2QEW | Genus

Total Genus 211

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	211
sequence length	620
structure length	613
Chain Sequence	PQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Lyase
source organism	Rattus norvegicus
publication title	Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid. pubmed doi rcsb
molecule keywords	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
total genus	211
structure length	613
sequence length	620
ec nomenclature	ec 4.1.1.32: Phosphoenolpyruvate carboxykinase (GTP).
pdb deposition date	2007-06-26

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00821	PEPCK_GTP	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain
A	PF17297	PEPCK_N	Phosphoenolpyruvate carboxykinase N-terminal domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.170.8.10	Mainly Beta	Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 2	Phosphoenolpyruvate Carboxykinase, domain 2	2qewA02
3.40.449.10	Alpha Beta	3-Layer(aba) Sandwich	Phosphoenolpyruvate Carboxykinase; domain 1	Phosphoenolpyruvate Carboxykinase, domain 1	2qewA01
3.90.228.20	Alpha Beta	Alpha-Beta Complex	Phosphoenolpyruvate Carboxykinase; domain 3	Phosphoenolpyruvate Carboxykinase; domain 3	2qewA03

1K3CA 4YWBA 1M51A 4WPVA 1II2A 2RKAA 5I67A 4YW9A 4WOUA 4GMMA 4GNQA 5FH5A 2QF2A 3MOFA 1KHGA 2PY7X 4OX2A 3DT7A 1OENA 1KHFA 1KHEA 2PC9A 4YWDA 2RKEA 2QEWA 4GNOA 2OLRA 4WIEA 2OLQA 5FH3A 2RKDA 1OS1A 1J3BA 3DT4A 5FH1A 4WIUA 2RK8A 1K3DA 4R43A 4RCGA 4GNPA 1YTMA 4WPTA 1YGGA 2FAHA 4GNLA 3DT2A 4GMUA 5FH0A 2QZYA 1AYLA 2QF1A 3DTBA 4WPUA 5FH2A 1KHBA 4GNMA 1NHXA 5FH4A 2PXZX 2ZCIA 2GMVA 1YLHA 2RK7A 3MOEA 3MOHA 4YW8A 4GMWA 4WL8A 2FAFA 1XKVA 1AQ2A 1YVYA 4GMZA 2QEYA
chains in the Genus database with same CATH superfamily

