2GMV | Genus

Total Genus 203

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	203
sequence length	613
structure length	602
Chain Sequence	NLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEALGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLVLGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWDKEVEDIEKYLVDQVNADLPCEIEREILALKQRISQM

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Lyase
source organism	Homo sapiens
publication title	C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. pubmed doi rcsb
molecule keywords	Phosphoenolpyruvate carboxykinase, cytosolic
total genus	203
structure length	602
sequence length	613
chains with identical sequence	B
ec nomenclature	ec 4.1.1.32: Phosphoenolpyruvate carboxykinase (GTP).
pdb deposition date	2006-04-07

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00821	PEPCK_GTP	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain
A	PF17297	PEPCK_N	Phosphoenolpyruvate carboxykinase N-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.170.8.10	Mainly Beta	Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 2	Phosphoenolpyruvate Carboxykinase, domain 2	2gmvA02
3.40.449.10	Alpha Beta	3-Layer(aba) Sandwich	Phosphoenolpyruvate Carboxykinase; domain 1	Phosphoenolpyruvate Carboxykinase, domain 1	2gmvA01
3.90.228.20	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 3	Phosphoenolpyruvate Carboxykinase; domain 3	2gmvA03

3MOHA 1K3CA 1K3DA 1M51A 4WIEA 5FH4A 4WL8A 1II2A 4WIUA 2PC9A 4YWBA 1J3BA 2FAHA 2GMVA 3DTBA 4WPVA 5FH3A 4YW8A 5FH0A 1KHGA 2PY7X 2RK7A 5FH5A 2RKAA 2OLQA 2OLRA 2PXZX 4GMUA 4GMWA 3DT7A 4WPUA 1OENA 4GNLA 4WOUA 5FH2A 3MOFA 2FAFA 1AQ2A 3MOEA 4GNOA 5I67A 1YLHA 4GNQA 1NHXA 1KHBA 2QF2A 2QF1A 1YVYA 4R43A 4OX2A 4WPTA 1YTMA 2QEYA 4GMZA 1KHFA 4GNMA 1OS1A 2ZCIA 4GNPA 5FH1A 2RKEA 3DT4A 1XKVA 2RKDA 4YW9A 2QZYA 1YGGA 4RCGA 3DT2A 2RK8A 4YWDA 2QEWA 1KHEA 1AYLA 4GMMA
chains in the Genus database with same CATH superfamily

