;  5FPF A;  4ZZX A;  5FH5 A;  1GS0 A;  4GNQ A;  3UDD A;  4OQA C;  4UI5 A;  1UK1 A;  4L0V A;  1AYL A;  4BJB A;  1KHG A;  4L2G A;  2QF2 A;  2QEW A;  4BUA A;  4W6E A;  4PNS A;  4R43 A;  4BU5 A;  4L0T A;  3L3L A;  4GMM A;  4F1Q A;  4UVN A;  2RK8 A;  4N4T A;  4W5I A;  4PAX A;  4M7B A;  2RCW A;  1KHF A;  4TJW A;  4OA7 A;  1OEN A;  4KRS A;  2RD6 A;  4R6E A;  2OLQ A;  4L0I A;  2PXZ X;  4L2K A;  4L10 A;  3MOF A;  4L32 A;  4KZU A;  4UVU A;  4PNR A;  4TKI A;  4AVU A;  4GNL A;  4OQB C;  4XHU A;  3GEY A;  4K4E A;  4IUE A;  5C5R A;  4UI4 A;  4UVV A;  4W5S A;  3UA9 A;  5I67 A;  3DTB A;  5ADS A;  4BUV A;  5FPG A;  2PAW A;  5AL1 A;  4PNM A;  2GMV A;  4GMW A;  4L33 A;  4UND A;  1YGG A;  4HLH A;  4L7U A;  4MSG A;  2PC9 A;  3MHK A;  3GJW A;  1K3D A;  4L6S A;  4UFU A;  4BUU A;  4L2F A;  3KCZ A;  4PNQ A;  4J21 A;  2QEY A;  3KR7 A;  4L6Z A;  5ETY A;  4LI6 A;  4HL5 A;  4AVW A;  4BUD A;  4F0E A;  3P0P A;  4BJ9 A;  3U9H A;  4UVT A;  4YW8 A;  2RKD A;  4WL8 A;  4PNN A;  3DT4 A;  4MT9 A;  1YVY A;  5FH0 A;  5ADR A;  4N3R A;  1PAX A;  3MOE A;  4UHG A;  4K4F A;  3P0Q A;  4TOR A;  4HMH A;  4BUY A;  4GMU A;  5AL3 A;  4L7P A;  3CE0 A;  4TOS A;  4GV4 A;  1YTM A;  4J3M A;  4J1Z A;  4WPU A;  4TK0 A;  1UK0 A;  4BUX A;  4YWD A;  3DT2 A;  4L09 A;  2PQF A;  4L34 A;  4U6A A;  4MSK A;  4UVS A;  4WPT A;  4UVL A;  4OPX C;  4WPV A;  5ECE A;  4L31 A;  3GOY A;  4PNT A;  3HKV A;  4UI6 A;  2PY7 X;  4BU3 A;  4YWB A;  4L7O A;  4GNO A;  4UFY A;  1NHX A;  5LX6 A;  5AL2 A;  1AQ2 A;  5LXP A;  4UW1 A;  2QZY A;  4UX4 A;  4GNM A;  5AKW A;  4ZZZ A;  3UH2 A;  4HLK A;  1J3B A;  4DQY C;  2ZCI A;  4UVX A;  4RCG A;  4TK5 A;  4L0S A;  1WOK A;  4PJT A;  2RKE A;  2X5Y A;  4PML A;  2FAF A;  4L70 A;  3MHJ A;  5EBT A;  5C5Q A;  3SE2 A;  3U9Y A;  5FH3 A;  4GV2 A;  2OLR A;  4I9I A;  2FAH A;  4GV7 A;  1M51 A;  3GN7 A;  4RV6 A;  2RKA A;  4HKN A;  4HLM A;  4N4V A;  4TKG A;  5AKU A;  3KJD A;  5DCZ A;  4J3L A;  4BJC A;  3KR8 A;  3C49 A;  4GMZ A;  4WOU A;  3FHB A;  3MOH A;  1XKV A;  4OX2 A;  4L7L A;  4YW9 A;  5ADT A;  4HHY A;  4F1L A;  4TJU A;  4UI3 A;  1A26 A;  5FH2 A;  4UVW A;  3SMJ A;  4UUH A;  4HKI A;  4UVZ A;  4BU7 A;  4TVJ A;  4ZZY A;  1KHB A;  4PJV A;  4KZQ A;  3PAX A;  4PY4 A;  5FH4 A;  3W51 A;  4BU9 A;  4BU6 A;  4J22 A;  4HKK A;  4GV0 A;  4UI8 A;  3DT7 A;  4TKF A;  4HHZ A;  4BUE A;  5LYH A;  4BU8 A;  5A00 A;  4X52 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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