4BU8A 1K3CA 5I67A 1M51A 4WPVA 1II2A 4L7PA 4HMHA 4BUWA 3P0NA 4L2GA 4BJCA 5ETYA 4BUDA 4PMLA 2QF2A 4L0VA 4BUEA 3MHKA 5FPGA 5ADTA 4W5IA 4AVWA 4BU5A 4UI3A 4GNOA 2QEWA 4HL5A 2PAXA 4X52A 5FPFA 5FH1A 3CE0A 5EBTA 5ADSA 2RK8A 4J1ZA 4PNSA 4GNPA 4WPTA 5FH0A 4BU6A 3L3MA 4TKGA 2QZYA 3BLJA 4HLHA 3C49A 4UI8A 2QF1A 5FH2A 4WPUA 4PNLA 4PNNA 4TORA 4GNMA 4UVVA 5DCZA 4OQAC 3P0QA 4UVXA 4HKKA 4M7BA 4BUTA 1WOKA 2X5YA 2RK7A 4K4FA 4L09A 3GOYA 4MT9A 3MOHA 4YW8A 3SMJA 4HYFA 4L7RA 5AKUA 5C5RA 2FAFA 5AKWA 1A26A 4TKFA 4UFYA 4GV7A 4HKIA 2RKAA 4MSGA 4YW9A 5FH5A 3MOFA 4TK5A 1EFYA 4OQBC 1KHGA 4OX2A 4L0IA 4UXBA 1KHEA 5C5PA 2RKEA 4UFUA 5AL1A 4LI7A 4BUIA 4BUAA 4HLKA 4MSKA 1OS1A 1J3BA 4GV0A 4GV2A 4WIUA 3W51A 3UH4A 4UVPA 4KZUA 4UHGA 1K3DA 4R43A 4RCGA 4L7OA 4L70A 4BU3A 1YGGA 2FAHA 4W6EA 4TJWA 4OPXC 4L32A 4UVYA 1AYLA 4HLGA 5AL5A 3DTBA 3KR7A 3L3LA 1KHBA 4KZLA 1UK0A 4UX4A 4TJUA 4UVNA 4TOSA 1NHXA 5FH4A 4UI7A 4BJ9A 4BU7A 4TK0A 4HLFA 4L10A 4U6AA 3U9HA 4L6SA 5LXPA 4AVUA 4UVZA 5ADRA 5LYHA 1AQ2A 4K4EA 4GMZA 2QEYA 4L6ZA 4BU9A 4PY4A 4PNTA 3GEYA 4GMMA 4F0EA 4ZZYA 4W5SA 4TKIA 4HHZA 4UVUA 4PNRA 4UW1A 4BJBA 4R6EA 3MHJA 3KJDA 4TJYA 3P0PA 2PC9A 4YWDA 4F1LA 4IUEA 4R5WA 1UK1A 4L34A 4XHUA 4WIEA 2OLQA 4L0BA 4BUUA 4BUSA 2RKDA 3DT4A 4HKNA 4J3LA 4L2KA 4PNQA 1YTMA 3C4HA 4BFPA 5AL2A 4L0SA 5C5QA 4BUYA 5AEHA 4J22A 4L33A 4UUHA 4BUVA 4UVLA 4F1QA 2PXZX 3SMIA 2ZCIA 5AL3A 4BS4A 4UNDA 1YLHA 4PNMA 3GN7A 2PAWA 4TVJA 4UI4A 4WL8A 4UVTA 4I9IA 1XKVA 4UVOA 4BUFA 1YVYA 3GJWA 5FH3A 4BUXA 4YWBA 4L7NA 4N4TA 1GS0A 4WOUA 4L7UA 2RD6A 4N4VA 4UI5A 4UVWA 4GNQA 5ECEA 4HHYA 4UVSA 2RCWA 3UA9A 4UI6A 5A00A 2PY7X 3U9YA 3DT7A 4DQYC 1OENA 1KHFA 4J21A 4PJVA 4OA7A 2OLRA 4PAXA 3PAXA 3FHBA 4ZZZA 1PAXA 2RF5A 4PJTA 4N3RA 4DVIA 4J3MA 4GNLA 3DT2A 4GMUA 4KRSA 3SE2A 4L0TA 4L7LA 2PQFA 4L31A 3HKVA 5AL4A 4RV6A 4KZQA 3KCZA 4HLMA 3KR8A 5ADQA 2GMVA 4LI8A 4GV4A 3MOEA 3UDDA 4GMWA 4L2FA 5LX6A 3UH2A 4ZZXA 4LI6A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1K3C A;  4YWB A;  1M51 A;  4WPV A;  1II2 A;  2RKA A;  5I67 A;  4YW9 A;  4WOU A;  4GMM A;  4GNQ A;  5FH5 A;  2QF2 A;  3MOF A;  1KHG A;  2PY7 X;  4OX2 A;  3DT7 A;  1OEN A;  1KHF A;  1KHE A;  2PC9 A;  4YWD A;  2RKE A;  2QEW A;  4GNO A;  2OLR A;  4WIE A;  2OLQ A;  5FH3 A;  2RKD A;  1OS1 A;  1J3B A;  3DT4 A;  5FH1 A;  4WIU A;  2RK8 A;  1K3D A;  4R43 A;  4RCG A;  4GNP A;  1YTM A;  4WPT A;  1YGG A;  2FAH A;  4GNL A;  3DT2 A;  4GMU A;  5FH0 A;  2QZY A;  1AYL A;  2QF1 A;  3DTB A;  4WPU A;  5FH2 A;  1KHB A;  4GNM A;  1NHX A;  5FH4 A;  2PXZ X;  2ZCI A;  2GMV A;  1YLH A;  2RK7 A;  3MOE A;  3MOH A;  4YW8 A;  4GMW A;  4WL8 A;  2FAF A;  1XKV A;  1AQ2 A;  1YVY A;  4GMZ A;  2QEY A; 