3MOHA 4WIEA 3GEYA 3KCZA 4K4EA 4L0TA 3CE0A 4L32A 5ETYA 4AVUA 1J3BA 2FAHA 2GMVA 3DTBA 4LI7A 4HL5A 4TVJA 4BFPA 1KHGA 4LI8A 4UVLA 4KZQA 5FPFA 5FH5A 2OLQA 4GMWA 3UA9A 4W5IA 1OENA 4HMHA 4PNTA 4UX4A 1EFYA 4R5WA 4ZZXA 4PAXA 2FAFA 3KJDA 4L33A 5AL3A 4OQAC 3MOEA 4GNOA 4PNNA 4L7NA 3C4HA 4UI5A 4GV0A 1NHXA 4IUEA 3P0PA 4L6ZA 4KZUA 4BU3A 4BUIA 4F1LA 4WPTA 3C49A 1YTMA 2QEYA 3HKVA 4GV7A 4HLMA 4XHUA 4GNMA 5AEHA 4HKNA 4PNRA 4UVSA 4BUEA 2RKEA 5ADTA 4TJYA 4X52A 3BLJA 4YW9A 4LI6A 4UVTA 5C5QA 4M7BA 1UK1A 3GN7A 3PAXA 1A26A 4L0SA 4BUVA 4UVOA 5FH3A 4F0EA 4ZZZA 4WPVA 4L09A 1PAXA 4BU7A 4F1QA 4WIUA 4YWBA 4PJVA 3W51A 5ADRA 4UI4A 4W5SA 4UI3A 2PY7X 4TORA 4TK5A 3P0QA 4TKGA 4L2KA 4ZZYA 4L6SA 4BUXA 4UI7A 5FH2A 4HLGA 4HLKA 4TK0A 1AQ2A 4UVVA 5I67A 3U9YA 4L7OA 4GNQA 4KRSA 4MSKA 2QF1A 4UI8A 3GJWA 1YVYA 4TOSA 4UVWA 4OX2A 4UNDA 4UW1A 4UVNA 4W6EA 1KHFA 3L3LA 4J3LA 3SMJA 4BUUA 4L0BA 1XKVA 2RKDA 4L0VA 4J21A 3UH2A 2QZYA 4UFYA 4HKIA 3DT2A 3KR8A 2PAWA 4HLFA 4PNLA 4BUSA 5DCZA 5ADQA 2QEWA 4R6EA 4UFUA 4BJ9A 5FH1A 4BU6A 4BUTA 1M51A 3UH4A 1II2A 2PC9A 5C5RA 2RF5A 3FHBA 4HYFA 4BU8A 4YW8A 4TJWA 5LYHA 3L3MA 3MHKA 2RD6A 4L7PA 3DT7A 4UVPA 4GNLA 4WOUA 4N4VA 4U6AA 4PNQA 4J1ZA 4L2FA 4OA7A 4L7LA 4J22A 1YLHA 5AKUA 1KHBA 1WOKA 4R43A 4UXBA 5AL4A 4OPXC 4HHYA 2ZCIA 4GNPA 4TKIA 3U9HA 4UVZA 3SMIA 4RCGA 3P0NA 5LX6A 4L7UA 4UVYA 4HLHA 4UHGA 2RK8A 4YWDA 4AVWA 4DVIA 4I9IA 4GV2A 4PNSA 4OQBC 4KZLA 1K3CA 1K3DA 4L34A 4PY4A 5FH4A 4WL8A 4N4TA 3UDDA 3MHJA 2PQFA 4TKFA 4BU5A 4BUDA 4UUHA 4L2GA 5FH0A 4L70A 2RCWA 2RK7A 5AL1A 5ECEA 4BS4A 4UVXA 4BUAA 2RKAA 1GS0A 2OLRA 2PXZX 4MT9A 4GMUA 5C5PA 5EBTA 4WPUA 4DQYC 4BU9A 4K4FA 4BUWA 4BUYA 4HHZA 5ADSA 3MOFA 2X5YA 4PJTA 4UVUA 4L10A 4HKKA 5AL5A 2QF2A 5AKWA 4L0IA 4MSGA 4BJCA 4BUFA 4N3RA 4PMLA 5LXPA 3SE2A 4GMZA 4RV6A 1OS1A 4TJUA 3DT4A 3GOYA 5A00A 1UK0A 4PNMA 1YGGA 4L31A 4L7RA 4UI6A 5FPGA 3KR7A 2PAXA 4J3MA 5AL2A 4GV4A 4BJBA 1KHEA 1AYLA 4GMMA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3MOH A;  1K3C A;  1K3D A;  1M51 A;  4WIE A;  5FH4 A;  4WL8 A;  1II2 A;  4WIU A;  2PC9 A;  4YWB A;  1J3B A;  2FAH A;  2GMV A;  3DTB A;  4WPV A;  5FH3 A;  4YW8 A;  5FH0 A;  1KHG A;  2PY7 X;  2RK7 A;  5FH5 A;  2RKA A;  2OLQ A;  2OLR A;  2PXZ X;  4GMU A;  4GMW A;  3DT7 A;  4WPU A;  1OEN A;  4GNL A;  4WOU A;  5FH2 A;  3MOF A;  2FAF A;  1AQ2 A;  3MOE A;  4GNO A;  5I67 A;  1YLH A;  4GNQ A;  1NHX A;  1KHB A;  2QF2 A;  2QF1 A;  1YVY A;  4R43 A;  4OX2 A;  4WPT A;  1YTM A;  2QEY A;  4GMZ A;  1KHF A;  4GNM A;  1OS1 A;  2ZCI A;  4GNP A;  5FH1 A;  2RKE A;  3DT4 A;  1XKV A;  2RKD A;  4YW9 A;  2QZY A;  1YGG A;  4RCG A;  3DT2 A;  2RK8 A;  4YWD A;  2QEW A;  1KHE A;  1AYL A;  4GMM A; 
#chains in the Genus database with same CATH topology
 3MOH A;  4WIE A;  3GEY A;  3KCZ A;  4K4E A;  4L0T A;  3CE0 A;  4L32 A;  5ETY A;  4AVU A;  1J3B A;  2FAH A;  2GMV A;  3DTB A;  4LI7 A;  4HL5 A;  4TVJ A;  4BFP A;  1KHG A;  4LI8 A;  4UVL A;  4KZQ A;  5FPF A;  5FH5 A;  2OLQ A;  4GMW A;  3UA9 A;  4W5I A;  1OEN A;  4HMH A;  4PNT A;  4UX4 A;  1EFY A;  4R5W A;  4ZZX A;  4PAX A;  2FAF A;  3KJD A;  4L33 A;  5AL3 A;  4OQA C;  3MOE A;  4GNO A;  4PNN A;  4L7N A;  3C4H A;  4UI5 A;  4GV0 A;  1NHX A;  4IUE A;  3P0P A;  4L6Z A;  4KZU A;  4BU3 A;  4BUI A;  4F1L A;  4WPT A;  3C49 A;  1YTM A;  2QEY A;  3HKV A;  4GV7 A;  4HLM A;  4XHU A;  4GNM A;  5AEH A;  4HKN A;  4PNR A;  4UVS A;  4BUE A;  2RKE A;  5ADT A;  4TJY A;  4X52 A;  3BLJ A;  4YW9 A;  4LI6 A;  4UVT A;  5C5Q A;  4M7B A;  1UK1 A;  3GN7 A;  3PAX A;  1A26 A;  4L0S A;  4BUV A;  4UVO A;  5FH3 A;  4F0E A;  4ZZZ A;  4WPV A;  4L09 A;  1PAX A;  4BU7 A;  4F1Q A;  4WIU A;  4YWB A;  4PJV A;  3W51 A;  5ADR A;  4UI4 A;  4W5S A;  4UI3 A;  2PY7 X;  4TOR A;  4TK5 A;  3P0Q A;  4TKG A;  4L2K A;  4ZZY A;  4L6S A;  4BUX A;  4UI7 A;  5FH2 A;  4HLG A;  4HLK A;  4TK0 A;  1AQ2 A;  4UVV A;  5I67 A;  3U9Y A;  4L7O A;  4GNQ A;  4KRS A;  4MSK A;  2QF1 A;  4UI8 A;  3GJW A;  1YVY A;  4TOS A;  4UVW A;  4OX2 A;  4UND A;  4UW1 A;  4UVN A;  4W6E A;  1KHF A;  3L3L A;  4J3L A;  3SMJ A;  4BUU A;  4L0B A;  1XKV A;  2RKD A;  4L0V A;  4J21 A;  3UH2 A;  2QZY A;  4UFY A;  4HKI A;  3DT2 A;  3KR8 A;  2PAW A;  4HLF A;  4PNL A;  4BUS A;  5DCZ A;  5ADQ A;  2QEW A;  4R6E A;  4UFU A;  4BJ9 A;  5FH1 A;  4BU6 A;  4BUT A;  1M51 A;  3UH4 A;  1II2 A;  2PC9 A;  5C5R A;  2RF5 A;  3FHB A;  4HYF A;  4BU8 A;  4YW8 A;  4TJW A;  5LYH A;  3L3M A;  3MHK A;  2RD6 A;  4L7P A;  3DT7 A;  4UVP A;  4GNL A;  4WOU A;  4N4V A;  4U6A A;  4PNQ A;  4J1Z A;  4L2F A;  4OA7 A;  4L7L A;  4J22 A;  1YLH A;  5AKU A;  1KHB A;  1WOK A;  4R43 A;  4UXB A;  5AL4 A;  4OPX C;  4HHY A;  2ZCI A;  4GNP A;  4TKI A;  3U9H A;  4UVZ A;  3SMI A;  4RCG A;  3P0N A;  5LX6 A;  4L7U A;  4UVY A;  4HLH A;  4UHG A;  2RK8 A;  4YWD A;  4AVW A;  4DVI A;  4I9I A;  4GV2 A;  4PNS A;  4OQB C;  4KZL A;  1K3C A;  1K3D A;  4L34 A;  4PY4 A;  5FH4 A;  4WL8 A;  4N4T A;  3UDD A;  3MHJ A;  2PQF A;  4TKF A;  4BU5 A;  4BUD A;  4UUH A;  4L2G A;  5FH0 A;  4L70 A;  2RCW A;  2RK7 A;  5AL1 A;  5ECE A;  4BS4 A;  4UVX A;  4BUA A;  2RKA A;  1GS0 A;  2OLR A;  2PXZ X;  4MT9 A;  4GMU A;  5C5P A;  5EBT A;  4WPU A;  4DQY C;  4BU9 A;  4K4F A;  4BUW A;  4BUY A;  4HHZ A;  5ADS A;  3MOF A;  2X5Y A;  4PJT A;  4UVU A;  4L10 A;  4HKK A;  5AL5 A;  2QF2 A;  5AKW A;  4L0I A;  4MSG A;  4BJC A;  4BUF A;  4N3R A;  4PML A;  5LXP A;  3SE2 A;  4GMZ A;  4RV6 A;  1OS1 A;  4TJU A;  3DT4 A;  3GOY A;  5A00 A;  1UK0 A;  4PNM A;  1YGG A;  4L31 A;  4L7R A;  4UI6 A;  5FPG A;  3KR7 A;  2PAX A;  4J3M A;  5AL2 A;  4GV4 A;  4BJB A;  1KHE A;  1AYL A;  4GMM A; 
#chains in the Genus database with same CATH homology
 3MOH A;  4WIE A;  3GEY A;  3KCZ A;  4K4E A;  4L0T A;  3CE0 A;  4L32 A;  5ETY A;  4AVU A;  1J3B A;  2FAH A;  2GMV A;  3DTB A;  4LI7 A;  4HL5 A;  4TVJ A;  4BFP A;  1KHG A;  4LI8 A;  4UVL A;  4KZQ A;  5FPF A;  5FH5 A;  2OLQ A;  4GMW A;  3UA9 A;  4W5I A;  1OEN A;  4HMH A;  4PNT A;  4UX4 A;  1EFY A;  4R5W A;  4ZZX A;  4PAX A;  2FAF A;  3KJD A;  4L33 A;  5AL3 A;  4OQA C;  3MOE A;  4GNO A;  4PNN A;  4L7N A;  3C4H A;  4UI5 A;  4GV0 A;  1NHX A;  4IUE A;  3P0P A;  4L6Z A;  4KZU A;  4BU3 A;  4BUI A;  4F1L A;  4WPT A;  3C49 A;  1YTM A;  2QEY A;  3HKV A;  4GV7 A;  4HLM A;  4XHU A;  4GNM A;  5AEH A;  4HKN A;  4PNR A;  4UVS A;  4BUE A;  2RKE A;  5ADT A;  4TJY A;  4X52 A;  3BLJ A;  4YW9 A;  4LI6 A;  4UVT A;  5C5Q A;  4M7B A;  1UK1 A;  3GN7 A;  3PAX A;  1A26 A;  4L0S A;  4BUV A;  4UVO A;  5FH3 A;  4F0E A;  4ZZZ A;  4WPV A;  4L09 A;  1PAX A;  4BU7 A;  4F1Q A;  4WIU A;  4YWB A;  4PJV A;  3W51 A;  5ADR A;  4UI4 A;  4W5S A;  4UI3 A;  2PY7 X;  4TOR A;  4TK5 A;  3P0Q A;  4TKG A;  4L2K A;  4ZZY A;  4L6S A;  4BUX A;  4UI7 A;  5FH2 A;  4HLG A;  4HLK A;  4TK0 A;  1AQ2 A;  4UVV A;  5I67 A;  3U9Y A;  4L7O A;  4GNQ A;  4KRS A;  4MSK A;  2QF1 A;  4UI8 A;  3GJW A;  1YVY A;  4TOS A;  4UVW A;  4OX2 A;  4UND A;  4UW1 A;  4UVN A;  4W6E A;  1KHF A;  3L3L A;  4J3L A;  3SMJ A;  4BUU A;  4L0B A;  1XKV A;  2RKD A;  4L0V A;  4J21 A;  3UH2 A;  2QZY A;  4UFY A;  4HKI A;  3DT2 A;  3KR8 A;  2PAW A;  4HLF A;  4PNL A;  4BUS A;  5DCZ A;  5ADQ A;  2QEW A;  4R6E A;  4UFU A;  4BJ9 A;  5FH1 A;  4BU6 A;  4BUT A;  1M51 A;  3UH4 A;  1II2 A;  2PC9 A;  5C5R A;  2RF5 A;  3FHB A;  4HYF A;  4BU8 A;  4YW8 A;  4TJW A;  5LYH A;  3L3M A;  3MHK A;  2RD6 A;  4L7P A;  3DT7 A;  4UVP A;  4GNL A;  4WOU A;  4N4V A;  4U6A A;  4PNQ A;  4J1Z A;  4L2F A;  4OA7 A;  4L7L A;  4J22 A;  1YLH A;  5AKU A;  1KHB A;  1WOK A;  4R43 A;  4UXB A;  5AL4 A;  4OPX C;  4HHY A;  2ZCI A;  4GNP A;  4TKI A;  3U9H A;  4UVZ A;  3SMI A;  4RCG A;  3P0N A;  5LX6 A;  4L7U A;  4UVY A;  4HLH A;  4UHG A;  2RK8 A;  4YWD A;  4AVW A;  4DVI A;  4I9I A;  4GV2 A;  4PNS A;  4OQB C;  4KZL A;  1K3C A;  1K3D A;  4L34 A;  4PY4 A;  5FH4 A;  4WL8 A;  4N4T A;  3UDD A;  3MHJ A;  2PQF A;  4TKF A;  4BU5 A;  4BUD A;  4UUH A;  4L2G A;  5FH0 A;  4L70 A;  2RCW A;  2RK7 A;  5AL1 A;  5ECE A;  4BS4 A;  4UVX A;  4BUA A;  2RKA A;  1GS0 A;  2OLR A;  2PXZ X;  4MT9 A;  4GMU A;  5C5P A;  5EBT A;  4WPU A;  4DQY C;  4BU9 A;  4K4F A;  4BUW A;  4BUY A;  4HHZ A;  5ADS A;  3MOF A;  2X5Y A;  4PJT A;  4UVU A;  4L10 A;  4HKK A;  5AL5 A;  2QF2 A;  5AKW A;  4L0I A;  4MSG A;  4BJC A;  4BUF A;  4N3R A;  4PML A;  5LXP A;  3SE2 A;  4GMZ A;  4RV6 A;  1OS1 A;  4TJU A;  3DT4 A;  3GOY A;  5A00 A;  1UK0 A;  4PNM A;  1YGG A;  4L31 A;  4L7R A;  4UI6 A;  5FPG A;  3KR7 A;  2PAX A;  4J3M A;  5AL2 A;  4GV4 A;  4BJB A;  1KHE A;  1AYL A;  4GMM A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2GMVA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations