The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
203
|
sequence length |
613
|
structure length |
602
|
Chain Sequence |
NLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEALGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLVLGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWDKEVEDIEKYLVDQVNADLPCEIEREILALKQRISQM
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase.
pubmed doi rcsb |
| molecule tags |
Lyase
|
| source organism |
Homo sapiens
|
| molecule keywords |
Phosphoenolpyruvate carboxykinase, cytosolic
|
| total genus |
203
|
| structure length |
602
|
| sequence length |
613
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
4.1.1.32: Phosphoenolpyruvate carboxykinase (GTP). |
| pdb deposition date | 2006-04-07 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00821 | PEPCK_GTP | Phosphoenolpyruvate carboxykinase C-terminal P-loop domain |
| A | PF17297 | PEPCK_N | Phosphoenolpyruvate carboxykinase N-terminal domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Beta Complex | Phosphoenolpyruvate Carboxykinase; domain 2 | Phosphoenolpyruvate Carboxykinase, domain 2 | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Phosphoenolpyruvate Carboxykinase; domain 1 | Phosphoenolpyruvate Carboxykinase, domain 1 | ||
| Alpha Beta | Alpha-Beta Complex | Phosphoenolpyruvate Carboxykinase; domain 3 | Phosphoenolpyruvate Carboxykinase; domain 3 |
#chains in the Genus database with same CATH superfamily 2PC9 A; 2RKA A; 1OEN A; 4GMZ A; 4WPV A; 2RKD A; 5FH0 A; 2FAH A; 1J3B A; 2OLR A; 4WPT A; 5I67 A; 2QEY A; 3MOF A; 4GNQ A; 4RCG A; 3DT4 A; 3DT7 A; 1NHX A; 1KHG A; 3DT2 A; 2ZCI A; 1YGG A; 2RKE A; 4WL8 A; 2PXZ X; 3MOH A; 2RK7 A; 3DTB A; 5FH5 A; 2PY7 X; 2OLQ A; 2RK8 A; 1KHF A; 1XKV A; 2QZY A; 4WPU A; 4GMM A; 1K3C A; 3MOE A; 5FH1 A; 4YWD A; 1II2 A; 5FH4 A; 4GMW A; 1M51 A; 1KHB A; 5FH2 A; 4GNL A; 4GNP A; 1YLH A; 4YW9 A; 2FAF A; 2GMV A; 4R43 A; 5FH3 A; 2QF2 A; 1AQ2 A; 1K3D A; 4OX2 A; 4WIE A; 1AYL A; 4WOU A; 1KHE A; 2QEW A; 4GNO A; 1YVY A; 4WIU A; 4YW8 A; 1YTM A; 4GNM A; 2QF1 A; 1OS1 A; 4GMU A; 4YWB A; #chains in the Genus database with same CATH topology 4GV4 A; 4TVJ A; 4UI3 A; 2RCW A; 4OQA C; 5FPG A; 1J3B A; 5A00 A; 4L7L A; 4RCG A; 4L0B A; 4BJC A; 3DT4 A; 4BS4 A; 5LXP A; 1NHX A; 1KHG A; 1WOK A; 4LI8 A; 2RKE A; 3SMI A; 5FH5 A; 3GOY A; 4UFU A; 4K4F A; 4TKG A; 5AL3 A; 4BUU A; 1KHF A; 4WPU A; 4J22 A; 4BUW A; 4L0S A; 4KZQ A; 4BU6 A; 3MOE A; 1GS0 A; 4F1Q A; 4N4T A; 5FH4 A; 4ZZY A; 4UVU A; 3FHB A; 4TK0 A; 3MHK A; 4KRS A; 4GNL A; 4U6A A; 1YLH A; 3U9H A; 5LYH A; 4HLF A; 2QF2 A; 1UK0 A; 1AQ2 A; 1UK1 A; 4L33 A; 1K3D A; 3BLJ A; 4L6Z A; 3KR7 A; 4R5W A; 2QEW A; 5AL2 A; 4J3M A; 1EFY A; 3HKV A; 4L6S A; 1YVY A; 4HMH A; 4MSK A; 5AL5 A; 3UH4 A; 1YTM A; 4GNM A; 4PNR A; 1OS1 A; 5DCZ A; 3SMJ A; 4TOS A; 2RKA A; 4HKN A; 4HKI A; 3W51 A; 4BFP A; 4UVO A; 4L34 A; 4BUF A; 5I67 A; 4TOR A; 2QEY A; 4ZZZ A; 5FPF A; 4BUA A; 4L2K A; 4HHZ A; 4PNL A; 2PXZ X; 4GV0 A; 2RK7 A; 4BUV A; 3DTB A; 3KCZ A; 4BUE A; 4OQB C; 2OLQ A; 4PNQ A; 4BJ9 A; 1XKV A; 4BUT A; 4UW1 A; 5C5P A; 3L3L A; 4ZZX A; 4YWD A; 4HLM A; 1M51 A; 4L0T A; 4MT9 A; 1KHB A; 4LI7 A; 4UND A; 1PAX A; 4J3L A; 4L7U A; 4L32 A; 4TKI A; 3PAX A; 4GNP A; 4UVY A; 4MSG A; 2GMV A; 4OPX C; 3CE0 A; 4AVW A; 5ADQ A; 4L09 A; 4R6E A; 4BUI A; 2PQF A; 4OX2 A; 4WIE A; 4PAX A; 4BU3 A; 4BUY A; 4W5S A; 4L7R A; 4PJT A; 4PML A; 4YW8 A; 2RD6 A; 3C4H A; 4UVV A; 4UVL A; 2QF1 A; 4KZU A; 4TJU A; 4OA7 A; 4X52 A; 4HLG A; 3KR8 A; 1OEN A; 4GMZ A; 4WPV A; 2RKD A; 3L3M A; 2FAH A; 2OLR A; 4L10 A; 4BU5 A; 4WPT A; 4UUH A; 3MOF A; 4UI5 A; 3DT2 A; 2ZCI A; 1YGG A; 3GN7 A; 3MOH A; 4UI8 A; 4L0V A; 4TJW A; 4UFY A; 5AL1 A; 2PY7 X; 2RK8 A; 4W5I A; 3UH2 A; 4GV2 A; 4GMM A; 1K3C A; 5FH1 A; 1II2 A; 4L0I A; 3GJW A; 4GMW A; 4HLK A; 4BUS A; 4TJY A; 4TKF A; 4UVT A; 2RF5 A; 4HLH A; 4M7B A; 3UDD A; 4F0E A; 5FH2 A; 4L2G A; 4L7O A; 4YW9 A; 4L7P A; 5ADS A; 4PNM A; 4UVP A; 4UHG A; 4L70 A; 2PAW A; 4I9I A; 4WOU A; 3MHJ A; 4UX4 A; 3GEY A; 4W6E A; 1KHE A; 4GNO A; 4IUE A; 4UI7 A; 4TK5 A; 4WIU A; 5AL4 A; 4PNT A; 4L31 A; 4R43 A; 3P0Q A; 4BJB A; 5ADR A; 3UA9 A; 4PJV A; 2PC9 A; 4UVS A; 5ETY A; 5FH0 A; 4LI6 A; 5ADT A; 4UI6 A; 4PY4 A; 4BUX A; 4GNQ A; 3DT7 A; 4L7N A; 4WL8 A; 3P0N A; 4BU8 A; 4KZL A; 5AKW A; 5AEH A; 3C49 A; 4UVX A; 4UVW A; 4UVN A; 4K4E A; 4DQY C; 2QZY A; 4N3R A; 2X5Y A; 4DVI A; 4RV6 A; 5AKU A; 4HKK A; 4HL5 A; 5C5R A; 5LX6 A; 4GV7 A; 4UI4 A; 2PAX A; 3P0P A; 1A26 A; 3U9Y A; 4UXB A; 5ECE A; 3KJD A; 4L2F A; 4PNN A; 4HYF A; 4BU7 A; 2FAF A; 4BU9 A; 4AVU A; 5FH3 A; 4J1Z A; 4BUD A; 4XHU A; 3SE2 A; 5EBT A; 1AYL A; 4F1L A; 4PNS A; 4UVZ A; 4N4V A; 5C5Q A; 4GMU A; 4J21 A; 4HHY A; 4YWB A; #chains in the Genus database with same CATH homology 4GV4 A; 4TVJ A; 4UI3 A; 2RCW A; 4OQA C; 5FPG A; 1J3B A; 5A00 A; 4L7L A; 4RCG A; 4L0B A; 4BJC A; 3DT4 A; 4BS4 A; 5LXP A; 1NHX A; 1KHG A; 1WOK A; 4LI8 A; 2RKE A; 3SMI A; 5FH5 A; 3GOY A; 4UFU A; 4K4F A; 4TKG A; 5AL3 A; 4BUU A; 1KHF A; 4WPU A; 4J22 A; 4BUW A; 4L0S A; 4KZQ A; 4BU6 A; 3MOE A; 1GS0 A; 4F1Q A; 4N4T A; 5FH4 A; 4ZZY A; 4UVU A; 3FHB A; 4TK0 A; 3MHK A; 4KRS A; 4GNL A; 4U6A A; 1YLH A; 3U9H A; 5LYH A; 4HLF A; 2QF2 A; 1UK0 A; 1AQ2 A; 1UK1 A; 4L33 A; 1K3D A; 3BLJ A; 4L6Z A; 3KR7 A; 4R5W A; 2QEW A; 5AL2 A; 4J3M A; 1EFY A; 3HKV A; 4L6S A; 1YVY A; 4HMH A; 4MSK A; 5AL5 A; 3UH4 A; 1YTM A; 4GNM A; 4PNR A; 1OS1 A; 5DCZ A; 3SMJ A; 4TOS A; 2RKA A; 4HKN A; 4HKI A; 3W51 A; 4BFP A; 4UVO A; 4L34 A; 4BUF A; 5I67 A; 4TOR A; 2QEY A; 4ZZZ A; 5FPF A; 4BUA A; 4L2K A; 4HHZ A; 4PNL A; 2PXZ X; 4GV0 A; 2RK7 A; 4BUV A; 3DTB A; 3KCZ A; 4BUE A; 4OQB C; 2OLQ A; 4PNQ A; 4BJ9 A; 1XKV A; 4BUT A; 4UW1 A; 5C5P A; 3L3L A; 4ZZX A; 4YWD A; 4HLM A; 1M51 A; 4L0T A; 4MT9 A; 1KHB A; 4LI7 A; 4UND A; 1PAX A; 4J3L A; 4L7U A; 4L32 A; 4TKI A; 3PAX A; 4GNP A; 4UVY A; 4MSG A; 2GMV A; 4OPX C; 3CE0 A; 4AVW A; 5ADQ A; 4L09 A; 4R6E A; 4BUI A; 2PQF A; 4OX2 A; 4WIE A; 4PAX A; 4BU3 A; 4BUY A; 4W5S A; 4L7R A; 4PJT A; 4PML A; 4YW8 A; 2RD6 A; 3C4H A; 4UVV A; 4UVL A; 2QF1 A; 4KZU A; 4TJU A; 4OA7 A; 4X52 A; 4HLG A; 3KR8 A; 1OEN A; 4GMZ A; 4WPV A; 2RKD A; 3L3M A; 2FAH A; 2OLR A; 4L10 A; 4BU5 A; 4WPT A; 4UUH A; 3MOF A; 4UI5 A; 3DT2 A; 2ZCI A; 1YGG A; 3GN7 A; 3MOH A; 4UI8 A; 4L0V A; 4TJW A; 4UFY A; 5AL1 A; 2PY7 X; 2RK8 A; 4W5I A; 3UH2 A; 4GV2 A; 4GMM A; 1K3C A; 5FH1 A; 1II2 A; 4L0I A; 3GJW A; 4GMW A; 4HLK A; 4BUS A; 4TJY A; 4TKF A; 4UVT A; 2RF5 A; 4HLH A; 4M7B A; 3UDD A; 4F0E A; 5FH2 A; 4L2G A; 4L7O A; 4YW9 A; 4L7P A; 5ADS A; 4PNM A; 4UVP A; 4UHG A; 4L70 A; 2PAW A; 4I9I A; 4WOU A; 3MHJ A; 4UX4 A; 3GEY A; 4W6E A; 1KHE A; 4GNO A; 4IUE A; 4UI7 A; 4TK5 A; 4WIU A; 5AL4 A; 4PNT A; 4L31 A; 4R43 A; 3P0Q A; 4BJB A; 5ADR A; 3UA9 A; 4PJV A; 2PC9 A; 4UVS A; 5ETY A; 5FH0 A; 4LI6 A; 5ADT A; 4UI6 A; 4PY4 A; 4BUX A; 4GNQ A; 3DT7 A; 4L7N A; 4WL8 A; 3P0N A; 4BU8 A; 4KZL A; 5AKW A; 5AEH A; 3C49 A; 4UVX A; 4UVW A; 4UVN A; 4K4E A; 4DQY C; 2QZY A; 4N3R A; 2X5Y A; 4DVI A; 4RV6 A; 5AKU A; 4HKK A; 4HL5 A; 5C5R A; 5LX6 A; 4GV7 A; 4UI4 A; 2PAX A; 3P0P A; 1A26 A; 3U9Y A; 4UXB A; 5ECE A; 3KJD A; 4L2F A; 4PNN A; 4HYF A; 4BU7 A; 2FAF A; 4BU9 A; 4AVU A; 5FH3 A; 4J1Z A; 4BUD A; 4XHU A; 3SE2 A; 5EBT A; 1AYL A; 4F1L A; 4PNS A; 4UVZ A; 4N4V A; 5C5Q A; 4GMU A; 4J21 A; 4HHY A; 4YWB A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