#chains in the Genus database with same CATH topology
 4BU8 A;  1K3C A;  5I67 A;  1M51 A;  4WPV A;  1II2 A;  4L7P A;  4HMH A;  4BUW A;  3P0N A;  4L2G A;  4BJC A;  5ETY A;  4BUD A;  4PML A;  2QF2 A;  4L0V A;  4BUE A;  3MHK A;  5FPG A;  5ADT A;  4W5I A;  4AVW A;  4BU5 A;  4UI3 A;  4GNO A;  2QEW A;  4HL5 A;  2PAX A;  4X52 A;  5FPF A;  5FH1 A;  3CE0 A;  5EBT A;  5ADS A;  2RK8 A;  4J1Z A;  4PNS A;  4GNP A;  4WPT A;  5FH0 A;  4BU6 A;  3L3M A;  4TKG A;  2QZY A;  3BLJ A;  4HLH A;  3C49 A;  4UI8 A;  2QF1 A;  5FH2 A;  4WPU A;  4PNL A;  4PNN A;  4TOR A;  4GNM A;  4UVV A;  5DCZ A;  4OQA C;  3P0Q A;  4UVX A;  4HKK A;  4M7B A;  4BUT A;  1WOK A;  2X5Y A;  2RK7 A;  4K4F A;  4L09 A;  3GOY A;  4MT9 A;  3MOH A;  4YW8 A;  3SMJ A;  4HYF A;  4L7R A;  5AKU A;  5C5R A;  2FAF A;  5AKW A;  1A26 A;  4TKF A;  4UFY A;  4GV7 A;  4HKI A;  2RKA A;  4MSG A;  4YW9 A;  5FH5 A;  3MOF A;  4TK5 A;  1EFY A;  4OQB C;  1KHG A;  4OX2 A;  4L0I A;  4UXB A;  1KHE A;  5C5P A;  2RKE A;  4UFU A;  5AL1 A;  4LI7 A;  4BUI A;  4BUA A;  4HLK A;  4MSK A;  1OS1 A;  1J3B A;  4GV0 A;  4GV2 A;  4WIU A;  3W51 A;  3UH4 A;  4UVP A;  4KZU A;  4UHG A;  1K3D A;  4R43 A;  4RCG A;  4L7O A;  4L70 A;  4BU3 A;  1YGG A;  2FAH A;  4W6E A;  4TJW A;  4OPX C;  4L32 A;  4UVY A;  1AYL A;  4HLG A;  5AL5 A;  3DTB A;  3KR7 A;  3L3L A;  1KHB A;  4KZL A;  1UK0 A;  4UX4 A;  4TJU A;  4UVN A;  4TOS A;  1NHX A;  5FH4 A;  4UI7 A;  4BJ9 A;  4BU7 A;  4TK0 A;  4HLF A;  4L10 A;  4U6A A;  3U9H A;  4L6S A;  5LXP A;  4AVU A;  4UVZ A;  5ADR A;  5LYH A;  1AQ2 A;  4K4E A;  4GMZ A;  2QEY A;  4L6Z A;  4BU9 A;  4PY4 A;  4PNT A;  3GEY A;  4GMM A;  4F0E A;  4ZZY A;  4W5S A;  4TKI A;  4HHZ A;  4UVU A;  4PNR A;  4UW1 A;  4BJB A;  4R6E A;  3MHJ A;  3KJD A;  4TJY A;  3P0P A;  2PC9 A;  4YWD A;  4F1L A;  4IUE A;  4R5W A;  1UK1 A;  4L34 A;  4XHU A;  4WIE A;  2OLQ A;  4L0B A;  4BUU A;  4BUS A;  2RKD A;  3DT4 A;  4HKN A;  4J3L A;  4L2K A;  4PNQ A;  1YTM A;  3C4H A;  4BFP A;  5AL2 A;  4L0S A;  5C5Q A;  4BUY A;  5AEH A;  4J22 A;  4L33 A;  4UUH A;  4BUV A;  4UVL A;  4F1Q A;  2PXZ X;  3SMI A;  2ZCI A;  5AL3 A;  4BS4 A;  4UND A;  1YLH A;  4PNM A;  3GN7 A;  2PAW A;  4TVJ A;  4UI4 A;  4WL8 A;  4UVT A;  4I9I A;  1XKV A;  4UVO A;  4BUF A;  1YVY A;  3GJW A;  5FH3 A;  4BUX A;  4YWB A;  4L7N A;  4N4T A;  1GS0 A;  4WOU A;  4L7U A;  2RD6 A;  4N4V A;  4UI5 A;  4UVW A;  4GNQ A;  5ECE A;  4HHY A;  4UVS A;  2RCW A;  3UA9 A;  4UI6 A;  5A00 A;  2PY7 X;  3U9Y A;  3DT7 A;  4DQY C;  1OEN A;  1KHF A;  4J21 A;  4PJV A;  4OA7 A;  2OLR A;  4PAX A;  3PAX A;  3FHB A;  4ZZZ A;  1PAX A;  2RF5 A;  4PJT A;  4N3R A;  4DVI A;  4J3M A;  4GNL A;  3DT2 A;  4GMU A;  4KRS A;  3SE2 A;  4L0T A;  4L7L A;  2PQF A;  4L31 A;  3HKV A;  5AL4 A;  4RV6 A;  4KZQ A;  3KCZ A;  4HLM A;  3KR8 A;  5ADQ A;  2GMV A;  4LI8 A;  4GV4 A;  3MOE A;  3UDD A;  4GMW A;  4L2F A;  5LX6 A;  3UH2 A;  4ZZX A;  4LI6 A; 
#chains in the Genus database with same CATH homology
 4BU8 A;  1K3C A;  5I67 A;  1M51 A;  4WPV A;  1II2 A;  4L7P A;  4HMH A;  4BUW A;  3P0N A;  4L2G A;  4BJC A;  5ETY A;  4BUD A;  4PML A;  2QF2 A;  4L0V A;  4BUE A;  3MHK A;  5FPG A;  5ADT A;  4W5I A;  4AVW A;  4BU5 A;  4UI3 A;  4GNO A;  2QEW A;  4HL5 A;  2PAX A;  4X52 A;  5FPF A;  5FH1 A;  3CE0 A;  5EBT A;  5ADS A;  2RK8 A;  4J1Z A;  4PNS A;  4GNP A;  4WPT A;  5FH0 A;  4BU6 A;  3L3M A;  4TKG A;  2QZY A;  3BLJ A;  4HLH A;  3C49 A;  4UI8 A;  2QF1 A;  5FH2 A;  4WPU A;  4PNL A;  4PNN A;  4TOR A;  4GNM A;  4UVV A;  5DCZ A;  4OQA C;  3P0Q A;  4UVX A;  4HKK A;  4M7B A;  4BUT A;  1WOK A;  2X5Y A;  2RK7 A;  4K4F A;  4L09 A;  3GOY A;  4MT9 A;  3MOH A;  4YW8 A;  3SMJ A;  4HYF A;  4L7R A;  5AKU A;  5C5R A;  2FAF A;  5AKW A;  1A26 A;  4TKF A;  4UFY A;  4GV7 A;  4HKI A;  2RKA A;  4MSG A;  4YW9 A;  5FH5 A;  3MOF A;  4TK5 A;  1EFY A;  4OQB C;  1KHG A;  4OX2 A;  4L0I A;  4UXB A;  1KHE A;  5C5P A;  2RKE A;  4UFU A;  5AL1 A;  4LI7 A;  4BUI A;  4BUA A;  4HLK A;  4MSK A;  1OS1 A;  1J3B A;  4GV0 A;  4GV2 A;  4WIU A;  3W51 A;  3UH4 A;  4UVP A;  4KZU A;  4UHG A;  1K3D A;  4R43 A;  4RCG A;  4L7O A;  4L70 A;  4BU3 A;  1YGG A;  2FAH A;  4W6E A;  4TJW A;  4OPX C;  4L32 A;  4UVY A;  1AYL A;  4HLG A;  5AL5 A;  3DTB A;  3KR7 A;  3L3L A;  1KHB A;  4KZL A;  1UK0 A;  4UX4 A;  4TJU A;  4UVN A;  4TOS A;  1NHX A;  5FH4 A;  4UI7 A;  4BJ9 A;  4BU7 A;  4TK0 A;  4HLF A;  4L10 A;  4U6A A;  3U9H A;  4L6S A;  5LXP A;  4AVU A;  4UVZ A;  5ADR A;  5LYH A;  1AQ2 A;  4K4E A;  4GMZ A;  2QEY A;  4L6Z A;  4BU9 A;  4PY4 A;  4PNT A;  3GEY A;  4GMM A;  4F0E A;  4ZZY A;  4W5S A;  4TKI A;  4HHZ A;  4UVU A;  4PNR A;  4UW1 A;  4BJB A;  4R6E A;  3MHJ A;  3KJD A;  4TJY A;  3P0P A;  2PC9 A;  4YWD A;  4F1L A;  4IUE A;  4R5W A;  1UK1 A;  4L34 A;  4XHU A;  4WIE A;  2OLQ A;  4L0B A;  4BUU A;  4BUS A;  2RKD A;  3DT4 A;  4HKN A;  4J3L A;  4L2K A;  4PNQ A;  1YTM A;  3C4H A;  4BFP A;  5AL2 A;  4L0S A;  5C5Q A;  4BUY A;  5AEH A;  4J22 A;  4L33 A;  4UUH A;  4BUV A;  4UVL A;  4F1Q A;  2PXZ X;  3SMI A;  2ZCI A;  5AL3 A;  4BS4 A;  4UND A;  1YLH A;  4PNM A;  3GN7 A;  2PAW A;  4TVJ A;  4UI4 A;  4WL8 A;  4UVT A;  4I9I A;  1XKV A;  4UVO A;  4BUF A;  1YVY A;  3GJW A;  5FH3 A;  4BUX A;  4YWB A;  4L7N A;  4N4T A;  1GS0 A;  4WOU A;  4L7U A;  2RD6 A;  4N4V A;  4UI5 A;  4UVW A;  4GNQ A;  5ECE A;  4HHY A;  4UVS A;  2RCW A;  3UA9 A;  4UI6 A;  5A00 A;  2PY7 X;  3U9Y A;  3DT7 A;  4DQY C;  1OEN A;  1KHF A;  4J21 A;  4PJV A;  4OA7 A;  2OLR A;  4PAX A;  3PAX A;  3FHB A;  4ZZZ A;  1PAX A;  2RF5 A;  4PJT A;  4N3R A;  4DVI A;  4J3M A;  4GNL A;  3DT2 A;  4GMU A;  4KRS A;  3SE2 A;  4L0T A;  4L7L A;  2PQF A;  4L31 A;  3HKV A;  5AL4 A;  4RV6 A;  4KZQ A;  3KCZ A;  4HLM A;  3KR8 A;  5ADQ A;  2GMV A;  4LI8 A;  4GV4 A;  3MOE A;  3UDD A;  4GMW A;  4L2F A;  5LX6 A;  3UH2 A;  4ZZX A;  4LI6 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2QEWA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations